Pharmacokinetics of orally and intravenously administered riboflavin in healthy humans

American Journal of Clinical Nutrition

Volumn 63, Issue 1, 1996, Pages 54-66

  Zempleni, Janos ^b   Galloway, John R ^b   McCormick, Donald B ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

flavins; human; intravenous riboflavin administration; oral riboflavin administration; Riboflavin pharmacokinetics

Indexed keywords

FLAVOPROTEIN; RIBOFLAVIN;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG EXCRETION; DRUG HALF LIFE; DRUG METABOLISM; DRUG URINE LEVEL; ENZYME ACTIVITY; ENZYME RELEASE; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; RANDOMIZED CONTROLLED TRIAL; VITAMIN INTAKE;

EID: 0030023376     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/63.1.54     Document Type: Article

References (42)

1. Levy G, Jusko WJ. Factors affecting the absorption of riboflavin in man. J Pharm Sci 1966;55:285-9.
2. Jusko WJ, Levy G. Absorption, metabolism, and excretion of riboflavin-5′-phosphate in man. J Pharm Sci 1967;56:58-62.
3. Mayersohn M, Feldman S, Gibaldi M. Bile salt enhancement of riboflavin and flavin mononucleotide absorption in man. J Nutr 1969; 98:288-96.
4. Wiegand RG, Buddenhagen JD, Endicott CJ. Multiple dosing excretion kinetics. J Pharm Sci 1963;52:268-73.
5. Jusko WJ, Levy G. Pharmacokinetic evidence of saturable renal tubular reabsorption of riboflavin. J Pharm Sci 1970;59:765-72.
6. Levy G, Jusko WJ. Apparent renal tubular secretion of riboflavin in man. J Pharm Sci 1966,55:1322 (letter).
7. Bateman NE, Uccellini DA. Effect of formulation on the bioavailability of retinol. d-α-tocopherol and riboflavin. J Pharm Pharmacol 1984; 36:461-4.
8. Thakker KM, Sitren HS, Gregory JF, Schmidt GL, Baumgartner TG. Dosage form and formulation effects on the bioavailability of vitamin E. riboflavin, and vitamin B-6 from multivitamin preparations. Am J Clin Nutr 1987;45:1472-9.
9. Zempleni J, Kübler W. Utilization of intravenously infused pyridoxine in humans. Clin Chim Acta 1994;229:27-36.
10. McCormick DB. Metabolism of riboflavin. In: Rivlin RS, ed. Riboflavin. New York: Plenum Press, 1975.153-98.
11. Ohkawa H, Ohishi N, Yagi K. A simple method for micro-determination of flavins in human serum and whole blood by high-performance liquid chromatography. Biochem Int 1982;4:187-94.
12. Aw TY, Jones DP, McCormick DB. Uptake of riboflavin by isolated rat liver cells. J Nutr 1983;113:1249-54.
13. 6, biotin, and C. Proc Soc Exp Biol Med 1993;202:265-70.
14. Merrill AH, Shapira G, McCormick DB. Recent findings concerning mammalian riboflavin-binding proteins. In: Massey V, Williams CH, eds. Flavins and flavoproteins. New York: Elsevier North Holland, 1982:508-13.
15. Lopez-Anaya A, Mayersohn M. Quantification of riboflavin, riboflavin 5′-phosphate and flavin adenine dinucleotide in plasma and urine by high-performance liquid chromatography. J Chromatogr 1987;423: 105-13.
16. Rivlin RS. Hormonal regulation of riboflavin metabolism. In: Rivlin RS, ed. Riboflavin. New York: Plenum Press, 1975:393-426.
17. Lee S-S, McCormick DB. Thyroid hormone regulation of flavocoenzyme biosynthesis. Arch Biochem Biophys 1985;237:197-201.
18. Chan V, Jones A, Liendo-Ch P, McNeilly A, Landon J, Besser GM, The relationship between circadian variations in circulating thyrotrophin. thyroid hormones and prolactin. Clin Endocrinol 1978;9: 337-49.
19. Lentner C, ed. Geigy scientific tables. Vol 3. Physical chemistry, composition of blood, hematology, somatometric data. 8th ed. Basel, Switzerland: Ciba-Geigy, 1984.
20. Zempleni J, Link G, Kübler W. The transport of thiamine, riboflavin and pyridoxal 5′-phosphate by human placenta. Int J Vitam Nutr Res 1992;62:165-72.
21. Pietta P, Calatroni A, Rava A. Hydrolysis of riboflavin nucleotides in plasma monitored by high-performance liquid chromatography. J Chromatogr 1982;229:445-9.
22. Gatautis VJ, Naito HK. Liquid-chromatographic determination of urinary riboflavin. Clin Chem 1981;27:1672-5.
23. Taussky HH. Creatinine and creatine in urine and serum. Standard Methods Clin Chem 1961;3:99-113.
24. Bonruchsen R, Lundgren J. Comparison of the ADH and the Weld-mark procedures for determining alcohol. Acta Pharmacol Toxicol 1957;13:256-66.
25. Gibaldi M, Perrier D. Pharmacokinetics. New York: Marcel Dekker, 1982.
26. Colquhoun D Lectures on biostatistics. London: Oxford University Press, 1971.
27. Sauberlich HE, Skala JH, Dowdy RP. Laboratory tests for the assessment of nutritional status, Boca Raton, FL: CRC Press, 1974.
28. Lentner C, ed. Geigy scientific tables. Vol 1. Units of measurement, body fluids, composition of the body, nutrition. 8th ed. Basel. Switzerland: Ciba-Geigy, 1981.
29. Bois FY, Tozer TN, Hauck WW, Chen M-L, Patnaik R, Williams RL. Bioequivalence: performance of several measures of extent of absorption. Pharmacol Res 1994;11:715-22.
30. Matsui K, Kasai S. Chemical synthesis of nekoflavin. In: Yagi K, ed. Flavins and flavoproteins 1993. Berlin: Walter deGruyter, 1993:31-4.
31. Ohkawa H, Ohishi N, Yagi K. New metabolites of riboflavin appear in human urine. J Biol Chem 1983;258:5623-8.
32. Mascher H, Kikuta C. High-performance liquid Chromatographic determination of total thiamine in human plasma for oral bioavailability studies. J Pharm Sci 1993;82:56-9.
33. 6-Versorgungszustandes beim Menschen. 6. Mitteilung. S-PLP. Die Aussagefähigkeit des Parameters.) Int J Vitam Nutr Res 1983;53:166-78 (in German).
34. 6 by high-performance liquid chromatography with post-column derivatization. J Pharm Sci 1993; 82:972-4.
35. Said HM, Ghishan FK, Greene HL, Hollander D. Developmental maturation of riboflavin intestinal transport in the rat. Pediatr Res 1985;19:1175-8.
36. Bois FY, Tozer TN, Hauck WW, Chen M-L, Patnaik R, Williams RL. Bioequivalence: performance of several measures of rate of absorption. Pharmacol Res 1994;11:966-74.
37. Stripp B. Intestinal absorption of riboflavin by man. Acta Pharmacol Toxicol 1965;22:353-62.
38. Merrill AH Jr, McCormick DB. Affinity Chromatographic purification and properties of flavokinase (ATP:riboflavin 5′-phosphotransferase) from rat liver. J Biol Chem 1980;255:1335-8.
39. Oka M, McCormick DB. Complete purification and general characterization of FAD synthetase from rat liver. J Biol Chem 1987,262: 7418-22.
40. Frigg M, Hartmann D, Straub OC Biotin kinetics in serum of cattle after intravenous and oral dosing. Int J Vitam Nutr Res 1994;64:36-40.
41. Jusko WJ, Levy W Absorption, protein binding, and elimination of riboflavin. In: Rivlin RS, ed. Riboflavin. New York: Plenum Press, 1975:100-52.
42. Chastain JL, McCormick DB. Flavin catabolites: identification and quantitation in human urine. Am J Clin Nutr 1987;46:830-4.