Novel 4H-1,3,4-oxadiazin-5(6H)-ones with hydrophobic and long alkyl chains: Design, synthesis, and bioactive diversity on inhibition of monoamine oxidase, chitin biosynthesis and tumor cell

European Journal of Medicinal Chemistry

Volumn 44, Issue 5, 2009, Pages 2113-2121

  Ke, Shao Yong ^a   Qian, Xu Hong ^a   Liu, Feng Yi ^b   Wang, Ni ^b   Yang, Qing ^b   Li, Zhong ^a  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b DALIAN UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

1,3,4 Oxadiazin 5(6H) ones; Bioactive diversity; Heterocycle

Indexed keywords

2 (2 CHLOROPHENYL) 4 (NONAN 5 YL) 4H 1,3,4 OXADIAZIN 5(6H) ONE; 2 (2 ETHOXYLPYRIDIN 3 YL) 4 (NONAN 5 YL) 4H 1,3,4 OXADIAZIN 5(6H) ONE; 2 (2,4 DICHLOROPHENYL) 4 (NONAN 5 YL) 4H 1,3,4 OXADIAZIN 5(6H) ONE; 2 (3 METHYLPHENYL) 4 (BUTOXYCARBONYLETHYL) 4H 1,3,4 OXADIAZIN 5(6H) ONE; 2 (3,4,5 TRIMETHYLPHENYL) 4 (NONAN 5 YL) 4H 1,3,4 OXADIAZIN 5(6H) ONE; 2 (3,5 DIMETHYLPHENYL) 4 (NONAN 5 YL) 4H 1,3,4 OXADIAZIN 5(6H) ONE; 2 (4 CHLOROPHENYL) 4 (NONAN 5 YL) 4H 1,3,4 OXADIAZIN 5(6H) ONE; 2 (4 ETHYLPHENYL) 4 (NONAN 5 YL) 4H 1,3,4 OXADIAZIN 5(6H) ONE; 2 (4 FLUOROPHENYL) 4 (CYANOETHYL) 4H 1,3,4 OXADIAZIN 5(6H) ONE; 2 (4E THYLPHENYL) 4 (CYANOETHYL) 4H 1,3,4 OXADIAZIN 5(6H) ONE; 2 (BENZO[D][1,3]DIOXOL 5 YL) 4 (NONAN 5 YL) 4H 1,3,4 OXADIAZIN 5(6H) ONE; 2 (NAPHTHALEN 2 YL) 4 (NONAN 5 YL) 4H 1,3,4 OXADIAZIN 5(6H) ONE; 2 PHENYL 4 (CYANOETHYL) 4H 1,3,4 OXADIAZIN 5(6H) ONE; AMINE OXIDASE (FLAVIN CONTAINING); ANTINEOPLASTIC AGENT; CHITIN; CHLORINE DERIVATIVE; HYDRAZINE DERIVATIVE; MONOAMINE OXIDASE INHIBITOR; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; BIOSYNTHESIS; CANCER CELL CULTURE; CONCENTRATION (PARAMETERS); CYCLIZATION; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HYDROPHOBICITY; LUNG CANCER; PROSTATE CANCER; TUMOR CELL;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CHITIN; DRUG DESIGN; HUMANS; HYDROPHOBICITY; LUNG NEOPLASMS; MALE; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; OXADIAZOLES; PROSTATIC NEOPLASMS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 62549129822     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.10.015     Document Type: Article

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