Lactate as a metabolic signal of gene expression;Laktat als metabolisches signal der genexpression

Deutsche Zeitschrift fur Sportmedizin

Volumn 59, Issue 12, 2008, Pages 280-286

  Brooks, G A ^a   Brooks, T G ^a   Brooks, S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Energy source; Gluconeogenic precursor; Lactate shuttle; Mitochondrial biogenesis; Monocarboxylate transport protein (MCT); Physical exercise; Reactive oxygen species (ROS); Signaling molecule

Indexed keywords

EID: 62549093942     PISSN: 03445925     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

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2. Bergman BC, Wolfel EE, Butterfield GE, Lopaschuk G, Casazza GA, Horning MA, Brooks GA: Active muscle and whole body lactate kinetics after endurance training in men. J Appl Physiol 87 (1999) 1684-1696.
3. Brooks GA: Lactate shuttles in nature. Biochem Soc Trans. 30 (2002) 258-264.
4. Brooks GA, Brown MA, Butz CE, Sicurello JP, Dubouchaud H: Cardiac and skeletal muscle mitochondria have a monocarboxylate transporter MCT1. J Appl Physiol 87 (1999) 1713-1718.
5. Brooks GA, Butterfield GE, Wolfe RR, Groves BM, Mazzeo RS, Sutton JR, Wolfel EE, Reeves JT: Increased dependence on blood glucose after acclimatization to 4,300m. J Appl Physiol 70 (1991) 919-927.
6. Brooks GA, Butterfield GE, Wolfe RR, Groves BM, Mazzeo RS, Sutton JR, Wolfel EE, Reeves JT: Decreased reliance on lactate during exercise after acclimatization to 4,300m. J Appl Physiol 71(1991) 333-341.
7. Brooks GA, Dubouchaud H, Brown M, Sicurello JP, Butz CE: Role of mitochondrial lactate dehydrogenase and lactate oxidation in the 'intra-cellular lactate shuttle'. Proc Natl Acad Sci USA 96:1129-1134, 1999.
8. Brooks GA und Gladden LB: METABOLIC SYSTEMS: Non-oxidative (Glycolytic and Phosphagen), in: Tipton CM (Hrsg.): EXERCISE PHYSIOLOGY: PEOPLE AND IDEAS. American Physiological Society, 2003, 322-360.
9. Brooks GA, Wolfel EE, Butterfield GE, Cymerman A, Roberts AC, Mazzeo RS, Reeves JT: Poor relationship between arterial [Laktat] and leg net release during steady-rate exercise at 4,300 m altitude. Am J Physiol 275 (1998) 1192-1201.
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24. Miller BF, Fattor JA, Jacobs KA, Horning MA, Suh SH, Navazio F, Brooks GA: Metabolic and cardiorespiratory responses to an exogenous Laktat infusion during rest and exercise: "The Lactate Clamp" Am J Physiol Endocrinol Metab 283 (2002) 889-898.
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