Poor relationship between arterial [lactate] and leg net release during exercise at 4,300 m altitude

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 275, Issue 4 44-4, 1998, Pages

  Brooks, George A ^a   Wolfel, Eugene E ^b   Butterfield, Gail E ^b   Cymerman, Allen ^b   Roberts, Amy C ^b   Mazzeo, Robert S ^b   Reeves, John T ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NONE

Author keywords

Acclimatization; Adaptation; Blockade; Environment; Epinephrine; Exertion; Hypoxia; Norepinephrine

Indexed keywords

ADRENALIN; BETA ADRENERGIC RECEPTOR BLOCKING AGENT;

ADRENERGIC SYSTEM; ALTITUDE ACCLIMATIZATION; ARTICLE; BETA ADRENERGIC RECEPTOR BLOCKING; CONTROLLED STUDY; ERGOMETRY; EXERCISE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; HYPOXEMIA; LACTATE BLOOD LEVEL; LEG BLOOD FLOW; MALE; MUSCLE METABOLISM; NORMAL HUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; THERMODILUTION;

EID: 0031768125     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1998.275.4.r1192     Document Type: Article

References (33)

1. Ahlborg. G. Mechanism of glycogenolysis in nonexercising human muscle during and after exercise. Am. J. Physiol. 248 (Endocrinol. Metab. 11): E540-E545, 1985.
2. Bang, O. The lactate content of the blood during and after muscular exercise in man. Skand. Arch. Physiol. 74, Suppl. 10: 49-82, 1936.
3. Brooks, G. A. Current concepts in lactate exchange. Med. Sci. Sports Exerc. 23: 895-906, 1991.
4. Brooks, G. A. Iron deficiency and physical performance: experimental studies. In: Iron Nutrition in Health and Disease, edited by Leif Hallberg and Nils-Georg Asp. London: Libbey, 1996, p. 183-194.
5. Brooks, G. A., G. E. Butterfield, R. R. Wolfe, B. M. Groves, R. S. Mazzeo, J. R. Sutton, E. E. Wolfel, and J. T. Reeves. Decreased reliance on lactate during exercise after acclimatization to 4,300 m. J. Appl. Physiol. 71: 333-341, 1991.
6. Brooks, G. A., E. E. Wolfel, B. M. Groves, P. R. Bender, G. E. Butterfield, A. Cymerman, R. S. Mazzeo, J. R. Sutton, R. R. Wolfe, and J. T. Reeves. Muscle accounts for glucose disposal but not blood lactate appearance during exercise after acclimatization to 4,300 m. J. Appl. Physiol. 72: 2435-2445, 1992.
7. Butterfield, G. E., J. Gates, S. Fleming, G. A. Brooks, J. R. Sutton, and J. T. Reeves. Increased energy intake minimizes weight loss in men at high altitude. J. Appl. Physiol. 72: 1741-1748, 1992.
8. 2. J. Appl. Physiol. 68: 833-842, 1990.
9. Desplanches, D., H. Hoppeler, L. Tuscher, M. H. Mayet, H. Spielvogel, G. Ferretti, B. Kayser, B. Leuenberger, A. Grunenfelder, and R. Favier. Muscle tissue adaptations of high-altitude natives to training in chronic hypoxia or acute normoxia. J. Appl. Physiol. 81: 1946-1951, 1996.
10. Edwards, H. T. Lactic acid at rest and work at high altitudes. Am. J. Physiol. 116: 367-375, 1936.
11. Faintrenie, G., and A. Géloën. Alpha-1 adrenergic regulation of lactate production in white adipocytes. J. Pharmacol. Exp. Ther. 277: 235-238, 1995.
12. Gertz, E. W., J. A. Wisneski, R. Neese, J. A. Bristow, G. L. Searle, and J. T. Hanlon. Myocardial lactate metabolism: evidence of lactate release during net chemical extraction in man. Circulation 63: 1273-1279, 1981.
13. Gladden, L. B. Net lactate uptake during progressive steady-level contractions in canine skeletal muscle. J. Appl. Physiol. 71: 514-520, 1991.
14. Green, H. J., J. R. Sutton, E. E. Wolfel, J. T. Reeves, G. E. Butterfield, and G. A. Brooks. Altitude acclimatization and energy metabolic adaptations in skeletal muscle during exercise. J. Appl. Physiol. 73: 2701-2708, 1992.
15. Hochachka, P. W. The lactate paradox: analysis of underlying mechanisms. Ann. Sports Med. 4: 184-188, 1989.
16. Juhlin-Dannfelt, A., and H. Åström. Influence of β-adrenoceptor blockade on leg blood flow and lactate release in man. Scand. J. Clin. Lab. Invest. 39: 179-183, 1979.
17. Kayser, B. Lactate during exercise at high altitude. Eur. J. Appl. Physiol. 74: 195-205, 1996.
18. Kiens, B., B. Essen-Gustavson, N. J. Christensen, and B. Saltin. Skeletal muscle substrate utilization during submaximal exercise in man: effects of endurance training. J. Physiol. (Lond.) 469: 459-478, 1993.
19. Maher, J. T., L. G. Jones, and L. H. Hartley. Effects of high-altitude exposure on submaximal endurance capacity of men. J. Appl. Physiol. 37: 895-898, 1974.
20. Mazzeo, R. S., G. A. Brooks, G. E. Butterfield, A. Cymerman, A. C. Roberts, M. Selland, E. E. Wolfel, and J. T. Reeves. β-Adrenergic blockade does not prevent the lactate response to exercise after acclimatization to high altitude. J. Appl. Physiol. 76: 610-615, 1994.
21. Mazzeo, R. S., G. A. Brooks, G. E. Butterfield, D. A. Podolin, E. E. Wolfel, and J. T. Reeves. Acclimatization to high altitude increases muscle sympathetic activity both at rest and during exercise. Am. J. Physiol. 269 (Regulatory Integrative Comp. Physiol. 38): R201-R207, 1995.
22. Poole, R. C., and A. P. Halestrap. Transport of lactate and other monocarboxylates across mammalian plasma membranes. Am. J. Physiol. 264 (Cell Physiol. 33): C761-C782, 1993.
23. Reeves, J. T., E. E. Wolfel, H. J. Green, R. S. Mazzeo, A. J. Young, J. R. Sutton, and G. A. Brooks. Oxygen transport during exercise at high altitude and the lactate paradox: lessons from Operation Everest II and Pikes Peak. In: Exercise and Sport Sciences Reviews. Baltimore, MD: Williams and Wilkins, 1992, vol. 20, p. 275-296.
24. Richter, E. A., B. Kienes, B. Saltin, N. J. Christensen, and G. Savard. Skeletal muscle glucose uptake during dynamic exercise in humans: role of muscle mass. Am. J. Physiol. 254 (Endocrinol. Metab. 17): E555-E561, 1988.
25. Roberts, A. C., G. E. Butterfield, A. Cymerman, J. T. Reeves, E. E. Wolfel, and G. A. Brooks. Acclimatization to 4,300 m altitude decreases reliance on fat as a substrate. J. Appl. Physiol. 81: 1762-1771, 1996.
26. Roberts, A. C., G. E. Butterfield, J. T. Reeves, A. Cymerman, E. E. Wolfel, and G. A. Brooks. Altitude and β-blockade augment glucose utilization during submaximal exercise. J. Appl. Physiol. 80: 606-615, 1996.
27. 2 uptake and lactate metabolism. J. Appl. Physiol. 62: 1845-1851, 1987.
28. Stainsby, W. N., and H. G. Welch. Lactate metabolism of contracting dog skeletal muscle in situ. Am. J. Physiol. 211: 177-183, 1966.
29. Stanley, W. C., E. W. Gertz, J. A. Wisneski, D. L. Morris, R. Neese, and G. A. Brooks. Lactate metabolism in exercising human skeletal muscle: evidence for lactate extraction during net lactate release. J. Appl. Physiol. 60: 1116-1120, 1986.
30. Wahren, J., P. Felig, G. Ahlborg, and L. Jorfeldt. Glucose metabolism during leg exercise in man. J. Clin. Invest. 50: 2715-2725, 1971.
31. Wasserman, D. H., P. E. Williams, D. B. Lacy, R. E. Goldstein, and A. D. Cherrington. Exercise-induced fall in insulin and hepatic carbohydrate metabolism during muscular work. Am. J. Physiol. 256 (Endocrinol. Metab. 19): E500-E509, 1989.
32. Wolfel, E. E., B. M. Groves, G. A. Brooks, G. E. Butterfield, R. S. Mazzeo, L. G. Moore, J. R. Sutton, P. R. Bender, T. E. Dahms, R. E. McCullough, R. G. McCullough, S.-Y. Huang, S.-F. Sun, R. F. Grover, H. N. Hultgren, and J. T. Reeves. Oxygen transport during steady-state submaximal exercise in chronic hypoxia. J. Appl. Physiol. 70: 1129-1136, 1991.
33. 2 uptake during exercise with β-adrenergic blockade at 4,300 m. J. Appl. Physiol. 85: 1092-1102, 1998.