Epidural, intrathecal and plasma pharmacokinetic study of epidural ropivacaine in PLGA-microspheres in sheep model

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 72, Issue 1, 2009, Pages 54-61

  Ratajczak Enselme, Maja ^a   Estebe, Jean Pierre ^a   Dollo, Gilles ^a   Chevanne, François ^a   Bec, David ^a   Malinovsky, Jean Marc ^a   Ecoffey, Claude ^a   Le Corre, Pascal ^a  

^a UNIVERSITÉ DE RENNES 1   (France)

Author keywords

Epidural space; Intrathecal space; Microdialysis; PLGA microspheres; Ropivacaine

Indexed keywords

BUPIVACAINE; ETIDOCAINE; MICROSPHERE; POLYGLACTIN; ROPIVACAINE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BOLUS INJECTION; CONTINUOUS INFUSION; CONTROLLED STUDY; DIALYSATE LEVEL; DRUG CEREBROSPINAL FLUID LEVEL; DRUG DOSAGE FORM COMPARISON; DRUG DOSE INCREASE; DRUG RELEASE; DRUG UPTAKE; ENCAPSULATION; EWE; EXPERIMENTAL MODEL; FEMALE; MAXIMUM PLASMA CONCENTRATION; MICRODIALYSIS; NONHUMAN; SPRAY DRYING;

AMIDES; ANALGESIA, EPIDURAL; ANESTHETICS, LOCAL; ANIMALS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CHEMISTRY, PHARMACEUTICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DELIVERY SYSTEMS; LACTIC ACID; MENINGES; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; POLYGLYCOLIC ACID; POLYMERS; SHEEP;

EID: 62949204406     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2008.11.003     Document Type: Article

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