Increased expression of CD208 (DC-LAMP) in epidermal keratinocytes of psoriatic lesions

Journal of Dermatology

Volumn 36, Issue 3, 2009, Pages 144-149

  Higaki, Megumu ^a   Higaki, Yuko ^b   Kawashima, Makoto ^b  

^a JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

CD208 (DC LAMP); Dendritic cell markers; Immunohistochemistry; Keratinocytes; Psoriasis

Indexed keywords

CD209 ANTIGEN; CD83 ANTIGEN; DENDRITIC CELL LYSOSOME ASSOCIATED MEMBRANE PROTEIN; GAMMA INTERFERON; HLA DR ANTIGEN; LANGERIN; PHORBOL 13 ACETATE 12 MYRISTATE; T6 ANTIGEN;

ADULT; ARTICLE; CELL DIFFERENTIATION; CLINICAL ARTICLE; CONTROLLED STUDY; DENDRITIC CELL; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INNATE IMMUNITY; KERATINOCYTE; MALE; PROTEIN EXPRESSION; PSORIASIS;

ADULT; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD; ANTIGENS, CD1; CASE-CONTROL STUDIES; CELL ADHESION MOLECULES; CELL DIFFERENTIATION; CELLS, CULTURED; FEMALE; HLA-DR ANTIGENS; HUMANS; IMMUNOGLOBULINS; IMMUNOHISTOCHEMISTRY; INTERFERON-GAMMA, RECOMBINANT; KERATINOCYTES; LECTINS, C-TYPE; LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEINS; MALE; MANNOSE-BINDING LECTINS; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; NEOPLASM PROTEINS; PSORIASIS; RECEPTORS, CELL SURFACE; TETRADECANOYLPHORBOL ACETATE;

EID: 62749180825     PISSN: 03852407     EISSN: 13468138     Source Type: Journal    
DOI: 10.1111/j.1346-8138.2009.00609.x     Document Type: Article

References (13)

1. Bowcock AM, Krueger JG. Getting under the skin: the immunogenetics of psoriasis. Nat Rev Immunol 2005 5 : 699 711.
2. Boyman O, Conrad C, Tonel G, Gilliet M, Nestle FO. The pathogenic role of tissue-resident immune cells in psoriasis. Trends Immunol 2007 28 : 51 57.
3. Terajima S, Higaki M, Igarashi Y, Nogita T, Kawashima M. An important role of tumor necrosis factor-alpha in the induction of adhesion molecules in psoriasis. Arch Dermatol Res 1998 290 : 246 252.
4. Abrams JR, Kelley SL, Hayes E et al. Blockade of T lymphocyte costimulation with cytotoxic T lymphocyte-associated antigen 4-immunoglobulin (CTLA4Ig) reverses the cellular pathology of psoriatic plaques, including the activation of keratinocytes, dendritic cells, and endothelial cells. J Exp Med 2000 192 : 681 694.
5. Ebner S, Ehammer Z, Holzmann S et al. Expression of C-type lectin receptors by subsets of dendritic cells in human skin. Int Immunol 2004 16 : 877 887.
6. Figdor CG, van Kooyk Y, Adema GJ. C-type lectin receptors on dendritic cells and Langerhans cells. Nat Rev Immunol 2002 2 : 77 84.
7. Sarafian V, Jans R, Poumay Y. Expression of lysosome-associated membrane protein 1 (Lamp-1) and galectins in human keratinocytes is regulated by differentiation. Arch Dermatol Res 2006 298 : 73 81.
8. Ghadially R, Reed JT, Elias PM. Stratum corneum structure and function correlates with phenotype in psoriasis. J Invest Dermatol 1996 107 : 558 564.
9. Fukuya Y, Higaki M, Higaki Y, Kawashima M. Effect of vitamin D3 on the increased expression of Bcl-xL in psoriasis. Arch Dermatol Res 2002 293 : 620 625.
10. Lowes MA, Chamian F, Abello MV et al. Increase in TNF-alpha and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a). Proc Natl Acad Sci USA 2005 102 : 19057 19062.
11. de Saint-Vis B, Vincent J, Vandenabeele S et al. A novel lysosome-associated membrane glycoprotein, DC-LAMP, induced upon DC maturation, is transiently expressed in MHC class II compartment. Immunity 1998 9 : 325 336.
12. Kanao H, Enomoto T, Kimura T et al. Overexpression of LAMP3/TSC403/DC-LAMP promotes metastasis in uterine cervical cancer. Cancer Res 2005 65 : 8640 8645.
13. Jans R, Sartor M, Jadot M, Poumay Y. Calcium entry into keratinocytes induces exocytosis of lysosomes. Arch Dermatol Res 2004 296 : 30 41.