Influence of storage relative humidity on the dispersion of salmeterol xinafoate powders for inhalation

Journal of Pharmaceutical Sciences

Volumn 98, Issue 3, 2009, Pages 1015-1027

  Das, Shyamal ^a   Larson, Ian ^a   Young, Paul ^b   Stewart, Peter ^a  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Agglomerate; Dispersion; Dry powder inhaler; Relative humidity; Salmeterol xinafoate; Storage stability

Indexed keywords

LACTOSE; SALMETEROL XINAFOATE;

ARTICLE; DISPERSION; DRUG FORMULATION; DRUG STORAGE; HUMIDITY; SCANNING ELECTRON MICROSCOPY; THERMOGRAVIMETRY;

EID: 62849124937     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21500     Document Type: Article

References (31)

1. Borgstrom L, Asking L, Lipniunas P. 2005. An in vivo and in vitro comparison of two powder inhalers following storage at hot/humid conditions. J Aerosol Med 18:304-310.
2. Stewart PJ. 1986. Particle interaction in pharmaceutical systems. Pharm Int 7:146-149.
3. Zimon AD, editor. 1982. Adhesion in a gas medium. Sources of adhesion. In: Adhesion of dust and powder. 2nd edition. New York: Consultants Bureau. pp 93-144.
4. Podczeck F, Newton JM, James MB. 1996. The influence of constant and changing relative humidity of the air on the autoadhesion force between pharmaceutical powder particles. Int J Pharm 145:221-229.
5. Young PM, Price R, Tobyn MJ, Buttrum M, Dey F. 2003. Effect of humidity on aerosolization of micronized drugs. Drug Dev Ind Pharm 29:959-966.
6. Hindle M, Makinen GM. 1996. Effects of humidity on the in vitro aerosol performance and aerodynamic size distribution of cromolyn sodium for inhalation. Eur J Pharm Sci 4:S142.
7. Braun MA, Oschmann R, Schmidt PT. 1996. Influence of excipients and storage humidity on the deposition of disodium cromoglycate (DSCG) in the twin impinger. Int J Pharm 135:53-62.
8. Young PM, Price R. 2004. The influence of humidity on the aerosolisation of micronised and SEDS produced salbutamol sulphate. Eur J Pharm Sci 22:235-240.
9. Lida K, Hayakawa Y, Okamoto H, Danjo K, Luenberger H. 2004. Influence of storage humidity on the in vitro inhalation properties of salbutamol sulphate dry powder with surface covered lactose carrier. Chem Pharm Bull 52:444-446.
10. Zeng XM, MacRitchie HB, Marriott C, Martin GP. 2007. Humidity-induced changes of the aerodynamic properties of dry powder aerosol formulations containing different carriers. Int J Pharm 333:45-55.
11. Harjunen P, Lankinen T, Salonen H, Lehto VP, Jarvinen K. 2003. Effects of carriers and storage of formulation on the lung deposition of a hydrophobic and hydrophilic drug from a DPI. Int J Pharm 263:151-163.
12. Maggi L, Bruni R, Conte U. 1999. Influence of moisture on the performance of a new dry powder inhaler. Int J Pharm 177:83-91.
13. Adi H, Larson I, Chiou H, Young P, Traini D, Stewart P. 2006. Agglomerate strength and dispersion of salmeterol xinafoate from powder mixtures for inhalation. Pharm Res 23:2556-2565.
14. Islam N, Stewart P, Larson I, Hartley P. 2004. Effect of carrier size on the disperson of salmeterol xinafoate from interactive mixtures. J Pharm Sci 93:1030-1038.
15. Louey MD, Stewart PJ. 2002. Particle interactions involved in aerosol dispersion of ternary interactive mixtures. Pharm Res 19:1524-1531.
16. Always B, Sangchantra R, Stewart PJ. 1996. Modelling the dissolution of diazepam in lactose interactive mixtures. Int J Pharm 130:213-224.
17. Liu J, Stewart PJ. 1998. Deaggregation during the dissolution of Benzodiazepines in Interactive mixtures. J Pharm Sci 87:1632-1638.
18. Crooks MJ, Ho R. 1976. Ordered mixing in direct compression of tablets. Powder Technol 14:161-167.
19. Callahan JC, Cleary GW, Elefant M, Kaplan G, Kensler T, Nash RA. 1982. Equilibrium moisture content of pharmaceutical excipients. Drug Dev Ind Pharm 8:355-369.
20. Berard V, Lesniewska E, Andres C, Pertuy D, Laroche C, Pourcelot Y. 2002. Affinity scale between a carrier and a drug in DPI studied by atomic force microscopy. Int J Pharm 247:127-137.
21. Visser J. 1995. Particle adhesion and removal: A review. Particulate Sci Technol 12:169-196.
22. Eastman T, Zhu DM. 1996. Adhesion forces between surface-modified AFM tips and a mica surface. Langmuir 12:2589-2862.
23. Price R, Young PM, Edge S, Staniforth JN. 2002. The influence of relative humidity on particulate interactions in carrier-based dry powder inhaler formulations. Int J Pharm 246:47-59.
24. Xu L, Lio A, Ogletree DF, Salmeron M. 1998. Wetting and capillary phenomena of water on mica. J Phys Chem B 102:540-548.
25. Podczeck F, Newton JM, James MB. 1997. Influence of relative humidity of storage air on the adhesion and autoadhesion of micronized particles to particulate and compacted powder surfaces. J Colloid Interface Sci 187:484-491.
26. Podczeck F, Newton JM, James MB. 1996. The influence of constant and changing relative humidity of the air on the autoadhesion force between pharmaceutical powder particles. Int J Pharm 145:221-229.
27. Podczeck F, Newton JM, James MB. 1995. Assessment of adhesion and autoadhesion forces between particles and surfaces. Part II. The investigation of adhesion phenomenoa of salmeterol xinafoate and lactose monohydrate particles in particle-on-particle and particle-on surface contact. J Adhes Sci Technol 9:475-486.
28. Jashnani RN, Byron PR, Dalby RN. 1995. Testing of dry powder aerosol formulations in different environmental conditions. Int J Pharm 113:123-130.
29. Podczeck F, Newton JM, James MB. 1997. Variations in the adhesion force between a drug and a carrier particles as a result of changes in the relative humidity of the air. Int J Pharm 149:151-160.
30. Padmadisastra Y, Kennedy RA, Stewart PJ. 1994. Influence of carrier moisture adsorption capacity on the degree of adhesion of interactive mixtures. Int J Pharm 104:R1-R4.
31. Padmadisastra Y, Kennedy RA, Stewart PJ. 1994. Solid bridge formation in sulphonamide-Emdex interactive systems. Int J Pharm 112:55-63.