Amygdala-kindling induces a lasting reduction of GABA-immunoreactive neurons in a discrete area of the ipsilateral piriform cortex

Synapse

Volumn 29, Issue 4, 1998, Pages 299-309

  Lehmann, Holger ^a   Ebert, Ulrich ^a   Löscher, Wolfgang ^a  

^a UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

Author keywords

Epilepsy; GABA; Immunohistochemistry; Kindling; Rats; Seizures

Indexed keywords

4 AMINOBUTYRIC ACID; ANTICONVULSIVE AGENT;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ELECTROSTIMULATION; EPILEPSY; FEMALE; GABAERGIC TRANSMISSION; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; NEUROCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; PYRIFORM CORTEX; RAT; SEIZURE;

AMYGDALA; ANIMALS; CEREBRAL CORTEX; ELECTRIC STIMULATION; FEMALE; GAMMA-AMINOBUTYRIC ACID; IMMUNOHISTOCHEMISTRY; KINDLING, NEUROLOGIC; NEURONS; RATS; RATS, WISTAR;

EID: 0031870728     PISSN: 08874476     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2396(199808)29:4<299::AID-SYN2>3.0.CO;2-0     Document Type: Article

References (44)

1. Babb, T.L., Pretorius, J.K., Kupfer, W.R., and Feldblum, S. (1989) Recovery of decreased glutamate decarboxylase immunoreactivity after rat hippocampal kindling. Epilepsy Res., 3:18-30.
2. Bradford, H.F. (1995) Glutamate, GABA and epilepsy. Progr. Neurobiol. 47:477-511.
3. Burnham, W.M. (1989) The GABA hypothesis of kindling: recent assay studies. Neurosci. Biobehav. Rev., 13:281-288.
4. Cain, D.P., Corcoran, M.E., Desborough, K.A., and McKitrick, D.J. (1988) Kindling in the deep prepyriform cortex of the rat. Exp. Neurol., 100:203-209.
5. Callahan, P.M., Paris, J.M., Cunningham, K.A., and Shinnick-Gallagher, P. (1991) Decrease of GABA-immunoreactive neurons in the amygdala after electrical kindling in the rat. Brain Res., 555:335-339.
6. Cavazos, J.E., Das, I., and Sutula, T.P. (1994) Neuronal loss induced in limbic pathways by kindling: Evidence for induction of hippocampal sclerosis by repeated brief seizures. J. Neurosci., 14:3106-3121.
7. De Curtis, M., Biella, G., Forti, M., and Panzica, F. (1994) Multifocal spontaneous epileptic activity induced by restricted bicuculline ejection in the piriform cortex of the isolated guinea pig brain. J. Neurophysiol., 71:2463-2476.
8. During, M.J., Ryder, K.M., and Spencer, D.D. (1995) Hippocampal GABA transporter function in temporal-lobe epilepsy. Nature, 376: 174-177.
9. Ebert, U., and Löscher, W. (1995) Strong induction of c-fos in the piriform cortex during focal seizures evoked from different limbic brain sites. Brain Res., 671:338-344.
10. Ebert, U., Schoen, S.W., and Löscher, W. (1996) Remote activation of microglia in the ventral posterior thalamic nuclei by kindling electrodes. Neuroforum, 2 (Suppl.) H:155.
11. Freeman, F.G., and Jarvis, M.F. (1981) The effect of interstimulation interval on the assessment and stability of kindled seizure threshold. Brain Res. Bull., 7:629-633.
12. Gale, K. (1988) Progression and generalization of seizure discharge: Anatomical and neurochemical substrates. Epilepsia, 29(Suppl. 2):S15-S34.
13. Glass, M., and Dragunow, M. (1995) Neurochemical and morphological changes associated with human epilepsy. Brain Res. Rev., 21:29-41.
14. Haberly, L.B., and Price, J.L. (1978) Association and commissural fiber systems of the olfactory cortex of the rat. I. Systems originating in the piriform cortex and adjacent areas. J. Comp. Neurol., 178:711-740.
15. Haberly, L.B., and Sutula, T.P. (1992) Neuronal processes that underlie expression of kindled epileptiform events in the piriform cortex in vivo. J. Neurosci., 12:2211-2224.
16. Halonen, T., Tortorella, A., Zrebeet, H., and Gale, K. (1994) Posterior piriform and perirhinal cortex relay seizures evoked from the area tempestas: Role of excitatory and inhibitory amino acid receptors. Brain Res., 652:145-148.
17. Hönack, D., Wahnschaffe, U., and Löscher, W. (1991) Kindling from stimulation of a highly sensitive locus in the posterior part of the piriform cortex. Comparison with amygdala kindling and effects of antiepileptic drugs. Brain Res., 538:196-202.
18. Houser, C.R. (1991) GABA neurons in seizure disorders: A review of immunocytochemical studies. Neurochem. Res., 16:295-308.
19. Itagaki, S., and Kimura, H. (1986) Retardation of GABA-transaminase in some brain regions of amygdala-kindled rats. Brain Res., 381:77-84.
20. Kamphuis, W, and Lopes Da Silva, F.H. (1990) The kindling model of epilepsy: The role of GABAergic inhibition. Neurosci. Res. Commun., 6:1-10.
21. Kamphuis, W., Wadman, W.J., Buijs, R.M., and Lopes Da Silva, F.H. (1986) Decrease in number of hippocampal gamma-aminobutyric acid (GABA) immunoreactive cells in the rat kindling model of epilepsy. Exp. Brain Res., 64:491-495.
22. Kamphuis, W., Huisman, E., Wadman, W.J., and Lopes Da Silva, F.H. (1989) Decrease in GABA immunoreactivity and alterations of GABA metabolism after kindling in the rat hippocampus. Exp. Brain Res., 74:375-386.
23. Kaura, S., Bradford, H.F., Young, A.M.J., Croucher, M.J., and Hughes, P.D. (1995) Effect of amygdaloid kindling on the content and release of amino acids from the amygdaloid complex: In vivo and in vitro studies. J. Neurochem., 65:1240-1249.
24. Lehmann, H., Ebert, U., and Löscher, W. (1996) Immunocytochemical localization of GABA immunoreactivity in dentate granule cells of normal and kindled rats. Neurosci. Lett., 212:41-44.
25. Löscher, W. (1989) GABA and the epilepsies. Experimental and clinical considerations. In: GABA. Basic Research and Clinical Applications. 260-300. N.G. Bowery and G. Nistico, eds. Rome, Pythagora Press, pp 260-300.
26. Löscher, W. (1993) Basic aspects of epilepsy. Curr. Opin. Neurol. Neurosurg., 6:223-232.
27. Löscher, W., and Ebert, U. (1996) The role of the piriform cortex in kindling. Progr. Neurobiol., 50:427-481.
28. Löscher, W., and Schwark, W.S. (1987) Further evidence for abnormal GABAergic circuits in amygdala-kindled rats. Brain Res., 420:385-390.
29. Löscher, W., Ebert, U., Wahnschaffe, U., and Rundfeldt, C. (1995) Susceptibility of different cell layers of the anterior and posterior part of the piriform cortex to electrical stimulation and kindling: Comparison with the basolateral amygdala and "area tempestas." Neuroscience, 66:265-276.
30. Lothman, E.W. (1992) Basic mechanisms of the epilepsies. Curr. Opin. Neurol. Neurosurg., 5:216-223.
31. Lothman, E.W., Bertram, E.H., and Stringer, J.L. (1991) Functional anatomy of hippocampal seizures. Prog. Neurobiol., 37:1-82.
32. Ludvig, N., and Moshé, S.L. (1988) Deep prepiriform cortex lesion and development of amygdala kindling. Epilepsia, 29:401-403.
33. McNamara, J.O. (1984) Kindling: An animal model of complex partial epilepsy. Ann. Neurol., 16(Suppl):S72-S76.
34. Morimoto, K. (1989) Seizure-triggering mechanisms in the kindling model of epilepsy: Collapse of GABA-mediated inhibition and activation of NMDA receptors. Neurosci. Biobehav. Rev., 13:253-260.
35. Oertel, W.H., Schmechel, D.E., Tappaz, M.L., and Kopin, I.J. (1981) Production of a specific antiserum to rat brain glutamic acid decarboxylase by injection of an antigen-antibody complex. Neuroscience, 6:2689-2700.
36. Paxinos, G., and Watson, C. (1986) The Rat Brain in Stereotaxic Coordinates, 2nd ed. Sydney, Academic Press.
37. Racine, R.J. (1972) Modification of seizure activity by electrical stimulation: II. Motor seizure. Electroencephalogr. Clin. Neurophysiol., 32:281-294.
38. Racine, R.J., Ivy, G.O., and Milgram, N.W. (1989) Kindling: Clinical relevance and anatomical substrate. In: The Clinical Relevance of Kindling. T.G. Bolwig, and M.R. Trimble, Chichester, John Wiley & Sons, pp 15-34.
39. Rainnie, D.G., Asprodini, E.K., and Shinnick-Gallagher, P. (1992) Kindling-induced long-lasting changes in synaptic transmission in the basolateral amygdala. J. Neurophysiol., 67:443-454.
40. Sato, M., Racine, R.J., and McIntyre, D.C. (1990) Kindling: Basic mechanisms and clinical validity. Electroencephalogr. Clin. Neurophysiol., 76:459-472.
41. Sigma Immunochemicals (1993) Product No. A-0310. Monoclonal Anti-GABA, Mouse Ascites Fluid, Clone GB-69. St. Louis, MO, Sigma Publications; Sigma Chemical Company.
42. 28k) and glutamate decarboxylase gene expression after kindling induced seizures. Mol. Brain Res., 9:179-190.
43. Wahnschaffe, U., Ebert, U., and Löscher, W. (1993) The effect of lesions of the posterior piriform cortex on amygdala kindling in the rat. Brain Res., 615:295-303.
44. Wood, J.D., Russell, M.P., Kurylo, E., and Newstead, J.D. (1979) Stability of synaptosomal GABA levels and their use in determining the in vivo effects of drugs: convulsant agents. J. Neurochem., 33:61-68.