Intra-operative radiotherapy (IORT) in pancreatic cancer: Joint analysis of the ISIORT-Europe experience

Radiotherapy and Oncology

Volumn 91, Issue 1, 2009, Pages 54-59

  Valentini, Vincenzo ^a   Calvo, Felipe ^b   Reni, Michele ^c   Krempien, Robert ^d   Sedlmayer, Felix ^e   Buchler, Markus W ^d   Carlo, Valerio Di ^f   Doglietto, Giovanni B ^a   Fastner, Gerd ^e   Garcia Sabrido, José L ^b   Mattiucci, GianCarlo ^a   Morganti, Alessio G ^a   Passoni, Paolo ^c   Roeder, Falk ^d   D'Agostino, Giuseppe R ^a  

^a CATHOLIC UNIVERSITY   (Italy)

^b HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^c Hospitale San Raffaele   (Italy)

^d UNIVERSITY OF HEIDELBERG   (Germany)

^e Institut für Allgemein Familien und Präventivmedizin   (Austria)

^f SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

IORT; Joint analysis; Pancreatic cancer

Indexed keywords

ADULT; AGED; ARTICLE; CANCER DIAGNOSIS; CANCER SURGERY; CANCER SURVIVAL; DISTANT METASTASIS; EXTERNAL BEAM RADIOTHERAPY; FOLLOW UP; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; INTRAOPERATIVE RADIOTHERAPY; MAJOR CLINICAL STUDY; OVERALL SURVIVAL; PANCREAS CANCER; POSTOPERATIVE CARE; PRIORITY JOURNAL; TREATMENT DURATION;

ADENOCARCINOMA; COMBINED MODALITY THERAPY; EUROPE; FEMALE; FOLLOW-UP STUDIES; HUMANS; INTRAOPERATIVE PERIOD; MALE; PANCREATIC NEOPLASMS; PROPORTIONAL HAZARDS MODELS; RADIOTHERAPY DOSAGE; SURVIVAL RATE; TREATMENT OUTCOME;

EID: 62549121270     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.radonc.2008.07.020     Document Type: Article

References (37)

1. Jemal A., Siegel R., Ward E., et al. Cancer statistics, 2007. CA Cancer J Clin 57 (2007) 43-66
2. Brennan M.F. Adjuvant therapy following resection for pancreatic adenocarcinoma. Surg Oncol Clin N Am 13 (2004) 555-561
3. Sohn T.A., Yeo C.J., Cameron J.L., et al. Resected adenocarcinoma of the pancreas - 616 patients: results, outcomes, and prognostic indicators. J Gastrointest Surg 4 (2000) 567-579
4. Kinsella T.J., and Sindelar W.F. Intraoperative radiotherapy for pancreatic carcinoma. Experimental and clinical studies. Cancer 78 (1996) 598-604
5. Oken M.M., Creech R.H., Tormey D.C., et al. Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol 5 (1982) 649-655
6. Radiation Therapy Oncology Group. Cooperative Group common toxicity criteria v 2.0 1999. Available from: www.rtog.org/members/toxicity/tox.html.
7. Kaplan F.L., and Meier P. Non parametric estimation from incomplete observations. Am J Stat Assoc 53 (1958) 457-481
8. Peto R., and Peto J. Asymptomatically efficient rank invariant procedures. J R Stat Soc 135 (1972) 185-207
9. Cox D.R. Regression model and life tables. J R Stat Soc 34 (1972) 187-220
10. Alexakis N., Halloran C., Rarati M., et al. Current standards of surgery for pancreatic cancer. Br J Cancer 91 (2004) 1410-1427
11. Russo S., Butler B., Ove R., and Blackstock A.W. Locally advanced pancreatic cancer: a review. Semin Oncol 34 (2007) 327-333
12. Sindelar W.F., Kinsella T.J., Tepper J., et al. Experimental and clinical studies with intraoperative radiotherapy. Surg Gynecol Obstet 157 (1983) 205-219
13. Sindelar W.F., Hoekstra H., Restrepo C., and Kinsella T.J. Pathological tissue changes following intraoperative radiotherapy. Am J Clin Oncol 9 (1986) 504-509
14. Kinsella T.J., Sindelar W.F., DeLuca A.M., et al. Tolerance of the canine bladder to intraoperative radiation therapy: An experimental study. Int J Radiat Oncol Biol Phys 14 (1988) 939-946
15. Kinsella T.J., DeLuca A.M., Barnes M., et al. Threshold dose for peripheral neuropathy following intraoperative radiotherapy (IORT) in a large animal model. Int J Radiat Oncol Biol Phys 20 (1991) 697-701
16. Sindelar W.F., Tepper J., and Travis E.L. Tolerance of bile duct to intraoperative irradiation. Surgery 92 (1982) 533-540
17. Sindelar W.F., Tepper J.E., Kinsella T.J., et al. Late effects of intraoperative radiation therapy on retroperitoneal tissues, intestine, and bile duct in a large animal model. Int J Radiat Oncol Biol Phys 29 (1994) 781-788
18. Sindelar W.F., Johnstone P.A., Hoekstra H., et al. Normal tissue tolerance to IORT: the NCI experimental studies. In: Gunderson L.L., Willett C.G., Harrison L.B., et al. (Eds). Intraoperative irradiation: techniques and results (1999), Humana Press, Totowa, NJ 131-146
19. Sindelar W.F., and Kinsella T.J. Studies of intraoperative radiotherapy in carcinoma of the pancreas. Ann Oncol 10 Suppl 4 (1999) 226-230
20. Gillette EL, Gillette SM, Vujaskovic Z, et al. Influence of volume on canine ureters and peripheral nerves irradiated intraoperatively. In: Schildberg FW, Willich N, Kramling H., editors. Intraoperative radiation therapy: proceedings of the 4th international IORT symposium. Munich, Germany: Verlag, DieBlaue Eule; 1993. p. 61-3.
21. Gillette E.L., Gillette S.M., and Powers B.E. Studies at Colorado State University of normal tissue tolerance of beagles to IORT, EBRT or a combination. In: Gunderson L.L., Willett C.G., Harrison L.B., et al. (Eds). Intraoperative irradiation: techniques and results (1999), Humana Press, Totowa (NJ) 147-164
22. Manabe T., Baba N., Ono K., et al. Radical pancreatectomy with intraoperative radiation therapy for pancreatic head cancer. In: Abe M., and Takahashi M. (Eds). Intraoperative radiation therapy. Proc. of the 3rd international symposium on intraoperative radiation therapy (1991), Pergamon Press, New York 249-250
23. Evans D.B., Termuhlen P.M., Byrd D.J., et al. Intraoperative radiation therapy following pancreaticoduodenectomy. Ann Surg 218 (1993) 54-60
24. Zerbi A., Fossati V., and Parolini D. Intraoperative radiation therapy adjuvant to resection in the treatment of pancreatic cancer. Cancer 73 (1994) 2930-2935
25. Termuhlen P.M., Evans D.B., and Willet C.G. IORT in pancreatic carcinoma. In: Gunderson L.L., Willett C.G., Harrison L.B., and Calvo F.A. (Eds). Intraoperative irradiation (1999), Humana Press, Totowa 201-223
26. Valentini V., Morganti A.G., Macchia G., et al. Intraoperative radiation therapy in resected pancreatic carcinoma: long-term analysis. Int J Radiat Oncol Biol Phys 70 (2008) 1094-1099
27. Calvo FA, Meirino RM, de la Mata MD, et al. Intraoperative radiotherapy. In: Halperin EC, editors. Principles and practice of radiation oncology, 5th ed. Philadelphia: Wilkins; 2008. p. 397-406.
28. Stephens J., Kuhn J., O'Brien J., et al. Surgical morbidity, mortality, and long-term survival in patients with peripancreatic cancer following pancreaticoduodenectomy. Am J Surg 174 (1997) 600-603
29. Abrams RA and Choo J. Pancreatic cancer. In: Churchill Livingstone, editors. Clinical radiation oncology; 2007. p. 1076-77.
30. Pisters P.W., Abbruzzese J.L., Janjan N.A., et al. Rapid-fractionation preoperative chemoradiation, pancreaticoduodenectomy, and intraoperative radiation therapy for resectable pancreatic adenocarcinoma. J Clin Oncol 16 (1998) 3843-3850
31. Huguet F., André T., Hammel P., et al. Impact of chemoradiotherapy after disease control with chemotherapy in locally advanced pancreatic adenocarcinoma in GERCOR phase II and III studies. J Clin Oncol 25 (2007) 326-331
32. Spitz F.R., Abbruzzese J.L., Lee J.E., et al. Preoperative and postoperative chemoradiation strategies in patients treated with pancreaticoduodenectomy for adenocarcinoma of the pancreas. J Clin Oncol 15 (1997) 928-937
33. Hoffman J.P., Lipsitz S., Pisansky T., et al. A Phase II study of preoperative gemcitabine with radiation therapy and chemotherapy for patients with localized, resectable adenocarcinoma of the pancreas. J Clin Oncol 16 (1998) 317-323
34. Lawrence T.S., Chang E.Y., Hahn T.M., Hertel L.W., and Shewach D.S. Radiosensitization of pancreatic cancer cells by 2′,2′-difluoro-2′-deoxycytidine. Int J Radiat Oncol Biol Phys 34 (1996) 867-872
35. Moore A.M., Cardenes H., Johnson C.S., et al. A phase II study of gemcitabine in combination with radiation therapy in patients with localized, unresectable, pancreatic cancer: a Hoosier Oncology Group trial. J Clin Oncol 22 (2004) 4105
36. Safran H., King T.P., Choy H., et al. Paclitaxel and concurrent radiation for locally advanced pancreatic and gastric cancer. A phase I study. J Clin Oncol 15 (1997) 901-907
37. Boz G., De Paoli A., Roncandin M., et al. Radiation therapy combined with chemotherapy for inoperable pancreatic carcinoma. Tumori 77 (1991) 61-64