The effects of physical exercise on plasma levels of relaxin, NTproANP, and NTproBNP in patients with ischemic heart disease

European Journal of Medical Research

Volumn 14, Issue 3, 2009, Pages 106-112

  Heringlake, Matthias ^a   Kox, T ^b   Poeling, J ^b   Klaus, S ^c   Hanke, T ^a   Franz, N ^b   Eberhardt, F ^a   Heinze, H ^a   Armbruster, F P ^d   Bahlmann, L ^e  

^a UNIVERSITY OF LÜBECK   (Germany)

^b Schuchtermann Klinik   (Germany)

^c Herz Jesu Krankenhaus   (Germany)

^d IMMUNDIAGNOSTIK AG   (Germany)

^e Krankenhaus Weser Egge   (Germany)

Author keywords

Cardiorenal integration; Coronary artery disease; Heart failure; Hemodynamics; Natriuretic peptides; Right heart catheterization

Indexed keywords

ATRIAL NATRIURETIC FACTOR; BRAIN NATRIURETIC PEPTIDE; POLYPEPTIDE; RELAXIN;

AGED; ARTICLE; BICYCLE ERGOMETRY; CARDIOPULMONARY FUNCTION; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE MARKER; DISEASE SEVERITY; EXERCISE; HEART CATHETERIZATION; HEART FAILURE; HEART OUTPUT; HORMONE BLOOD LEVEL; HORMONE DETERMINATION; HUMAN; ISCHEMIC HEART DISEASE; MALE; PROGNOSIS; VASODILATATION;

EID: 63349088246     PISSN: 09492321     EISSN: None     Source Type: Journal    
DOI: 10.1186/2047-783x-14-3-106     Document Type: Article

References (16)

1. Conrad KP, Nowak J. Emerging role of relaxin in renal and cardiovascular function. Am J Physiol Regul Integr Comp Physiol 287: 250-261, 2004.
2. Fisher C, MacLean M, Morecroft I, Seed A, Johnston F, Hillier C, McMurray J. Is the pregnancy hormone relaxin also a vasodilator peptide secreted by the heart? Circulation 106:292-295, 2002.
3. Dschietzig T, Richter C, Bartsch C, Laule M, Armbruster FP, Baumann G, Stangl K. The pregnancy hormone relaxin is a player in human heart failure. FASEB J 15:2187-2195, 2001.
4. Fisher C, Berry C, Blue L, Morton JJ, McMurray J. N-terminal pro B type natriuretic peptide, but not the new putative cardiac hormone relaxin, predicts prognosis in patients with chronic heart failure. Heart 89: 879-881, 2003.
5. Kupari M, Mikkola TS, Turto H, Lommi J. Is the pregnancy hormone relaxin an important player in human heart failure? Eur J Heart Fail 7: 195-198, 2005.
6. Krüger S, Graf J, Merx MW, Sttckel T, Kunz D, Hanrath P, Janssens U. Relaxin kinetics during dynamic exercise in patients with chronic heart failure. Eur J Intern Med 15: 54-56, 2004.
7. Heringlake M, Heide C, Bahlmann L, Eichler W, Pagel H, Schmucker P, Wergeland R, Armbruster FP, Klaus S. Effects of tilting and volume loading on plasma levels and urinary excretion of relaxin, NT-pro-ANP, and NT-proBNP in male volunteers. J Appl Physiol 97:173-179, 2004.
8. Sundsfjord JA, Thibault G, Larochelle P, Cantin M. Identification and plasma concentrations of the N-terminal fragment of proatrial natriuretic factor in man. J Clin Endocrinol Metab 66: 605-610, 1988.
9. Mueller T, Gegenhuber A, Poelz W, Haltmayer M. Comparison of the Biomedica NT-proBNP enzyme immunoassay and the Roche NTproBNP chemiluminescence immunoassay: implications for the prediction of symptomatic and asymptomatic structural heart disease. Clin Chem 49: 976-979, 2003.
10. Williams SG, Cooke GA, Wright DJ, Parsons WJ, Riley RL, Marshall P, Tan LB. Peak exercise cardiac power output - A direct indicator of cardiac function strongly predictive of prognosis in chronic heart failure. Eur Heart J 22: 1496-1503, 2001.
11. Bromley PD, Hodges LD, Brodie DA. Physiological range of peak cardiac power output in healthy adults. Clin Physiol Funct Imaging 26: 240-246, 2006.
12. Szepietowska B, Gorska M, Szelachowska M. Plasma relaxin concentration is related to beta-cell function and insulin sensitivity in women with type 2 diabetes mellitus. Diabetes Res Clin Pract 79: 1-3, 2008.
13. Schöndorf T, Lübben G, Hoopmann M, Borchert M, Forst T, Hohberg C, Löbig M, Armbruster FP, Roth W, Grabellus M, Pfützner A. Relaxin expression correlates significantly with serum fibrinogen variation in response to antidiabetic treatment in women with type 2 diabetes mellitus. Gynecol Endocrinol 23: 356-60, 2007.
14. Dschietzig T, Bartsch C, Kinkel T, Baumann G, Stangl K. Myocardial relaxin counteracts hypertrophy in hypertensive rats. Ann N Y Acad Sci 1041: 441-443, 2005.
15. Scharhag J, Herrmann M, Weissinger M, Herrmann, W, Kindermann W. N-terminal B-type natriuretic peptide concentrations are similarly increased by 30 minutes of moderate and brisk walking in patients with coronary artery disease. Clin Res Cardiol 96: 218-226, 2007.
16. Kato M, Kinugawa T, Omodani H, Osaki S, Ogino K, Hisatome I, Miyakoda H, Fujimoto Y. Augmented response in plasma atrial natriuretic peptide to dynamic exercise in patients with congestive heart failure. Jpn Circ J 60: 909-916, 1996.