Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4

Journal of Biological Chemistry

Volumn 284, Issue 7, 2009, Pages 4695-4704

  Schnitzler, Michael Mederos ^a   Rinné, Susanne ^a   Skrobek, Lennart ^a   Renigunta, Vijay ^a   Schlichthörl, Günter ^a   Derst, Christian ^a   Gudermann, Thomas ^a   Daut, Jürgen ^a   Preisig Müller, Regina ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOPHYSICAL PROPERTIES; CHANNEL ASSEMBLY; CO-EXPRESSION; DOMINANT-NEGATIVE MUTANTS; FLUORESCENCE RESONANCE ENERGY TRANSFER; HETEROTETRAMERS; HISTIDINE RESIDUES; N-TERMINAL; POTASSIUM CHANNELS; TETRAMERIZATION; VOLTAGE DEPENDENCE; WILD TYPES; X-CHANNEL; YEAST TWO-HYBRID ASSAYS; ZINC IONS;

ENERGY TRANSFER; FLUORESCENCE; ZINC;

AMINO ACIDS;

ARGININE; HISTIDINE; POTASSIUM CHANNEL; POTASSIUM CHANNEL KV2.1; POTASSIUM CHANNEL KV6.3; POTASSIUM CHANNEL KV6.4; UNCLASSIFIED DRUG; VALINE; KCNB1 PROTEIN, HUMAN; KCNB1 PROTEIN, RAT; KCNG3 PROTEIN, HUMAN; KCNG3 PROTEIN, RAT; SHAB POTASSIUM CHANNEL; VOLTAGE GATED POTASSIUM CHANNEL;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL STRAIN COS7; CELL STRAIN HEK293; CHO CELL; CONTROLLED STUDY; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENE EXPRESSION; GENE MUTATION; HUMAN; IMMUNOPRECIPITATION; MOLECULAR INTERACTION; MUTANT; NONHUMAN; NUCLEOTIDE SEQUENCE; OOCYTE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN STRUCTURE; RAT; SITE DIRECTED MUTAGENESIS; WILD TYPE; XENOPUS LAEVIS; ANIMAL; CELL STRAIN COS1; CERCOPITHECUS; GENETICS; METABOLISM; MISSENSE MUTATION; PHYSIOLOGY; PROTEIN MOTIF; PROTEIN QUATERNARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; TWO HYBRID SYSTEM;

AMINO ACID MOTIFS; AMINO ACID SUBSTITUTION; ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; FLUORESCENCE RESONANCE ENERGY TRANSFER; HISTIDINE; HUMANS; MUTATION, MISSENSE; POTASSIUM CHANNELS, VOLTAGE-GATED; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; RATS; SHAB POTASSIUM CHANNELS; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 63249101246     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M808786200     Document Type: Article

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