Endothelial Progenitor Cell (EPC) capture to aid vascular repair following coronary stenting: A new frontier in stent technology?

EuroIntervention

Volumn 4, Issue , 2008, Pages C67-C71

  Houtgraaf, Jaco H ^a   Duckers, Hendricus J ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITHROMBOCYTIC AGENT; ATORVASTATIN; CD14 ANTIGEN; CD31 ANTIGEN; CD45 ANTIGEN; VASCULOTROPIN RECEPTOR 2; ANTIINFLAMMATORY AGENT; IMMUNOSUPPRESSIVE AGENT;

ANGIOGENESIS; ANTIBODY TITER; ARTICLE; BIOENGINEERING; CELL DIFFERENTIATION; CELL INTERACTION; CELL MIGRATION; CELL PROLIFERATION; CORONARY ARTERY DISEASE; CORONARY STENTING; DISEASE REGISTRY; DISEASE SEVERITY; ENDOTHELIAL PROGENITOR CELL; ENDOTHELIUM; EXTRACELLULAR MATRIX; FEASIBILITY STUDY; FLOW CYTOMETRY; HEART INFARCTION; HUMAN; NEOINTIMA; NONHUMAN; PERCUTANEOUS CORONARY INTERVENTION; PHENOTYPE; PROTEIN EXPRESSION; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; STENT THROMBOSIS; VASCULAR SURGERY; CORONARY BLOOD VESSEL; CYTOLOGY; DRUG EFFECT; DRUG ELUTING STENT; EQUIPMENT DESIGN; PATHOLOGY; PHYSIOLOGY; REGENERATION; REVIEW; STEM CELL; VASCULAR ENDOTHELIUM; WOUND HEALING;

ANTI-INFLAMMATORY AGENTS; CORONARY DISEASE; CORONARY VESSELS; DRUG-ELUTING STENTS; ENDOTHELIUM, VASCULAR; EQUIPMENT DESIGN; HUMANS; IMMUNOSUPPRESSIVE AGENTS; REGENERATION; STEM CELLS; WOUND HEALING;

EID: 63149104800     PISSN: 1774024X     EISSN: 19696213     Source Type: Journal    
DOI: None     Document Type: Article

References (60)

1. Suzuki T, Kopia G, Hayashi S, Bailey LR, Llanos G, Wilensky R, Klugherz BD, Papandreou G, Narayan P, Leon MB, Yeung AC, Tio F, Tsao PS, Falotico R, Carter AJ. Stent-based delivery of sirolimus reduces neointimal formation in a porcine coronary model. Circulation, 2001; 104(10): 1188-1193.
2. Farb A, Heller PF, Shroff S, Cheng L, Kolodgie FD, Carter AJ, Scott DS, Froehlich J, Virmani R. Pathological analysis of local delivery of paclitaxel via a polymer-coated stent. Circulation, 2001;104(4): 473-479.
3. Daemen J. and P.W. Serruys, Drug-eluting stent update 2007: Part I. A survey of current and future generation drug-eluting stents: Meaningful advances or more of the same? Circulation, 2007;116(3): 316-328.
4. Joner M, Finn AV, Farb A, Mont EK, Kolodgie FD, Ladich E, Kutys R, Skorija K, Gold HK, Virmani R. Pathology of drug-eluting stents in humans: Delayed healing and late thrombotic risk. J Am Coll Cardiol, 2006. 48(1): 193-202.
5. Finn AV, Joner M, Nakazawa G, Kolodgie F, Newell J, John MC, Gold HK, Virmani R. Pathological correlates of late drug-eluting stent thrombosis: Strut coverage as a marker of endothelialization. Circulation, 2007;115(18): 2435-2441.
6. Finn AV, Nakazawa G, Joner M, Kolodgie FD, Mont EK, Gold HK, Virmani R. Vascular responses to drug eluting stents: Importance of delayed healing. Arterioscler Thromb Vasc Biol, 2007; 27(7): 1500-1510.
7. Hofma SH, van der Giessen WJ, van Dalen BM, Lemos PA, McFadden EP, Sianos G, Ligthart JM, van Essen D, de Feyter PJ, Serruys PW. Indication of long-term endothelial dysfunction after sirolimus-eluting stent implantation. Eur Heart J, 2006;27(2): 166-170.
8. van Beusekom HM, Saia F, Zindler JD, Lemos PA, Swager-Ten Hoor SL, van Leeuwen MA, de Feijter PJ, Serruys PW, van der Giessen WJ Drug-eluting stents show delayed healing: Paclitaxel more pronounced than sirolimus. Eur Heart J, 2007; 28(8): 974-979.
9. Kotani J, Awata M, Nanto S, Uematsu M, Oshima F, Minamiguchi H, Mintz GS, Nagata S. Incomplete neointimal coverage of sirolimus-eluting stents: Angioscopic findings. J Am Coll Cardiol, 2006;47(10): 2108-2111.
10. Daemen J. and P.W. Serruys, Drug-eluting stent update 2007: Part II: Unsettled issues. Circulation, 2007;116(8): 961-968.
11. Pfisterer M, Brunner-La Rocca HP, Buser PT, Rickenbacher P, Hunziker P, Mueller C, Jeger R, Bader F, Osswald S, Kaiser C Late clinical events after clopidogrel discontinuation may limit the benefit of drug-eluting stents: An observational study of drug-eluting versus bare-metal stents. J Am Coll Cardiol, 2006;48(12): 2584-2591.
12. Iakovou I, Schmidt T, Bonizzoni E, Ge L, Sangiorgi GM, Stankovic G, Airoldi F, Chieffo A, Montorfano M, Carlino M, Michev I, Corvaja N, Briguori C, Gerckens U, Grube E, Colombo A. Incidence, predictors, and outcome of thrombosis after successful implantation of drug-eluting stents. Jama, 2005;293(17): 2126-2130.
13. Ong AT, McFadden EP, Regar E, de Jaegere PP, van Domburg RT, Serruys PW. Late angiographic stent thrombosis (LAST) events with drugeluting stents. J Am Coll Cardiol, 2005;45(12): 2088-2092.
14. Kipshidze N, Dangas G, Tsapenko M, Moses J, Leon MB, Kutryk M, Serruys P. Role of the endothelium in modulating neointimal formation: Vasculoprotective approaches to attenuate restenosis after percutaneous coronary interventions. J Am Coll Cardiol, 2004;44(4): 733-739.
15. Asahara T, Masuda H, Takahashi T, Kalka C, Pastore C, Silver M, Kearne M, Magner M, Isner JM. Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization. Circ Res, 1999;85(3): 221-228.
16. Crosby JR, Kaminski WE, Schatteman G, Martin PJ, Raines EW, Seifert RA, Bowen-Pope DF. Endothelial cells of hematopoietic origin make a significant contribution to adult blood vessel formation. Circ Res, 2000. 87(9): 728-730.
17. Asahara T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T, Witzenbichler B, Schatteman G, Isner JM. Isolation of putative progenitor endothelial cells for angiogenesis. Science, 1997;275(5302): 964-967.
18. Kawamoto A., Asahara T., Role of progenitor endothelial cells in cardiovascular disease and upcoming therapies. Catheter Cardiovasc Interv, 2007;70(4): 477-484.
19. Young PP, Vaughan DE, Hatzopoulos AK. Hatzopoulos, Biologic properties of endothelial progenitor cells and their potential for cell therapy. Prog Cardiovasc Dis, 2007;49(6): 421-429.
20. Schatteman GC, Dunnwald M, Jiao C. Biology of bone marrowderived endothelial cell precursors. Am J Physiol Heart Circ Physiol, 2007;292(1): H1-18.
21. Ward M.R., Stewart D.J., Kutryk M.J. Endothelial progenitor cell therapy for the treatment of coronary disease, acute MI, and pulmonary arterial hypertension: Current perspectives. Catheter Cardiovasc Interv, 2007;70(7): 983-998.
22. Gehling UM, Ergun S, Schumacher U, Wagener C, Pantel K, Otte M, Schuch G, Schafhausen P, Mende T, Kilic N, Kluge K, Schafer B, Hossfeld DK, Fiedler W. In vitro differentiation of endothelial cells from AC133-positive progenitor cells. Blood, 2000;95(10): 3106-3112.
23. Lin Y, Weisdorf DJ, Solovey A, Hebbel RP Origins of circulating endothelial cells and endothelial outgrowth from blood. J Clin Invest, 2000;105(1): 71-77.
24. Fernandez Pujol B, Lucibello FC, Gehling UM, Lindemann K, Weidner N, Zuzarte ML, Adamkiewicz J, Elsasser HP, Muller R, Havemann K. Endothelial-like cells derived from human CD14 positive monocytes. Differentiation, 2000;65(5): 287-300.
25. Eggermann J, Kliche S, Jarmy G, Hoffmann K, Mayr-Beyrle U, Debatin KM, Waltenberger J, Beltinger C. Endothelial progenitor cell culture and differentiation in vitro: A methodological comparison using human umbilical cord blood. Cardiovasc Res, 2003;58(2): 478-486.
26. Sieveking DP, Buckle A, Celermajer DS, Ng MK. Strikingly different angiogenic properties of endothelial progenitor cell subpopulations: Insights from a novel human angiogenesis assay. J Am Coll Cardiol, 2008;51(6): 660-668.
27. Inoue T, Sata M, Hikichi Y, Sohma R, Fukuda D, Uchida T, Shimizu M, Komoda H, Node K. Mobilization of CD34-positive bone marrowderived cells after coronary stent implantation: Impact on restenosis. Circulation, 2007;115(5): 553-561.
28. Wojakowski W. and M. Tendera, Mobilization of bone marrowderived progenitor cells in acute coronary syndromes. Folia Histochem Cytobiol, 2005;43(4): 229-232.
29. Shintani S, Murohara T, Ikeda H, Ueno T, Honma T, Katoh A, Sasaki K, Shimada T, Oike Y, Imaizumi T. Mobilization of endothelial progenitor cells in patients with acute myocardial infarction. Circulation, 2001;103(23): 2776-2779.
30. Massa M, Rosti V, Ferrario M, Campanelli R, Ramajoli I, Rosso R, De Ferrari GM, Ferlini M, Goffredo L, Bertoletti A, Klersy C, Pecci A, Moratti R, Tavazzi L Increased circulating hematopoietic and endothelial progenitor cells in the early phase of acute myocardial infarction. Blood, 2005;105(1): 199-206.
31. Vasa M, Fichtlscherer S, Aicher A, Adler K, Urbich C, Martin H, Zeiher AM, Dimmeler S. Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease. Circ Res, 2001;89(1): E1-7.
32. Werner N., Nickenig G. Influence of cardiovascular risk factors on endothelial progenitor cells: Limitations for therapy? Arterioscler Thromb Vasc Biol, 2006;26(2): 257-266.
33. Heiss C, Keymel S, Niesler U, Ziemann J, Kelm M, Kalka C. Impaired progenitor cell activity in age-related endothelial dysfunction. J Am Coll Cardiol, 2005;45(9): 1441-1448.
34. Michaud SE, Dussault S, Haddad P, Groleau J, Rivard A. Circulating endothelial progenitor cells from healthy smokers exhibit impaired functional activities. Atherosclerosis, 2006;187(2): 423-432.
35. Tepper OM, Galiano RD, Capla JM, Kalka C, Gagne PJ, Jacobowitz GR, Levine JP, Gurtner GC. Human endothelial progenitor cells from type II diabetics exhibit impaired proliferation, adhesion, and incorporation into vascular structures. Circulation, 2002;106(22): 2781-2786.
36. Chen JZ, Zhang FR, Tao QM, Wang XX, Zhu JH, Zhu JH. Number and activity of endothelial progenitor cells from peripheral blood in patients with hypercholesterolaemia. Clin Sci (Lond), 2004;107(3): 273-280.
37. George J, Herz I, Goldstein E, Abashidze S, Deutch V, Finkelstein A, Michowitz Y, Miller H, Keren G Number and adhesive properties of circu-lating endothelial progenitor cells in patients with in-stent restenosis. Arterioscler Thromb Vasc Biol, 2003;23(12): E57-60.
38. Schmidt-Lucke C, Rossig L, Fichtlscherer S, Vasa M, Britten M, Kamper U, Dimmeler S, Zeiher AM Reduced number of circulating endothelial progenitor cells predicts future cardiovascular events: Proof of concept for the clinical importance of endogenous vascular repair. Circulation, 2005;111(22): 2981-2987.
39. Werner N, Kosiol S, Schiegl T, Ahlers P, Walenta K, Link A, Bohm M, Nickenig G Circulating endothelial progenitor cells and cardiovascular outcomes. N Engl J Med, 2005;353(10): 999-1007.
40. Hill JM, Zalos G, Halcox JP, Schenke WH, Waclawiw MA, Quyyumi AA, Finkel T. Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N Engl J Med, 2003. 348(7): 593-600.
41. Urbich C., Dimmeler S. Risk factors for coronary artery disease, circulating endothelial progenitor cells, and the role of HMG-CoA reductase inhibitors. Kidney Int, 2005;67(5): 1672-1676.
42. Laufs U, Werner N, Link A, Endres M, Wassmann S, Jurgens K, Miche E, Bohm M, Nickenig G Physical training increases endothelial progenitor cells, inhibits neointima formation, and enhances angiogenesis. Circulation, 2004;109(2): 220-226.
43. Asahara T, Takahashi T, Masuda H, Kalka C, Chen D, Iwaguro H, Inai Y, Silver M, Isner JM. VEGF contributes to postnatal neovascularization by mobilizing bone arrow-derived endothelial progenitor cells. Embo J, 1999;18(14): 3964-3972.
44. Strehlow K, Werner N, Berweiler J, Link A, Dirnagl U, Priller J, Laufs K, Ghaeni L, Milosevic M, Bohm M, Nickenig G. Estrogen increases bone marrow-derived endothelial progenitor cell production and diminishes neointima formation. Circulation, 2003;107(24): 3059-3065.
45. Heeschen C, Aicher A, Lehmann R, Fichtlscherer S, Vasa M, Urbich C, Mildner-Rihm C, Martin H, Zeiher AM, Dimmeler S. Erythropoietin is a potent physiologic stimulus for endothelial progenitor cell mobilization. Blood, 2003;102(4): 1340-1346.
46. Llevadot J, Murasawa S, Kureishi Y, Uchida S, Masuda H, Kawamoto A, Walsh K, Isner JM, Asahara T. HMG-CoA reductase inhibitor mobilizes bone marrow-derived endothelial progenitor cells. J Clin Invest, 2001; 108(3): 399-405.
47. Assmus B, Urbich C, Aicher A, Hofmann WK, Haendeler J, Rossig L, Spyridopoulos I, Zeiher AM, Dimmeler S. HMG-CoA reductase inhibitors reduce senescence and increase proliferation of endothelial progenitor cells via regulation of cell cycle regulatory genes. Circ Res, 2003;92(9): 1049-1055.
48. Dimmeler S, Aicher A, Vasa M, Mildner-Rihm C, Adler K, Tiemann M, Rutten H, Fichtlscherer S, Martin H, Zeiher AM. HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway. J Clin Invest, 2001;108(3): 391-397.
49. Walter DH, Rittig K, Bahlmann FH, Kirchmair R, Silver M, Murayama T, Nishimura H, Losordo DW, Asahara T, Isner JM. Statin therapy accelerates reendothelialization: A novel effect involving mobilization and incorporation of bone marrow-derived endothelial progenitor cells. Circulation, 2002;105(25): 3017-3024.
50. Scott NA, Candal FJ, Robinson KA, Ades EW. Seeding of intracoronary stents with immortalized human microvascular endothelial cells. Am Heart J, 1995;129(5): 860-866.
51. Ong AT, Aoki J, Kutryk MJ, Serruys PW. How to accelerate the endothelialization of stents. Arch Mal Coeur Vaiss, 2005;98(2): 123-126.
52. Flugelman M.Y, Dichek D.A. Seeding of intracoronary stents with endothelial cells: Current status and future prospects. J Interv Cardiol, 1995;8(4): 383-385.
53. Hedman M, Hartikainen J, Syvanne M, Stjernvall J, Hedman A, Kivela A, Vanninen E, Mussalo H, Kauppila E, Simula S, Narvanen O, Rantala A, Peuhkurinen K, Nieminen MS, Laakso M, Yla-Herttuala S. Safety and feasibility of catheter-based local intracoronary vascular endothelial growth factor gene transfer in the prevention of postangioplasty and in-stent restenosis and in the treatment of chronic myocardial ischemia: Phase II results of the Kuopio Angiogenesis Trial (KAT). Circulation, 2003;107(21): 2677-2683.
54. Laitinen M, Hartikainen J, Hiltunen MO, Eranen J, Kiviniemi M, Narvanen O, Makinen K, Manninen H, Syvanne M, Martin JF, Laakso M, Yla-Herttuala S. Catheter-mediated vascular endothelial growth factor gene transfer to human coronary arteries after angioplasty. Hum Gene Ther, 2000;11(2): 263-270.
55. Swanson N, Hogrefe K, Javed Q, Malik N, Gershlick AH. Vascular endothelial growth factor (VEGF)-eluting stents: In vivo effects on thrombosis, endothelialization and intimal hyperplasia. J Invasive Cardiol, 2003;15(12): 688-692.
56. Walter DH, Cejna M, Diaz-Sandoval L, Willis S, Kirkwood L, Stratford PW, Tietz AB, Kirchmair R, Silver M, Curry C, Wecker A, Yoon YS, Heidenreich R, Hanley A, Kearney M, Tio FO, Kuenzler P, Isner JM, Losordo DW. Local gene transfer of phVEGF-2 plasmid by gene-eluting stents: An alternative strategy for inhibition of restenosis. Circulation, 2004;110(1): 36-45.
57. Aoki J, Serruys PW, van Beusekom H, Ong AT, McFadden EP, Sianos G, van der Giessen WJ, Regar E, de Feyter PJ, Davis HR, Rowland S, Kutryk MJ. Endothelial progenitor cell capture by stents coated with antibody against CD34: The HEALING-FIM (Healthy Endothelial Accelerated Lining Inhibits Neointimal Growth-First In Man) Registry. J Am Coll Cardiol, 2005;45(10): 1574-1579.
58. Duckers HJ, Silber S, Winter R, Heijer P, Rensing B, Rau M, Mudra H, Benit E, Verheye S, Wijns W, Serruys P.W., Circulating endothelial progenitor cells predictangiographic and IVUS outcome following percutaneous coronary interventions in the HEALING-II trial: Evaluation of an endothelial progenitor cell capturing stent. EuroIntervention, 2007;3: 67-75.
59. Duckers HJ, Soulie T, Heijer P, Rensing B, de Winter R, Rau M, Mudra H, Silber S, Benit E, Verheye S, Wijns W, Serruys PW. Accelarated vascular repair following percutaneous coronary intervention by capture of endothelial progenitor cells promotes regression of neointimal growth at long term follow up: Final results of the HEALING II trial using an endothelial progenitor cell capturing stent (Genous R stent). EuroIntervention, 2007;3: 350-358.
60. Co M, Tay E, Lee CH, Poh KK, Low A, Lim J, Lim IH, Lim YT, Tan HC. Use of endothelial progenitor cell capture stent (Genous Bio-Engineered R Stent) during primary percutaneous coronary intervention in acute myocardial infarction: Intermediate-to long-term clinical follow-up. Am Heart J, 2008;155(1): 128-132.