Analysis of memory and effector CD8+ T cell subsets in chronic graft-versus-host disease

International Journal of Immunopathology and Pharmacology

Volumn 22, Issue 1, 2009, Pages 195-205

  D'Asaro, M ^a   Salerno, A ^a   Dieli, Francesco ^a   Caccamo, N ^a  

^a UNIVERSITY OF PALERMO   (Italy)

Author keywords

Cytotoxic; Graft versus host disease; Human; T cells

Indexed keywords

CD45RA ANTIGEN; CD8 ANTIGEN; CHEMOKINE RECEPTOR CCR7; CYCLOSPORIN A; GRANZYME A; METHOTREXATE; PERFORIN; PREDNISONE;

ADULT; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; APOPTOSIS; ARTICLE; CD8+ T LYMPHOCYTE; CELL MEDIATED CYTOTOXICITY; CELL PROLIFERATION; CHRONIC GRAFT VERSUS HOST DISEASE; CONTROLLED STUDY; DOWN REGULATION; EFFECTOR CELL; FEMALE; HEMATOLOGIC MALIGNANCY; HUMAN; HUMAN CELL; IMMUNOPATHOGENESIS; LYMPHOCYTE COUNT; MALE; MEMORY CELL; PHENOTYPIC VARIATION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN CONTENT; PROTEIN EXPRESSION; T LYMPHOCYTE SUBPOPULATION;

EID: 62649125795     PISSN: 03946320     EISSN: None     Source Type: Journal    
DOI: 10.1177/039463200902200122     Document Type: Article

References (31)

1. Shlomchik WD. Graft-versus-host disease. Nat Rev Immunol 2007; 7:340-52.
2. Zhang C, Todorov I, Zhang Z, et al. Donor CD4+ and B cells in transplants induce chronic graft versus host disease with autoimmune manifestations. Blood 2006; 107:2993-3001.
3. Kansu E. The pathophysiology of chronic graft-versus-host disease. Int J Hemat 2004; 79:209-15.
4. Socié G. Chronic graft-versus-host disease: clinical features and grading systems. Int J Hemat 2004; 79: 216-20.
5. Yamashita K, Choi U, Woltz PC, et al. Severe chronic graft-versus-host disease is, characterized by a preponderance of CD4+ effector memory cells relative to central memory cells. Blood 2004; 103: 3986-8.
6. Cerottini JC, MacDonald HR. The cellular basis of T-cell memory. Annu Rev Immunol 1989; 7:77-89.
7. Wherry EJ, Teichgräber V, Becker TC, et al. Lineage relationship and protective immunity of memory CD8 T cell subsets. Nat Immunol 2003; 4:225-34.
8. D'Asaro M, Dieli F, Caccamo N, Musso M, Porretto F, Salerno A. Increase of CCR7-CD45RA+ CD8 T cells (TEMRA) in chronic graft-versus-host disease. Leukemia 2006; 20:545-7.
9. Filipovich AH, Weisdorf D, Pavletic S, et al. National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. Diagnosis and Staging Working Group Report. Biol Blood Marrow Transplant 2005; 11:945-55.
10. Kroger CJ, Alexander-Miller MA. Dose-dependent modulation of CD8 and functional avidity as a result of peptide encounter. Immunology 2007; 122:167-78.
11. Zhang Y, Joe G, Hexner E, Zhu J, Emerson SG. Alloreactive memory T cells are responsible for the persistence of graft-versus-host disease. J Immunol 2005; 174:3051-8.
12. Shlomchik WD, Matte C, Liu JL, Jain D and McNiff J. CD8+ but not CD4 T cells require cognate interactions with target tissue to mediate GVHD across only minor H antigen but CD4 and CD8 T cells both require direct leukemic contact for GVL. Blood 2005; 106(ASH Annual Meeting Abstract), Abstract 580.
13. Sprent J, Schaefer M, Lo D, Korngold R. Properties of purified T cell subsets. II. In vivo responses to class I vs. class II H-2 differences. J Exp Med 1986; 163: 998-1011.
14. Sprent J, Schaefer M, Gao EK, Korngold R. Role of T cell subsets in lethal graft-versus-host disease (GVHD) directed to class I versus class II H-2 differences. I. L3T4+ cells can either augment or retard GVHD elicited by Lyt-2+ cells in class I different hosts. J Exp Med 1988; 167:556-69.
15. Hamilton BL. L3T4-positive T cells participate in the induction of graft-vs-host disease in response to minor histocompatibility antigens. J Immunol 1987; 139:2511-5.
16. Korngold R, Sprent J. Surface markers of T cells causing lethal graft-vs-host disease to class I vs class II H-2 differences. J Immunol 1985; 135:3004-10.
17. Korngold R, Sprent J. Variable capacity of L3T4+ T cells to cause lethal graft-versus-host disease across minor histocompatibility barriers in mice. J Exp Med 1987; 6:1552-64.
18. Sprent J, Korngold R. T cell subsets controlling graft-v-host disease in mice. Transplant Proc 1987; 19:41-7.
19. Hollander GA, Widmer B, Burakoff SJ. Loss of normal thymic repertoire and persistence of autoreactive T cells in graft vs host disease. J Immunol 1994; 152:1609-17.
20. Gallardo D, Garcia-López J, Sureda A, et al. Low-dose donor CD8+ cells in the CD4-depleted graft prevent allogeneic marrow graft rejection and severe graft-versus-host disease for chronic myeloid leukemia patients in first chronic phase. Bone Marrow Transplant 1997; 20:945-52.
21. Champlin R, Ho W, Gajewski J, et al. Selective depletion of CD8+ T lymphocytes for prevention of graft-versus-host disease after allogeneic bone marrow transplantation. Blood 1990; 76:418-23.
22. Blaser BW, Roychowdhury S, Kim DJ, et al. Donor-derived IL-15 is critical for acute allogeneic graft-versus-host disease. Blood 2005; 105:894-901.
23. Roychowdhury S, Blaser BW, Freud AG, et al. IL-15 but not IL-2 rapidly induces lethal xenogeneic graft-versus-host disease. Blood 2005; 106:2433-5.
24. Champagne P, Ogg GS, King AS, et al. Skewed maturation of memory HIV-specific CD8 T lymphocytes. Nature 2001; 410:106-11.
25. Geginat J, Lanzavecchia A, Sallusto F. Proliferation and differentiation potential of human CD8+ memory T-cell subsets in response to antigen or homeostatic cytokines. Blood 2003; 101:4260-6.
26. Charles J, Kroger CJ, Alexander-Miller MA. Dose-dependent modulation of CD8 and functional avidity as a result of peptide encounter. Immunology 2007; 122:167-78.
27. Maile R, Siler CA, Kerry SE, Midkiff KE, Collins E, Frelinger JA. Peripheral CD8-tuning dynamically modulates the size and responsiveness of an antigen-specific T cell pool in vivo. J. Immunol 2005; 174: 619-27.
28. hi T cell responses to the same antigen. Eur J Inummol 2006; 36:397-410.
29. Kienzle N, Olver S, Buttigieg K, et al. Progressive differentiation and commitment of CD8+ T cells to a poorly cytolytic CD8low phenotype in the presence of IL-4. J Immunol 2005; 174:2021-9.
30. Kienzle N, Baz A, Kelso A. Profiling the CD8low phenotype, an alternative career choice for CD8 T cells during primary differentiation. Immunol Cell Biol 2004; 82:75-83.
31. Dunne PJ, Faint JM, Gudgeon NH, et al. Epstein-Barr virus-specific CD8(+) T cells that re-express CD45RA are apoptosis-resistant memory cells that retain replicative potential. Blood 2002; 100:933-40.