Aberrant E2F activation by polyglutamine expansion of androgen receptor in SBMA neurotoxicity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 10, 2009, Pages 3818-3822

  Suzuki, Eriko ^a,b   Zhao, Yue ^a   Ito, Saya ^a,b   Sawatsubashi, Shun ^a,b   Murata, Takuya ^a   Furutani, Takashi ^c   Shirode, Yuko ^a,b   Yamagata, Kaoru ^a,b   Tanabe, Masahiko ^a   Kimura, Shuhei ^a   Ueda, Takashi ^a   Fujiyama, Sally ^a,b   Lim, Jinseon ^a   Matsukawa, Hiroyuki ^a   Kouzmenko, Alexander P ^a,b   Aigaki, Toshiro ^d   Tabata, Tetsuya ^a   Takeyama, Ken Ichi ^a   Kato, Shigeaki ^a,b  

^a UNIVERSITY OF TOKYO   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c ASTELLAS PHARMA INC   (Japan)

^d TOKYO METROPOLITAN UNIVERSITY   (Japan)

Author keywords

Neurodegenerative disease; Retinoblastoma protein; Transcriptional regulation

Indexed keywords

ANDROGEN RECEPTOR; HISTONE DEACETYLASE 1; NEUROTROPHIC FACTOR; POLYGLUTAMINE; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DEACETYLATION; DROSOPHILA; GENE MUTATION; GENETIC SCREENING; HORMONE PROTEIN COMPLEX; KENNEDY DISEASE; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; TRANSACTIVATION;

ANDROGENS; ANIMALS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; E2F TRANSCRIPTION FACTORS; HUMANS; LIGANDS; MUSCULAR ATROPHY, SPINAL; MUTANT PROTEINS; NERVE DEGENERATION; PEPTIDES; PROTEIN BINDING; RECEPTORS, ANDROGEN; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION;

EID: 62649094404     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0809819106     Document Type: Article

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