Cell integrity and mitochondrial function after Mirasol-PRT treatment for pathogen reduction of apheresis-derived platelets: Results of a three-arm in vitro study

Transfusion and Apheresis Science

Volumn 40, Issue 2, 2009, Pages 79-85

  Picker, Susanne M ^a   Steisel, Alexander ^a   Gathof, Birgit S ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Apoptosis; Mirasol; Mitochondrial function; Pathogen reduction

Indexed keywords

LACTATE DEHYDROGENASE; LACTIC ACID; PADGEM PROTEIN; RIBOFLAVIN;

APHERESIS; APOPTOSIS; ARTICLE; BLOOD GAS ANALYSIS; CELL DEATH; CONTROLLED STUDY; DEVICE; ENZYME ACTIVITY; ENZYME ASSAY; GAMMA IRRADIATION; HUMAN; HUMAN CELL; IN VITRO STUDY; INFECTION CONTROL; MEDICAL TECHNOLOGY; METABOLIC PARAMETERS; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; NONHUMAN; PATHOGEN REDUCTION; THROMBOCYTE; ULTRAVIOLET IRRADIATION;

BLOOD PLATELETS; BLOOD PRESERVATION; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; PHOTOSENSITIZING AGENTS; PLATELET TRANSFUSION; PLATELETPHERESIS; RIBOFLAVIN; ULTRAVIOLET RAYS;

EID: 62949235839     PISSN: 14730502     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.transci.2009.01.013     Document Type: Article

References (53)

1. Strammer S.L., Glynn S.A., Kleinman S.H., Strong D.M., Caglioti S., Wright D.J., et al. National heart, lung, and blood institute nucleic acid test study group. Detection of HIV-1 and HCV infections among antibody-negative blood donors by nuclei acid-amplification testing. National heart, lung, and blood institute nucleic acid test study group. N Eng J Med 35 (2004) 760-768
2. Li J., De Korte D., Woolum M.D., Ruane P.H., Keil S.D., Lockerbie O., et al. Pathogen reduction of buffy-coat platelet concentrates using riboflavin and light: comparisons with pathogen reduction technology-treated apheresis platelet products. Vox Sang 87 (2004) 82-90
3. Goodrich L., Douglas I., and Urioste M. Riboflavin photoinactivation procedure inactivates significant levels of bacteria and produces a culture negative product. Transfusion 42 (2002) 16S
4. Goodrich L., Ghielli M., Hansen E., Woolum M., Gampp D., Goodrich R., et al. Riboflavin and UV light inactivate enveloped and non-enveloped viruses in platelet concentrates under conditions, which maintain cell quality. Vox Sang 83 (2002) 111
5. Goodrich R.P. Inactivation of viruses in blood products (platelets, plasma, and red cells). Transfus Clin Biol 8 (2001) 103S
6. Kumar V., Motheral T., Luzniak G., and Goodrich R.P. Mirasol pathogen reduction technology: riboflavin-based plasma process inactivates intracellular and extracellular human immunodeficiency virus. J Clin Apher 18 (2003) 84
7. Ruane P.H., Edrich R., Gampp D., Keil S.D., Leonard R.L., and Goodrich R.P. Photochemical inactivation of selected viruses and bacteria in platelet concentrates using riboflavin and light. Transfusion 44 (2004) 877-885
8. Code of Federal Regulation, FDA, Vitamin B. CFR 21; Part 582.5695; 1998.
9. Piper J., Hansen E., and Woolum M. Evaluation of genotoxicity and acute toxicity risk associated with a riboflavin-based pathogen inactivation process. Int J Toxicol 20 (2001) 404
10. Zempleni J., Galloway J.R., and McCormick D.B. Pharmacokinetics of orally and intravenously administered riboflavin in healthy humans. Am J Clin Nutr 63 (1996) 54-66
11. Unna K., and Greslin J. Studies on the toxicity and pharmacology of riboflavin. J Pharmacol Exp Ther 75 (1942) 75-80
12. - production by riboflavin, lumichrome and lumiflavin. Int J Biochem Biophys 26 (1989) 186
13. Kale H., Harikumar P., Nair P.M., and Netrawali M.S. Assessment of the genotoxic potential of riboflavin and lumiflavin. Effect of metabolic enzymes. Mutat Res 298 (1992) 9-16
14. Hardwick C.C., Herivel T.R., Hernandez S.C., Ruane P.H., and Goodrich R.P. Separation, identification and quantification of riboflavin and its photoproducts using HPLC with fluorescence detection: a method to support pathogen reduction technology. Photochem Photobiol 80 (2004) 609-615
15. Akkerman J.W. Regulation of carbohydrate metabolism in platelets: a review. Thromb Haemost 39 (1978) 12-24
16. Li J., Xia Y., Bertino A.M., Coburn J.P., and Kuter D.J. The mechanism of apoptosis in human platelets during storage. Transfusion 40 (2000) 1320-1329
17. Picker S.M., Speer R., and Gathof B.S. Functional characteristics of buffy-coat PLTs photochemically treated with amotosalen-HCl for pathogen inactivation. Transfusion 44 (2004) 420-427
18. Snyder E.L., Beardsley D.S., Smith B.R., Horne W., Johson R., Wooten T., et al. Storage of platelet concentrates after high-dose ultraviolet B irradiation. Transfusion 31 (1991) 491-496
19. Murphy S. Platelet storage for transfusion. Semin Hematol 22 (1985) 165-177
20. Li H., Zhu H., Xu C.J., and Yuan J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the fas pathway of apoptosis. Cell 94 (1998) 491-501
21. Perrotta P.L., Perrotta C.L., and Snyder E.L. Apoptotic activity in stored human platelets. Transfusion 43 (2003) 526-535
22. Guidelines for the collection of blood and blood components and the usage of blood products (hemotherapy), Rev. ed. German Medical Association and Paul-Ehrlich-Institute. Cologne: Deutscher Ärzteverlag; 2005.
23. Li J., Goodrich L., Hansen E., Edrich E., Gampp D., and Goodrich R.P. Platelet glycolytic flux increases stimulated by ultraviolet-induced stress is not the direct cause of platelet morphology and activation changes: possible implications for the role of glucose in platelet storage. Transfusion 45 (2005) 1750-1758
24. Li J., Lockerbie O., De Korte D., Rice J., McLean R., and Goodrich R.P. Evaluation of platelet mitochondria integrity after treatment with Mirasol pathogen reduction technology. Transfusion 45 (2005) 920-926
25. Perez-Pujol S., Tonda R., Lozano M., Fuste B., Lopez-Vilchez I., Galan A.M., et al. Effects of a new pathogen reduction technology (Mirasol-PRT) on functional aspects of platelet concentrates. Transfusion 45 (2005) 911-919
26. Goodrich R.P., Li J., Pieters H., Crookes R., Roodt J., and Heyns A.P. Correlation of in vitro platelet quality measurements with in vivo platelet viability in human subjects. Vox Sang 90 (2006) 279-285
27. Darzynkiewicz Z., Bedner E., and Smolewski P. Flow cytometry in analysis of cell cycle and apoptosis. Seminars Hematol 38 (2001) 179-193
28. Verhoeven A.J., Verhaar R., Gouwerok E.G., and de Korte D. The mitochondrial membrane potential in human platelets: a sensitive parameter for platelet quality. Transfusion 45 (2005) 82-89
29. Kilkson H., Holme S., and Murphy S. Platelet metabolism during storage of platelet concentrates at 22° C. Blood 64 (1984) 406-414
30. Janetzko K., Klinger M., Mayaudon V., Lin L., Eichler H., and Klüter H. Storage characteristics of split double-dose platelet concentrates derived from apheresis and treated with amotosalen-HCl and UVA light for pathogen inactivation. Infus Ther Transfus Med 29 (2002) 193-198
31. Rhenen van D.J., Vermeij J., Mayaudon V., Hind C., Lin L., and Corash L. Functional characteristics of S-59 photochemically treated platelet concentrates derived from buffy-coats. Vox Sang 79 (2000) 206-214
32. Snyder E.L., Beardsley D.S., Smith B.R., Horne W., Johnson R., Wooten T., et al. Storage of platelet concentrates after high-dose ultraviolet B irradiation. Transfusion 31 (1991) 491-496
33. Mondoro T.H., Shafer B.C., and Vostal J.G. Restoration of in vitro responses in platelets stored in plasma. Am J Clin Pathol 111 (1999) 693-699
34. Bode A.P. Platelet activation may explain the storage lesion in platelet concentrates. Blood Cells 16 (1990) 109-125
35. Seghatchian J. Platelet storage lesion: an update on the impact of various leukoreduction processes on the biological response modifiers. Transfus Apher Sci 34 (2006) 125-130
36. Shapira S., Friedman Z., Shapiro H., Presseizen K., Radnay J., and Ellis M.H. The effect of storage on the expression of platelet membrane phosphatidylserine and the subsequent impact on the coagulant function of stored platelets. Transfusion 40 (2000) 1257-1263
37. Seghatchian J., and Krailadsiri P. Platelet storage lesion and apoptosis: are they related?. Transfus Apher Sci 24 (2001) 103-105
38. Leytin V., and Freedman J. Platelet apoptosis in stored platelet concentrates and other models. Transfus Apher Sci 28 (2003) 285-295
39. Xia Y., Li J., Bertino A., and Kuter D.J. Thrombopoietin and the TPO receptor during platelet storage. Transfusion 40 (2000) 976-987
40. AuBuchon J.P., Herschel L., Roger J., Taylor H., Whitley P., Li J., et al. Efficacy of apheresis platelets treated with riboflavin and ultraviolet light for pathogen reduction. Transfusion 45 (2005) 1335-1341
41. Dekkers D.W., De Cuyper I.M., van der Meer P.F., Verhoeven A.J., and de Korte D. Influence of pH on stored human platelets. Transfusion 47 (2007) 1889-1895
42. Gawaz M.P. Blood platelets (2001), Georg Thieme Verlag Stuttgart, New York
43. Muenzer J., Weinbach E.C., and Wolfe S.M. Oxygen consumption of human blood platelets. Effect of inhibitors on thrombin-induced oxygen burst. Biochim Biophys Acta 376 (1975) 243-248
44. Kirtland S.J., and Baum H. Mitochondrial respiration and the thrombin-induced release reaction of platelets. Biochem Pharmacol 23 (1974) 1859-1870
45. Muenzer J., Weinbach E.C., and Wolfe S.M. Oxygen consumption of human blood platelets. Effect of thrombin. Biochim Biophys Acta 376 (1975) 237-242
46. Pickett W.C., and Cohen P. Mechanism of the thrombin-mediated burst in oxygen consumption by human platelets. J Biol Chem 251 (1976) 2536-2538
47. Mürer E.H. Release reaction and energy metabolism in blood platelets with special reference to the burst in oxygen uptake. Biochim Biophys Acta 162 (1968) 320-326
48. Rognoni F., Viganò V., and Colombo Pirola L. Influence of platelet anti-aggregants on mitochondrial respiration of platelets. Boll Soc Ital Cardiol 22 (1977) 2140-2146
49. Abou-Khalil S., Abou-Khalil W.H., and Yunis A.A. Mechanism of interaction of ticlopidine and its analogues with the energy-conserving mechanism in mitochondria. Biochem Pharmacol 35 (1986) 1855-1859
50. Abou-Khalil W.H., Lim L.O., Yunis A.A., and Abou-Khalil S. Effects of ticlopidine, a new platelet antiaggregating agent, and its analogues on mitochondrial metabolism. Oxidative phosphorylation, protein synthesis and DNA polymerase activity. Biochem Pharmacol 33 (1984) 3893-3898
51. Kaufman R.M. Platelets: testing, dosing and the storage lesion-recent advances. Hematol Am Coc Hematol Educ Program (2006) 492-496
52. Rinder H.M., Snyder E.L., Tracey J.B., Dinecco D., Wang C., Baril L., et al. Reversibility of severe metabolic stress in stored platelets after in vitro plasma rescue or in vivo transfusion: restoration of secretory function and maintenance of platelet survival. Transfusion 43 (2003) 1230-1237
53. Cavalho H., Alguero C., Santos M., de Sousa G., Trindada H., and Seghatchian J. The combined effect of platelet storage media and intercept pathogen reduction technology on platelet activation/activability and cellular apoptosis/necrosis: Lisbon-RBS experience. Transfus Apher Sci 34 (2006) 187-192