Development and testing of particulate formulations for the nasal delivery of antibodies

Journal of Controlled Release

Volumn 135, Issue 2, 2009, Pages 127-135

  Kaye, Richard S ^a   Purewal, Tarlochan S ^b   Alpar, Oya H ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b NONE   (United Kingdom)

Author keywords

Antibody; Inhaled; Nasal; Spray dried

Indexed keywords

AEROSIL; AEROSOLISATION PROPERTIES; AIRBORNE INFECTIONS; AQUEOUS MEDIAS; CAST MODELS; CELL VIABILITIES; CRYSTALLINITY; DOSE DEPOSITIONS; DRY POWDERS; ENZYME LINKED IMMUNO-SORBENT ASSAYS; EPITHELIAL CELLS; FORMULATION PROCESS; HIGH-SPEED VIDEOS; HUMAN IGG; IN-VITRO; INHALED; LASER DIFFRACTIONS; LIQUID FEEDS; MAGNESIUM STEARATES; NASAL; NASAL CAVITIES; NASAL DELIVERIES; POTENTIAL SITES; SPRAY-DRIED; SPRAY-DRIED POWDERS; SPRAY-DRYING; SYSTEMIC ADMINISTRATIONS; THERAPEUTIC ANTIBODIES;

AMINO ACIDS; CELL CULTURE; CURING; DEWATERING; DISSOLUTION; ELECTROPHORESIS; GELATION; MAGNESIUM; MAGNESIUM POWDER; POLYSACCHARIDES; POWDERS; SODIUM; SODIUM CHLORIDE; SUGARS; WATER CONTENT;

ANTIBODIES;

AEROSIL; ALBUMIN; DISACCHARIDE; IMMUNOGLOBULIN; IMMUNOGLOBULIN G ANTIBODY; LACTOSE; LEUCINE; MAGNESIUM STEARATE; SODIUM CHLORIDE;

AEROSOL; ANIMAL CELL; ARTICLE; CELL VIABILITY; DRUG FORMULATION; DRUG STABILITY; DRY POWDER; EPITHELIUM CELL; NASOPHARYNX; NONHUMAN; NOSE CAVITY; PRIORITY JOURNAL; SPRAY DRYING; TURBINATE;

ADMINISTRATION, INTRANASAL; AEROSOLS; ANTIBODIES; CHEMISTRY, PHARMACEUTICAL; DESICCATION; DOSAGE FORMS; DRUG DELIVERY SYSTEMS; EXCIPIENTS; HUMANS; MICROSCOPY, ELECTRON, SCANNING; PARTICLE SIZE; POWDERS;

EID: 63149131275     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2008.11.009     Document Type: Article

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