Influence of 1B ischemic ventricular tissue on the automaticity of purkinje fibers: A simulation study

Computers in Cardiology

Volumn 34, Issue , 2007, Pages 617-620

  Ramirez E ^a,b   Saiz J ^b   Trenor B ^b   Ferrero Jr , J M ^b   Molto G ^b   Hernandez V ^b  

^a Instituto Tecnológico de Cuautla   (Mexico)

^b UNIVERSITAT POLITÈCNICA DE VALÈNCIA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ACTION POTENTIALS; CARDIAC ARRHYTHMIAS; COMPUTER MODELS; ELECTRICAL ACTIVITIES; NORMAL ZONES; PURKINJE CELLS; SIMULATION STUDIES;

CARDIOLOGY; ELECTROPHYSIOLOGY; FIBERS;

MUSCLE;

EID: 62949113731     PISSN: 02766574     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/CIC.2007.4745561     Document Type: Conference Paper

References (16)

1. De Groot JR, Wilms-Schopman FJ, Opthof T, Remme CA and Coronel R. Late ventricular arrhythmias during acute regional ischemia in the isolated blood perfused pig heart. Role of electrical cellular coupling. Cardiovascular Research 2001; 50:362-372.
2. Kaplinsky E, Ogawa S, Balke CW and Dreifus LS. Two periods of early ventricular arrhythmia in the canine acute myocardial infarction model. Circulation 1979; 60:397-403.
3. Arnar DO and Martins JB. Purkinje involvement in arrhythmias after coronary artery reperfusion. Am J Physiol Heart Circ Physiol 2002; 282: H1189-H1196.
4. Verkerk AO, Veldkamp MW, Coronel R, Wilders R and van Ginneken ACG. Effects of cell-to-cell uncoupling and catecholamines on Purkinje and ventricular action potentials: implications for phase-1b arrhythmias. Cardiovascular Research 2001; 51: 30-40.
5. Picard S, Rene Rouet R, Ducouret P, Puddu PE, Flais F, Criniti A, Monti F and Gerard JL. KATP channels and 'border zone' arrhythmias: role of the repolarization dispersion between normal and ischaemic ventricular regions. British Journal of Pharmacology 1999;127:1687- 1695
6. DiFrancesco D and Noble D. A model of cardiac electrical activity incorporating ionic pumps and concentration changes. Philos Trans R Soc Lond B Biol Sci 1985; 307: 353-398.
7. Luo CH, Rudy Y. A dynamic model of the cardiac ventricular action potential: I. Simulations of ionic currents and concentration changes. Circulation Research 1994; 74:1071-1096.
8. Faber GM, Rudy Y. Action potential and contractibility changes in [Na(+)](i) overloaded cardiac myocytes: a simulation study. Biophysics Journal 2000; 78:2392-2404.
9. Pollard A, Cascio W, Fast V and Knisley S. Modulation of triggered activity by uncoupling in the ischemic border. A model study with phase 1b-like conditions. Cardiovasc Res 2002; 56:381-392.
10. Zipes DP. Mechanisms of clinical arrhythmias. J Cardiovasc Electrophysiol 2002; 14:902-912.
11. Antzelevitch C. Basic mechanisms of reentrant arrhythmias. Curr Opin Cardiol 2001; 16:1-7.
12. Rodriguez-Sinovas, A. y Cinca, J. (1999). [Sudden death (II). Myocardial ischemia and ventricular arrhythmias in experimental models: triggering mechanisms], Rev Esp Cardiol 1999; 52:851-859.
13. K. Walton MK and Fozzard HA. Experimental study of the conducted action potential in cardiac Purkinje strands. Biophysical Journal 1983; 44:1-8.
14. Rohr S. Role of gap junctions in the propagation of the cardiac action potential. Cardiovascular Research 2004; 62: 309-322
15. Shaw R. and Rudy Y. Ionic mechanisms of propagation in cardiac tissue. Roles of the sodium and L-type calcium currents during reduced excitability and decreased gap junction coupling. Circ Res 1997; 81: 727-41.
16. Romero L, Trenor B, Ferrero (Jr) JM and Saiz J. A sensitivity study of the safety factor for conduction in the myocardium. Computers in Cardiology 2005; Vol. 32:873876.