Effect of Humidity on Aerosolization of Micronized Drugs

Drug Development and Industrial Pharmacy

Volumn 29, Issue 9, 2003, Pages 959-966

  Young, Paul M ^a   Price, Robert ^a   Tobyn, Michael J ^a   Buttrum, Mark ^b   Dey, Fiona ^b  

^a University of Bath   (United Kingdom)

^b Respiratory Technology   (United Kingdom)

Author keywords

Dry powder aerosolization; Humidity; In vitro

Indexed keywords

CROMOGLYCATE DISODIUM; SALBUTAMOL SULFATE; TRIAMCINOLONE ACETONIDE;

AEROSOL; ARTICLE; CHEMISTRY; DRY POWDER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMIDITY; IN VITRO STUDY; INHALATIONAL DRUG ADMINISTRATION; PARTICLE SIZE; POWDER; SCANNING ELECTRON MICROSCOPY; X RAY POWDER DIFFRACTION;

ADMINISTRATION, INHALATION; AEROSOLS; CHEMISTRY, PHARMACEUTICAL; HUMIDITY; POWDERS;

EID: 0242321673     PISSN: 03639045     EISSN: None     Source Type: Journal    
DOI: 10.1081/DDC-120025453     Document Type: Article

References (19)

1. Coelho, M.C.; Harnby, N. Moisture bonding in powders. Powder Technology 1978, 2, 201-205.
2. Bailey, A.G. Electrostatic phenomena during powder handling. Powder Technology 1984, 37, 71-85.
3. Peart, J.; Staniforth, J.N.; Byron, P.R.; Meakin, B.J. Electrostatic charge interactions in pharmaceutical dry powder aerosols. Proceedings of Respiratory Drug Delivery V, 1996, 85-93.
4. Smeltzer, E.E.; Weaver, M.L.; Klinzing, G.E. Individual electrostatic particle interaction in pneumatic transport. Powder Technology 1982, 33, 31-42.
5. Schubert, H. Capillary forces-modeling and application in particulate technology. Powder Technology 1984, 37, 105-116.
6. Eaves, T.; Jones, T.M. Effect of moisture on the tensile strength of bulk solids II: fine particle-size materials with varying inherent coherence. J. Pharm. Sci. 1972, 61, 343-349.
7. Jashnani, R.N.; Byron, P.R. Dry powder aerosol generation in different environments: performance comparisons of albuterol, albuterol sulfate, albuterol adipate and albuterol state. Int. J. Pharm. 1996, 130, 13-24.
8. Jashnani, R.N.; Byron, P.R.; Dalby, R.N. Testing of dry powder aerosol formulations in different environmental conditions. Int. J. Pharm. 1995, 113, 123-130.
9. Hindle, M.; Makinen, G.M. Effects of humidity on the in-vitro aerosol performance and aerodynamic size distribution of cromolyn sodium for inhalation. Eur. J. Pharm. Sci. 1996, 4, S142.
10. Braun, M.A.; Oschmann, R.; Schmidt, P.T. Influence of excipents and storage humidity on the deposition of disodium cromoglycate (DSCG) in the twin impinger. Int. J. Pharm. 1996, 135, 53-62.
11. Clarke, M.J.; Potter, U.J.; Gilpin, C.; Tobyn, M.J.; Staniforth, J.N. Imaging of hygroscopic ultrafine pharmaceutical powders using low temperature and environmental scanning electron microscopy. Pharm. Pharmacol. Commun. 1998, 4, 419-425.
12. Richardson, G.M.; Malthus, R.S. Salts for static control of humidity at relatively low levels. J. Appl. Chem. 1955, 5, 557-567.
13. Hallworth, G.W.; Westmoreland, D.G. The twin impinger: a simple device for assessing the delivery of drugs from metered dose pressurized aerosol inhalers. J. Pharm. Pharmacol. 1987, 39, 966-972.
14. Wetterlin, K. Turbuhaler: a new powder inhaler for administration of drugs to the airways. Pharm. Res. 1988, 5, 506-508.
15. Cox, J.S.G.; Woodard, G.D.; McCrone, W.C. Solid-state chemistry of cromolyn sodium. J. Pharm. Sci. 1971, 60, 1458-1465.
16. Hartshorhe, N.H.; Woodard, G.D. Mesomorphism in the system disodium chromoclycate-water. Mol. Crys. Liq. Crys. 1973, 23, 343-368.
17. Chen, R.L.; Young, V.G.; Lechuga-Ballesteros, D.; Grant, D.J.W. Solid-state behavior of cromolyn sodium hydrates. J. Pharm. Sci. 1999, 88, 1191-1200.
18. Price, R.; Young, P.M.; Edge, S.; Staniforth, J.N. The influence of relative humidity on particulate interactions in carrier-based dry powder inhaler formulations. Int. J. Pharm. 2002, in press.
19. Young, P.M.; Price, R.; Tobyn, M.J.; Buttrum, M.; Dey, F. Investigation into the effect of humidity on drug-drug interactions using the atomic force microscope. J. Pharm. Sci. 2002, in press.