Intravenous micronutrient therapy (Myers' Cocktail) for fibromyalgia: A placebo-controlled pilot study

Journal of Alternative and Complementary Medicine

Volumn 15, Issue 3, 2009, Pages 247-257

  Ali, Ather ^a   Njike, Valentine Yanchou ^a   Northrup, Veronika ^a   Sabina, Alyse B ^a   Williams, Anna Leila ^a   Liberti, Lauren S ^a   Perlman, Adam I ^b   Adelson, Harry ^a   Katz, David L ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANALGESIC AGENT; ANTIRHEUMATIC AGENT; ASCORBIC ACID; BENZYL ALCOHOL; DEXPANTHENOL; GLUCONATE CALCIUM; HYDROXOCOBALAMIN; MAGNESIUM CHLORIDE; MYERS COCKTAIL; NICOTINAMIDE; PLACEBO; PYRIDOXINE; RIBOFLAVIN; RINGER LACTATE SOLUTION; THIAMINE; UNCLASSIFIED DRUG; WATER;

ADULT; AGED; ARTICLE; BECK DEPRESSION INVENTORY; BLOOD PRESSURE; CLINICAL ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEPRESSION; DOUBLE BLIND PROCEDURE; DYSPEPSIA; FEASIBILITY STUDY; FEMALE; FIBROMYALGIA; HUMAN; INFUSION; INSOMNIA; INTEGRATIVE MEDICINE; INTERVENTION STUDY; INTROSPECTION; MALE; MEDICAL RESEARCH; MOOD; OUTCOME ASSESSMENT; PAIN; PILOT STUDY; PRIORITY JOURNAL; QUALITY OF LIFE; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; RHEUMATOLOGY; SAFETY; SAMPLE SIZE; SIDE EFFECT; TEACHING HOSPITAL; THERAPY EFFECT; UNITED STATES; UNIVERSITY HOSPITAL; VISUAL ANALOG SCALE;

ADULT; ASCORBIC ACID; CALCIUM GLUCONATE; DOUBLE-BLIND METHOD; DRUG COMBINATIONS; FEMALE; FIBROMYALGIA; HUMANS; INFUSIONS, INTRAVENOUS; MAGNESIUM CHLORIDE; MALE; MIDDLE AGED; PAIN MEASUREMENT; PANTOTHENIC ACID; PILOT PROJECTS; TREATMENT OUTCOME; VITAMIN B COMPLEX;

EID: 62649149858     PISSN: 10755535     EISSN: None     Source Type: Journal    
DOI: 10.1089/acm.2008.0410     Document Type: Article

References (52)

1. Wolfe F, et al. The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis Rheum 1990;33: 160-172.
2. Wolfe F, et al. The prevalence and characteristics of fibromyalgia in the general population. Arthritis Rheum 1995;38: 19-28.
3. Wolfe F, et al. A prospective, longitudinal, multicenter study of service utilization and costs in fibromyalgia. Arthritis Rheum 1997;40:1560-1570.
4. Goldenberg DL, Burckhardt C, Crofford L. Management of fibromyalgia syndrome. JAMA 2004;292:2388-2395.
5. Green GA. Understanding NSAIDs: from aspirin to COX-2. Clin Cornerstone 2001;3:50-60.
6. Carville SF, et al. EULAR evidence-based recommendations for the management of fibromyalgia syndrome. Ann Rheum Dis 2008;67:536-541.
7. Bennett RM, et al. Tramadol and acetaminophen combination tablets in the treatment of fibromyalgia pain: A doubleblind, randomized, placebo-controlled study. Am J Med 2003;114:537-545.
8. Bennett RM, et al. Impact of fibromyalgia pain on health-related quality of life before and after treatment with tramadol/ acetaminophen. Arthritis Rheum 2005;53:519-527.
9. Clark S, Tindall E, Bennett RM. A double blind crossover trial of prednisone versus placebo in the treatment of fibrositis. J Rheumatol 1985;12:980-983.
10. Wolfe F, Cathey MA, Hawley DJ. A double-blind placebo controlled trial of fluoxetine in fibromyalgia. Scand J Rheumatol 1994;23:255-259.
11. Crofford LJ, et al. Pregabalin for the treatment of fibromyalgia syndrome: Results of a randomized, double-blind, placebo-controlled trial. Arthritis Rheum 2005;52:1264-1273.
12. U.S. Food and Drug Administration. FDA Approves First Drug for Treating Fibromyalgia. 2007. Online document at: www.fda.gov/bbs/topics/NEWS/2007/ NEW01656.html Accessed May 2008.
13. Arnold LM, et al. A 14-week, randomized, double-blinded, placebo-controlled monotherapy trial of pregabalin in patients with fibromyalgia. J Pain 2008;9:792-805.
14. Arnold LM, et al. A randomized, double-blind, placebo-controlled trial of duloxetine in the treatment of women with fibromyalgia with or without major depressive disorder. Pain 2005;119:5-15.
15. Arnold LM, et al. A double-blind, multicenter trial comparing duloxetine with placebo in the treatment of fibromyalgia patients with or without major depressive disorder. Arthritis Rheum 2004;50:2974-2984.
16. Russell IJ, et al. Efficacy and safety of duloxetine for treatment of fibromyalgia in patients with or without major depressive disorder: Results from a 6-month, randomized, double-blind, placebo-controlled, fixed-dose trial. Pain 2008; 136:432-444.
17. Donaldson MS, Speight N, Loomis S. Fibromyalgia syndrome improved using a mostly raw vegetarian diet: An observational study. BMC Complement Altern Med 2001; 1:7.
18. Hanninen O, et al. Antioxidants in vegan diet and rheumatic disorders. Toxicology 2000;155:45-53.
19. Bramwell B, et al. The use of ascorbigen in the treatment of fibromyalgia patients: A preliminary trial. Altern Med Rev 2000;5:455-462.
20. Dykman KD, et al. The effects of nutritional supplements on the symptoms of fibromyalgia and chronic fatigue syndrome. Integr Physiol Behav Sci 1998;33:61-71.
21. Pioro-Boisset M, Esdaile JM, Fitzcharles MA. Alternative medicine use in fibromyalgia syndrome. Arthritis Care Res 1996;9:13-17.
22. Lind BK, et al. Use of complementary and alternative medicine providers by fibromyalgia patients under insurance coverage. Arthritis Rheum 2007;57:71-76.
23. Ernst E. Complementary medicine. Curr Opin Rheumatol 2003;15:151-155.
24. Singh BB, et al. Effectiveness of acupuncture in the treatment of fibromyalgia. Altern Ther Health Med 2006;12:34-41.
25. Wahner-Roedler DL, et al. Use of complementary and alternative medical therapies by patients referred to a fibromyalgia treatment program at a tertiary care center. Mayo Clin Proc 2005;80:55-60.
26. Sarac AJ, Gur A. Complementary and alternative medical therapies in fibromyalgia. Curr Pharm Des 2006; 12:47-57.
27. Russell IJ, et al. Treatment of fibromyalgia syndrome with Super Malic: A randomized, double blind, placebo controlled, crossover pilot study. J Rheumatol 1995;22:953-958.
28. Volkmann H, et al. Double-blind, placebo-controlled crossover study of intravenous S-adenosyl-L-methionine in patients with fibromyalgia. Scand J Rheumatol 1997;26:206-211.
29. Gaby AR. Intravenous nutrient therapy: The "Myers' cocktail". Altern Med Rev 2002;7:389-403.
30. Yale-Griffin Prevention Research Center. Intravenous Micronutrient Therapy (IVMT) for Fibromyalgia Syndrome: A Pilot Study. 2003: NIH, Grant #AT 00942-01A1.
31. Lonsdale D, et al. Evaluation of the biochemical effects of administration of intravenous nutrients using erythrocyte ATP/ADP ratios. Altern Med Rev 1999;4:37-44.
32. Massey PB. Reduction of fibromyalgia symptoms through intravenous nutrient therapy: Results of a pilot clinical trial. Altern Ther Health Med 2007;13:32-34.
33. Gaby A. Intravenous vitamin and mineral therapy. In: Nutritional Therapy in Medical Practice. Seattle, WA, 1998. Online document at: www. wrightgabynutrition.com/gaby/ page4.html Accessed January 18, 2009.
34. Okifuji A, et al. A standardized manual tender point survey. I. Development and determination of a threshold point for the identification of positive tender points in fibromyalgia syndrome. J Rheumatol 1997; 24:377-383.
35. Burckhardt CS, Clark SR, Bennett RM. The fibromyalgia impact questionnaire: Development and validation. J Rheumatol 1991;18:728-33.
36. Beck A, Steer R, Garbin M. Psychometric properties of the Beck Depression Inventory: Twenty-five years of evaluation. Clin Psychol Rev 1988;8:77-100.
37. Burckhardt CS, et al. Assessing depression in fibromyalgia patients. Arthritis Care Res, 1994;7:35-39.
38. Ware JE Jr, Sherbourne CD. The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care 1992;30:473-483.
39. Kaptchuk TJ, et al. Sham device v inert pill: Randomised controlled trial of two placebo treatments. BMJ 2006;332: 391-397.
40. Koshi EB, Short CA. Placebo theory and its implications for research and clinical practice: A review of the recent literature. Pain Pract 2007;7:4-20.
41. Gillis ME, et al. The health effects of at-home written emotional disclosure in fibromyalgia: A randomized trial. Ann Behav Med 2006;32:135-146.
42. Menzies V, Taylor AG, Bourguignon C. Effects of guided imagery on outcomes of pain, functional status, and self-efficacy in persons diagnosed with fibromyalgia. J Altern Complement Med 2006;12:23-30.
43. Hammond A, Freeman K. Community patient education and exercise for people with fibromyalgia: A parallel group randomized controlled trial. Clin Rehabil 2006;20:835-846.
44. Martin DP, et al. Improvement in fibromyalgia symptoms with acupuncture: Results of a randomized controlled trial. Mayo Clin Proc 2006;81:749-757.
45. Holman AJ, Myers RR. A randomized, double-blind, placebo-controlled trial of pramipexole, a dopamine agonist, in patients with fibromyalgia receiving concomitant medications. Arthritis Rheum 2005; 52:2495-2505.
46. Anand A. Role of magnesium in alleviating pain: Newer insights. J Pain Symptom Manage 2000;20:1-2.
47. Eisinger J, et al. Selenium and magnesium status in fibromyalgia. Magnes Res 1994;7:285-288.
48. Sendur OF, et al. The relationship between serum trace element levels and clinical parameters in patients with fibromyalgia. Rheumatol Int 2008;28:1117-1121.
49. O'Dowd P. B12 supplementation: Must be parenteral. Med Health R I 2000;83:252-253.
50. Goldenberg DL, et al. High frequency of fibromyalgia in patients with chronic fatigue seen in a primary care practice. Arthritis Rheum 1990;33:381-387.
51. Russell IJ, et al. Treatment of primary fibrositis/fibromyalgia syndrome with ibuprofen and alprazolam: A doubleblind, placebo-controlled study. Arthritis Rheum 1991;34: 552-560.
52. Eisinger J, et al. Protein peroxidation, magnesium deficiency and fibromyalgia. Magnes Res 1996;9:313-316.