Investigation of the pruritogenic effects of histamine, serotonin, tryptase, substance P and interleukin-2 in healthy dogs

Veterinary Dermatology

Volumn 20, Issue 2, 2009, Pages 105-110

  Carr, Melissa N ^a   Torres, Sheila M F ^a   Koch, Sandra N ^a   Reiter, Lisa V ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; ANALGESIC AGENT; HISTAMINE; HISTAMINE AGONIST; INTERLEUKIN 2; SEROTONIN; SEROTONIN RECEPTOR AFFECTING AGENT; SUBSTANCE P; TRYPTASE;

ANIMAL; ANIMAL DISEASE; ARTICLE; CHEMICALLY INDUCED DISORDER; DOG; DOG DISEASE; FEMALE; PRURITUS;

ANALGESICS, NON-NARCOTIC; ANIMALS; DOG DISEASES; DOGS; FEMALE; HISTAMINE; HISTAMINE AGONISTS; INTERLEUKIN-2; NEUROTRANSMITTER AGENTS; PRURITUS; SEROTONIN; SEROTONIN AGENTS; SUBSTANCE P; TRYPTASES;

CANIS FAMILIARIS; MUS;

EID: 62549140132     PISSN: 09594493     EISSN: 13653164     Source Type: Journal    
DOI: 10.1111/j.1365-3164.2008.00716.x     Document Type: Article

References (28)

1. Yosipovitch G, Greaves MW, Schmelz M. Itch. The Lancet 2003 361 : 690 4.
2. Twycross R, Greaves MW, Handwerker H et al. Itch: scratching more than the surface. Quarterly Journal of Medicine 2003 96 : 7 26.
3. Greaves MW. Recent advances in pathophysiology and current management of itch. Annals of the Academy of Medicine, Singapore 2007 36 : 788 92.
4. Davidson S, Zhang X, Yoon CH, Khasabov SG, Simone DA, Giesler GJ. The itch-producing agents histamine and cowhage activate separate populations of primate spinothalamic tract neurons. Journal of Neuroscience 2007 27 : 10007 14.
5. Gnirs K, Prélaud P. Cutaneous manifestations of neurological diseases: review of neuro-pathophysiology and diseases causing pruritus. Veterinary Dermatology 2005 16 : 137 46.
6. Marsella R, Nicklin CF. Intradermal skin test reactivity to histamine and substance P is blunted in dogs with atopic dermatitis. Veterinary Dermatology 2001 12 : 149 54.
7. Schwartzman RM. The reaction of canine skin to histamine and 48/80. Journal of Investigative Dermatology 1965 44 : 39 42.
8. Thomsen JS, Sonne M, Benfeldt E, Jensen SB, Serup J, Menn ÉT. Experimental itch in sodium lauryl sulphate-inflamed and normal skin in humans. A randomized, double-blind, placebo-controlled study of histamine and other inducers of itch. British Journal of Dermatology 2002 146 : 792 800.
9. Heyer G, Hornstein OP, Handwerker HO. Skin reactions and itch sensation induced by epicutaneous histamine application in atopic dermatitis and controls. Journal of Investigative Dermatology 1989 93 : 492 6.
10. Simone DA, Ngeow JY, Whitehouse J, Becerra-Cabal L, Putterman GJ, LaMotte RH. The magnitude and duration of itch produced by intracutaneous injections of histamine. Somatosensory Research 1987 5 : 81 92.
11. Ständer S, Steinhoff M, Schmelz M, Weisshaar E, Metze D, Luger T. Neurophysiology of pruritus. Cutaneous elicitation of itch. Archives of Dermatology 2003 139 : 1463 70.
12. Mayo MJ, Handem I, Saldana S, Jacobe H, Getachew Y, Rush AJ. Sertraline as a first-line treatment for cholestatic pruritus. Hepatology 2007 45 : 666 74.
13. Murphy M, Reaich D, Pai P, Finn P, Carmichael AJ. A randomized, placebo-controlled, double-blind trial of ondansetron in renal itch. British Journal of Dermatology 2003 148 : 314 7.
14. Davis MP, Frandsen JL, Walsh D, Andresen S, Taylor S. Mirtazapine for pruritus. Journal of Pain and Symptom Management 2003 25 : 288 91.
15. Ui H, Andoh T, Lee J, Nojima H, Kuraishi Y. Potent pruritogenic action of tryptase mediated by PAR-2 receptor and its involvement in anti-pruritic effect of nafamostat mesilate in mice. European Journal of Pharmacology 2006 530 : 172 8.
16. Molino M, Barnathan ES, Numerof R et al. Interactions of mast cell tryptase with thrombin receptors and PAR-2. Journal of Biological Chemistry 1997 272 : 4043 9.
17. Steinhoff M, Neisius U, Ikoma A et al. Proteinase-activated receptor-2 mediates itch: a novel pathway for pruritus in human skin. Journal of Neuroscience 2003 23 : 6176 80.
18. Steinhoff M, Vergnolle N, Young SH et al. Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism. Nature Medicine 2000 6 : 151 8.
19. Ebertz JM, Hirshman CA, Kettelkamp NS, Uno H, Hanifin JM. Substance P-induced histamine release in human cutaneous mast cells. Journal of Investigative Dermatology 1987 88 : 682 5.
20. Hägermark O, Hökfelt T, Pernow B. Flare and itch induced by substance P in human skin. Journal of Investigative Dermatology 1978 71 : 233 5.
21. Gaspari AA, Lotze MT, Rosenberg SA, Stern JB, Katz SI. Dermatologic changes associated with interleukin 2 administration. Journal of the American Medical Association 1987 258 : 1624 9.
22. Wahlgren C, Hägermark O, Linder MT, Scheynius A. Itch and inflammation induced by intradermally injected interleukin-2 in atopic dermatitis patients and healthy subjects. Archives of Dermatological Research 1995 287 : 572 80.
23. Darsow U, Scharein E, Bromm B, Ring J. Skin testing of the pruritogenic activity of histamine and cytokines (interleukin-2 and tumour necrosis factor-alpha) at the dermal-epidermal junction. British Journal of Dermatology 1997 137 : 415 7.
24. Arthur RP, Shelley WB. The peripheral mechanism of itch in man. In : Wolstenholme GEW, O'Connor M, eds. Pain and Itch: Nervous Mechanisms. Boston, MA : Little, Brown and Company, 1959 : 84 97.
25. Joglekar GV, Bhide MB, Balwani JH. An experimental method for screening antipruritic agents. British Journal of Dermatology 1963 75 : 117 9.
26. Koenigstein H. Experimental study of itch stimuli in animals. Archives of Dermatology and Syphilology 1948 57 : 828 49.
27. Osifo GN. Structure activity relationships in the pruritogenicity of chloroquine and amodiaquine metabolites in a dog model. Journal of Dermatological Science 1991 2 : 92 6.
28. Osifo GN. An animal model of chloroquine-induced pruritus. Nigerian Journal of Physiological Sciences 1987 3 : 31 5.