Tyrosine phosphorylation of vitreous inflammatory and angiogenic peptides and proteins in diabetic retinopathy

Investigative Ophthalmology and Visual Science

Volumn 50, Issue 3, 2009, Pages 1378-1382

  Reverter, Jordi L ^a   Nadal, Jeroni ^b   Fernández Novell, Josep María ^c   Ballester, Joan ^b   Ramió Lluch, Laura ^b   Rivera, María Montserrat ^b   Elizalde, Javier ^b   Abengoechea, Santiago ^b   Guinovart, Joan J ^c   Rodríguez Gil, Joan Enric ^b  

^a HOSPITAL UNIVERSITARI GERMANS TRIAS I PUJOL   (Spain)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^c UNIVERSITY OF BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ANGIOGENIC PROTEIN; ANGIOGENIN; CHEMOKINE; COLONY STIMULATING FACTOR; EPITHELIAL DERIVED NEUTROPHIL ACTIVATING FACTOR 78; GAMMA INTERFERON; INSULIN; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 13; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 7; INTERLEUKIN 8; MACROPHAGE DERIVED CHEMOKINE; MACROPHAGE INFLAMMATORY PROTEIN 1; MONOKINE; ONCOSTATIN M; RAMIPRIL; RANTES; STATIN; STEM CELL FACTOR; TRANSFORMING GROWTH FACTOR BETA1; TYROSINE; ANGIOGENIC FACTOR; AUTACOID; CYTOKINE; EYE PROTEIN; PEPTIDE;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETIC RETINOPATHY; HUMAN; IMMUNOBLOTTING; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; VITRECTOMY; VITREOUS BODY; METABOLISM; MIDDLE AGED; PHOSPHORYLATION; PROTEIN MICROARRAY;

ANGIOGENESIS INDUCING AGENTS; CYTOKINES; DIABETES MELLITUS, TYPE 2; DIABETIC RETINOPATHY; EYE PROTEINS; HUMANS; IMMUNOBLOTTING; INFLAMMATION MEDIATORS; MALE; MIDDLE AGED; PEPTIDES; PHOSPHORYLATION; PROTEIN ARRAY ANALYSIS; TYROSINE; VITRECTOMY; VITREOUS BODY;

EID: 62649103318     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.08-2736     Document Type: Article

References (36)

1. Aiello LP, Gardner TW, King GL, et al. Diabetic retinopathy. Diabetes Care. 1998;21:143-156.
2. Frank RN. Diabetic retinopathy. N Engl J Med. 2004;350:48-58.
3. Aronson D. Hyperglycemia and the pathobiology of diabetic complications. Adv Cardiol. 2008;45:1-16.
4. Jo N, Wu GS, Rao NA. Upregulation of chemokine expression in the retinal vasculature in ischemia-reperfusion injury. Invest Ophthalmol Vis Sci. 2003;44:4054-4060.
5. Mitamura Y, Harada C, Harada T. Role of cytokines and trophic factors in the pathogenesis of diabetic retinopathy. Curr Diabetes Rev. 2005;1:73-81.
6. Yuuki T, Kanda T, Kimura Y, et al. Inflammatory cytokines in vitreous fluid and serum of patients with diabetic vitreoretinopathy. J Diabetes Complications. 2001;15:257-259.
7. Jo N, Wu GS, Rao NA. Upregulation of chemokine expression in the retinal vasculature in ischemia-reperfusion injury. Invest Ophthalmol Vis Sci. 2003;44:4054-4560.
8. Kim T, Kim SJ, Kim K, et al. Profiling of vitreous proteomes from proliferative diabetic retinopathy and nondiabetic patients. Proteomics. 2007;7:4203-4215.
9. García-Ramírez M, Canals F, Hernández C, et al. Proteomic analysis of human vitreous fluid by fluorescence-based difference gel electrophoresis (DIGE): a new strategy for identifying potential candidates in the pathogenesis of proliferative diabetic retinopathy. Diabetologia. 2007;50:1294-1303.
10. Gao BB, Chen X, Timothy N, Aiello LP, Feener EP. Characterization of the vitreous proteome in diabetes without diabetic retinopathy and diabetes with proliferative diabetic retinopathy. J Proteome Res. 2008;7:2516-2525.
11. Cohen P. Protein phosphorylation and hormone action. Proc R Soc Lond B Biol Sci. 1988;22:234:115-144.
12. Schlessinger J. Cell signalling by receptor tyrosine kinases. Cell. 2000;103:211-225.
13. Mohamed Q, Gillies MC, Wong TY. Management of diabetic retinopathy: a systematic review. JAMA. 2007;298:902-916.
14. Standards of medical care in diabetes-2007; American Diabetes Association. Diabetes Care. 2007;30:S42-S47.
15. Bradford MM. A rapid and sensitive for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72:248-254.
16. Merchant ML, Klein JB. Proteomics and diabetic nephropathy. Semin Nephrol. 2007;27:627-636.
17. Bagley CJ, Woodcock JM, Guthridge MA, Stomski FC, López AF. Structural and functional hot spots in cytokine receptors. Int J Hematol. 2001;73:299-307.
18. Heinrich PC, Behrmann I, Haan S, Hermanns HM, Müller-Newen G, Schaper F. Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem J. 2003;374:1-20.
19. Darnay BG, Aggarwal BB. Inhibition of protein tyrosine phosphatases causes phosphorylation of tyrosine-331 in the p60 TNF receptor and inactivates the receptor-associated kinase. FEBS Lett. 1997;410:361-367.
20. Corvera S, Witehead RE, Mottola C, Czech MP. The insulin-like growth factor II receptor is phosphorylated by a tyrosine kinase in adipocyte plasma membranes. J Biol Chem. 1986;261:7675-7679.
21. Veikkola T, Karkkainen M, Claesson-Welsh L, Alitalo K. Regulation of angiogenesis via vascular endothelial growth factor receptors. Cancer Res. 2000;60:203-212.
22. Robb RJ, Kutny RM, Panico M, Morris HR, Chowdhry V. Amino acid sequence and post-translational modification of human interleukin 2. Proc Natl Acad Sci USA. 1984;81:6486-6490.
23. Fiskerstrand C, Sargan D. Nucleotide sequence of ovine interleukin-1 beta. Nucleic Acids Res. 1990;18:7165.
24. Tanigawa K, Fujihara M, Sakamoto R, Yanahira S, Ohtsuki K. Characterization of bovine angiogenin-1 and lactogenin-like protein as glycyrrhizin-binding proteins and their in vitro phosphorylation by C-kinase. Biol Pharm Bull. 2001;24:443-447.
25. Cicik E, Tekin H, Akar S, et al. Interleukin-8, Nitric oxide and glutathione status in proliferative vitreoretinopathy and proliferative diabetic retinopathy. Ophthalmic Res. 2003;35:251-255.
26. Funatsu H, Yamashita H, Ikeda T, Mimura T, Eguchi S, Hori S. Vitreous levels of interleukin-6 and vascular endothelial growth factor are related to diabetic macular edema. Ophthalmology. 2003;110:1690-1696.
27. Er H, Doǧanay S, Ozerol E, Yürekli M. Adrenomedullin and leptin levels in diabetic retinopathy and retinal diseases. Ophthalmologica. 2005;219:107-111.
28. Funatsu H, Yamashita H, Noma H, et al. Aqueous humor levels of cytokines are related to vitreous levels and progression of diabetic retinopathy in diabetic patients. Graefes Arch Clin Exp Ophthalmol. 2005;243:3-8.
29. Demircan N, Safran BG, Soylu M, Ozcan AA, Sizmaz S. Determination of vitreous interleukin-1 (IL-1) and tumour necrosis factor (TNF) levels in proliferative diabetic retinopathy. Eye. 2006;20: 1366-1369.
30. Maier R, Weger M, Haller-Schober EM, et al. Multiplex bead analysis of vitreous and serum concentrations of inflammatory and proangiogenic factors in diabetic patients. Mol Vis. 2008;14:637-643.
31. Noma H, Funatsu H, Yamasaki M, et al. Aqueous humour levels of cytokines are correlated to vitreous levels and severity of macular oedema in branch retinal vein occlusion. Eye. 2008;22:42-48.
32. Krook A, Roth RA, Jiang XJ, Zierath JR, Wallberg-Henriksson H. Insulin-stimulated Akt kinase activity is reduced in skeletal muscle from NIDDM subjects. Diabetes. 1998;47:1281-1286.
33. Eldar-Finkelman H, Shreyer SA, Shinohara MM, LeBoeuf RC, Krebs EG. Increased glycogen synthase kinase-3 activity in diabetes- and obesity-prone C57BL/6J mice. Diabetes. 1999;48:1662-1666.
34. db/db mice. J Endocrinol. 2000;167:107-115.
35. Ali TK, Matragoon S, Pillai BA, Liou GI, El-Remessy AB. Peroxynitrite mediates retinal neurodegeneration by inhibiting nerve growth factor survival signaling in experimental and human diabetes. Diabetes. 2008;57:889-898.
36. Jonnala RR, Buccafusco JJ. Inhibition of nerve growth factor signaling by peroxynitrite. J Neurosci Res. 2001;63:27-34.