Down-regulation of microfilamental network-associated proteins in leukocytes of breast cancer patients: Potential application to predictive diagnosis

Cancer Genomics and Proteomics

Volumn 6, Issue 1, 2009, Pages 31-40

  Braun, Michael ^a   Fountoulakis, Michael ^b   Papadopoulou, Ageliki ^b   Vougas, Kostas ^b   Seidel, Ilka ^a   Höller, Tobias ^a   Yeghiazaryan, Kristina ^a   Schild, Hans H ^a   Kuhn, Walther ^a   Golubnitschaja, Olga ^a  

^a UNIVERSITY OF BONN   (Germany)

^b Biomedical Research Foundation   (Greece)

Author keywords

Breast cancer; Clinical proteomics; Disease specific molecular patterns; Microfilamental network; Predictive diagnosis

Indexed keywords

ACTIN; CALGRANULIN A; MICROFILAMENTAL NETWORK ASSOCIATED PROTEIN; PEPTIDES AND PROTEINS; PROFILIN; PROTEIN; PROTEOME; RHO GDI BETA; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGE; ARTICLE; BENIGN TUMOR; BREAST BIOPSY; BREAST CANCER; CANCER DIAGNOSIS; CANCER PATIENT; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; LEUKOCYTE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NEEDLE BIOPSY; NON INVASIVE PROCEDURE; NUCLEOTIDE SEQUENCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRECANCER; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MAPPING; PROTEOMICS; SENSITIVITY AND SPECIFICITY; UNINDEXED SEQUENCE; WESTERN BLOTTING;

EID: 63049096390     PISSN: 11096535     EISSN: 17906245     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. WHO Cancer [http://www.who.int/mediacentre/factsheets/fs297/en/ index.html]
2. Ross JS and Hortobagyi GN: Molecular oncology of breast cancer. Jones & Bartlett Press; 2005.
3. Braun M, Pölcher M, Schrading S, Zivanovic O, Kowalski T, Flucke U, Leutner C, Park-Simon TW, Rudlowski C, Kuhn W and Kuhl CK: Influence of preoperative MRI on the surgical management of patients with operable breast cancer. Breast Cancer Res Treat 111: 179-187, 2008.
4. Golubnitschaja O, Yeghiazaryan K, Wunderlich K, Schlid HH and Flammer J: Disease proteomics reveals altered basic gene expression regulation in leukocytes of Normal-Tension and Primary Open-Angle glaucoma patients. Proteomics Clin Appl 1: 1316-1323, 2007.
5. Yeghiazaryan K, Mamlouk S, Trog D, Moenkemann H, Braun M, Kuhn W, Schild H and Golubnitschaja O: Irradiated breast cancer patients demonstrate subgroup-specific regularities in protein expression patterns of circulating leukocytes. Cancer Genomics Proteomics 4: 411-418, 2007.
6. Golubnitschaja O: Clinical proteomics in application to predictive diagnostics and personalized treatment of diabetic patients. Current Proteomics 5: 35-44, 2008.
7. Golubnitschaja O: Cell cycle checkpoints: the role and evaluation for early diagnosis of senescence, cardiovascular, cancer, and neurodegenerative diseases. Amino Acids 32: 359-371, 20047.
8. Cebioglu M, Schild HH and Golubnitschaja O: Diabetes mellitus as a risk factor for cancer: stress or viral etiology? Infect Disord Drug Targets 8: 76-87, 2008.
9. Yeghiazaryan K, Bauriedel G, Schild HH and Golubnitschaja O: Prediction of degeneration of native and bioprosthetic aortic valves: issue-related particularities of diabetes mellitus. Infect Disord Drug Targets 8: 88-99, 2008.
10. Golubnitschaja-Labudova O, Liu R, Decker C, Zhu P, Haefliger IO and Flammer J: Altered gene expression in lymphocytes of patients with normal-tension glaucoma. Curr Eye Res 21: 867-876, 2000.
11. Shevchenko A, Wilm M, Vorm O and Mann M: Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. Anal Chem 68: 850-858, 1996.
12. Liu CR, Ma CS, Ning JY, You JF, Liao SL and Zheng J: Differential thymosin beta 10 expression levels and actin filament organization in tumor cell lines with different metastatic potential. Chin Med J (Engl) 117: 213-218, 2004.
13. Rosenblum MD and Shivers RR: 'Rings'of F-actin form around the nucleus in cultured human MCF7 adenocarcinoma cells upon exposure to both taxol and taxotere. Comp Biochem Physiol C Toxicol Pharmacol 125: 121-131, 2000.
14. Bharadwaj S, Thanawala R, Bon G, Falcioni R and Prasad GL: Resensitization of breast cancer cells to anoikis by tropomyosin-1: role of Rho kinase-dependent cytoskeleton and adhesion. Oncogene 24: 8291-8303, 2005.
15. Vassy J, Portet S, Beil M, Millot G, Fauvel-Lafève F, Gasset G and Schoevaert D: Weightlessness acts on human breast cancer cell line MCF-7. Adv Space Res 32: 1595-603, 2003.
16. Birukova AA, Smurova K, Birukov KG, Usatyuk P, Liu F, Kaibuchi K, Ricks-Cord A, Natarajan V, Alieva I, Garcia JG and Verin AD: Micrombule disassembly induces cytoskeletal remodeling and lung vascular barrier dysfunction: role of Rho-dependent mechanisms. J Cell Physiol 201: 55-70, 2004.
17. Meloni MA, Galleri G, Pippia P and Cogoli-Greuter M: Cytoskeleton changes and impaired motility of monocytes at modelled low gravity. Protoplasma 229: 243-249, 2006.
18. Fritz G, Just I and Kaina B: Rho GTPases are over-expressed in human tumors. Int J Cancer 81: 682-687, 1999.
19. Vicente-Manzanares M, Rey M, Pérez-Martínez M, Yáñez-Mó M, Sancho D, Cabrero JR, Barreiro O, de la Fuente H, Itoh K and Sánchez-Madrid F: The RhoA effector mDia is induced during T-cell activation and regulates actin polymerization and cell migration in T lymphocytes. J Immunol 171: 1023-1034, 2003.
20. Southwick FS and Young CL: The actin released from profiling-actin complexes is insufficient to account for the increase in F-actin in chemoattractant-stimulated polymorphonuclear leukocytes. J Cell Biol 110: 1965-1973, 1990.
21. Fratelli M, Demol H, Puype M, Casagrande S, Eberini I, Salmona M, Bonetto V, Mengozzi M, Duffieux F, Miclet E, Bachi A, Vandekerckhove J, Gianazza E and Ghezzi P: Identification by redox proteomics of glutathionylated proteins in oxidatively stressed human T lymphocytes. Proc Natl Acad Sci USA 99: 3505-3510, 2002.
22. Janke J, Schlüter K, Jandrig B, Theile M, Kölble K, Arnold W, Grinstein E, Schwartz A, Estevéz-Schwarz L, Schlag PM, Jockusch BM and Scherneck S: Suppression of tumorigenicity in breast cancer cells by the microfilament protein profilin 1. J Exp Med 191: 1675-1686, 2000.
23. Wang W, Wyckoff JB, Frohlich VC, Oleynikov Y, Hüttelmaier S, Zavadil J, Cermak L, Bottinger EP, Singer RH, White JG, Segall JE and Condeelis JS: Single cell behavior in metastatic primary mammary tumors correlated with gene expression patterns revealed by molecular profiling. Cancer Res 62: 6278-6288, 2002.
24. Wittenmayer N, Jandrig B, Rothkegel M, Schlüter K, Arnold W, Haensch W, Scherneck S and Jockusch BM: Tumor suppressor activity of profilin requires a functional actin binding site. Mol Biol Cell 15: 1600-1608, 2004.
25. Roy P and Jacobson K: Overexpression of profilin reduces the migration of invasive breast cancer cells. Cell Motil Cytoskeleton 57: 84-95, 2004.
26. Cross SS, Hamdy FC, Deloulme JC and Rehman I: Expression of S100 proteins in normal human tissues and common cancers using tissue microarrays: S100A6, S 100A8, S100A9 and S100A11 are all overexpressed in common cancers. Histopathology 46: 256-269, 2005.
27. Passey RJ, Xu K, Hume DA and Geczy CL: S100A8: emerging functions and regulation. J Leukoc Biol 66: 549-556, 1999.
28. Wicki R, Franz C, Scholl FA, Heizmann CW and Schäfer BW: Repression of the candidate tumor suppressor gene S100A2 in breast cancer is mediated by site-specific hypermethylation. Cell Calcium 22: 243-254, 1997.
29. Schnekenburger J, Schick V, Krüger B, Manitz MP, Sorg C, Nacken W, Kerkhoff C, Kahlert A, Mayerle J, Domschke W and Lerch MM: The calcium binding protein S100A9 is essential for pancreatic leukocyte infiltration and induces disruption of cell-cell contacts. J Cell Physiol 216: 558-567, 2008.
30. Somiari RI, Sullivan A, Russell S, Somiari S, Hu H, Jordan R, George A, Katenhusen R, Buchowiecka A, Arciero C, Brzeski H, Hooke J and Shriver C: High-throughput proteomic analysis of human infiltrating ductal carcinoma of the breast. Proteomics 3: 1863-1873, 2003.