Increased densities of monocarboxylate transporter MCT1 after chronic hyperglycemia in rat brain

Brain Research

Volumn 1257, Issue , 2009, Pages 32-39

  Canis, Martin ^a,c   Maurer, Martin H ^a,d   Kuschinsky, Wolfgang ^a   Duembgen, Lutz ^b   Duelli, Roman ^a,e  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b Institute of Mathematical Statistics and Actuarial Science   (Switzerland)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^d SYGNIS Bioscience   (Germany)

^e UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Hyperglycemia; LCGU; MCT1; Streptozotocin

Indexed keywords

GLUCOSE; GLUCOSE TRANSPORTER; LACTIC ACID; MONOCARBOXYLATE TRANSPORTER 1; STREPTOZOCIN; COTRANSPORTER; MONOCARBOXYLATE TRANSPORT PROTEIN 1; MONOCARBOXYLATE TRANSPORTER;

ANALYTICAL PARAMETERS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; AUTORADIOGRAPHY; BRAIN LEVEL; BRAIN NERVE CELL; BRAIN REGION; BRAIN TISSUE; CHRONIC HYPERGLYCEMIA; CONTROLLED STUDY; ENDOTHELIUM CELL; GLUCOSE UTILIZATION; HYPERGLYCEMIA; IMMUNOCYTOCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; UPREGULATION; ANIMAL; BRAIN; CHEMICALLY INDUCED DISORDER; CHRONIC DISEASE; IMMUNOHISTOCHEMISTRY; METABOLISM; SPRAGUE DAWLEY RAT;

RATTUS;

ANIMALS; AUTORADIOGRAPHY; BRAIN; CHRONIC DISEASE; GLUCOSE; HYPERGLYCEMIA; IMMUNOHISTOCHEMISTRY; MONOCARBOXYLIC ACID TRANSPORTERS; RATS; RATS, SPRAGUE-DAWLEY; STREPTOZOCIN; SYMPORTERS; UP-REGULATION;

EID: 63349094337     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2008.12.005     Document Type: Article

References (33)

1. Bergersen, L.H., 2006. Lactate in the brain-without turning sour. Tidsskr. Nor. Laegeforen. 126, 2094-2097.
2. Chiry, O., Pellerin, L., Monnet-Tschudi, F., Fishbein, W.N., Merezhinskaya, N., Magistretti, P.J., Clarke, S., 2006. Expression of the monocarboxylate transporter MCT1 in the adult human brain cortex. Brain Res. 1070, 65-70.
3. Duelli, R., Staudt, R., Zeller, K., Kuschinsky, W., 1997. Glucose metabolism and glucose transporter density during chronic hyperglycemia in rat brain. Pflugers Archiv. Eur. J. Physiol. 433 (Suppl. 6), R90.
4. Duelli, R., Staudt, R., Duembgen, L., Kuschinsky, W., 1999. Increase in glucose transporter densities of Glut3 and decrease of glucose utilization in rat brain after one week of hypoglycemia. Brain Res. 831, 254-262.
5. Duelli, R., Maurer, M.H., Staudt, R., Heiland, S., Duembgen, L., Kuschinsky, W., 2000. Increased cerebral glucose utilization and decreased glucose transporter Glut1 during chronic hyperglycemia in rat brain. Brain Res. 858, 338-347.
6. Fuller, W.A., 1987. In: Fuller, W.A. (Ed.), Measurement Error Models. John Wiley, New York, pp. 30-49.
7. Gerhart, D.Z., Enerson, B.E., Zhdankina, O.Y., Leino, R.L., Drewes, L.R., 1997. Expression of monocarboxylate transporter MCT1 by brain endothelium and glia in adult and suckling rats. Am. J. Physiol. 273, 207-213.
8. Halestrap, A.P., Price, N.T., 1999. The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation. Biochem. J. 343, 281-299.
9. Hawkins, R.A., Mans, A.M., 1991. Regional blood-brain barrier transport of ketone bodies in portacaval-shunted rats. Am. J. Physiol. 261, 647-652.
10. Hertz, L., Dienel, G.A., 2005. Lactate transport and transporters: general principles and functional roles in brain cells. J. Neurosci. Res. 79, 11-18.
11. Leino, R.L., Gerhart, D.Z., Drewes, L.R., 1999. Monocarboxylate transporter (MCT1) abundance in brains of suckling and adult rats: a quantitative electron microscopic immunogold study. Brain Res. Dev. Brain Res. 113, 47-54.
12. Leino, R.L., Gerhart, D.Z., Duelli, R., Enerson, B.E., Drewes, L.R., 2001. Diet-induced ketosis increases monocarboxylate transporter (MCT1) levels in rat brain. Neurochem. Int. 38, 519-527.
13. Magistretti, P.J., Pellerin, L., 1996. Cellular bases of brain energy metabolism and their relevance to functional brain imaging: evidence for a prominent role of astrocytes. Cereb. Cortex 6, 50-61.
14. Magistretti, P.J., Pellerin, L., 1999. Astrocytes couple synaptic activity to glucose utilization in the brain. NIPS 14, 177-182.
15. Maurer, M.H., Canis, M., Kuschinsky, W., Duelli, R., 2004. Correlation between local monocarboxylate transporter 1 (MCT1) and glucose transporter 1 (GLUT1) densities in the adult rat brain. Neurosci. Lett. 355, 105-108.
16. McCulloch, J., Kelly, P.A., Ford, I., 1982. Effect of apomorphine on the relationship between local cerebral glucose utilization and local cerebral blood flow (with an appendix on its statistical analysis). J. Cereb. Blood Flow Metab. 2, 487-499.
17. Mitchell, G.A., Kassovska-Bratinova, S., Boukaftane, Y., Robert, M.F., Wang, S.P., Ashmarina, L., Lambert, M., Lapierre, P., Potier, E., 1995. Medical aspects of ketone body metabolism. Clin. Invest. Med. 18, 193-216.
18. Nehlig, A., Pereira de Vasconcelos, A., 1993. Glucose and ketone body utilization by the brain of neonatal rats. Prog. Neurobiol. 40, 163-221.
19. Pellerin, L., Pellegri, G., Martin, J.L., Magistretti, P.J., 1998. Expression of monocarboxylate transporter mRNAs in mouse brain: support for a distinct role of lactate as an energy substrate for the neonatal vs. adult brain. Proc. Natl. Acad. Sci. U. S. A. 95, 3990-3995.
20. Pellerin, L., Bergersen, L.H., Halestrap, A.P., Pierre, K., 2005. Cellular and subcellular distribution of monocarboxylate transporters in cultured brain cells and in the adult brain. J. Neurosci. Res. 79, 55-64.
21. Pierre, K., Pellerin, L., 2005. Monocarboxylate transporters in the central nervous system: distribution, regulation and function. J. Neurochem. 94, 1-14.
22. Pierre, K., Parent, A., Jayet, P.Y., Halestrap, A.P., Scherrer, U., Pellerin, L., 2007. Enhanced expression of three monocarboxylate transporter isoforms in the brain of obese mice. J. Physiol. 583, 469-486.
23. Price, N.T., Jackson, V.N., Halestrap, A.P., 1998. Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past. Biochem. J. 329, 321-328.
24. Puchowicz, M.A., Xu, K., Sun, X., Ivy, A., Emancipator, D., LaManna, J.C., 2007. Diet-induced ketosis increases capillary density without altered blood flow in rat brain. Am. J. Physiol. Endocrinol. Metab. 292 (6), E1607-E1615.
25. Py, G., Lambert, K., Milhavet, O., Eydoux, N., Prefaut, C., Mercier, J., 2002. Effects of streptozotocin-induced diabetes on markers of skeletal muscle metabolism and monocarboxylate transporter 1 to monocarboxylate transporter 4 transporters. Metabolism 51, 807-813.
26. Salceda, R., Vilchis, C., Coffe, V., Hernandez-Munoz, R., 1998. Changes in the redox state in the retina and brain during the onset of diabetes in rats. Neurochem. Res. 23, 893-897.
27. Sokoloff, L., Reivich, M., Kennedy, C., Des-Rosiers, M.H., Patlak, C.S., Pettigrew, K.D., Sakurada, O., Shinohara, M., 1977. The [14C]deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat. J. Neurochem. 28, 897-916.
28. Tsacopoulos, M., Magistretti, P.J., 1996. Metabolic coupling between glia and neurons. J. Neurosci. 16, 877-885.
29. Vannucci, S.J., Simpson, I.A., 2003. Developmental switch in brain nutrient transporter expression in the rat. Am. J. Physiol. Endocrinol. Metab. 285, E1127-E1134.
30. Vannucci, S.J., Maher, F., Simpson, I.A., 1997. Glucose transporter proteins in brain: delivery of glucose to neurons and glia. Glia 21, 2-21.
31. Zeller, K., Duelli, R., Vogel, J., Kuschinsky, W., 1995a. Distribution of Glut3 in different brain structures shown by a new autoradiographic method. Pflugers Archiv. Eur. J. Physiol. 429 (Suppl. 6), R63.
32. Zeller, K., Duelli, R., Vogel, J., Schrock, H., Kuschinsky, W., 1995b. Autoradiographic analysis of the regional distribution of Glut3 glucose transporters in the rat brain. Brain Res. 698, 175-179.
33. Zeller, K., Rahner-Welsch, S., Kuschinsky, W., 1997. Distribution of Glut1 glucose transporters in different brain structures compared to glucose utilization and capillary density of adult rat brains. J. Cereb. Blood Flow Metab. 17, 204-209.