Probing of the cis-5-phenyl proline scaffold as a platform for the synthesis of mechanism-based inhibitors of the Staphylococcus aureus sortase SrtA isoform

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 7, 2009, Pages 2886-2893

  Kudryavtsev, Konstantin V ^a   Bentley, Matthew L ^b   McCafferty, Dewey G ^b  

^a MOSCOW STATE UNIVERSITY   (Russian Federation)

^b DUKE UNIVERSITY   (United States)

Author keywords

Inhibitor; Sortase; Staphylococcus aureus; Vinyl sulfone

Indexed keywords

ACRYLONITRILE; CYSTEINE; ELECTROPHILE; ENZYME INHIBITOR; ESTER DERIVATIVE; ISOPROTEIN; METHYL 2 ETHENESULFONYL 5 OXO 3 PHENYLTETRAHYDROLPYRROLIZINE 7A CARBOXYLATE; METHYL 2 ETHENESULFONYL 5 OXO 3 PYRIDIN 3 YLTETRAHYDROLPYRROLIZINE 7A CARBOXYLATE; METHYL 3 (3,4 DIMETHOXYPHENYL) 2 ETHENESULFONYL 5 OXOTETRAHYDROPYRROLIZINE 7A CARBOXYLATE; METHYL 4 ETHENESULFONYL 2 (2 METHOXYCARBONYLETHYL) 5 PYRIDIN 3 YLPYRROLIDINE 2 CARBOXYLATE; METHYL 5 (3,4 DIMETHOXYPHENYL) 4 ETHENESULFONYL 2 (2 METHOXYCARBONYLETHYL)PYRROLIDINE 2 CARBOXYLATE; PYRROLIDINE DERIVATIVE; SORTASE; SORTASE A; SULFONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CYCLOADDITION; DRUG BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME MODIFICATION; NONHUMAN; STAPHYLOCOCCUS AUREUS;

AMINOACYLTRANSFERASES; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CYSTEINE ENDOPEPTIDASES; ENZYME INHIBITORS; PROLINE; PROTEIN ISOFORMS; STAPHYLOCOCCUS AUREUS; SULFONES;

STAPHYLOCOCCUS AUREUS;

EID: 62949147788     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.02.008     Document Type: Article

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