Autoantibodies against glomerular endothelial cells in anti-neutrophil cytoplasmic autoantibody-associated systemic vasculitis

Nephrology

Volumn 14, Issue 1, 2009, Pages 11-15

  Hu, Nan ^a   Westra, Johanna ^a   Huitema, Minke G ^a   Stegeman, Coen A ^a   Limburg, Piet C ^a   Kallenberg, Cees G M ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

AECA; ANCA; ANCA associated vasculitis; Endothelial activation

Indexed keywords

ANTI ENDOTHELIAL CELL AUTOANTIBODY; AUTOANTIBODY; CELL ADHESION MOLECULE; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ADULT; AGED; ANCA ASSOCIATED VASCULITIS; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GLOMERULUS EPITHELIUM; HUMAN; HUMAN CELL; MALE; MICROSCOPIC POLYANGIITIS; PRIORITY JOURNAL; SERUM; UMBILICAL VEIN; WEGENER GRANULOMATOSIS;

ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC; ANTIBODY-DEPENDENT CELL CYTOTOXICITY; AUTOANTIBODIES; CELLS, CULTURED; FEMALE; HUMANS; MALE; MIDDLE AGED; VASCULITIS;

EID: 63149182898     PISSN: 13205358     EISSN: 14401797     Source Type: Journal    
DOI: 10.1111/j.1440-1797.2008.01068.x     Document Type: Article

References (27)

1. Jennette JC, Falk RJ. Small-vessel vasculitis. N. Engl. J. Med. 1997 337 : 1512 23.
2. Kallenberg CG, Heeringa P, Stegeman CA. Mechanisms of disease: Pathogenesis and treatment of ANCA-associated vasculitides. Nat. Clin. Pract. Rheumatol. 2006 2 : 661 70.
3. Falk RJ, Terrell RS, Charles LA, Jennette JC. Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro. Proc. Natl. Acad. Sci. USA 1990 87 : 4115 19.
4. Mulder AH, Heeringa P, Brouwer E, Limburg PC, Kallenberg CG. Activation of granulocytes by anti-neutrophil cytoplasmic antibodies (ANCA): A Fc gamma RII-dependent process. Clin. Exp. Immunol. 1994 98 : 270 78.
5. Xiao H, Heeringa P, Hu P et al. Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice. J. Clin. Invest. 2002 110 : 955 63.
6. Chan TM, Frampton G, Jayne DR, Perry GJ, Lockwood CM, Cameron JS. Clinical significance of anti-endothelial cell antibodies in systemic vasculitis: A longitudinal study comparing anti-endothelial cell antibodies and anti-neutrophil cytoplasm antibodies. Am. J. Kidney Dis 1993 22 : 387 92.
7. Frampton G, Jayne DR, Perry GJ, Lockwood CM, Cameron JS. Autoantibodies to endothelial cells and neutrophil cytoplasmic antigens in systemic vasculitis. Clin. Exp. Immunol. 1990 82 : 227 32.
8. Gobel U, Eichhorn J, Kettritz R et al. Disease activity and autoantibodies to endothelial cells in patients with Wegener's granulomatosis. Am. J. Kidney Dis. 1996 28 : 186 94.
9. Holmen C, Christensson M, Pettersson E et al. Wegener's granulomatosis is associated with organ-specific antiendothelial cell antibodies. Kidney Int. 2004 66 : 1049 60.
10. Savage CO, Pottinger BE, Gaskin G, Lockwood CM, Pusey CD, Pearson JD. Vascular damage in Wegener's granulomatosis and microscopic polyarteritis: Presence of anti-endothelial cell antibodies and their relation to anti-neutrophil cytoplasm antibodies. Clin. Exp. Immunol. 1991 85 : 14 19.
11. Sebastian JK, Mahr AD, Ahmed SS et al. Antiendothelial cell antibodies in patients with Wegener's granulomatosis: Prevalence and correlation with disease activity and manifestations. J. Rheumatol. 2007 34 : 1027 31.
12. Del PN, Guidali L, Sironi M et al. Anti-endothelial cell IgG antibodies from patients with Wegener's granulomatosis bind to human endothelial cells in vitro and induce adhesion molecule expression and cytokine secretion. Arthritis Rheum. 1996 39 : 758 66.
13. Muller Kobold AC, van Wijk RT, Franssen CF, Molema G, Kallenberg CG, Tervaert JW. In vitro up-regulation of E-selectin and induction of interleukin-6 in endothelial cells by autoantibodies in Wegener's granulomatosis and microscopic polyangiitis. Clin. Exp. Rheumatol. 1999 17 : 433 40.
14. Jennette JC, Falk RJ, Andrassy K et al. Nomenclature of systemic vasculitides. Proposal of an international consensus conference. Arthritis Rheum. 1994 37 : 187 92.
15. Satchell SC, Tasman CH, Singh A et al. Conditionally immortalized human glomerular endothelial cells expressing fenestrations in response to VEGF. Kidney Int. 2006 69 : 1633 40.
16. Mulder AB, Blom NR, Smit JW et al. Basal tissue factor expression in endothelial cell cultures is caused by contaminating smooth muscle cells. Reduction by using chymotrypsin instead of collagenase. Thromb. Res. 1995 80 : 399 411.
17. Pierangeli SS, Liu X, Espinola R et al. Functional analyses of patient-derived IgG monoclonal anticardiolipin antibodies using in vivo thrombosis and in vivo microcirculation models. Thromb. Haemost. 2000 84 : 388 95.
18. Lindqvist KJ, Osterland CK. Human antibodies to vascular endothelium. Clin. Exp. Immunol. 1971 9 : 753 60.
19. Chanseaud Y, Garcia de la Pena-Lefebvre P, Guilpain P et al. IgM and IgG autoantibodies from microscopic polyangiitis patients but not those with other small- and medium-sized vessel vasculitides recognize multiple endothelial cell antigens. Clin. Immunol. 2003 109 : 165 78.
20. Garcia de la Pena-Lefebvre P, Chanseaud Y, Tamby MC et al. IgG reactivity with a 100-kDa tissue and endothelial cell antigen identified as topoisomerase 1 distinguishes between limited and diffuse systemic sclerosis patients. Clin. Immunol. 2004 111 : 241 51.
21. Cong M, Chen M, Zhang JJ, Hu Z, Zhao MH. Anti-endothelial cell antibodies in antineutrophil cytoplasmic antibodies negative pauci-immune crescentic glomerulonephritis. Nephrology (Carlton) 2008 13 : 228 34.
22. Yu F, Zhao MH, Zhang YK, Zhang Y, Wang HY. Anti-endothelial cell antibodies (AECA) in patients with propylthiouracil (PTU)-induced ANCA positive vasculitis are associated with disease activity. Clin. Exp. Immunol. 2005 139 : 569 74.
23. Holmen C, Elsheikh E, Christensson M et al. Anti endothelial cell autoantibodies selectively activate SAPK/JNK signalling in Wegener's granulomatosis. J. Am. Soc. Nephrol. 2007 18 : 2497 508.
24. Chan TM, Frampton G, Staines NA, Hobby P, Perry GJ, Cameron JS. Different mechanisms by which anti-DNA MoAbs bind to human endothelial cells and glomerular mesangial cells. Clin. Exp. Immunol. 1992 88 : 68 74.
25. Belizna C, Tervaert JW. Specificity, pathogenecity, and clinical value of antiendothelial cell antibodies. Semin. Arthritis Rheum. 1997 27 : 98 109.
26. Mayet WJ, Schwarting A, Meyer zum Buschenfelde KH. Cytotoxic effects of antibodies to proteinase 3 (C-ANCA) on human endothelial cells. Clin. Exp. Immunol. 1994 97 : 458 65.
27. Ballieux BE, Zondervan KT, Kievit P et al. Binding of proteinase 3 and myeloperoxidase to endothelial cells: ANCA-mediated endothelial damage through ADCC? Clin. Exp. Immunol. 1994 97 : 52 60.