Balkan endemic nephropathy: A still unsolved puzzle

Journal of Nephrology

Volumn 21, Issue 5, 2008, Pages 673-680

  Schiller, Adalbert ^a   Gusbeth Tatomir, Paul ^b   Pavlovic, Nikola ^c   Ferluga, Dusan ^d   Spasovski, Goce ^e   Covic, Adrian ^b  

^a VICTOR BABES UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

^b C I PARHON NATIONAL INSTITUTE OF ENDOCRINOLOGY   (Romania)

^c Faculty of Medicine   (Serbia)

^d UNIVERSITY OF LJUBLJANA   (Slovenia)

^e University Clinical Center Skopje   (Macedonia)

Author keywords

Balkan endemic nephropathy; Chronic tubulointerstitial nephropathy; End stage renal disease; Etiology; Pathogenesis

Indexed keywords

ALBUMIN; BETA 2 MICROGLOBULIN; CYTOCHROME P450 2D6; CYTOCHROME P450 3A5; CYTOKERATIN; ERYTHROPOIETIN; GLUTATHIONE TRANSFERASE; HYDROCARBON; LAMININ; NEOPTERIN; PHOSPHATIDYLCHOLINE STEROL ACYLTRANSFERASE; PORPHOBILINOGEN SYNTHASE; VIMENTIN;

CHROMOSOME ABERRATION; CLINICAL FEATURE; COMPUTER ASSISTED TOMOGRAPHY; DISEASE SURVEILLANCE; EARLY DIAGNOSIS; ECHOGRAPHY; ENVIRONMENTAL EXPOSURE; GENE OVEREXPRESSION; GENETIC PREDISPOSITION; GENETIC SUSCEPTIBILITY; GEOGRAPHIC DISTRIBUTION; GLOMERULUS FILTRATION RATE; HEMODIALYSIS; HORMONE BLOOD LEVEL; HUMAN; HYPERTENSION; INCIDENCE; INTERSTITIAL NEPHRITIS; INTRAVENOUS UROGRAPHY; KIDNEY FUNCTION; KIDNEY SIZE; KIDNEY TRANSPLANTATION; KIDNEY TUBULE EPITHELIUM; NORMOCHROMIC NORMOCYTIC ANEMIA; NUCLEAR MAGNETIC RESONANCE IMAGING; ONSET AGE; PATHOGENESIS; PREVALENCE; PROTEIN URINE LEVEL; PROTEINURIA; REVIEW; SEASONAL VARIATION; TUBULAR DYSFUNCTION; UREMIA; VIRUS INFECTION; KIDNEY; PATHOLOGY;

BALKAN NEPHROPATHY; HUMANS; KIDNEY;

EID: 63249118399     PISSN: 11218428     EISSN: 17246059     Source Type: Journal    
DOI: None     Document Type: Review

References (53)

1. Danilović V, Djurišić M, Mokranjac M, Stojimirović B, Živojinović J, Stojaković P. [Chronic nephritis due to lead poisoning by digestive route (flour)] [In French]. Presse Med. 1957;65:2039-2040.
2. Tanchev Y, Dorossiev D. The first clinical description of Balkan endemic nephropathy (1956) and its validity 35 years later. IARC Sci Publ. 1991;115:21-28.
3. Gluhovschi GH, Stefanović V, Dimitrov T, et al. [Balkan Endemic Nephropathy] [in Romanian]. Timisoara, Romania: Ed. Helicon Banat; 1994.
4. Stefanović V. Balkan endemic nephropathy: a need for novel aetiological approaches. QJM. 1998;91:457-463.
5. Dinev I. Results of long term observations of patients and healthy individuals who emigrated from the village of Karash and settled in villages near Sofia. In: Strahinjić S, Stefanoviae V, eds. Current Research in Endemic (Balkan) Nephropathy. Niš, Serbia: University Press; 1983:279-281.
6. Batuman V. Fifty years of Balkan endemic nephropathy: daunting questions, elusive answers. Kidney Int. 2006;69:644-646.
7. Dimitrov PS, Simeonov VA, Stein AD. Balkan endemic nephropathy in Vratza, Bulgaria, 1964-1987: an epidemiologic analysis of population-based disease registers. Eur J Epidemiol. 2001;17:847-853.
8. Bukvic D, Jankovic S, Arsenovic A, Djukanovic L. Balkan endemic nephropathy is still present in the Kolubara region, Serbia. Ren Fail. 2005;27:565-569.
9. Djukanovic L, Radovic M, Bakovic J, et al. Epidemiology of end-stage renal disease and current status of hemodialysis in Yugoslavia. Int J Artif Organs. 2002;25:852-859.
10. Radovanović Z. Epidemiological characteristics of Balkan endemic nephropathy in eastern regions of Yugoslavia. IARC Sci Publ. 1991;115:11-20.
11. Radovanović Z. Balkan endemic nephropathy in Serbia: current status and future research. Facta Universitatis (Series Medicine and Biology). 2002;9:26-30.
12. Polenaković MH, Stefanović V. Balkan nephropathy. In: Davison AM, Cameron JS, Grunfeld JP, Kerr DN, Ritz E, Winearls CG, eds. Oxford Textbook of Clinical Nephrology. 2nd ed. Oxford, UK: Oxford University Press; 1998.
13. Dimitrov P, Tsolova S, Georgieva R, et al. Clinical markers in adult offspring of families with and without Balkan endemic nephropathy. Kidney Int. 2006;69:723-729.
14. Djukanović L, Bukvić D, Marić I, et al. Open questions on Balkan nephropathy. Nephrol Dial Transplant. 2001;16:27-29.
15. Djukanovic L, Bukvic D, Maric I. Creatinine clearance and kidney size in Balkan endemic nephropathy patients. Clin Nephrol. 2004;61:384-386.
16. Danilović V. Endemic nephropathy in Yugoslavia. In: Strahinjic S, Stefanovic V, eds. Endemic (Balkan) Nephropathy: Proceedings of the 4th Symposium, Nis, Serbia, 1979. Nis, Serbia: Institute of Nephrology and Haemodialysis; 1981:1-5.
17. Maric I, Bukvic D, Bogdanovic M, et al. Cross-sectional study in the Balkan endemic nephropathyvillage of Vreoci (Serbia). Bantao Journal 2006;4:5-8.
18. Markovic N, Ignjatovic I, Cukuranovic R, Petrovic B, Kocic B, Stefanovic V. Decreasing incidence of urothelial cancer in a Balkan endemic nephropathy region in Serbia: a surgery based study from 1969 to 1998. Pathol Biol (Paris). 2005;53:26-29.
19. Ferluga D, Hvala A, Vizjak A, Trnaeevie S, Halilbašić A. Renal function, protein excretion, and pathology of Balkan endemic nephropathy: Part III: light and electron microscopic studies. Kidney Int. 1991;40:S57-S67.
20. Čukuranovič R, Stefanovič N, Savič V, Stefanovič V. Quantitative analysis of the renal changes Balkan endemic nephropathy. Int Urol Nephrol. 1998;30:229-236.
21. Savič V, Čukuranovič R, Stefanovič N, Stefanovič V. Damage to the kidney in Balkan endemic nephropathy: initial lesions, target structures and pathomorphogenesis. Facta Universitatis (Series Medicine and Biology). 2002;9:92-94.
22. Apostolov K, Spaic P. Evidence of a viral aetiology in endemic (Balkan) nephropathy. Lancet. 1975;2:1271-1273.
23. Georgescu L, Litvac B, Diosi P, Plavosin L, Herzog G. Viruses in endemic (Balkan) nephropathy [letter]. Lancet. 1976;15:1086.
24. Stoian M, Hozoc M, Iosipenco M, Nastac E, Melencu M. Serum antibodies to papova viruses (BK and SV40) in subjects from the area with Balkan endemic nephropathy. Virologie. 1983;34:113-117.
25. Uzelac-Keserovic B, Spasic P, Bojanic N, et al. Isolation of a coronavirus from kidney biopsies of endemic Balkan nephropathy patients. Nephron. 1999;81:141-145.
26. Riquelme C, Escors D, Ortego J, Sanchez CM, Uzelac-Keserovic B, Apostolov K. Nature of the virus associated with endemic Balkan nephropathy. Emerg Infect Dis. 2002;8:869-870.
27. Toncheva D, Galabov AS, Laich A, et al. Urinary neopterin concentrations in patients with Balkan endemic nephropathy. Kidney Int. 2003;64:1817-1821.
28. Stefanovic V, Toncheva D, Atanasova S, Polenakovic M. Etiology of Balkan endemic nephropathy and associated urothelial cancer. Am J Nephrol. 2006;26:1-11.
29. Maksimovic ZJ. Selenium deficiency and Balkan endemic nephropathy. Kidney Int. 1991;40:S12-S14.
30. Stefanovič V, Mitič-Zlatkovič M, Cukuranovič R, Vlahovic P. Increased urinary protein excretion in children from families with Balkan endemic nephropathy. Nephron Clin Pract. 2003; 95:116-120.
31. O'Brien E, Dietrich DR. Ochratoxin A: the continuing enigma. Crit Rev Toxicol. 2005;35:33-60.
32. Krogh P, Axelsen NH, Elling F, et al. Experimental porcine nephropathy: changes of renal function and structure induced by ochratoxin-A-contaminated food. Acta Pathol Microbiol Scand. 1974;246:1-24.
33. Hassen W, Abid S, Achour A, Creppy E, Bacha H. Ochratoxin A and beta2-microglobulinuria in healthy individuals and in chronic interstitial nephropathy patients in the centre of Tunisia: a hot spot of Ochratoxin A exposure. Toxicology. 2004;199:185-193.
34. Ribar S, Mesarič M, Bauman M. High-performance liquid chromatographic determination of sphinganine and sphingosine in serum and urine of subjects from an endemic nephropathy area in Croatia. J Chromatogr B Biomed Sci Appl. 2001;754:511-519.
35. Ivic M. The problem of etiology of endemic nephropathy. Acta Fac Med Naiss. 1970;1:29-37.
36. Arlt VM, Stiborova M, Schmeiser HH. Aristolochic acid and 'Chinese herbs nephropathy': a review of the evidence to date. Mutagenesis. 2002;17:265-277.
37. Cosyns JP, Jadoul M, Squifflet JP, et al. Chinese herbs nephropathy: a clue to Balkan endemic nephropathy? Kidney Int. 1994;45:1680-1688.
38. Hranjec T, Kovac A, Kos J, et al. Endemic nephropathy: the case for chronic poisoning by aristolochia. Croat Med J. 2005;46:699-701.
39. Cosyns JP. Aristolochic acid and 'Chinese herbs nephropathy': a review of the evidence to date. Drug Saf. 2003;26:33-48.
40. Feder GL, Radovanovic Z, Finkelman RB. Relationship between weathered coal deposits and the etiology of Balkan endemic nephropathy. Kidney Int. 1991;40:S9-S11.
41. Goldberg MC, Feder GL, Radovanovic Z. Correlation of Balkan endemic nephropathy with fluorescent organic compounds in shallow ground water. Applied Hydrogeology. 1994;2:15-23.
42. Orem WH, Tatu CA, Lerch HE, et al. Identification and environmental significance of the organic compounds in water supplies associated with Balkan endemic nephropathy region in Romania. J Environ Health. 2004;3:49-57.
43. Toncheva DI, Gerov TD, Tzoneva MT, Bouchakliev ZP. Spontaneous and induced chromosome aberrations in Balkan endemic nephropathy. Kidney Int. 1991;40:S97-S101.
44. Toncheva D, Dimitrov T. Genetic predisposition to Balkan endemic nephropathy. Nephron 1996;72:564-569.
45. Pavlovic NM, Varghese Z, Persaud JW, et al. Partial lecithin:cholesterol acyltransferase deficiency in Balkan endemic nephropathy. Kidney Int. 1991;40:S102-S105.
46. Djordjevic VB, Strahinjic S, Koracevic D, et al. δ-Aminolevulinate dehydratase measurements in Balkan endemic nephropathy. Kidney Int. 1991;40:S93-S96.
47. Nikolov I, Chernozemsky I, Idle J. Genetic predisposition to Balkan endemic nephropathy: ability hydroxylate debrisoquine as a host factor. In: Castegnaro M, Plestina R, Dirheimer G, Chernozemsky I, Bartasch H, eds. Mycotoxins, Endemic Nephropathy and Urinary Tract Tumors. Lyon, France: IARC; 1991:289-296.
48. Toncheva D, von Ahsen N, Atanasova S, et al. Identification of NQO1 and GSTs genotype frequencies in Bulgarian patients with Balkan endemic nephropathy. J Nephrol. 2004;17:384-389.
49. Atanasova S, von Ahsen N, Dimitrov T, et al. First study of NAT1 and NAT2 polymorphisms in Bulgarian patients with Balkan endemic nephropathy and healthy controls. Biotechnology and Biotechnological Equipment. 2004;18:95-103.
50. 450 among patients with Balkan endemic nephropathy. Clin Biochem. 2005;38:223-228.
51. Andonova R, Sarueva A, Horvath V, et al. Balkan endemic nephropathy and genetic variants of glutathione S-transferases. J Nephrol. 2004;17:390-398.
52. Atanasova S, von Ahsen N, Dimitrov T, et al. MDR1 haplotypes modify BEN disease risk: a study in Bulgarian patients with Balkan endemic nephropathy compared to healthy controls. Nephron Exp Nephrol. 2004;96:e7-e13.
53. Nenov DV, Nenov DS. Balkan nephropathy: a disorder of renal embryogenesis? Am J Nephrol. 2002;22:260-265.