Balancing the benefit and risk of oral antiplatelet agents in coronary artery bypass surgery

Annals of Thoracic Surgery

Volumn 80, Issue 2, 2005, Pages 768-779

  Cannon, Christopher P ^a   Mehta, Shamir R ^b   Aranki, Sary F ^b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ANTITHROMBOCYTIC AGENT; APROTININ; CLOPIDOGREL; TICLOPIDINE; TRANEXAMIC ACID;

CAUSE OF DEATH; CLINICAL TRIAL; CORONARY ARTERY BYPASS SURGERY; CORONARY ARTERY DISEASE; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; DRUG MEGADOSE; GRAFT OCCLUSION; HEART INFARCTION; HEART MUSCLE ISCHEMIA; HOSPITAL COST; HUMAN; MORTALITY; POSTOPERATIVE HEMORRHAGE; PRIORITY JOURNAL; REVIEW; STROKE; TREATMENT OUTCOME;

ADMINISTRATION, ORAL; ASPIRIN; CARDIOVASCULAR DISEASES; CLINICAL TRIALS; CORONARY ARTERY BYPASS; GRAFT OCCLUSION, VASCULAR; HUMANS; PLATELET AGGREGATION INHIBITORS; POSTOPERATIVE HEMORRHAGE; RISK ASSESSMENT; TICLOPIDINE;

EID: 22544461360     PISSN: 00034975     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.athoracsur.2004.09.058     Document Type: Review

References (85)

1. D.T. Mangano Cardiovascular morbidity and CABG surgery - a perspective epidemiology, costs, and potential therapeutic solutions J Card Surg 10 Suppl 1995 366 368
2. R. Ascione, C.T. Lloyd, M.J. Underwood, A.A. Lotto, A.A. Pitsis, G.D. Angelini Inflammatory response after coronary revascularization with or without cardiopulmonary bypass Ann Thorac Surg 69 2000 1198 1204
3. L.H. Edmunds Inflammatory response to cardiopulmonary bypass Ann Thorac Surg 66 Suppl 1998 S12 S16
4. A. Herskowitz, D.T. Mangano Inflammatory cascade a final common pathway for perioperative injury? Anesthesiology 85 1996 957 960
5. J.G. Motwani, E.J. Topol Aortocoronary saphenous vein graft disease pathogenesis, predisposition and prevention Circulation 97 1998 916 931
6. G.W. Roach, M. Kanchuger, C.M. Mangano Adverse cerebral outcomes after coronary bypass surgery N Engl J Med 335 1996 1857 1863
7. M.A. Borger, J. Ivanov, R.D. Weisel, V. Rao, C.M. Peniston Stroke during coronary bypass surgery principal role of cerebral macroemboli Eur J Cardiothorac Surg 19 2001 627 632
8. Antithrombotic Trialists' Collaboration Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high-risk patients Br Med J 324 2002 71 86
9. D.T. Mangano Multicenter Study of Perioperative Ischemia Research Group Aspirin and mortality from coronary bypass surgery N Engl J Med 347 2002 1309 1317
10. J.H. Chesebro, V. Fuster, L.R. Elveback Effect of dipyridamole and aspirin on late vein-graft patency after coronary bypass operations N Engl J Med 310 1984 209 214
11. S. Goldman, J. Copeland, T. Moritz Improvement in early saphenous vein graft patency after coronary artery bypass graft surgery with antiplatelet therapy results of a Veterans Administration Cooperative Study Circulation 77 1988 1324 1332
12. T.P. Gavaghan, V. Gebski, D.W. Baron Immediate postoperative aspirin improves graft patency early and late after coronary artery bypass graft surgery Circulation 83 1991 1526 1533
13. D.P. Taggart, A. Siddiqui, D.J. Wheatley Low-dose preoperative aspirin therapy, postoperative blood loss, and transfusion requirements Ann Thorac Surg 50 1990 425 428
14. Eagle KA, Guyton RA, Davidoff R, et al. ACC/AHA 2004 guideline update for coronary artery bypass graft surgery: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (American College of Cardiology Web site). Available at: http://www.acc.org/ clinical/guidelines/cabg/cabg.pdf. Accessed on Nov. 22, 2004.
15. G. D'Ancona, H.W. Donias, R.L. Karamanoukian, J. Bergsland, H.L. Karamanoukian OPCAB therapy survey off-pump clopidogrel, aspirin or both survey Heart Surg Forum 4 2001 354 358
16. W.D. Johnson, K.L. Kayser, A.J. Hartz, S.F. Saedi Aspirin use and survival after coronary artery bypass surgery Am Heart J 123 1992 603 608
17. S. Goldman, J. Copeland, T. Moritz Saphenous vein graft patency one year after coronary artery bypass surgery and effects of antiplatelet therapy results of a Veterans Administration Cooperative Study Circulation 80 1989 1190 1197
18. B.G. Brown, R.A. Cukingnan, T. deRouen Improved graft patency in patients treated with platelet-inhibiting therapy after coronary bypass surgery Circulation 72 1985 138 146
19. Antiplatelet Trialists' Collaboration Collaborative overview of randomized trials of antiplatelet therapy. II: Maintenance of vascular graft or arterial patency by antiplatelet therapy Br Med J 308 1994 159 168
20. P.D. Stein, J.E. Dalen, S. Goldman, P. Theroux Antithrombotic therapy in patients with saphenous vein and internal mammary artery bypass grafts Chest 119 2001 278S 282S
21. M. Klein, P.R. Keith, H.P. Dauben Aprotinin counterbalances an increased risk of peri-operative hemorrhage in CABG patients pre-treated with aspirin Eur J Cardiothorac Surg 14 1998 360 366
22. L.J. Dacey, J.J. Munoz, E.R. Johnson Effect of preoperative aspirin use on mortality in coronary artery bypass grafting patients Ann Thorac Surg 70 2000 1986 1990
23. F.H. Edwards, R.E. Clark, M. Schwartz Coronary artery bypass grafting the Society of Thoracic Surgeons National Database experience Ann Thorac Surg 57 1994 12 19
24. M. Chevigne, J.L. David, P. Rigo, R. Limet Effect of ticlopidine on saphenous vein bypass patency rates a double-blind study Ann Thorac Surg 37 1984 371 378
25. R. Limet, J.L. David, P. Margotteaux, M.P. Larock, P. Rigo Prevention of aorta-coronary bypass graft occlusion. Beneficial effect of ticlopidine on early and late patency rates of venous coronary bypass grafts: a double-blind study J Thorac Cardiovasc Surg 94 1987 773 783
26. C. Müller, H.J. Büttner, J. Petersen, H. Roskamm A randomized comparison of clopidogrel and aspirin versus ticlopidine and aspirin after the placement of coronary-artery stents Circulation 101 2000 590 593
27. C.P. Juergens, A.M. Wong, D.Y. Leung A randomized comparison of clopidogrel and aspirin versus ticlopidine and aspirin after coronary stent implantation Am Heart J 147 2004 E15
28. K.A.A. Fox, S.R. Mehta, R. Peters Benefits and risks of the combination of clopidogrel and aspirin in patients undergoing surgical revascularization for non-ST-elevation acute coronary syndrome. The clopidogrel in unstable angina to prevent recurrent ischemic events (CURE) trial Circulation 110 2004 1202 1208
29. CAPRIE Steering Committee A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE) Lancet 348 1996 1329 1339
30. D.L. Bhatt, D.P. Chew, A.T. Hirsch, P.A. Ringleb, W. Hacke, E. Topol Superiority of clopidogrel versus aspirin in patients with prior cardiac surgery Circulation 103 2001 363 368
31. Clopidogrel in Unstable Angina to Prevent Recurrent Events Trial Investigators Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation N Engl J Med 345 2001 494 502
32. S.R. Mehta, S. Yusuf, R.J.G. Peters Effects of pre-treatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention the PCI-CURE study Lancet 358 2001 527 533
33. S.R. Steinhubl, P.B. Berger, J.T. Mann Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention. A randomized controlled trial JAMA 288 2002 2411 2420
34. E. Braunwald, E.M. Antman, J.W. Beasley ACC/AHA 2002 guideline update for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction - summary article a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on the Management of Patients with Unstable Angina) Circulation 106 2002 1893 1900
35. T.R. Love, W.G. Hendren, D.D. O'Keefe, W.M. Daggett Transfusion of predonated autologous blood in elective cardiac surgery Ann Thorac Surg 43 1987 508 512
36. S. Belisle, J.F. Hardy Hemorrhage and the use of blood products after adult cardiac operations myths and realities Ann Thorac Surg 62 1996 1908 1917
37. R.C. Woodman, L.A. Harker Bleeding complications associated with cardiopulmonary bypass Blood 76 1990 1680 1697
38. T.B. Ferguson, L.H. Muhlbaier, D.L. Salai, A.S. Wechsler Coronary bypass grafting after failed elective and failed emergent percutaneous angioplasty J Thorac Cardiovasc Surg 95 1988 761 772
39. J.H. Chesebro, G. Knatterud, R. Roberts Thrombolysis in myocardial infarction (TIMI) trial, phase I: a comparison between intravenous tissue plasminogen activator and intravenous streptokinase: clinical findings through hospital discharge Circulation 76 1987 142 154
40. The PURSUIT Trial Investigators Inhibition of platelet glycoprotein IIb/IIIa with eptifibatide in unstable angina and non-Q-wave myocardial infarction N Engl J Med 339 1998 436 443
41. J.J. Munoz, N.J. Birkmeyer, L.J. Dacey Trends in rates of re-exploration for hemorrhage after coronary artery bypass surgery Ann Thorac Surg 68 1999 1321 1325
42. S. Yende, R.G. Wunderink Effect of clopidogrel on bleeding after coronary artery bypass surgery Crit Care Med 29 2001 2271 2275
43. L.T. Goodnough, W. Soersiarso, J.D. Birlmeier, H.G. Welsh The economic impact of inappropriate blood transfusion in coronary artery bypass graft surgery Am J Med 94 1993 509 514
44. L.J. Dacey, J.J. Munoz, Y.R. Baribeau Reexploration for hemorrhage following coronary artery bypass grafting incidence and risk factors Arch Surg 133 1998 442 447
45. A. Weerasinghe, K.M. Taylor The platelet in cardiopulmonary bypass Ann Thorac Surg 66 1998 2145 2152
46. S.F. Khuri, J.A. Wolfe, M. Josa Hematologic changes during and after cardiopulmonary bypass and their relationship to the bleeding time and nonsurgical blood loss J Thorac Cardiovasc Surg 104 1992 94 107
47. A.S. Kestin, C.R. Valeri, S.F. Khuri The platelet function defect of cardiopulmonary bypass Blood 82 1993 107 117
48. D.S. Morse, D.H. Adams, B. Magnani Platelet and neutrophil activation during cardiac surgical procedures impact of cardiopulmonary bypass Ann Thorac Surg 65 1998 691 695
49. P. Gluszko, B. Rucinski, J. Musial Fibrinogen receptors in platelet adhesion to surfaces of extracorporeal circuits Am J Physiol 252 1987 H615 H621
50. N. Kieffer, J. Guichard, J. Breton-Gorius Dynamic redistribution of major platelet surface receptors after contact-induced platelet activation and spreading Am J Pathol 140 1992 57 73
51. T.F. Slaughter, T.H. LeBleu, J.M. Douglas Characterization of prothrombin activation during cardiac surgery by hemostatic molecular markers Anesthesiology 80 1994 520 526
52. B. Blauhut, W. Harringer, P. Bettelheim Comparison of the effects of aprotinin and tranexamic acid on blood loss and related variables after cardiopulmonary bypass J Thorac Cardiovasc Surg 108 1994 1083 1091
53. P. Zilla, R. Fasol, P. Groscurth, N. Klepetko, H. Reichenspurner, E. Wolner Blood platelets in cardiopulmonary bypass operations recovery occurs after initial stimulation, rather than continual activation J Thorac Cardiovasc Surg 97 1989 379 388
54. G.J. Despotis, K.S. Filos, T.N. Zoys, C.W. Hogue, E. Spitznagel, D.G. Lappas Factors associated with excessive postoperative blood loss and hemostatic transfusion requirements a multivariate analysis in cardiac surgical patients Anesth Analg 82 1996 13 21
55. B. Liu, A. Belboul, S. Larsson, D. Roberts Factors influencing haemostasis and blood transfusion in cardiac surgery Perfusion 11 1996 131 143
56. M. Torosian, E.L. Michelson, J. Morganroth, H. MacVaugh Aspirin- and coumadin-related bleeding after coronary artery bypass graft surgery Ann Intern Med 89 1978 325 328
57. E.L. Michelson, J. Morganroth, M. Torosian, H. MacVaugh Relation of preoperative use of aspirin to increased mediastinal blood loss after coronary artery bypass graft surgery J Thorac Cardiovasc Surg 76 1978 694 697
58. V.A. Ferraris, S.P. Ferraris, F.C. Lough, W.R. Berry Preoperative aspirin ingestion increases operative blood loss after coronary artery bypass grafting Ann Thorac Surg 45 1988 71 74
59. G.K. Sethi, J.G. Copeland, S. Goldman, T. Moritz, K. Zadina, W.G. Henderson Implications of preoperative administration of aspirin in patients undergoing coronary artery bypass grafting. Department of Veteran's Affairs Cooperative Study on Antiplatelet Therapy J Am Coll Cardiol 15 1990 15 20
60. G. Bashein, M.L. Nessly, A.L. Rice, R.B. Counts, G.A. Misbach Preoperative aspirin therapy and reoperation for bleeding after coronary artery bypass surgery Arch Intern Med 151 1991 89 93
61. P. Kallis, J.A. Tooze, S. Talbot, D. Cowans, D.H. Bevan, T. Treasure Pre-operative aspirin decreases platelet aggregation and increases post-operative blood loss - a prospective, randomised, placebo-controlled, double-blind clinical trial in 100 patients with chronic stable angina Eur J Cardiothorac Surg 8 1994 404 409
62. D.L. Reich, G.C. Patel, F. Vela-Cantos, C. Bodian, C. Lansman Aspirin does not increase homologous blood requirements in elective coronary bypass surgery Anesth Analg 79 1994 4 8
63. V.A. Ferraris, S.P. Ferraris, O. Joseph, P. Wehner, R.M. Mentzer Aspirin and postoperative bleeding after coronary artery bypass grafting Ann Surg 235 2002 820 827
64. K.J. Tuman, R.J. McCarthy, C.J. O'Connor, W.E. McCarthy, A.D. Ivankovich Aspirin does not increase allogenic blood transfusion in reoperative coronary artery surgery Anesth Analg 83 1996 1178 1184
65. A. Vuylsteke, A. Oduro, E. Cardan, R.D. Latimer Effect of aspirin in coronary artery bypass grafting J Cardiothorac Vasc Surg 11 1997 831 834
66. R.H. Hongo, J. Ley, S.E. Dick, R.R. Yee The effect of clopidogrel in combination with aspirin when given before coronary artery bypass grafting J Am Coll Cardiol 40 2002 231 237
67. D.C. Peters, S. Noble Aprotinin. An update of its pharmacology and therapeutic use in open heart surgery and coronary artery bypass surgery Drugs 57 1999 233 260
68. W.M. Weightman, N.M. Gibbs, C.R. Weidmann The effect of preoperative aspirin-free interval on red blood cell transfusion requirements in cardiac surgical patients J Cardiothorac Vasc Anesth 16 2002 54 58
69. M. Genoni, R. Tavakoli, C. Hofer, O. Bertel, M. Turina Clopidogrel before urgent coronary artery bypass J Thorac Cardiovasc Surg 126 2003 288 289
70. J.G. Ray, S. Deniz, A. Olivieri Increased blood product use among coronary artery bypass patients prescribed preoperative aspirin and clopidogrel BMC Cardiovasc Disord 3 2003 3
71. P.A. Carpino, R.M. Bojar, K.R. Khabbaz, H. Rastegar, K.G. Warner Clopidogrel therapy prior to coronary artery bypass surgery does not increase bleeding complications or use of blood products (Abstract S120) Crit Care Med 29 Suppl 2001 314
72. H. Karabulut, F. Toraman, S. Evrenkaya, O. Goksel, S. Tarcan, C. Alhan Clopidogrel does not increase bleeding and allogeneic blood transfusion in coronary artery surgery Eur J Cardiothor Surg 25 2004 419 423
73. R.J.G. Peters, S.R. Mehta, K.A.A. Fox Effects of aspirin dose when used alone or in combination with clopidogrel in patients with acute coronary syndromes. Observations from the clopidogrel in unstable angina to prevent recurrent events (CURE) study Circulation 108 2003 1682 1687
74. Dutch TIA Trial Study Group A comparison of two doses of aspirin (30 mg vs. 283 mg per day) in patients after a transient ischemic attack or minor ischemic stroke N Engl J Med 325 1991 1261 1266
75. E.J. Topol, D. Easton, R.A. Harrington Randomized, double-blind, placebo-controlled, international trial of the oral IIb/IIIa antagonist lotrafiban in coronary and cerebrovascular disease Circulation 108 2003 399 406
76. M.S. Sabatine, C.P. Cannon, C.M. Gibson, J.L. Lopez-Sendon, G. Montalescot, P. Theroux, M.J. Claeys, F. Cools, K.A. Hill, A.M. Skene, C.H. McCabe, E. Braunwald for the CLARITY-TIMI 28 Investigators Addition of clopidogrel to aspirin and fibrinolytic therapy for myocardial infarction with ST-segment elevation N Engl J Med 352 2005 1248 1250
77. J.N. George, S.J. Shattil Clinical importance of acquired abnormalities of platelet function N Engl J Med 324 1991 27 39
78. A.A. Weber, M. Braun, T. Hohlfeld, B. Schwippert, D. Tschope, K. Schror Recovery of platelet function after discontinuation of clopidogrel treatment in healthy volunteers Br J Clin Pharmacol 52 2001 333 336
79. N.M. Gibbs, W.M. Weightman, N.M. Thackray The effects of recent aspirin ingestion on platelet function in cardiac surgical patients J Cardiothorac Vasc Anesth 15 2001 55 59
80. B.P. Bidstrup, B.J. Hunt, S. Sheikh, R.N. Parratt, J.M. Bidstrup, R.N. Sapsford Amelioration of the bleeding tendency of preoperative aspirin after aortocoronary bypass grafting Ann Thorac Surg 69 2000 541 547
81. J.M. Alvarez, L.R. Jackson, C. Chatwin, J.J. Smolich Low-dose postoperative aprotinin reduces mediastinal drainage and blood product use in patients undergoing primary coronary artery bypass grafting who are taking aspirin a prospective, randomized, double-blind, placebo-controlled trial J Thorac Cardiovasc Surg 122 2001 457 463
82. J.H. Levy Platelet inhibitors and bleeding in cardiac surgical patients Ann Thorac Surg 70 2000 S9 S11
83. J.H. Lemmer Clinical experience in coronary bypass surgery for abciximab-treated patients Ann Thorac Surg 70 2000 S33 S37
84. E. Akowuah, V. Shrivastava, G. Cooper Coronary artery bypass graft surgery in patients with recent exposure to clopidogrel and aspirin therapy J Am Coll Cardiol 41 2003 1421 1422
85. M. Poullis, R. Manning, M. Laffan, D.O. Haskard, K.M. Taylor, R.C. Landis The antithrombotic effect of aprotinin actions mediated via the protease-activated receptor 1 J Thorac Cardiovasc Surg 120 2000 370 378