Structure of the Trypanosoma brucei U6 snRNA gene promoter

Molecular and Biochemical Parasitology

Volumn 88, Issue 1-2, 1997, Pages 13-23

  Nakaar, Valerian ^a   Günzl, Arthur ^a,b   Ullu, Elisabetta ^a   Tschudi, Christian ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

A and B block elements; Transcription; tRNA gene; Trypanosome; U6 snRNA gene

Indexed keywords

RNA POLYMERASE; TRANSCRIPTION FACTOR;

ARTICLE; DNA FLANKING REGION; GENE CONTROL; GENE LOCATION; GENE STRUCTURE; GENETIC TRANSCRIPTION; MUTAGENESIS; PRIORITY JOURNAL; PROMOTER REGION; SACCHAROMYCES CEREVISIAE; TRYPANOSOMA BRUCEI;

ANIMALS; BASE SEQUENCE; DNA, PROTOZOAN; GENES, PROTOZOAN; MOLECULAR SEQUENCE DATA; MUTATION; PLASMIDS; PROMOTER REGIONS (GENETICS); RNA POLYMERASE III; RNA, PROTOZOAN; RNA, SMALL NUCLEAR; TRYPANOSOMA BRUCEI BRUCEI;

SACCHAROMYCES CEREVISIAE; TRYPANOSOMA; TRYPANOSOMA BRUCEI;

EID: 0343417075     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-6851(97)00078-9     Document Type: Article

References (24)

1. Geiduschek EP, Tocchini-Valentini GP. Transcription by RNA polymerase III. Annu Rev Biochem 1988;57:873-914.
2. Willis IM. RNA polymerase III. Eur J Biochem 1993;212:1-11.
3. Hernandez N. Transcription of vertebrate snRNA genes and related genes, in: McKnight S, Yamamoto KR, editors. Transcriptional Regulation. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, 1992:281-313.
4. Ser (formerly designated opal suppressor phosphoserine tRNA) gene is directed by multiple 5′-extragenic regulatory elements. J Biol Chem 1989;264:9696-702.
5. (Ser)Sec gene: a system that combines an internal B box and upstream elements also found in U6 snRNA genes. EMBO J 1991;10:599-606.
6. (Ser)Sec gene activity requires an upstream SPH motif. Nucleic Acids Res 1991;20:203-9.
7. Brow DA, Guthrie C. Transcription of a yeast U6 sn-R N A gene requires a polymerase III promoter element in a novel position. Genes Dev 1990;4:1345-56.
8. Eschenlauer JB, Kaiser MW, Gerlach VL, Brow DA. Architecture of a yeast U6 RNA gene promoter. Mol Cell Biol 1993;13:3015-26.
9. Margottin F, Dujardin G, Gerard M, Egly J-M, Huet J, Sentenac A. Participation of the TATA factor in transcription of the yeast U6 gene by RNA polymerase C. Science 1991;251:424-6.
10. Burnol A-F, Margottin F, Schultz P, Marsolier M-C, Oudet P, Sentenac A. Basal promoter and enhancer element of yeast U6 snRNA gene. J Mol Biol 1993;233:644-58.
11. Burnol A-F, Margottin F, Huet J, Almouzni G, Prioleau M-N, Mechali M, Sentenac A. TFIIIC relieves repression of U6 snRNA transcription by chromatin. Nature 1993;362:475-7.
12. Gerlach VL, Whitehall SK, Geiduschek EP, Brow DA. TFIIIB placement on a yeast U6 RNA gene in vivo is directed primarily by TFIIIC rather than by sequence-specific DNA contacts. Mol Cell Biol 1995;15:1455-66.
13. Marsolier MC, Tanaka S, Livingstone-Zatche JM, Grunstein M, Thoma F, Sentenac A. Genes Dev 1995;9:410-22.
14. Roberts S, Colbert T, Hahn S. TFIIIC determines RNA polymerase III specificity at the TATA-containing yeast U6 promoter. Genes Dev 1995;9:832-42.
15. Fantoni A, Dare AO, Tschudi C. RNA polymerase III-mediated transcription of the trypanosome U2 small nuclear RNA gene is controlled by both intragenic and extragenic regulatory elements. Mol Cell Biol 1994;14:2021-8.
16. Nakaar V, Dare AO, Hong D, Ullu E, Tschudi C. Upstream tRNA genes are essential for expression of small nuclear and cytoplasmic RNA genes in try-panosomes. Mol Cell Biol 1994;14:6736-42.
17. Nakaar V, Tschudi C, Ullu E. An unusual liaison: small nuclear and cytoplasmic RNA genes team up with tRNA genes in trypanosomatid protozoa. Parasitol Today 1995;11:225-8.
18. Kunkel TA. Rapid and efficient site-specific mutagenesis without phenotypic selection. Proc Natl Acad Sci USA 1985;82:488-92.
19. Gunzl A, Tschudi C, Nakaar V, Ullu E. Accurate transcription of the Trypanosoma brucei U2 small nuclear RNA gene in a homologous extract. J Biol Chem 1995;270:17287-91.
20. Goomer RS, Kunkel GR. The transcriptional start site for a human U6 small nuclear RNA gene is dictated by a compound promoter element consisting of the PSE and the TATA box. Nucleic Acids Res 1992;20: 49034912.
21. Ullu E, Weiner AM. Upstream sequences modulate the internal promoter of the human 7SL RNA gene. Nature 1985;318:371-4.
22. Cannon RE, Wu GJ, Railey JF. Functions of and interactions between the A and B blocks in adenovirus type 2-specific VARNA1 gene. Proc Natl Acad Sci USA 1986;83:1285-9.
23. Fabrizio P, Coppo A, Fruscoloni P, Benedetti P, Di Segni G, TocchiniValentini GP. Comparative mutational analysis of wild-type and stretched tRNA31eu gene promoters. Proc Natl Acad Sci USA 1987;84:8763-7.
24. Sherman D, Janz L, Hug M, Clayton C. Anatomy of the parp gene promoter of Trypanosoma brucei. EMBO J 1991;10:3379-86.