메뉴 건너뛰기




Volumn 6, Issue 1, 2009, Pages 74-81

The use of drug metabolism for prediction of intestinal permeability

Author keywords

BCS; BDDCS; Biopharmaceutics classification system; Biopharmaceutics drug disposition classification system; Drug permeability

Indexed keywords

CAFFEINE; CARBAMAZEPINE; CILOMILAST; CYCLOSPORIN; DESIPRAMINE; DILTIAZEM; ENALAPRIL; FLUINDOSTATIN; GALANTAMINE; GLUCOSE; ISOTRETINOIN; KETOPROFEN; KETOROLAC; LABETALOL; LEUCINE; LEVODOPA; MEMANTINE; METRONIDAZOLE; NAPROXEN; NEVIRAPINE; PHENAZONE; PHENOBARBITAL; PHENYLALANINE; PHENYTOIN; PIROXICAM; PRIMAQUINE; PROPRANOLOL; ROSIGLITAZONE; SALICYLIC ACID; UNINDEXED DRUG; DRUG;

EID: 62649128592     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp8001864     Document Type: Article
Times cited : (46)

References (67)
  • 1
    • 0028948839 scopus 로고
    • A theoretical basis for a biopharmaceutics drug classification: The correlation of in vitro drug product dissolution and in vivo bioavailability
    • Amidon, G. L.; Lennernas, H.; Shah, V. P.; Crison, J. R. A theoretical basis for a biopharmaceutics drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm. Res. 1995, 12, 413-420.
    • (1995) Pharm. Res , vol.12 , pp. 413-420
    • Amidon, G.L.1    Lennernas, H.2    Shah, V.P.3    Crison, J.R.4
  • 3
    • 0030797273 scopus 로고    scopus 로고
    • Human jejunal effective permeability and its correlation with preclinical drug absorption models
    • 7
    • Lennernas, H. Human jejunal effective permeability and its correlation with preclinical drug absorption models. J. Pharm. Pharmacol. 1997, 49 (7)), 627-638.
    • (1997) J. Pharm. Pharmacol , vol.49 , pp. 627-638
    • Lennernas, H.1
  • 4
    • 17644380257 scopus 로고    scopus 로고
    • Predicting drug disposition via application of BCS: Transport/absorption/elimination interplay and development of a Biopharmaceutics Drug Disposition Classification System
    • Wu, C.-Y.; Benet, L. Z. Predicting drug disposition via application of BCS: transport/absorption/elimination interplay and development of a Biopharmaceutics Drug Disposition Classification System. Pharm. Res. 2005, 22, 11-23.
    • (2005) Pharm. Res , vol.22 , pp. 11-23
    • Wu, C.-Y.1    Benet, L.Z.2
  • 6
    • 33846176619 scopus 로고    scopus 로고
    • A provisional biopharmaceutical classification of the top 200 oral drug products in the United States, Great Britain, Spain and Japan
    • Takagi, T.; Ramachandran, C.; Bermejo, M.; Yamashita, S.; Yu, L. X.; Amidon, G. L. A provisional biopharmaceutical classification of the top 200 oral drug products in the United States, Great Britain, Spain and Japan. Mol. Pharmaceutics 2006, 3, 631-643.
    • (2006) Mol. Pharmaceutics , vol.3 , pp. 631-643
    • Takagi, T.1    Ramachandran, C.2    Bermejo, M.3    Yamashita, S.4    Yu, L.X.5    Amidon, G.L.6
  • 7
    • 35649009910 scopus 로고    scopus 로고
    • Intestinal permeability and its relevance for absorption and elimination
    • Lennernas, H. Intestinal permeability and its relevance for absorption and elimination. Xenobiotica 2007, 37, 1015-1051.
    • (2007) Xenobiotica , vol.37 , pp. 1015-1051
    • Lennernas, H.1
  • 8
    • 33749645845 scopus 로고    scopus 로고
    • Martina, S. D.; Ismail, M. S.; Vesta, K. S. Cilomilast: Orally active selective phosphodiesterase-4 inhibitor for treatment of chronic obstructive pulmonary disease. Ann. Pharmacother. 2006, 40, 1822-1828.
    • Martina, S. D.; Ismail, M. S.; Vesta, K. S. Cilomilast: Orally active selective phosphodiesterase-4 inhibitor for treatment of chronic obstructive pulmonary disease. Ann. Pharmacother. 2006, 40, 1822-1828.
  • 9
    • 0020045455 scopus 로고
    • Diazepam absorption: Effects of age, sex, and Billroth gastrectomy
    • Ochs, H. R.; Otten, H.; Greenblatt, D. J.; Dengler, H. J. Diazepam absorption: effects of age, sex, and Billroth gastrectomy. Dig. Dis. Sci. 1982, 27, 225-230.
    • (1982) Dig. Dis. Sci , vol.27 , pp. 225-230
    • Ochs, H.R.1    Otten, H.2    Greenblatt, D.J.3    Dengler, H.J.4
  • 10
    • 0031742986 scopus 로고    scopus 로고
    • Link between drug absorption, solubility and permeability measurements in Caco-2 cells
    • Vaishali, P.; Stavchansky, S. Link between drug absorption, solubility and permeability measurements in Caco-2 cells. J. Pharm. Sci. 1998, 87, 1604-1607.
    • (1998) J. Pharm. Sci , vol.87 , pp. 1604-1607
    • Vaishali, P.1    Stavchansky, S.2
  • 11
    • 64649099610 scopus 로고    scopus 로고
    • Physicians' Desk Reference (PDR), 2008. P.O. Box 2244, Willison, VT, U.S.A.
    • Physicians' Desk Reference (PDR), 2008. P.O. Box 2244, Willison, VT, U.S.A.
  • 12
    • 0023735262 scopus 로고
    • Pharmacokinetics of ketorolac tromethamine in humans after intravenous, intramuscular and oral administration
    • Jung, D.; Mroszczak, E.; Bynum, L. Pharmacokinetics of ketorolac tromethamine in humans after intravenous, intramuscular and oral administration. Eur. J. Clin. Pharmacol. 1988, 35, 423-425.
    • (1988) Eur. J. Clin. Pharmacol , vol.35 , pp. 423-425
    • Jung, D.1    Mroszczak, E.2    Bynum, L.3
  • 13
    • 34548155549 scopus 로고    scopus 로고
    • Biopharmaceutics classification of selected β-blockers: Solubility and permeability class membership
    • Yang, Y.; Faustino, P. J.; Volpe, D. A.; Ellison, C. D.; Lyon, R. C.; Yu, L. X. Biopharmaceutics classification of selected β-blockers: Solubility and permeability class membership. Mol. Pharmaceutics 2007, 4, 608-614.
    • (2007) Mol. Pharmaceutics , vol.4 , pp. 608-614
    • Yang, Y.1    Faustino, P.J.2    Volpe, D.A.3    Ellison, C.D.4    Lyon, R.C.5    Yu, L.X.6
  • 14
    • 0020639019 scopus 로고
    • Human pharmacoki- netics and toxicity on high-dose metronidazole administered orally and intravenously
    • Urtasun, R. C.; Rabin, H. R.; Partington, J. Human pharmacoki- netics and toxicity on high-dose metronidazole administered orally and intravenously. Surgery 1983, 93 (1 Part 2), 145-148.
    • (1983) Surgery , vol.93 , Issue.1 PART 2 , pp. 145-148
    • Urtasun, R.C.1    Rabin, H.R.2    Partington, J.3
  • 15
    • 0035696398 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of non-nucleoside reverse transcriptase inhibitors
    • Smith, P. F.; DiCenzo, R.; Morse, G. D. Clinical pharmacokinetics of non-nucleoside reverse transcriptase inhibitors. Clin. Pharmacokinet. 2001, 40, 893-905.
    • (2001) Clin. Pharmacokinet , vol.40 , pp. 893-905
    • Smith, P.F.1    DiCenzo, R.2    Morse, G.D.3
  • 17
    • 0021998680 scopus 로고
    • Pharmacokinetics of primaquine in man. I. Studies of the absolute bioavailability and effects of dose size
    • Mihaly, G. W.; Ward, S. A.; Edwards, G.; Nicholl, D. D.; Breckenridge, A. M. Pharmacokinetics of primaquine in man. I. Studies of the absolute bioavailability and effects of dose size. Br. J. Clin. Pharmacol. 1985, 19, 745-750.
    • (1985) Br. J. Clin. Pharmacol , vol.19 , pp. 745-750
    • Mihaly, G.W.1    Ward, S.A.2    Edwards, G.3    Nicholl, D.D.4    Breckenridge, A.M.5
  • 18
  • 21
    • 0025130214 scopus 로고
    • Pharmacokinetics of cephradine administered intravenously and orally to young and elderly subjects
    • Schwinghammer, T. L.; Norden, C. W.; Gill, E. Pharmacokinetics of cephradine administered intravenously and orally to young and elderly subjects. J. Clin. Pharmacol. 1990, 30, 893-899.
    • (1990) J. Clin. Pharmacol , vol.30 , pp. 893-899
    • Schwinghammer, T.L.1    Norden, C.W.2    Gill, E.3
  • 22
  • 23
    • 33745974941 scopus 로고    scopus 로고
    • Single-dose bioavailability of levetiracetam intravenous infusion relative to oral tablets and multiple-dose pharmacokinetics and tolerability of levetiracetam intravenous infusion with placebo in healthy subjects
    • Ramael, S.; Smedt, F. D.; Toublanc, N.; Otoul, C.; Boulanger, P.; Riethuisen, J.-M.; Stockis, A. Single-dose bioavailability of levetiracetam intravenous infusion relative to oral tablets and multiple-dose pharmacokinetics and tolerability of levetiracetam intravenous infusion with placebo in healthy subjects. Clin. Ther. 2006, 28, 734-744.
    • (2006) Clin. Ther , vol.28 , pp. 734-744
    • Ramael, S.1    Smedt, F.D.2    Toublanc, N.3    Otoul, C.4    Boulanger, P.5    Riethuisen, J.-M.6    Stockis, A.7
  • 24
    • 0031055732 scopus 로고    scopus 로고
    • The clinical pharmacokinetics of levofloxacin
    • Fish, D. N.; Chow, A. T. The clinical pharmacokinetics of levofloxacin. Clin. Pharmacokinet. 1997, 32, 101-119.
    • (1997) Clin. Pharmacokinet , vol.32 , pp. 101-119
    • Fish, D.N.1    Chow, A.T.2
  • 25
    • 34248682649 scopus 로고    scopus 로고
    • Permeability classification of representative fluoroquinolones by a cell culture method
    • Volpe, D. A. Permeability classification of representative fluoroquinolones by a cell culture method. AAPS J. 2004, 6 (2), 1-6.
    • (2004) AAPS J , vol.6 , Issue.2 , pp. 1-6
    • Volpe, D.A.1
  • 26
  • 27
    • 0027196234 scopus 로고
    • Loracarbef. A review of its microbial activity, pharmacokinetic properties and therapeutic efficacy
    • Brogden, R. N.; McTavish, D. Loracarbef. A review of its microbial activity, pharmacokinetic properties and therapeutic efficacy. Drugs 1993, 45, 716-736.
    • (1993) Drugs , vol.45 , pp. 716-736
    • Brogden, R.N.1    McTavish, D.2
  • 28
    • 0024846315 scopus 로고
    • Pharmacokinetics of ofloxacin: An overview
    • 6C, 24S-30S
    • Flor, S. Pharmacokinetics of ofloxacin: An overview. Am. J. Med. 1989, 87 (6C), 24S-30S.
    • (1989) Am. J. Med , vol.87
    • Flor, S.1
  • 29
    • 0030897275 scopus 로고    scopus 로고
    • Use of probe drugs as predictors of drug metabolism in humans
    • Kivisto, K. T.; Kroemer, H. K. Use of probe drugs as predictors of drug metabolism in humans. J. Clin. Pharmacol. 1997, 37 (Suppl), 40S-8.
    • (1997) J. Clin. Pharmacol , vol.37 , Issue.SUPPL.
    • Kivisto, K.T.1    Kroemer, H.K.2
  • 31
    • 0034942625 scopus 로고    scopus 로고
    • A second generation phosphodi- esterase-4 inhibitor for asthma and chronic obstructive pulmonary disease
    • Giembycz, M. A. Cilomilast: A second generation phosphodi- esterase-4 inhibitor for asthma and chronic obstructive pulmonary disease. Expert Opin. Invest. Drugs. 2001, 10, 1361-1379.
    • (2001) Expert Opin. Invest. Drugs , vol.10 , pp. 1361-1379
    • Giembycz, M.A.C.1
  • 32
    • 0019958116 scopus 로고
    • Calcium-channel blocking agents
    • Leonard, R. G.; Talbert, R. L. Calcium-channel blocking agents. Clin. Pharm. 1982, 1, 17-33.
    • (1982) Clin. Pharm , vol.1 , pp. 17-33
    • Leonard, R.G.1    Talbert, R.L.2
  • 33
    • 0022981349 scopus 로고
    • Clinical pharmacokinetics of vera- pamil, nifedipine and diltiazem
    • Echizen, H.; Eichelbaum, M. Clinical pharmacokinetics of vera- pamil, nifedipine and diltiazem. Clin. Pharmacokinet. 1986, 11, 425-449.
    • (1986) Clin. Pharmacokinet , vol.11 , pp. 425-449
    • Echizen, H.1    Eichelbaum, M.2
  • 34
    • 0023920751 scopus 로고    scopus 로고
    • Tessari, p.; Pehling, G.; Nissen, S. L.; Gerich, J. E.; Service, F. J.; Rizza, R. A.; Haymond, M. W. Regulation of whole-body leucine metabolism with insulin during mixed-meal absorption in normal and diabetic humans. Diabetes 1988, 37, 512-519.
    • Tessari, p.; Pehling, G.; Nissen, S. L.; Gerich, J. E.; Service, F. J.; Rizza, R. A.; Haymond, M. W. Regulation of whole-body leucine metabolism with insulin during mixed-meal absorption in normal and diabetic humans. Diabetes 1988, 37, 512-519.
  • 35
    • 30344477961 scopus 로고    scopus 로고
    • Pharmaco- kinetic study of memantine in healthy and renally impaired subjects
    • Periclou, A.; Ventura, D.; Rao, N.; Abramowitz, W. Pharmaco- kinetic study of memantine in healthy and renally impaired subjects. Clin. Pharmacol. Ther. 2006, 79, 134-143.
    • (2006) Clin. Pharmacol. Ther , vol.79 , pp. 134-143
    • Periclou, A.1    Ventura, D.2    Rao, N.3    Abramowitz, W.4
  • 36
    • 0026666065 scopus 로고
    • Clinical pharmacokinetics of metronidazole and other nitroimidazole anti-infectives
    • Lau, A. H.; Lam, N. P.; Piscitelli, S. C.; Wilkes, L.; Danziger, L. H. Clinical pharmacokinetics of metronidazole and other nitroimidazole anti-infectives. Clin. Pharmacokinet. 1992, 23, 328-364.
    • (1992) Clin. Pharmacokinet , vol.23 , pp. 328-364
    • Lau, A.H.1    Lam, N.P.2    Piscitelli, S.C.3    Wilkes, L.4    Danziger, L.H.5
  • 37
    • 64649100222 scopus 로고
    • Evans, W. E, Schentag, J. J, Jusko, W. J, Eds, 3rd ed, Applied Therapeutics, Inc, Vancouver, WA
    • Evans, W. E., Schentag, J. J., Jusko, W. J., Eds. Applied Pharmacokinetics, 3rd ed.; Applied Therapeutics, Inc.: Vancouver, WA, 1992.
    • (1992) Applied Pharmacokinetics
  • 38
    • 0022251340 scopus 로고
    • Pharmacokinetics and beta-blocking effects of timolol in poor and extensive metabolizers of debrisoquin
    • McGourty, J. C.; Silas, J. H.; Fleming, J. J.; Mcburney, A.; Ward, J. W. Pharmacokinetics and beta-blocking effects of timolol in poor and extensive metabolizers of debrisoquin. Clin. Pharmacol. Ther. 1985, 38, 409-413.
    • (1985) Clin. Pharmacol. Ther , vol.38 , pp. 409-413
    • McGourty, J.C.1    Silas, J.H.2    Fleming, J.J.3    Mcburney, A.4    Ward, J.W.5
  • 39
    • 0025257110 scopus 로고
    • Pharmacokinetics and tissue penetration of fluconazole in humans
    • Brammer, K. W.; Farrow, P. R.; Faulkner, J. K. Pharmacokinetics and tissue penetration of fluconazole in humans. Rev. Infect. Dis. 1990, 12, S318-326.
    • (1990) Rev. Infect. Dis , vol.12
    • Brammer, K.W.1    Farrow, P.R.2    Faulkner, J.K.3
  • 41
    • 0025138732 scopus 로고
    • Pharmacology, pharmacodynamics and pharmacokinetics of sotalol
    • discussion 35A-36A
    • Antonaccio, M. J.; Gomoll, A. Pharmacology, pharmacodynamics and pharmacokinetics of sotalol. Am. J. Cardiol. 1990, 65, 12A- 21A; discussion 35A-36A.
    • (1990) Am. J. Cardiol , vol.65
    • Antonaccio, M.J.1    Gomoll, A.2
  • 43
    • 0027385324 scopus 로고
    • Pharmacokinetic and pharmacodynamic profiles of d-sotalol and d,l-sotalol
    • Funck-Brentano, C. Pharmacokinetic and pharmacodynamic profiles of d-sotalol and d,l-sotalol. Eur Heart J. 1993, 4 (Suppl. H), 30-35.
    • (1993) Eur Heart J , vol.4 , Issue.SUPPL. H , pp. 30-35
    • Funck-Brentano, C.1
  • 45
    • 0242353755 scopus 로고    scopus 로고
    • Enhanced intestinal absorption of drugs by activation of peptide transporter PEPT1 using proton-releasing polymer
    • Nozawa, T.; Toyobuku, H.; Kobayashi, D.; Kuruma, K.; Tsuji, A.; Tamai, I. Enhanced intestinal absorption of drugs by activation of peptide transporter PEPT1 using proton-releasing polymer. J. Pharm. Sci. 2003, 92, 2208-2216.
    • (2003) J. Pharm. Sci , vol.92 , pp. 2208-2216
    • Nozawa, T.1    Toyobuku, H.2    Kobayashi, D.3    Kuruma, K.4    Tsuji, A.5    Tamai, I.6
  • 46
    • 34248202064 scopus 로고    scopus 로고
    • Peptide transporter substrate identification during permeability screening in drug discovery: Comparison of transfected MDCK-hPepT1 Cells to Caco-2 cells
    • Balimane, P. V.; Chong, S.; Patel, K.; Quan, Y.; Timoszyk, J.; Han, Y.-H.; Wang, B.; Vig, B.; Faria, T. N. Peptide transporter substrate identification during permeability screening in drug discovery: Comparison of transfected MDCK-hPepT1 Cells to Caco-2 cells. Arch. Pharm. Res. 2007, 30, 507-518.
    • (2007) Arch. Pharm. Res , vol.30 , pp. 507-518
    • Balimane, P.V.1    Chong, S.2    Patel, K.3    Quan, Y.4    Timoszyk, J.5    Han, Y.-H.6    Wang, B.7    Vig, B.8    Faria, T.N.9
  • 48
    • 0028345208 scopus 로고
    • Transport mechanisms responsible for the absorption of loracarbef, cefixime, and cefuroxime axetil into human intestinal Caco-2 cells
    • Dantzig, A. H.; Duckworth, D. C.; Tabas, L. B. Transport mechanisms responsible for the absorption of loracarbef, cefixime, and cefuroxime axetil into human intestinal Caco-2 cells. Biochim. Biophys. Biomembr. 1994, 1191, 7-13.
    • (1994) Biochim. Biophys. Biomembr , vol.1191 , pp. 7-13
    • Dantzig, A.H.1    Duckworth, D.C.2    Tabas, L.B.3
  • 50
    • 2942682949 scopus 로고    scopus 로고
    • Biopharmaceutical characterization of sotalol-containing oral immediate release drug products
    • Axel, A.; Potthast, H.; Moessinger, J.; Sickmuller, B.; Oeser, H. Biopharmaceutical characterization of sotalol-containing oral immediate release drug products. Eur. J. Pharm. Biopharm. 2004, 58, 145-150.
    • (2004) Eur. J. Pharm. Biopharm , vol.58 , pp. 145-150
    • Axel, A.1    Potthast, H.2    Moessinger, J.3    Sickmuller, B.4    Oeser, H.5
  • 51
    • 40949148698 scopus 로고    scopus 로고
    • Effect of human renal cationic transporter inhibition on the pharmacokinetics of varenicline, a new therapy for smoking cessation: A in vitro-in vivo study
    • Feng, B.; Obach, R. S.; Burstein, A. H.; Clark, D. J.; de Morris, S. M.; Faessel, H. M. Effect of human renal cationic transporter inhibition on the pharmacokinetics of varenicline, a new therapy for smoking cessation: A in vitro-in vivo study. Clin. Pharmacol. Ther. 2008, 83, 567-576.
    • (2008) Clin. Pharmacol. Ther , vol.83 , pp. 567-576
    • Feng, B.1    Obach, R.S.2    Burstein, A.H.3    Clark, D.J.4    de Morris, S.M.5    Faessel, H.M.6
  • 52
    • 0034461768 scopus 로고    scopus 로고
    • Drug-like properties and the causes of poor solubility and poor permeability
    • Lipinski, C. A. Drug-like properties and the causes of poor solubility and poor permeability. J. Pharmacol. Toxicol. Methods 2000, 44, 235-249.
    • (2000) J. Pharmacol. Toxicol. Methods , vol.44 , pp. 235-249
    • Lipinski, C.A.1
  • 54
    • 0032217095 scopus 로고    scopus 로고
    • The fundamental variables of the biopharmaceutics classification (BCS): A commentary
    • Van de Waterbeemd, H. The fundamental variables of the biopharmaceutics classification (BCS): A commentary. Eur. J. Pharmacol. Sci. 1998, 7, 1-3.
    • (1998) Eur. J. Pharmacol. Sci , vol.7 , pp. 1-3
    • Van de Waterbeemd, H.1
  • 55
    • 0033178249 scopus 로고    scopus 로고
    • Pharmacokinetics and metabolism in early drug discovery
    • Smith, D. A.; van de Waterbeemd, H. Pharmacokinetics and metabolism in early drug discovery. Curr. Opin. Chem. Biol. 1999, 3, 373-378.
    • (1999) Curr. Opin. Chem. Biol , vol.3 , pp. 373-378
    • Smith, D.A.1    van de Waterbeemd, H.2
  • 56
    • 36048955673 scopus 로고    scopus 로고
    • Thummel, K. E. Gut instincts: CYP3A4 and intestinal drug metabolism. J. Clin. Invest. 2007, 117, 3173-3176.
    • Thummel, K. E. Gut instincts: CYP3A4 and intestinal drug metabolism. J. Clin. Invest. 2007, 117, 3173-3176.
  • 57
    • 0342437515 scopus 로고    scopus 로고
    • Enzyme-catalyzed processes of first-pass hepatic and intestinal drug extraction
    • Thummel, K. E.; Kunze, K. L.; Shen, D. D. Enzyme-catalyzed processes of first-pass hepatic and intestinal drug extraction. Adv. Drug Delivery Rev. 1997, 27, 99-127.
    • (1997) Adv. Drug Delivery Rev , vol.27 , pp. 99-127
    • Thummel, K.E.1    Kunze, K.L.2    Shen, D.D.3
  • 58
    • 0031718551 scopus 로고    scopus 로고
    • Clinical pharmacology of rivastigmine: A new- generation acetylcholinesterase inhibitor for the treatment of Alzheimer's disease
    • Polinsky, R. J. Clinical pharmacology of rivastigmine: a new- generation acetylcholinesterase inhibitor for the treatment of Alzheimer's disease. Clin. Ther. 1998, 20, 634-647.
    • (1998) Clin. Ther , vol.20 , pp. 634-647
    • Polinsky, R.J.1
  • 59
    • 35648935952 scopus 로고    scopus 로고
    • Kinetic determination of hepatic clearance: Plasma protein binding and hepatic uptake
    • Baker, M.; Parton, T. Kinetic determination of hepatic clearance: Plasma protein binding and hepatic uptake. Xenobiotica 2007, 37, 1110-1134.
    • (2007) Xenobiotica , vol.37 , pp. 1110-1134
    • Baker, M.1    Parton, T.2
  • 60
    • 0033407634 scopus 로고    scopus 로고
    • The biopharmaceutics classification system (BCS): Class III drugs - better candidates for BA/BE waiver
    • Blume, H. H.; Schug, B. S. The biopharmaceutics classification system (BCS): Class III drugs - better candidates for BA/BE waiver. Eur. J. Pharm. Sci. 1999, 9, 117-121.
    • (1999) Eur. J. Pharm. Sci , vol.9 , pp. 117-121
    • Blume, H.H.1    Schug, B.S.2
  • 62
    • 3843097202 scopus 로고    scopus 로고
    • Classification of orally administered drugs on the World Health Organization Model List of Essential Medicines according to the biopharmaceutics classification system
    • Linderberg, M.; Kopp, S.; Dressman, J. B. Classification of orally administered drugs on the World Health Organization Model List of Essential Medicines according to the biopharmaceutics classification system. Eur. J. Pharm. Biopharm. 2004, 58, 265-278.
    • (2004) Eur. J. Pharm. Biopharm , vol.58 , pp. 265-278
    • Linderberg, M.1    Kopp, S.2    Dressman, J.B.3
  • 63
    • 2642530433 scopus 로고    scopus 로고
    • Poli, J. E.; Yu, L. X.; Cook, J.; Amidon, G. L.; Borchardt, R. T.; Burnside, B. A.; Burton, P. S.; Chen, M.-L.; Conner, D. P.; Faustino, J.; Hawi, A. A.; Hussain, A. S.; Joshi, H. N.; Kwei, G.; Lee, V. H. L.; Lesko, L. J.; Lipper, R. A.; Loper, A. E.; Nerukar, S. G.; Polli, J. W.; Sanvordeker, D. R.; Taneja, R.; Upporr, R. S.; Vattikonda, C. S.; Wilding, I.; Zhang, G. Summary workshop report: Biopharmaceutics classification system - Implementation challenges and extension opportunities. J. Pharm. Sci. 2004, 93, 1375-1381.
    • Poli, J. E.; Yu, L. X.; Cook, J.; Amidon, G. L.; Borchardt, R. T.; Burnside, B. A.; Burton, P. S.; Chen, M.-L.; Conner, D. P.; Faustino, J.; Hawi, A. A.; Hussain, A. S.; Joshi, H. N.; Kwei, G.; Lee, V. H. L.; Lesko, L. J.; Lipper, R. A.; Loper, A. E.; Nerukar, S. G.; Polli, J. W.; Sanvordeker, D. R.; Taneja, R.; Upporr, R. S.; Vattikonda, C. S.; Wilding, I.; Zhang, G. Summary workshop report: Biopharmaceutics classification system - Implementation challenges and extension opportunities. J. Pharm. Sci. 2004, 93, 1375-1381.
  • 64
    • 1242337282 scopus 로고    scopus 로고
    • The 'high solubility' definition of the current FDA guidance on biopharmaceutics classification system may be too strict for acidic drugs
    • Yazdanian, M.; Briggs, K.; Jankovski, C.; Hawi, A. The 'high solubility' definition of the current FDA guidance on biopharmaceutics classification system may be too strict for acidic drugs. Pharm. Res. 2004, 21, 293-299.
    • (2004) Pharm. Res , vol.21 , pp. 293-299
    • Yazdanian, M.1    Briggs, K.2    Jankovski, C.3    Hawi, A.4
  • 65
    • 15244341878 scopus 로고    scopus 로고
    • Identification of biowaivers among Class II drugs: Theoretical justification and practical examples
    • Rinaki, E.; Dokoumetzidis, A.; Valsami, G.; Macheras, P. Identification of biowaivers among Class II drugs: Theoretical justification and practical examples. Pharm. Res. 2004, 21, 1567-1572.
    • (2004) Pharm. Res , vol.21 , pp. 1567-1572
    • Rinaki, E.1    Dokoumetzidis, A.2    Valsami, G.3    Macheras, P.4
  • 66
    • 14744272833 scopus 로고    scopus 로고
    • The use of biopharmaceutic classification of drugs in drug discovery and development: Current status and future extension
    • Lennernas, H.; Abrahamsson, B. The use of biopharmaceutic classification of drugs in drug discovery and development: Current status and future extension. J. Pharm. Pharmacol. 2005, 57, 273-285.
    • (2005) J. Pharm. Pharmacol , vol.57 , pp. 273-285
    • Lennernas, H.1    Abrahamsson, B.2
  • 67
    • 34447329572 scopus 로고    scopus 로고
    • Evaluation and suggested improvements of the biopharmaceutics classification system (BCS)
    • Fagerholm, U. Evaluation and suggested improvements of the biopharmaceutics classification system (BCS). J. Pharm. Pharmacol. 2007, 59, 751-757.
    • (2007) J. Pharm. Pharmacol , vol.59 , pp. 751-757
    • Fagerholm, U.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.