Preoperative Platelet inhibition with ASA does not influence postoperative blood loss following coronary artery bypass grafting

Thoracic and Cardiovascular Surgeon

Volumn 57, Issue 1, 2009, Pages 18-21

  Gulbins, H ^a   Malkoc, A ^b   Ennker, I C ^b   Ennker, J ^b  

^a UNIVERSITY HEART CENTER HAMBURG   (Germany)

^b Department of Cardiac Surgery   (Germany)

Author keywords

Asa; Aspirin; Cardiovascular surgery; Coronary bypass surgery; Platelet inhibition

Indexed keywords

ACETYLSALICYLIC ACID; ANTITHROMBOCYTIC AGENT;

ADULT; AGED; ARTICLE; BLOOD TRANSFUSION; CLINICAL EVALUATION; COMPARATIVE STUDY; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; DISEASE ASSOCIATION; DRUG WITHDRAWAL; EMERGENCY PATIENT; GROUPS BY AGE; HEART INFARCTION; HEART TAMPONADE; HEMOFILTRATION; HUMAN; INTENSIVE CARE UNIT; LENGTH OF STAY; MAJOR CLINICAL STUDY; MORTALITY; OPERATION DURATION; OUTCOME ASSESSMENT; PERIOPERATIVE PERIOD; POSTOPERATIVE COMPLICATION; POSTOPERATIVE HEMORRHAGE; PREOPERATIVE PERIOD; PRIORITY JOURNAL; REOPERATION; RETROSPECTIVE STUDY; RISK FACTOR; SCORING SYSTEM; SEX RATIO; STROKE; THERAPY DELAY; THROMBOCYTE AGGREGATION INHIBITION; DRUG ADMINISTRATION; FEMALE; MALE; MIDDLE AGED; OFF PUMP CORONARY SURGERY; PRACTICE GUIDELINE; PREOPERATIVE CARE; RISK ASSESSMENT; TIME; TREATMENT OUTCOME;

AGED; ASPIRIN; CORONARY ARTERY BYPASS; CORONARY ARTERY BYPASS, OFF-PUMP; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; MALE; MIDDLE AGED; PLATELET AGGREGATION INHIBITORS; POSTOPERATIVE HEMORRHAGE; PRACTICE GUIDELINES AS TOPIC; PREOPERATIVE CARE; REOPERATION; RETROSPECTIVE STUDIES; RISK ASSESSMENT; TIME FACTORS; TREATMENT OUTCOME;

EID: 62449238109     PISSN: 01716425     EISSN: 14391902     Source Type: Journal    
DOI: 10.1055/s-2008-1038791     Document Type: Article

References (18)

1. Tran H, Anand SS. Oral antiplatelet therapy in cerebrovascular disease, coronary artery disease, and peripheral arterial disease. JAMA 2004;292:1867-1874
2. Maree AO, Fitzgerald DJ. Aspirin and coronary artery disease. Thromb Haemost 2004;92:1175-1181
3. Zambahari R, Kwok OH, Javier S, Mak KH, Piyamitr S, Tri Ho HQ, Hwang JJ, Suryawan R, Chow WH. Clinical use of clopidogrel in acute coronary syndrome. Int J Clin Pract 2007;61:473-481
4. Dieker HJ, French JK, Joziasse IC, Brouwer MA, Elliott J, West TM, Webber BJ, Verheugt FW, White HD. Antiplatelet therapy and progression of coronary artery disease: a placebo-controlled trial with angiographic and clinical follow-up after myocardial infarction. Am Heart J 2007;153(66) : e1-e8
5. Moulton MJ, Creswell LL, Mackey ME, Cox JL, Rosenbloom M. Reexploration for bleeding is a risk factor for adverse outcomes after cardiac operations. J Thorac Cardiovasc Surg 1996;111:1037-1046
6. Karthik S, Grayson AD, McCarron EE, Pullan DM, Desmond MJ. Reexploration for bleeding after coronary artery bypass surgery: risk factors, outcomes, and the effect of time delay. Ann Thorac Surg 2004;78:527-534
7. Rawitscher RE, Jones JW, McCoy TA, Lindsley DA. A prospective study of aspirin's effect on red blood cell loss in cardiac surgery. J Cardiovasc Surg (Torino) 1991;32:1-7
8. Dempsey CM, Lim MS, Stacey SG. A prospective audit of blood loss and blood transfusion in patients undergoing coronary artery bypass grafting after clopidogrel and aspirin therapy. Crit Care Resusc 2004;6:248-252
9. Reich DL, Patel GC, Vela-Cantos F, Bodian C, Lansman S. Aspirin does not increase homologous blood requirements in elective coronary bypass surgery. Anesth Analg 1994;79:4-8
10. Shim JK, Choi YS, Oh YJ, Bang SO, Yoo KJ, Kwak YL. Effects of preoperative aspirin and clopidogrel therapy on perioperative blood loss and blood transfusion requirements in patients undergoing off-pump coronary artery bypass graft surgery. J Thorac Cardiovasc Surg 2007;134:59-64
11. Cannon CP, Mehta SR, Aranki SF. Balancing the benefit and risk of oral antiplatelet agents in coronary artery bypass surgery. Ann Thorac Surg 2005;80:768-779
12. Von Heymann C, Redlich U, Moritz M, Sander M, Vargas Hein O, Grubitzsch H, Konertz WF, Spies C. Aspirin and clopidogrel taken until 2 days prior to coronary artery bypass graft surgery is associated with increased postoperative drainage loss. Thorac Cardiovasc Surg 2005;53:341-345
13. Ascione R, Gosh A, Rogers CA, Cohen A, Monk C, Angelini GD. In-hospital patients exposed to clopidogrel before coronary artery bypass graft surgery: a word of caution. Ann Thorac Surg 2005;79:1210-1216
14. Picker SM, Kaleta T, Hekmat K, Kampe S, Gathof BS. Antiplatelet therapy preceding coronary artery surgery: implications for bleeding, transfusion requirements and outcome. Eur J Anaesthesiol 2007;24:332-339
15. Morawski W, Sanak M, Ciscowski M, Szczeklik M, Szczeklik W, Dropinski J, Waclawczyk T, Ilczok R, Bochenek A. Prediction of the excessive perioperative bleeding in patients undergoing coronary artery bypass grafting: role of aspirin and platelet glycoprotein III a polymorphism. J Thorac Cardiovasc Surg 2005;130:791-796
16. Liu G, McNicol PL, Macall P, Bellomo R, Przybylowski G, Bowkett J, Connellan J, McInnes F, Thurlow PJ. The effect of preoperative aspirin and/or heparin therapy on coagulation and postoperative blood loss after coronary artery bypass surgery. Crit Care Resusc 1999;1:139
17. Alghamdi AA, Moussa F, Fremes SE. Does the use of preoperative aspirin increase the risk of bleeding in patients undergoing coronary artery bypass grafting surgery? Systematic review and meta-analysis. J Card Surg 2007;22:247-256
18. Ouattara A, Bouzguenda H, Le Manach Y, Leger P, Mercadier A, Leprince P, Bonnet N, Montalescot G, Riou B, Coriat P. Impact of aspirin with or without clopidogrel on postoperative bleeding and blood transfusion in coronary surgical patients treated prophylactically with a low-dose of aprotinin. Eur Heart J 2007;28:1025-1032