Preparation and in vitro evaluation of benzylsulfanyl benzoxazole derivatives as potential antituberculosis agents

European Journal of Medicinal Chemistry

Volumn 44, Issue 5, 2009, Pages 2286-2293

  Klimešová, Věra ^a   Kočí, Jan ^a   Waisser, Karel ^a   Kaustová, Jarmila ^b   Möllmann, Ute ^c  

^a Charles University in Prague Faculty of Pharmacy   (Czech Republic)

^b Zdravotniho ustavu se sidlem v Ostrave   (Czech Republic)

^c HANS KNÖLL INSTITUTE   (Germany)

Author keywords

2 Benzylsulfanyl derivatives; Antimycobacterial activity; Benzoxazole; Multidrug resistant M. tuberculosis; Mycobacterium tuberculosis; Non tuberculous mycobacteria; Quantitative structure activity relationship

Indexed keywords

2 (2 CHLOROBENZYLSULFANYL)BENZOXAZOLE; 2 (2 FLUORO 6 CHLOROBENZYLSULFANYL)BENZOXAZOLE; 2 (2 FLUORO 6 NITROBENZYLSULFANYL)BENZOXAZOLE; 2 (2 FLUOROBENZYLSULFANYL)BENZOXAZOLE; 2 (2 NITROBENZYLSULFANYL)BENZOXAZOLE; 2 (2,4 DINITROBENZYLSULFANYL)BENZOXAZOLE; 2 (3 BROMOBENZYLSULFANYL)BENZOXAZOLE; 2 (3 CHLOROBENZYLSULFANYL)BENZOXAZOLE; 2 (3 CYANOBENZYLSULFANYL)BENZOXAZOLE; 2 (3 FLUOROBENZYLSULFANYL)BENZOXAZOLE; 2 (3 METHOXYBENZYLSULFANYL)BENZOXAZOLE; 2 (3 METHYLBENZYLSULFANYL)BENZOXAZOLE; 2 (3 NITROBENZYLSULFANYL)BENZOXAZOLE; 2 (3 TRIFLUOROMETHYLBENZYLSULFANYL)BENZOXAZOLE; 2 (3,4 DICHLOROBENZYLSULFANYL)BENZOXAZOLE; 2 (3,4 DIFLUOROBENZYLSULFANYL)BENZOXAZOLE; 2 (3,5 DINITROBENZYLSULFANYL)BENZOXAZOLE; 2 (4 BROMOBENZYLSULFANYL)BENZOXAZOLE; 2 (4 CHLOROBENZYLSULFANYL)BENZOXAZOLE; 2 (4 CYANOBENZYLSULFANYL)BENZOXAZOLE; 2 (4 FLUOROBENZYLSULFANYL)BENZOXAZOLE; 2 (4 METHOXYBENZYLSULFANYL)BENZOXAZOLE; 2 (4 METHYLBENZYLSULFANYL)BENZOXAZOLE; 2 (4 NITROBENZYLSULFANYL)BENZOXAZOLE; 2 (4 TRIFLUOROMETHYLBENZYLSULFANYL)BENZOXAZOLE; 2 [3,5 BIS(TRIFLUOROMETHYL)BENZYLSULFANYL]BENZOXAZOLE; 2 BENZYLSULFANYLBENZOXAZOLE; 3 (2 BENZOXAZOLYLSULFANYLMETHYL)BENZOTHIOAMIDE; 4 (2 BENZOXAZOLYLSULFANYLMETHYL)BENZOTHIOAMIDE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LIPOPHILICITY; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

ANTITUBERCULAR AGENTS; BENZOXAZOLES; DRUG RESISTANCE, MULTIPLE; HUMANS; HYDROPHOBICITY; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM TUBERCULOSIS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 62749177464     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.06.027     Document Type: Article

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