Fluorinated 1,2,4-triazolo[1,5-a]pyrimidine-6-carboxylic acid derivatives as antimycobacterial agents

Archiv der Pharmazie

Volumn 342, Issue 2, 2009, Pages 94-99

  Abdel Rahman, Hamdy M ^a   El Koussi, Nawal A ^a   Hassan, Hoda Y ^a  

^a Assiut University   (Egypt)

Author keywords

1,2,4 triazolo1,5 a pyrimidines; Antimycobacterial activity; Fluoroquinolone analogues; Mycobacterium tuberculosis

Indexed keywords

1,2,4 TRIAZOLO[1,5 A]PYRIMIDINE 6 CARBOXYLIC ACID DERIVATIVE; 4 4 BROMOBENZYL 7 OXO 2 (TRIFLUOROMETHYL) 4,7 DIHYDRO 7 OXO 1,2,4 TRIAZOLO[5,1 A]PYRIMIDINE 6 CARBOXYLIC ACID; 4 4 BROMOBENZYL 7 OXO 2 (TRIFLUOROMETHYL) 4,7 DIHYDRO 7 OXO 1,2,4 TRIAZOLO[5,1 A]PYRIMIDINE 6 CARBOXYLIC ACID ETHYL ESTER; 4 4 NITROBENZYL 7 OXO 2 (TRIFLUOROMETHYL) 4,7 DIHYDRO 1,2,4 TRIAZOLO[5,1 A]PYRIMIDINE 6 CARBOXYLIC ACID; 4 4 NITROBENZYL 7 OXO 2 (TRIFLUOROMETHYL) 4,7 DIHYDRO 1,2,4 TRIAZOLO[5,1 A]PYRIMIDINE 6 CARBOXYLIC ACID ETHYL ESTER; 4 ALLYL 7 OXO 2 (TRIFLUOROMETHYL) 4,7 DIHYDRO 1,2,4 TRIAZOLO[5,1 A]PYRIMIDINE 6 CARBOXYLIC ACID ETHYL ESTER; 4 ETHYL 7 OXO 2 (TRIFLUOROMETHYL) 4,7 DIHYDRO 1,2,4 TRIAZOLO[5,1 A]PYRIMIDINE 6 CARBOXYLIC ACID ETHYL ESTER; 4 METHYL 7 OXO 2 (TRIFLUOROMETHYL) 4,7 DIHYDRO 1,2,4 TRIAZOLO[5,1 A]PYRIMIDINE 6 CARBOXYLIC ACID; 4 METHYL 7 OXO 2 (TRIFLUOROMETHYL) 4,7 DIHYDRO 1,2,4 TRIAZOLO[5,1 A]PYRIMIDINE 6 CARBOXYLIC ACID ETHYL ESTER; 7 OXO 2 (TRIFLUOROMETHYL) 4,7 DIHYDRO 1,2,4 TRIAZOLO[5,1 A]PYRIMIDINE 6 CARBOXYLIC ACID; 7 OXO 2 (TRIFLUOROMETHYL) 4,7 DIHYDRO 1,2,4 TRIAZOLO[5,1 A]PYRIMIDINE 6 CARBOXYLIC ACID ETHYL ESTER; ANTIMYCOBACTERIAL AGENT; CIPROFLOXACIN; NALIDIXIC ACID; QUINOLONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; FLUORINATION; IC 50; MAMMAL CELL; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; VERO CELL;

ANIMALS; ANTITUBERCULAR AGENTS; CELL SURVIVAL; CERCOPITHECUS AETHIOPS; FLUOROQUINOLONES; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM TUBERCULOSIS; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES; VERO CELLS;

EID: 62549141042     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.200800113     Document Type: Article

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