Differentiation of human osteosarcoma cells by isolated phlorotannins is subtly linked to COX-2, iNOS, MMPs, and MAPK signaling: Implication for chronic articular disease

Chemico-Biological Interactions

Volumn 179, Issue 2-3, 2009, Pages 192-201

  Ryu, BoMi ^a   Li, Yong ^a,b   Qian, Zhong Ji ^a   Kim, Moon Moo ^c   Kim, Se Kwon ^a  

^a Pukyong National University   (South Korea)

^b Academy of Traditional Chinese Medicine and Materia Medica of Jilin Province   (China)

^c Dong Eui University   (South Korea)

Author keywords

Alkaline phosphatase (ALP) activity; Chronic articular diseases; Differentiation; Ecklonia cava; Matrix metalloproteinase 1,3,13; Phlorotannins

Indexed keywords

1 (3',5' DIHYDROXYPHENOXY) 7 (2'',4'',6'' TRIHYDROXYPHENOXY) 2,4,9 TRIHYDROXYDIBENZO 1,4 DIOXIN; ALKALINE PHOSPHATASE; CASEIN; COLLAGENASE 3; CYCLOOXYGENASE 2; DIECKOL; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERSTITIAL COLLAGENASE; MATRIX METALLOPROTEINASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN; STRESS ACTIVATED PROTEIN KINASE; STROMELYSIN; TANNIN DERIVATIVE; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTHRITIS; ARTHROPATHY; ARTICLE; BIOLOGICAL ACTIVITY; BROWN ALGA; CELL DIFFERENTIATION; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DRUG EFFECT; DRUG ISOLATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FETUS; HUMAN; HUMAN CELL; MINERALIZATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OSTEOSARCOMA CELL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ZYMOGRAPHY;

ALKALINE PHOSPHATASE; ARTHRITIS, RHEUMATOID; BENZOFURANS; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CYCLOOXYGENASE 2; DIOXANES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MATRIX METALLOPROTEINASES; MITOGEN-ACTIVATED PROTEIN KINASES; NITRIC OXIDE SYNTHASE TYPE II; OSTEOSARCOMA; PHAEOPHYTA; PHLOROGLUCINOL; PLANT EXTRACTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

ECKLONIA CAVA; LAMINARIACEAE; PHAEOPHYCEAE;

EID: 62549116528     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2009.01.006     Document Type: Article

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