Novel trans-2-aryl-cyclopropylamine analogues as potent and selective dipeptidyl peptidase IV inhibitors

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 6, 2009, Pages 2388-2399

  Tsai, Ting Yueh ^a   Hsu, Tsu ^a   Chen, Chiung Tong ^a   Cheng, Jai Hong ^a   Yeh, Teng Kuang ^a   Chen, Xin ^a   Huang, Chung Yu ^a   Chang, Chung Nien ^a   Yeh, Kai Chia ^a   Hsieh, Su Huei ^a   Chien, Chia Hui ^a   Chang, Yi Wei ^a   Huang, Chih Hsiang ^a   Huang, Yu Wen ^a   Huang, Chen Lung ^a   Wu, Ssu Hui ^a   Wang, Min Hsien ^a   Lu, Cheng Tai ^a   Chao, Yu Sheng ^a   Jiaang, Weir Torn ^a  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

Author keywords

Dipeptidyl peptidase IV; Inhibitor; trans 2 Aryl cyclopropylamine

Indexed keywords

3 [[2 (2 CYANO 4 FLUOROPYRROLIDIN 1 YL) 2 OXOETHYL]AMINO] 3 METHYL N [2 (3 CHLOROPHENYL)CYCLOPROPYL]BUTANAMIDE; CYCLOPROPYLAMINE DERIVATIVE; DIPEPTIDYL PEPTIDASE; DIPEPTIDYL PEPTIDASE 8; DIPEPTIDYL PEPTIDASE II; DIPEPTIDYL PEPTIDASE IV INHIBITOR; FIBROBLAST ACTIVATION PROTEIN; GLUCOSE; PROLINE IMINOPEPTIDASE; PROPYLAMINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG HALF LIFE; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; GLUCOSE TOLERANCE; IC 50; MALE; MOUSE; NONHUMAN; OBESITY; RAT; REACTION ANALYSIS; SINGLE DRUG DOSE; STRUCTURE ACTIVITY RELATION; TRANS ISOMER;

ANIMALS; ANTIGENS, CD26; CYCLOPROPANES; GLUCOSE TOLERANCE TEST; MAGNETIC RESONANCE SPECTROSCOPY; MICE; PROTEASE INHIBITORS; RATS; RATS, WISTAR; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP;

MUS; RATTUS;

EID: 62549138270     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.02.020     Document Type: Article

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