Probing cellular dynamics with a chemical signal generator

PLoS ONE

Volumn 4, Issue 3, 2009, Pages

  Kuczenski, Brandon ^a   Ruder, Warren C ^a   Messner, William C ^a   LeDuc, Philip R ^a  

^a CARNEGIE MELLON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; IONOMYCIN;

ARTICLE; CALCIUM CELL LEVEL; CELL ASSAY; CELL FUNCTION; CELL STIMULATION; CELLULAR STRESS RESPONSE; CHEMICAL STRESS; CONTROLLED STUDY; CYTOSOL; FIBROBLAST; FLOW RATE; HUMAN; HUMAN CELL; LAMINAR FLOW; MOLECULAR DYNAMICS; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; DRUG EFFECT; FLUORESCENCE MICROSCOPY; MICROFLUIDICS;

FIBROBLASTS; IONOMYCIN; MICROFLUIDICS; MICROSCOPY, FLUORESCENCE;

EID: 62849128811     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0004847     Document Type: Article

References (33)

1. Brandman O, Meyer T (2008) Feedback loops shape cellular signals in space and time. Science 322: 390-395.
2. Mettetal JT, Muzzey D, Gómez-Uribe C, van Oudenaarden A (2008) The frequency dependence of osmo-adaptation in Saccharomyces cerevisiae. Science 319: 482-484.
3. Bennett MR, Pang WL, Ostroff NA, Baumgartner BL, Nayak S, et al. (2008) Metabolic gene regulation in a dynamically changing environment. Nature 454: 1119-1122.
4. Hofer AM, Landolfi B, Debellis L, Pozzan T, Curcin S (1998) Free [Ca2+] dynamics measured in agonist-sensitive stores of single living intact cells: a new look at the refilling process. EMBO J 17: 1986-1995.
5. Berridge MJ, Bootman MD, Roderick HL (2003) Calcium Signalling: Dynamics, Homeostasis and Remodelling. Nat Rev Mol Cell Biol 4: 517-529.
6. Rizzuto R, Pozzan T (2006) Microdomains of Intracellular Ca2+: Molecular Determinants and Functional Consequences. Physiol Rev 86: 369-408.
7. Caroppo R, Colella M, Colasuonno A, DeLuisi A, Debellis L, et al. (2003) A Reassessment of the Effects of Luminal [Ca2+] on Inositol 1,4,5-Trisphosphate-induced Ca2+ Release from Internal Stores. J Biol Chem 278: 39503-39508.
8. Burdakov D, Petersen OH, Verkhratsky A (2005) Intraluminal calcium as a primary regulator of endoplasmic reticulum function. Cell Calcium 38: 303-310.
9. Walker GM, Ozers MS, Beebe DJ (2002) Insect cell culture in microfluidic devices. Biomed Microdev 4: 161-166.
10. Korin N, Bransky A, Dinnar U, Levenberg S (2007) A parametric study of human fibroblasts culture in a microchannel bioreactors. Lab Chip 7: 611-617.
11. Wheeler AR, Throndset WR, Whelan RJ, Leach AM, Zare RN, et al. (2003) Microfluidic device for single-cell analysis. Anal Chem 75: 3581-3586.
12. Gu W, Zhu X, Futai N, Cho BS, Takayama S (2004) Computerized microfluidic cell culture using elastomeric channels and braille displays. Proc Natl Acad Sci 101: 15861-15866.
13. Kenis PJA, Ismagilov RF, Whitesides GM (1999) Microfabrication inside capillaries using multiphase laminar flow patterning. Science 285: 83-85.
14. Kamholz AE, Weigl BH, Finlayson BA, Yager P (1999) Quantitative analysis of molecular interaction in a microfluidic channel: the T-Sensor. Anal Chem 71: 5340-5347.
15. Atencia J, Beebe DJ (2005) Controlled microfluidic interfaces. Nature 437: 648-655.
16. Takayama S, Ostuni E, LeDuc P, Naruse K, Ingber DE, et al. (2001) Subcellular positioning of small molecules. Nature 411: 1016.
17. Sawano A, Takayama S, Matsuda M, Miyawaki A (2002) Lateral Propagation of EGF Signaling after Local Stimulation Is Dependent on Receptor Density. Dev Cell 3: 245-257.
18. Lucchetta EM, Lee JH, Fu LA, Patel NH, Ismagilov RF (2005) Dynamics of drosophila embryonic patterning network perturbed in space and time using microfluidics. Nature 434: 1134-1138.
19. Wang F, Wang H, Wang J, Wang HY, Rummel PL, et al. (2008) Microfluidic delivery of small molecules into mammalian cells based on hydrodynamic focusing. Biotechnol Bioeng 100: 150-158.
20. Ellis-Davies GCR (2007) Caged compounds: photorelease technology for control of cellular chemistry and physiology. Nat Methods 4: 619-628.
21. Beta C, Wyatt D, Rappel WJ, Bodenschatz E (2007) Flow photolysis for spatiotemporal stimulation of single cells. Anal Chem 79: 3940-3944.
22. Kuczenski B, LeDuc PR, Messner WC (2007) Pressure-driven spatiotemporal control of the laminar flow interface in a microfluidic network. Lab Chip 7: 647-649.
23. Pressman BC (1976) Biological applications of ionophores. Annu Rev Biochem 45: 501-530.
24. Scarpa A, Baldassare J, Inesi G (1972) The Effect of Calcium Ionophores on Fragmented Sarcoplasmic Reticulum. J Gen Physiol 60: 735-749.
25. Albert PR, Tashjian AHJ (1986) Ionomycin acts as an ionophore to release TRH-regulated Ca2+ stores from GH4C1 cells. Am J Physiol 251: C887-91.
26. Morgan AJ, Jacob R (1994) Ionomycin enhances Ca2+ influx by stimulating store-regulated cation entry and not by a direct action at the plasma membrane. Biochem J 300: 665-672.
27. Dode L, Vilsen B, van Baelen K, Wuytack F, Clausen JD, et al. (2002) Dissection of the Functional Differences between Sarco(endo)plasmic Reticulum Ca2+-ATPase (SERCA) 1 and 3 Isoforms by Steady-state and Transient Kinetic Analyses. J Biol Chem 277: 45579-45591.
28. Lau BW, Colella M, Ruder WC, Ranieri M, Curci S, et al. (2005) Deoxycholic acid activates protein kinase C and phospholipase C via increased Ca2+ entry at plasma membrane. Gastroenterology 128: 695-707.
29. Ismagilov RF, Stroock AD, Kenis PJA, Whitesides G, Stone HA (2000) Experimental and theoretical scaling laws for transverse diffusive broadening in two-phase laminar flows in microchannels. Appl Phys Lett 76: 2376-2378.
30. Jimenez J (2005) The growth of a mixing layer in a laminar channel. J Fluid Mech 535: 245-254.
31. Yang M, Li CW, Yang J (2002) Cell docking and on-chip monitoring of cellular reactions with a controlled concentration gradient on a microfluidic device. Anal Chem 74: 3991-4001.
32. Araujo RP, Liotta LA (2006) A control theoretic paradigm for cell signaling networks: a simple complexity for a sensitive robustness. Curr Opin Chem Biol 10: 81-87.
33. Duffy DC, McDonald JC, Schueller OJA, Whitesides GM (1998) Rapid prototyping of microfluidic systems in poly(dimethylsiloxane). Anal Chem 70: 4974-4984.