Pyrrolnitrin and related pyrroles endowed with antibacterial activities against Mycobacterium tuberculosis

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 20, 1998, Pages 2931-2936

  Di Santo, Roberto ^a   Costi, Roberta ^a   Artico, Marino ^a   Massa, Silvio ^b   Lampis, Giorgio ^c   Deidda, Delia ^c   Pompei, Raffaello ^c  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF SIENA   (Italy)

^c UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMYCOBACTERIAL AGENT; CGT 17341; ISONIAZID; NITROIMIDAZOLE DERIVATIVE; OXAZOLIDINONE DERIVATIVE; PYRROLE DERIVATIVE; PYRROLNITRIN; STREPTOMYCIN; U 100480; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; DRUG CYTOTOXICITY; DRUG SYNTHESIS; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM AVIUM; MYCOBACTERIUM GORDONAE; MYCOBACTERIUM MARINUM; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; VERO CELL;

ANTI-BACTERIAL AGENTS; ANTIBIOTICS, ANTIFUNGAL; ANTITUBERCULAR AGENTS; DRUG THERAPY, COMBINATION; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM TUBERCULOSIS; PYRROLES; PYRROLNITRIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032552927     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00526-5     Document Type: Article

References (21)

1. 1. Duncan, K. Exp. Opin. Ther. Patents 1997, 7, 129-137.
2. 2. WHO Report on the Tuberculosis Epidemic, 1995, World Health Organization.
3. 3. Daniel, T.M. J. Lab. Med. 1990, 116, 277-282.
4. 4. Dooley, S.W.; Jarvis, W.R.; Martone, W.J.; Snider, D.E. Ann. Internal Med. 1992, 117, 257-259.
5. 5. Collins, F.M. Clin. Microbiol. Rev. 1989, 2, 360-377.
6. 6. (a) Niccolai, D.; Tarsi, L.; Thomas, R.J. Chem. Commun. 1997, 2333-2342.
7. (b) Ashtekar, D.R.; Costa-Pereira, R.; Shrinivasan, T.; Ayyer, R.; Vishvanathan, N.; Rittel, W. Diagn. Microbiol. Infect. Dis. 1991, 14, 465-471.
8. (c) Barbachyn, M.R.; Hutchinson, D.K.; Brickner, S.J.; Cynamon, M.H.; Kilburn, J.O.; Klemens, S.P.; Glickman, S.E.; Grega, K.C.; Hendges, S.K.; Toops, D.S.; Ford, C.W.; Zurenko, G.E. J. Med. Chem. 1996, 39, 680-685.
9. 7. (a) Nagarajan, K.; Shankar, R.G.; Rajappa, S.; Shenoy, S.; Costa-Pereira, R. Eur. J. Med. Chem. 1989, 24, 631-633.
10. (b) Ashtekar, D.R.; Costa-Pereira, R.; Nagarajan, K.; Vishvanathan, N.; Bhatt, A.D.; Rittel, W. Antimicrob. Agents Chemother. 1993, 37, 183-186.
11. 8. Fioravanti, R.; Biava, M.; Porretta, G.C.; Artico, M.; Lampis, G.; Deidda, D.; Pompei, R. Med. Chem. Res. 1997, 7, 87-97.
12. 9. (a) Arima, K.; Imanaka, H.; Kousaka, M.; Fukuda, A.; Tamura, G. J. Antibiotics 1965, Ser. A 18, 201-204.
13. (b) Nakano, H.; Umio, S.; Kariyone, K.; Tanaka, K.; Kishimoto, T.; Noguchi, H.; Ueda, I.; Nakamura, H.; Morimoto, Y. Tetrahedron Lett. 1966, 737-740.
14. 10. Massa, S.; Di Santo, R.; Costi, R.; Mai, A.; Artico, Marino; Retico, A.; Apuzzo, G.; Artico, Marco; Simonetti, G. Med. Chem. Res. 1993, 3, 192-199.
15. 11. Massa, S.; Di Santo, R.; Mai, A.; Botta, M.; Artico, M.; Panico, S.; Simonetti, G. Farmaco 1990, 45, 833-846.
16. 12. Di Santo, R.; Costi, R.; Artico, M.; Massa, S.; Musiu, C.; Milia, C.; Putzolu, M.; La Colla, P. Med. Chem. Res. 1997, 7, 98-108.
17. 13. (a) Di Santo, R.; Massa, S.; Artico, M. Farmaco 1993, 48, 209-229.
18. (b) van Leusen, A.M. Lectures in Heterocyclic Chemistry 1980, 5, S-111-S-122.
19. 14. National Comittee for Clinical Laboratory Standard, Antimycobacterial susceptibility testing. Proposed standard M24-P National Comittee For Clinical Laboratory Standard, 1995, Villanova, PA,.
20. 15. Clark, B.; Salfinger, M. Antimicrobial Agents and Susceptibility Tests: Mycobacteria. Manual of Clinical Microbiology, V ed., 1996, 1385-1404. Murray P.R.; Baron E.J.; Pfaller, M.A.; Tenover, F.C.; Volken R.H. in American Society for Microbiology, Washington, D.C.
21. 15. Clark, B.; Salfinger, M. Antimicrobial Agents and Susceptibility Tests: Mycobacteria. Manual of Clinical Microbiology, V ed., 1996, 1385-1404. Murray P.R.; Baron E.J.; Pfaller, M.A.; Tenover, F.C.; Volken R.H. in American Society for Microbiology, Washington, D.C.