Lactate in the brain - Without turning sour;Laktat i hjernen - Uten å surne

Tidsskrift for den Norske Laegeforening

Volumn 126, Issue 16, 2006, Pages 2094-2097

  Bergersen, Linda Hildegard ^a  

^a UNIVERSITY OF OSLO   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; KETONE BODY; LACTIC ACID; MEMBRANE PROTEIN; MONOCARBOXYLATE TRANSPORTER; PROTEIN MONOCARBOXYLATE TRANSPORTER 1; PROTEIN MONOCARBOXYLATE TRANSPORTER 2; PROTEIN MONOCARBOXYLATE TRANSPORTER 3; PROTEIN MONOCARBOXYLATE TRANSPORTER 4; PROTON; UNCLASSIFIED DRUG;

AEROBIC METABOLISM; ASTROCYTE; BRAIN CELL; BRAIN DEVELOPMENT; CELL MEMBRANE TRANSPORT; CELL PH; CIRCULATION; DIABETES MELLITUS; ENERGY METABOLISM; GLUCOSE BRAIN LEVEL; HUMAN; HYPOGLYCEMIA; NERVE CELL; PHYSICAL ACTIVITY; PROTEIN EXPRESSION; REST; REVIEW; STARVATION;

ASTROCYTES; BRAIN; ENERGY METABOLISM; HUMANS; LACTATES; MONOCARBOXYLIC ACID TRANSPORTERS; NEUROGLIA; NEURONS;

EID: 33748071455     PISSN: 00292001     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (27)

1. Aubert A, Costalat R, Magistretti PJ et al. Brain lactate kinetics: modeling evidence for neuronal lactate uptake upon activation. Proc Natl Acad Sci 2005; 102: 16448-53.
2. Pellerin L, Bergersen LH, Halestrap A P et al. Cellular and subcellular distribution of monocarboxylate transporters in cultured brain cells and in the adult brain. J Neurosci Res 2005; 79: 55-64.
3. Cremer JE. Substrate utilization and brain development. J Cereb Blood Flow Metab 1982; 2: 394-407.
4. Schurr A, Payne RS, Tseng MT et al. The glucose paradox in cerebral ischemia. New insights. Ann N Y Acad Sci 1999; 893: 386-90.
5. Schurr A, Payne RS, Miller JJ et al. Blockade of lactate transport exacerbates delayed neuronal damage in a rat model of cerebral ischemia. Brain Res 2001; 895: 268-72.
6. Dalsgaard MK, Quistorff B, Danielsen ER et al. A reduced cerebral metabolic ratio in exercise reflects metabolism and not accumulation of lactate within the human brain. J Physiol 2003; 554: 571-8.
7. Hassel B, Brathe A. Cerebral metabolism of lactate in vivo: evidence for neuronal pyruvate carboxylation. J Cereb Blood Flow Metab 2000; 20: 327-36.
8. Pellerin L, Pellegri G, Martin JL et al. Expression of monocarboxylate transporter mRNAs in mouse brain: support for a distinct role of lactate as an energy substrate for the neonatal vs. adult brain. Proc Natl Acad Sci USA 1998; 95: 3990-5.
9. Pellerin L, Magistretti PJ. Food for thought: challenging the dogmas. J Cereb Blood Flow Metab 2003; 23: 1282-6.
10. Brown AM, Wender R, Ransom BR. Metabolic substrates other than glucose support axon function in central white matter. J Neurosci Res 2001; 66: 839-43.
11. Cater HL, Chandratheva A, Benham CD et al. Lactate and glucose as energy substrates during, and after, oxygen deprivation in rat hippocampal acute and cultured slices. J Neurochem 2003; 87: 1381-90.
12. Allen NJ, Karadottir R, Attwell D. A preferential role for glycolysis in preventing the anoxic depolarization of rat hippocampal area CA1 pyramidal cells. J Neurosci 2005; 26: 848-59.
13. Cater HL, Benham CD, Sundstrom LE. Neuroprotective role of monocarboxylate transport during glucose deprivation in slice cultures of rat hippocampus. J Physiol 2001; 531: 459-66.
14. Gladden LB. Lactate metabolism: a new paradigm for the third millennium. J Physiol 2004; 558: 5-30.
15. Poole RC, Halestrap AP. Transport of lactate and other monocarboxylates across mammalian plasma membranes. Am J Physiol 1993; 264: C761-82.
16. Halestrap AP, Meredith D. The SLC16 gene family - from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. Pflugers Arch 2004; 447: 619-28.
17. Bergersen L, Wærhaug O, Helm J et al. A novel postsynaptic density protein: the monocarboxylate transporter MCT2 is colocalized with o 2 glutamate receptors in postsynaptic densities of parallel fiber-Purkinje cell synapses. Exp Brain Res 2001; 136: 523-34.
18. Rafiki A, Boulland JL, Halestrap AP et al. Highly differential expression of the monocarboxylate transporters MCT2 and MCT4 in the developing rat brain. Neuroscience 2003; 122: 677-88.
19. Bergersen LH, Magistretti PJ, Pellerin L. Selective postsynaptic co-localization of MCT2 with AMPA receptor GluR2/3 subunits at excitatory synapses exhibiting AMPA receptor trafficking. Cereb Cortex 2005; 15: 361-70.
20. Bergersen LH, Thomas M, Johannsson E et al. Cross-reinnervation changes the expression patterns of the monocarboxylate transporters MCT1 and MCT4: an experimental study in slow and fast rat skeletal muscle. Neuroscience 2006; 138: 1005-13.
21. Johannsson E, Lunde PK, Heddle C et al. Upregulation of the cardiac monocarboxylate transporter MCT1 in a rat model of congestive heart failure. Circulation 2001; 104: 729-34.
22. Bergersen L, Rafiki A, Ottersen OP. Immunogold cytochemistry identifies specialized membrane domains for monocarboxylate transport in the central nervous system. Neurochem Res 2002; 27: 89-96.
23. Pierre K, Pellerin L. Monocarboxylate transporters in the central nervous system: distribution, regulation and function. J Neurochem 2005; 94: 1-14.
24. Attwell D, Laughlin SB. An energy budget for signaling in the grey matter of the brain. J Cereb Blood Flow Metab 2001; 21: 1133-45.
25. Bliss TM, Sapolsky RM. Interactions among glucose, lactate and adenosine regulate energy substrate utilization in hippocampal cultures. Brain Res 2001; 899: 134-41.
26. Cronberg T, Rytter A, Asztely F et al. Glucose but not lactate in combination with acidosis aggravates ischemic neuronal death in vitro. Stroke 2004; 35: 753-7.
27. Pilegaard H, Terzis G, Halestrap A et al. Distribution of the lactate/H+ transporter isoforms MCT1 and MCT4 in human skeletal muscle. Am J Physiol 1999; 276: 843-8.