Bilateral microinjections of vigabatrin in the central piriform cortex retard amygdala kindling in rats

Neuroscience

Volumn 129, Issue 2, 2004, Pages 425-429

  Schwabe, K ^a   Ebert, U ^a   Loscher W ^a  

^a UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

Author keywords

epilepsy; epileptogenesis; GABA; seizures

Indexed keywords

4 AMINOBUTYRIC ACID; VIGABATRIN;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; KINDLING; NONHUMAN; PRIORITY JOURNAL; PYRIFORM CORTEX; RAT; SEIZURE; STIMULATION;

AMYGDALA; ANIMALS; ANTICONVULSANTS; ELECTRODES, IMPLANTED; FEMALE; GABA AGONISTS; GAMMA-AMINOBUTYRIC ACID; KINDLING, NEUROLOGIC; MICROINJECTIONS; OLFACTORY PATHWAYS; RATS; RATS, WISTAR; SEIZURES; VIGABATRIN;

EID: 6344226563     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2004.08.013     Document Type: Article

References (19)

1. K. Gale Role of the substantia nigra in the anticonvulsant actions of GABAergic drugs R.G. Fariello P.L. Morselli K.G. Lloyd L.F. Quesney J.J. Engel Neurotransmitters, seizures, and epilepsy II 1984 Raven Press New York 57 79
2. M. Gernert, P. Bloms-Funke, U. Ebert, W. Löscher Kindling causes persistent in vivo changes in firing rates and glutamate sensitivity of central piriform cortex neurons in rats Neuroscience 99 2000 217 227
3. M. Gernert, K.W. Thompson, W. Löscher, A.J. Tobin Genetically engineered GABA-producing cells demonstrate anticonvulsant effects and long-term transgene expression when transplanted into the central piriform cortex of rats Exp Neurol 176 2002 183 192
4. P. Goncalves, R. Insausti, T. Salmenpera, R. Kalviainen, A. Pitkänen MR volumetric analysis of the piriform cortex and cortical amygdala in chronic temporal lobe epilepsy Epilepsia 43 Suppl 8 2002 163
5. L.B. Haberly Parallel-distributed processing in olfactory cortex: new insights from morphological and physiological analysis of neuronal circuitry Chem Senses 26 2001 551 576
6. H. Lehmann, U. Ebert, W. Löscher Amygdala-kindling induces a lasting reduction of GABA-immunoreactive neurons in a discrete area of the ipsilateral piriform cortex Synapse 29 1998 299 309
7. W. Löscher, S. Czuczwar, R. Jäckel, M. Schwarz Effect of microinjections of g-vinyl GABA or isoniazid into substantia nigra on the development of amygdala kindling in rats Exp Neurol 95 1987 622 638
8. W. Löscher, U. Ebert The role of the piriform cortex in kindling Prog Neurobiol 50 1996 427 481
9. W. Löscher, U. Ebert Basic mechanisms of seizure propagation: targets for rational drug design and rational polypharmacy Epilepsy Res Suppl 11 1996 17 44
10. W. Löscher, H. Lehmann, U. Ebert Differences in the distribution of GABA- and GAD-immunoreactive neurons in the anterior and posterior piriform cortex of rats Brain Res 800 1998 21 31
11. D.C. McIntyre, M.E. Kelly The parahippocampal cortices and kindling Ann NY Acad Sci 911 2000 343 354
12. M.J. Neal, M.A. Shah Development of tolerance to the effects of vigabatrin (gamma-vinyl-GABA) on GABA release from rat cerebral cortex, spinal cord and retina Br J Pharmacol 100 1990 324 328
13. th edition 1998 Academic Press Sydney
14. R.J. Racine Modification of seizure activity by electrical stimulation: II Motor seizure. Electroenceph Clin Neurophysiol 32 1972 281 294
15. C. Rundfeldt, W. Löscher Development of tolerance to the anticonvulsant effect of vigabatrin in amygdala-kindled rats Eur J Pharmacol 213 1992 351 366
16. Schwabe K, Ebert U, Löscher W (2004) The central piriform cortex: anatomical connections and anticonvulsant effect of GABA elevation in the kindling model. Neuroscience 126:727-741.
17. K. Schwabe, U. Ebert, W. Löscher Bilateral lesions of the central but not anterior or posterior parts of the piriform cortex retard amygdala kindling in rats Neuroscience 101 2000 513 521
18. C. Shin, L.C. Rigsbee, J.O. McNamara Anti-seizure and anti-epileptogenic effect of gamma-vinyl gamma-aminobutyric acid in amygdaloid kindling Brain Res 398 1986 370 374
19. D.A. Wilson, R.J. Stevenson The fundamental role of memory in olfactory perception Trends Neurosci 26 2003 243 247