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Volumn 277, Issue 2, 2009, Pages 218-226

Synergistic effect of Sorafenib and Sunitinib with Enzastaurin, a selective protein kinase C inhibitor in renal cell carcinoma cell lines

Author keywords

Enzastaurin; Renal cell carcinoma; Sorafenib; Sunitinib; Synergism

Indexed keywords

ENZASTAURIN; GLYCOGEN SYNTHASE KINASE 3BETA; LY317615 HCL; S6 KINASE; SORAFENIB; SUNITINIB; UNCLASSIFIED DRUG;

EID: 62749137151     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2008.12.013     Document Type: Article
Times cited : (12)

References (38)
  • 3
    • 1442290393 scopus 로고    scopus 로고
    • Prognostic factors for survival in previously treated patients with metastatic renal cell carcinoma
    • Motzer R.J., Bacik J., Schwartz L.H., Reuter V., Russo P., Marion S., and Mazumdar M. Prognostic factors for survival in previously treated patients with metastatic renal cell carcinoma. J. Clin. Oncol. 22 (2004) 454-463
    • (2004) J. Clin. Oncol. , vol.22 , pp. 454-463
    • Motzer, R.J.1    Bacik, J.2    Schwartz, L.H.3    Reuter, V.4    Russo, P.5    Marion, S.6    Mazumdar, M.7
  • 4
    • 0032772880 scopus 로고    scopus 로고
    • Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma
    • Motzer R.J., Mazumdar M., Bacik J., Berg W., Amsterdam A., and Ferrara J. Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma. J. Clin. Oncol. 17 (1999) 2530-2540
    • (1999) J. Clin. Oncol. , vol.17 , pp. 2530-2540
    • Motzer, R.J.1    Mazumdar, M.2    Bacik, J.3    Berg, W.4    Amsterdam, A.5    Ferrara, J.6
  • 7
    • 0034676331 scopus 로고    scopus 로고
    • Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function
    • Krieg M., Haas R., Brauch H., Acker T., Flamme I., and Plate K.H. Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function. Oncogene 19 (2000) 5435-5443
    • (2000) Oncogene , vol.19 , pp. 5435-5443
    • Krieg, M.1    Haas, R.2    Brauch, H.3    Acker, T.4    Flamme, I.5    Plate, K.H.6
  • 9
    • 0034649507 scopus 로고    scopus 로고
    • Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling
    • Wykoff C.C., Pugh C.W., Maxwell P.H., Harris A.L., and Ratcliffe P.J. Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling. Oncogene 19 (2000) 6297-6305
    • (2000) Oncogene , vol.19 , pp. 6297-6305
    • Wykoff, C.C.1    Pugh, C.W.2    Maxwell, P.H.3    Harris, A.L.4    Ratcliffe, P.J.5
  • 10
    • 33846879810 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumor suppressor protein and clear cell renal carcinoma
    • Kaelin Jr. W.G. The von Hippel-Lindau tumor suppressor protein and clear cell renal carcinoma. Clin. Cancer Res. 13 (2007) 680s-684s
    • (2007) Clin. Cancer Res. , vol.13
    • Kaelin Jr., W.G.1
  • 12
    • 4644259265 scopus 로고    scopus 로고
    • Kinase inhibition with BAY 43-9006 in renal cell carcinoma
    • Ahmad T., and Eisen T. Kinase inhibition with BAY 43-9006 in renal cell carcinoma. Clin. Cancer Res. 10 (2004) 6388S-6392S
    • (2004) Clin. Cancer Res. , vol.10
    • Ahmad, T.1    Eisen, T.2
  • 14
    • 0026673043 scopus 로고
    • Platelet-derived growth factor-induced transcription of the vascular endothelial growth factor gene is mediated by protein kinase C
    • Finkenzeller G., Marme D., Weich H.A., and Hug H. Platelet-derived growth factor-induced transcription of the vascular endothelial growth factor gene is mediated by protein kinase C. Cancer Res. 52 (1992) 4821-4823
    • (1992) Cancer Res. , vol.52 , pp. 4821-4823
    • Finkenzeller, G.1    Marme, D.2    Weich, H.A.3    Hug, H.4
  • 15
    • 34250703569 scopus 로고    scopus 로고
    • Classical PKC isoforms in cancer
    • Martiny-Baron G., and Fabbro D. Classical PKC isoforms in cancer. Pharmacol. Res. 55 (2007) 477-486
    • (2007) Pharmacol. Res. , vol.55 , pp. 477-486
    • Martiny-Baron, G.1    Fabbro, D.2
  • 16
    • 0028082161 scopus 로고
    • Protein kinase C-a question of specificity
    • Dekker L.V., and Parker P.J. Protein kinase C-a question of specificity. Trends Biochem. Sci. 19 (1994) 73-77
    • (1994) Trends Biochem. Sci. , vol.19 , pp. 73-77
    • Dekker, L.V.1    Parker, P.J.2
  • 18
  • 21
    • 10244235304 scopus 로고    scopus 로고
    • Protein kinase C beta 1 and protein kinase C beta 2 activate p57 mitogen-activated protein kinase and block differentiation in colon carcinoma cells
    • Sauma S., Yan Z., Ohno S., and Friedman E. Protein kinase C beta 1 and protein kinase C beta 2 activate p57 mitogen-activated protein kinase and block differentiation in colon carcinoma cells. Cell Growth Differ. 7 (1996) 587-594
    • (1996) Cell Growth Differ. , vol.7 , pp. 587-594
    • Sauma, S.1    Yan, Z.2    Ohno, S.3    Friedman, E.4
  • 24
  • 25
    • 33748328365 scopus 로고    scopus 로고
    • Enzastaurin (LY317615), a protein kinase Cbeta inhibitor, inhibits the AKT pathway and induces apoptosis in multiple myeloma cell lines
    • Rizvi M.A., Ghias K., Davies K.M., Ma C., Weinberg F., Munshi H.G., Krett N.L., and Rosen S.T. Enzastaurin (LY317615), a protein kinase Cbeta inhibitor, inhibits the AKT pathway and induces apoptosis in multiple myeloma cell lines. Mol. Cancer Ther. 5 (2006) 1783-1789
    • (2006) Mol. Cancer Ther. , vol.5 , pp. 1783-1789
    • Rizvi, M.A.1    Ghias, K.2    Davies, K.M.3    Ma, C.4    Weinberg, F.5    Munshi, H.G.6    Krett, N.L.7    Rosen, S.T.8
  • 26
    • 34248631942 scopus 로고    scopus 로고
    • Antitumor activity of enzastaurin (LY317615.HCl) against human cancer cell lines and freshly explanted tumors investigated in in-vitro [corrected] soft-agar cloning experiments
    • Hanauske A.R., Oberschmidt O., Hanauske-Abel H., Lahn M.M., and Eismann U. Antitumor activity of enzastaurin (LY317615.HCl) against human cancer cell lines and freshly explanted tumors investigated in in-vitro [corrected] soft-agar cloning experiments. Invest. New Drugs 25 (2007) 205-210
    • (2007) Invest. New Drugs , vol.25 , pp. 205-210
    • Hanauske, A.R.1    Oberschmidt, O.2    Hanauske-Abel, H.3    Lahn, M.M.4    Eismann, U.5
  • 28
    • 40949101463 scopus 로고    scopus 로고
    • Enzastaurin, a protein kinase C beta inhibitor, suppresses signaling through the ribosomal S6 kinase and bad pathways and induces apoptosis in human gastric cancer cells
    • Lee K.W., Kim S.G., Kim H.P., Kwon E., You J., Choi H.J., Park J.H., Kang B.C., Im S.A., Kim T.Y., Kim W.H., and Bang Y.J. Enzastaurin, a protein kinase C beta inhibitor, suppresses signaling through the ribosomal S6 kinase and bad pathways and induces apoptosis in human gastric cancer cells. Cancer Res. 68 (2008) 1916-1926
    • (2008) Cancer Res. , vol.68 , pp. 1916-1926
    • Lee, K.W.1    Kim, S.G.2    Kim, H.P.3    Kwon, E.4    You, J.5    Choi, H.J.6    Park, J.H.7    Kang, B.C.8    Im, S.A.9    Kim, T.Y.10    Kim, W.H.11    Bang, Y.J.12
  • 35
    • 41949139667 scopus 로고    scopus 로고
    • Enzastaurin, an oral serine/threonine kinase inhibitor, as second- or third-line therapy of non-small-cell lung cancer
    • Oh Y., Herbst R.S., Burris H., Cleverly A., Musib L., Lahn M., and Bepler G. Enzastaurin, an oral serine/threonine kinase inhibitor, as second- or third-line therapy of non-small-cell lung cancer. J. Clin. Oncol. 26 (2008) 1135-1141
    • (2008) J. Clin. Oncol. , vol.26 , pp. 1135-1141
    • Oh, Y.1    Herbst, R.S.2    Burris, H.3    Cleverly, A.4    Musib, L.5    Lahn, M.6    Bepler, G.7
  • 37
    • 0021118703 scopus 로고
    • Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors
    • Chou T.C., and Talalay P. Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv. Enzyme Regulat. 22 (1984) 27-55
    • (1984) Adv. Enzyme Regulat. , vol.22 , pp. 27-55
    • Chou, T.C.1    Talalay, P.2
  • 38
    • 0036790090 scopus 로고    scopus 로고
    • An in vitro tumor model: analysis of angiogenic factor expression after chemotherapy
    • Keyes K., Cox K., Treadway P., Mann L., Shih C., Faul M.M., and Teicher B.A. An in vitro tumor model: analysis of angiogenic factor expression after chemotherapy. Cancer Res. 62 (2002) 5597-5602
    • (2002) Cancer Res. , vol.62 , pp. 5597-5602
    • Keyes, K.1    Cox, K.2    Treadway, P.3    Mann, L.4    Shih, C.5    Faul, M.M.6    Teicher, B.A.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.