Recognition of a Cysteine Substrate by E. coliγ-Glutamylcysteine Synthetase Probed by Sulfoximine-based Transition-state Analogue Inhibitors

Bioscience, Biotechnology and Biochemistry

Volumn 66, Issue 7, 2002, Pages 1500-1514

  Hiratake, Jun ^a   Irie, Takayuki ^a   Tokutake, Nobuya ^a   Oda, Juni’chi ^a,b  

^a KYOTO UNIVERSITY   (Japan)

^b FUKUI PREFECTURAL UNIVERSITY   (Japan)

Author keywords

E. coli glutamylcysteine synthetase; Substrate specificity; Sulfoximine; Transition state analogue inhibitor; Transition state stabilization

Indexed keywords

BUTHIONINE SULFOXIMINE; CYSTEINE; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; ENZYME INHIBITOR; GLUTAMATE CYSTEINE LIGASE;

ARTICLE; DRUG ANTAGONISM; ENZYME SPECIFICITY; ENZYMOLOGY; ESCHERICHIA COLI; KINETICS; MASS SPECTROMETRY; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYSICAL CHEMISTRY; SYNTHESIS; ULTRAVIOLET SPECTROPHOTOMETRY; X RAY CRYSTALLOGRAPHY;

BUTHIONINE SULFOXIMINE; CHEMISTRY, PHYSICAL; CRYSTALLOGRAPHY, X-RAY; CYSTEINE; ENZYME INHIBITORS; ESCHERICHIA COLI; GLUTAMATE-CYSTEINE LIGASE; INDICATORS AND REAGENTS; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; SPECTROPHOTOMETRY, ULTRAVIOLET; SUBSTRATE SPECIFICITY;

ESCHERICHIA COLI;

EID: 0036654787     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1271/bbb.66.1500     Document Type: Article

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