Receptor-based 3D-QSAR study for recognizing true binding mode of mercaptoacyldipeptides at the active site of neutral endopeptidase

Medicinal Chemistry

Volumn 5, Issue 1, 2009, Pages 50-65

  Zaheer ul Haq, ^a   Iqbal, Sadaf ^a  

^a UNIVERSITY OF KARACHI   (Pakistan)

Author keywords

Comparative molecular field analysis; Comparative molecular similarity analysis; Mercaptoacyldipeptides; Neutral endopeptidase

Indexed keywords

DIPEPTIDE; MEMBRANE METALLOENDOPEPTIDASE; MERCAPTOACYLDIPEPTIDE; UNCLASSIFIED DRUG; PROTEINASE INHIBITOR;

ARTICLE; CARDIOVASCULAR DISEASE; COMPARATIVE MOLECULAR FIELD ANALYSIS; COMPARATIVE MOLECULAR SIMILARITY INDICES ANALYSIS; CONTROLLED STUDY; DRUG CONFORMATION; DRUG DESIGN; DRUG POTENCY; DRUG PROTEIN BINDING; ENZYME ACTIVE SITE; HYDROGEN BOND; LIGAND BINDING; MOLECULAR DOCKING; MOLECULAR MODEL; PREDICTION; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; THREE DIMENSIONAL IMAGING; BINDING SITE; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; DRUG ANTAGONISM; METABOLISM; MULTIVARIATE ANALYSIS; PREDICTION AND FORECASTING; PROTEIN BINDING;

BINDING SITES; COMPUTER SIMULATION; DIPEPTIDES; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MULTIVARIATE ANALYSIS; NEPRILYSIN; PREDICTIVE VALUE OF TESTS; PROTEASE INHIBITORS; PROTEIN BINDING; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 62649102890     PISSN: 15734064     EISSN: None     Source Type: Journal    
DOI: 10.2174/157340609787049253     Document Type: Article

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