The Mia/Cd-rap gene expression is downregulated by the high-mobility group A proteins in mouse pituitary adenomas

Endocrine-Related Cancer

Volumn 14, Issue 3, 2007, Pages 875-886

  De Martino, Ivana ^a   Visone, Rosa ^a   Palmieri, Dario ^a   Cappabianca, Paolo ^a   Chieffi, Paolo ^a   Forzati, Floriana ^a   Barbieri, Antonio ^b   Kruhoffer, Mogens ^c   Lombardi, Gaetano ^a   Fusco, Alfredo ^a,d   Fedele, Monica ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b NATIONAL CANCER INSTITUTE   (Italy)

^c AARHUS UNIVERSITY HOSPITAL   (Denmark)

^d CEINGE BIOTECNOLOGIE AVANZATE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

HIGH MOBILITY GROUP A2 PROTEIN; OLIGONUCLEOTIDE;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ASSAY; CELL GROWTH; CELL PROLIFERATION; COMPARATIVE STUDY; CONTROLLED STUDY; DNA MICROARRAY; DOWN REGULATION; GENE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; GENE REPRESSION; GENETIC TRANSCRIPTION; HYPOPHYSIS; HYPOPHYSIS ADENOMA; HYPOPHYSIS CELL; MIA CD RAP GENE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROMOTER REGION; PROTEIN DNA BINDING; TUMOR SUPPRESSOR GENE; UNINDEXED SEQUENCE;

ADENOMA; ANIMALS; CELL PROLIFERATION; CLUSTER ANALYSIS; DOWN-REGULATION; EXTRACELLULAR MATRIX PROTEINS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HMGA PROTEINS; MICE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PITUITARY NEOPLASMS; PROMOTER REGIONS (GENETICS); RATS; TUMOR CELLS, CULTURED;

EID: 35948935118     PISSN: 13510088     EISSN: None     Source Type: Journal    
DOI: 10.1677/ERC-07-0036     Document Type: Article

References (31)

1. Ashar HR, Schoenberg Fejzo M, Tkachenko A, Zhou X, Fletcher JA, Weremowicz S, Morton CC & Chada K 1995 Disruption of the architectural factor HMCI-C: DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains. Cell 82 57-65.
2. Baldassarre G, Fedele M, Battista S, Vecchione A, Klein-Szanto AJ, Santoro M, Waldmann TA, Azimi N, Croce CM & Fusco A 2001 Onset of natural killer cell lymphomas in transgenic mice carrying a truncated HMGI-C gene by the chronic stimulation of the IL-2 and IL-15 pathway. PNAS 98 7970-7975.
3. Battista S, Martelli ML, Fedele M, Chiappetta G, Trapasso F, De Vita G, Battaglia C, Santoro M, Viglietto G, Fagin JA et al. 1995 A mutated p53 gene alters thyroid cell differentiation. Oncogene 11 2029-2037.
4. Berlingieri MT, Pierantoni GM, Giancotti V, Santoro M & Fusco A 2002 Thyroid cell transformation requires the expression of the HMGA1 proteins. Oncogene 21 2971-2980.
5. Blesch A, Bosserhoff AK, Apfel R, Behl C, Hessdoerfer B, Schmitt A, Jachimczak P, Lottspeich F, Buettner R & Bogdahn U 1994 Cloning of a novel malignant melanoma-derived growth-regulatory protein, MIA. Cancer Research 54 5695-5701.
6. Bosserhoff AK, Kondo S, Moser M, Dietz UH, Copeland NG, Gilbert DJ, Jenkins NA, Buettner R & Sandell LJ 1997 Mouse CD-RAP/MIA gene: structure, chromosomal localization, and expression in cartilage and chondrosarcoma. Developmental Dynamics 208 516-525.
7. Chansky H, Robbins JR, Cha S, Raskind WH, Conrad EU & Sandell LJ 1998 Expression of cartilage extracellular matrix and potential regulatory genes in a new human chondrosarcoma cell line. Journal of Orthopaedic Research 5 521-530.
8. Dietz UH & Sandell LJ 1996 Cloning of a retinoic acid-sensitive mRNA expressed in cartilage and during chondrogenesis. Journal of Biolgical Chemistry 271 3311-3316.
9. Eisen MB, Spellman PT, Brown PO & Botstein D 1998 Cluster analysis and display of genome-wide expression patterns. PNAS 95 14863-14868.
10. Fedele M, Berlingieri MT, Scala S, Chiariotti L, Viglietto G, Rippel V, Bullerdiek J, Santoro M & Fusco A 1998 Truncated and chimeric HMGI-C genes induce neoplastic transformation of NIH3T3 murine fibroblasts. Oncogene 17 413-418.
11. Fedele M, Battista S, Kenyon L, Baldassarre G, Fidanza V, Klein-Szanto AJ, Parlow AF, Visone R, Pierantoni GM, Outwater E et al. 2002 Overexpression of the HMGA2 gene in transgenic mice leads to the onset of pituitary adenomas. Oncogene 21 3190-3198.
12. Fedele M, Pentimalli F, Baldassarre G, Battista S, Klein-Szanto AJ, Kenyon L, Visone R, De Martino I, Ciarmiello A, Arra C et al. 2005 Transgenic mice overexpressing the wild-type form of the HMGA1 gene develop mixed growth hormone/prolactin cell pituitary adenomas and natural killer cell lymphomas. Oncogene 24 3427-3435.
13. Fedele M, Fidanza V, Battista S, Pentimalli F, Klein-Szanto AJ, Visone R, De Martino I, Curcio A, Morisco C, Del Vecchio L et al. 2006a Haploinsufficiency of the HMGA1 gene causes cardiac hypertrophy and myelo-lymphoproliferafive disorders in mice. Cancer Research 66 2536-2543.
14. Fedele M, Visone R, De Martino I, Troncone G, Palmieri D, Battista S, Ciarmiello A, Pallante P, Arra C, Melillo RM et al. 2006b HMGA2 induces pituitary tumorigenesis by enhancing E2F1 activity. Cancer Cell 6 459-471.
15. Fedele M, Pierantoni GM, Visone R & Fusco A 2006c Critical role of the HMGA2 gene in pituitary adenomas. Cell Cycle 5 2045-2048.
16. Finelli P, Pierantoni GM, Giardino D, Losa M, Rodeschini O, Fedele M, Valtorta E, Mortini P, Croce CM, Larizza L et al. 2002 The high mobility group A2 gene is amplified and overexpressed in human prolactinomas. Cancer Research 62 2398-2405.
17. Foti D, Chiefari E, Fedele M, Iuliano R, Brunetti L, Paonessa F, Manfioletti G, Barbetti F, Brunetti A, Croce CM et al. 2005 Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice. Nature Medicine 7 765-773.
18. Golob M, Buettner R & Bosserhoff AK 2000 Characterization of a transcription factor binding site, specifically activating MIA transcription in melanoma. Journal of Investigative Dermatology 115 42-47.
19. Johnson KR, Lehn DA & Reeves R 1989 Alternative processing of mRNA's coding for human HMG I and HMG Y proteins. Molecular Cell Biology 9 2114-2123.
20. Manfioletti G, Giancotti V, Bandiera A, Buratti E, Sautiewre P, Cary P, Crane-Robinson C, Coles B & Goodwin GH 1991 cDNA cloning of the HMGI-c phosphoprotein, a nuclear protein associated with neoplastic and undifferentiated phenotypes. Nucleic Acids Research 19 6793-6797.
21. Martinez Hoyos J, Fedele M, Battista S, Pentimalli F, Kruhoffer M, Arra C, Orntoft TF, Croce CM & Fusco A 2004 Identification of the genes up- and down-regulated by the high mobility group A1 (HMGA1) proteins: tissue specificity of the HMGA1-dependent gene regulation. Cancer Research 64 5728-5735.
22. Melillo RM, Pierantoni GM, Scala S, Battista S, Fedele M, Stella A, De Biasio MC, Chiappetta G, Fidanza V, Condorelli G et al. 2001 Critical role of the HMGI(Y) proteins in adipocytic cell growth and differentiation. Molecular Cell Biology 21 2485-2495.
23. Monaco C, Visconti R, Barone MV, Pierantoni GM, Berlingieri MT, De Lorenzo C, Mineo A, Vecchio G, Fusco A & Santoro M 2001 The RFG oligomerization domain mediates kinase activation and re-localization of the RET/PTC3 oncoprotein to the plasma membrane. Oncogene 20 599-608.
24. Poser I, Golob M, Buettner R & Bosserhoff AK 2003 Upregulation of HMG1 leads to melanoma inhibitory activity expression in malignant melanoma cells and contributes to their malignancy phenotype. Molecular Cell Biology 23 2991-2998.
25. Reeves R 2001 Molecular biology of HMGA proteins: hubs of nuclear function. Gene 277 63-81.
26. Riss D, Jin L, Qian X, Bayliss J, Scheithauer BW, Young WF Jr, Vidal S, Kovacs K, Raz A & Lloyd RV 2003 Differential expression of galectin-3 in pituitary tumors. Cancer Research 63 2251-2255.
27. Scala S, Portella G, Fedele M, Chiappetta G & Fusco A 2000 Adenovirus-mediated suppression of HMGI(Y) protein synthesis as potential therapy of human malignant neoplasias. PNAS 97 4256-4261.
28. Schoenmakers EF, Wanschura S, Mols R, Bullerdiek J, Van den Berghe H & Van de Ven WJ 1995 Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumours. Nature Genetics 4 436-444.
29. Thanos D & Maniatis T 1995 Virus induction of human IFN β gene expression requires the assembly of an enhanceosome. Cell 83 1091-1100.
30. Wood LJ, Maher JF, Bunton TE & Resar LM 2000 The oncogenic properties of the HMG-I gene family. Cancer Research 60 4256-4261.
31. Zhou X, Benson KF, Ashar HR & Chada K 1995 Mutation responsible for the mouse pygmy phenotype in the developmentally regulated factors HMGI-C. Nature 37 771-7747.