Metformin and atorvastatin reduce adhesion formation in a rat uterine horn model

Reproductive BioMedicine Online

Volumn 18, Issue 3, 2009, Pages 436-442

  Yilmaz, Bulent ^a   Aksakal, Orhan ^a   Gungor, Tayfun ^a   Sirvan, Levent ^a   Sut, Necdet ^b   Kelekci, Sefa ^c   Soysal, Sunullah ^a   Mollamahmutoglu, Leyla ^a  

^a ZEKAI TAHIR BURAK WOMEN S HEALTH EDUCATION AND RESEARCH HOSPITAL   (Turkey)

^b TRAKYA UNIVERSITY FACULTY OF MEDICINE   (Turkey)

^c Numune Education and Research Hospital   (Turkey)

Author keywords

Adhesion prevention; Atorvastatin; Metformin; Rat; Uterine horn model

Indexed keywords

ATORVASTATIN; METFORMIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAUTERIZATION; CONTROLLED STUDY; DISEASE SEVERITY; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG MEGADOSE; FEMALE; FIBROSIS; HISTOPATHOLOGY; INFLAMMATION; LOW DRUG DOSE; NONHUMAN; OUTCOME ASSESSMENT; PERITONEUM ADHESION; RAT; UTERUS HORN; UTERUS SYNECHIA;

EID: 63249134729     PISSN: 14726483     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1472-6483(10)60106-X     Document Type: Article

References (52)

1. Aarons CB, Cohen PA, Gower A et al. 2007 Statins (HMG-CoA reductase inhibitors) decrease postoperative adhesions by increasing peritoneal fibrinolytic activity. Annals of Surgery 245, 176-184.
2. Al-Chalabi HA, Otubo JA. 1987 Value of a single intraperitoneal dose of heparin in prevention of adhesion formation: an experimental evaluation in rats. International Journal of Fertility 32, 332-335.
3. Basbug M, Aygen E, Tayyar M et al. 1998 Hyaluronic acid plus heparin for improved efficacy in prevention of adhesion formation in rat uterine horn model. European Journal of Obstetrics, Gynecology and Reproductive Biology 78, 109-112.
4. Bell PM, Hadden DR 1997 Metformin. Endocrinology and Metabolism Clinics of North America 26, 523-537.
5. Bruni F, Pasqui AL, Pastorelli M et al. 2004 Effect of atorvastatin on different fibrinolysis mechanisms in hypercholesterolemic subjects. International Journal of Cardiology 95, 269-274.
6. Cheong YC, Laird SM, Li TC et al. 2001 Peritoneal healing and adhesion formation/reformation. Human Reproduction Update 7, 556-566.
7. Coll B, van Wijk JP, Parra S et al. 2006 Effects of rosiglitazone and metformin on postprandial paraoxonase-1 and monocyte chemoattractant protein-1 in human immunodeficiency virus-infected patients with lipodystrophy. European Journal of Pharmacology 544, 104-110.
8. Detaille D, Guigas B, Chauvin C et al. 2005 Metformin prevents high-glucose-induced endothelial cell death through a mitochondrial permeability transition-dependent process. Diabetes 54, 2179-2187.
9. diZerega GS 2000 Peritoneal Surgery. Springer, New York.
10. diZerega GS, Campeau JD 2001 Peritoneal repair and post-surgical adhesion formation. Human Reproduction Update 7, 547-555.
11. Ellis H 1997 The clinical significance of adhesions: focus on intestinal obstruction. European Journal of Surgery 577 (Suppl.), 5-9.
12. Ellis H, Moran BJ, Thompson JN et al. 1999 Adhesion-related hospital readmissions after abdominal and pelvic surgery: a prospective cohort study. Lancet 353, 1476-1480.
13. Falk K, Bjorquist P, Stromqvist M et al. 2001 Reduction of experimental adhesion formation by inhibition of plasminogen activator inhibitor type 1. British Journal of Surgery 88, 286-289.
14. Gin H, Roudaut MF, Vergnot V et al. 2003 Effect of metformin on fibrinolytic parameters in insulin-treated, type 2 diabetic patients. Diabetes and Metabolism 29, 505-508.
15. Golan A, Maymon R, Winograd I et al. 1995 Prevention of post-surgical adhesion formation using aspirin in a rodent model: a preliminary report. Human Reproduction 10, 1797-1800.
16. Gómez-García A, Martínez Torres G, Ortega-Pierres LE et al. 2007 Rosuvastatin and metformin decrease inflammation and oxidative stress in patients with hypertension and dyslipidemia. Revista Española de Cardiología 60, 1242-1249.
17. Grant P 1996 The effects of high- and medium-dose metformin therapy on cardiovascular risk factors in patients with type 2 diabetes. Diabetes Care 19, 64-66.
18. Haslinger B, Goedde MF, Toet KH et al. 2002 Simvastatin increases fibrinolytic activity in human peritoneal mesothelial cells independent of cholesterol lowering. Kidney International 62, 1611-1619.
19. Hattori Y, Suzuki K, Hattori S et al. 2006 Metformin inhibits cytokine-induced nuclear factor kappa B activation via AMP activated protein kinase activation in vascular endothelial cells. Hypertension 47, 1183-1188.
20. Hellebrekers BWJ, Trimbos-Kemper TCM, Trimbos JBMZ et al. 2000 Use of fibrinolytic agents in the prevention of postoperative adhesion formation. Fertility and Sterility 74, 203-212.
21. Holmdahl L, Falkenberg M, Ivarsson ML et al. 1997 Plasminogen activators and inhibitors in peritoneal tissue. APMIS: acta pathologica, microbiologica, et immunologica Scandinavica 105, 25-30.
22. Hooker GD, Taylor BM, Driman DK 1999 Prevention of adhesion formation with use of sodium hyaluronate-based bioresorbable membrane in a rat model of ventral hernia repair with polypropylene mesh - a randomized, controlled study. Surgery 125, 211-216.
23. Hundal HG, Ramlal T, Reyes R et al. 1992 Cellular mechanism of metformin action involves glucose transporter translocation from an intracellular pool to the plasma membrane in L6 muscle cells. Endocrinology 131, 1165-1173.
24. Keckstein J, Ulrich U, Sasse V et al. 1996 Reduction of postoperative adhesion formation after laparoscopic ovarian cystectomy. Human Reproduction 11, 579-582.
25. Kelekci S, Uygur D, Yilmaz B et al. 2007 Comparison of human amniotic membrane and hyaluronate/carboxymethylcellulose membrane for prevention of adhesion formation in rats. Archives of Gynecology and Obstetrics 276, 355-359.
26. Kelekci S, Yilmaz B, Oguz S et al. 2004 The efficacy of a hyaluronate/carboxymethylcellulose membrane in prevention of postoperative adhesion in a rat uterine horn model. Tohoku Journal of Experimental Medicine 204, 189-194.
27. Klip A, Guma A, Ramlal T et al. 1992 Stimulation of hexose transport by metformin in L6 muscle cells in culture. Endocrinology 130, 2535-2544.
28. Kucuk HF, Kaptanoglu L, Kurt N et al. 2007 The role of simvastatin on postoperative peritoneal adhesion formation in an animal model. European Surgical Research 39, 98-102.
29. Landin K, Tengborn L, Smith U 1994 Effects of metformin and metoprolol CR on hormones and fibrinolytic variables during a hyperinsulinemic euglycemic clamp in man. Thrombosis and Haemostasis 71, 783-787.
30. Leach RE, Burns JW, Dawe EJ et al. 1998 Reduction of postsurgical adhesion formation in the rabbit uterine horn model with use of hyaluronate/carboxymethylcellulose gel. Fertility and Sterility 69, 415-418.
31. Liakakos T, Thomakos N, Fine PM et al. 2001 Peritoneal adhesions: etiology, pathophysiology, and clinical significance. Recent advances in prevention and management. Digestive Surgery 18, 260-273.
32. Menzies D 1993 Postoperative adhesions: their treatment and relevance in clinical practice. Annals of the Royal College of Surgeons 75, 147-153.
33. Menzies D 1992 Peritoneal adhesions. Incidence, cause, and prevention. Surgery Annual 24, 27-45.
34. Nagi D, Yudkin J 1993 Effects of metformin on insulin resistance, risk factors for cardiovascular disease, and plasminogen activator inhibitor in NIDDM subjects. A study of two ethnic groups. Diabetes Care 16, 621.
35. Nappi C, Di Spiezio Sardo A, Greco E et al. 2007 Prevention of adhesions in gynaecological endoscopy. Human Reproduction Update 13, 379-394.
36. Nestler JE, Jakubowicz DJ, Evans WS et al. 1998 Effects of metformin on spontaneous and clomiphene-induced ovulation in the polycystic ovary syndrome. New England Journal of Medicine 338, 1876-1880.
37. Oktem M, Esinler I, Eroglu D et al. 2007 High-dose atorvastatin causes regression of endometriotic implants: a rat model. Human Reproduction 22, 1474-1480.
38. Ouslimani N, Peynet J, Bonnefont-Rousselot D et al. 2005 Metformin decreases intracellular production of reactive oxygen species in aortic endothelial cells. Metabolism 54, 829-834.
39. Rezaie-Majd A, Prager GW, Bucek RA et al. 2003 Simvastatin reduces the expression of adhesion molecules in circulating monocytes from hypercholesterolemic patients. Arteriosclerosis, Thrombosis, and Vascular Biology 23, 397-403.
40. Riad A, Du J, Stiehl S et al. 2007 Low-dose treatment with atorvastatin leads to anti-oxidative and anti-inflammatory effects in diabetes mellitus. European Journal of Pharmacology 569, 204-211.
41. Rodgers KE, Girgis W, St Amand K et al. 1998 Reduction of adhesion formation in rabbits by intraperitoneal administration of lazaroid formulations. Human Reproduction 13, 2443-2451.
42. Rosenson RS 2004 Statins in atherosclerosis: lipid-lowering agents with antioxidant capabilities. Atherosclerosis 173, 1-12.
43. Schonbeck U, Libby P 2004 Inflammation, immunity, and HMG-CoA reductase inhibitors: statins as antiinflammatory agents? Circulation 109 (Suppl. 1), II18-II26.
44. Scott-Coombes D, Whawell S, Vipond MN et al. 1995 Human intraperitoneal fibrinolytic response to elective surgery. British Journal of Surgery 82, 414-417.
45. Tiwari A, Bansal V, Chugh A et al. 2006 Statins and myotoxicity: a therapeutic limitation. Expert Opinion on Drug Safety 5, 651-666.
46. Urman B, Gomel V, Jetha N 1991 Effect of hyaluronic acid on postoperative intraperitoneal adhesion formation in the rat model. Fertility and Sterility 56, 563-567.
47. Vague P, Juhan-Vague I, Alessi M et al. 1987 Metformin decreases the elevated levels of plasminogen activator inhibitor plasma insulin and triglycerides in non diabetic obese subjects. Thrombosis and Haemostasis 57, 326-328.
48. Velazquez E, Mendoza S, Wang P et al. 1997 Metformin therapy is associated with a decrease in plasma plasminogen activator inhibitor-1, lipoprotein(2), and immunoreactive insulin levels in patients with the polycystic ovary syndrome. Metabolism 46, 454-157.
49. van der Wal JB, Jeekel J 2007 The use of statins in postoperative adhesion prevention. Annals of Surgery 245, 185-186.
50. Weber C, Erl W, Weber KS et al. 1997 HMG-CoA reductase inhibitors decrease CD11b expression and CD 11b-dependent adhesion of monocytes to endothelium and reduce increased adhesiveness of monocytes isolated from patients with hypercholesterolemia. Journal of the American College of Cardiology 30, 1212-1217.
51. Wiernsperger NF, Bailey CJ 1999 The antihyperglycemic effect of metformin: therapeutic and cellular mechanisms. Drugs 58, 31-39.
52. Wolfrum S, Jensen KS, Liao JK 2003 Endothelium-dependent effects of statins. Arteriosclerosis, Thrombosis, and Vascular Biology 23, 729-736.