Discordant architectural and cytological features in cutaneous sebaceous neoplasms-a classification dilemma: Report of 5 cases

American Journal of Dermatopathology

Volumn 31, Issue 1, 2009, Pages 31-36

  Kazakov, Dmitry V ^a   Kutzner, Heinz ^b   Spagnolo, Dominic V ^c   Rütten, Arno ^b   Mukensnabl, Petr ^a   Michal, Michal ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

^b Dermatopathologische Gemeinschaftspraxis   (Germany)

^c PATHWEST LABORATORY MEDICINE   (Australia)

Author keywords

Carcinoid pattern; Cutaneous adnexal tumors; DNA mismatch repair genes; MLH1; Muir Torre syndrome; Rippled pattern; Sebaceoma; Sebaceous carcinoma; Tumor infiltrating lymphocytes

Indexed keywords

PROTEIN MLH1;

ADULT; AGED; ANAMNESIS; ARTICLE; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; MALE; MISMATCH REPAIR; MUIR TORRE SYNDROME; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEBACEOUS CARCINOMA; SKIN TUMOR; CASE REPORT; CLASSIFICATION; IMMUNOHISTOCHEMISTRY; METABOLISM; MIDDLE AGED; PATHOLOGY; SEBACEOUS GLAND TUMOR;

AGED; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; SEBACEOUS GLAND NEOPLASMS;

EID: 62349114678     PISSN: 01931091     EISSN: None     Source Type: Journal    
DOI: 10.1097/DAD.0b013e31818520bf     Document Type: Article

References (20)

1. LeBoit PE, Burg G, Weedon D, et al. World Health Organization Classification of Tumours. Pathology and Genetics of Skin Tumours. Lyon, France: IARC Press; 2006.
2. Steffen C, Ackerman AB. Neoplasms with Sebaceous Differentiation. Philadelphia, PA: Lea & Febiger; 1994.
3. Ackerman A, Reddy VB, Soyer HP. Neoplasms with Follicular Differentiation. 2nd ed. New York, USA: Ardor Scribendi Publishers; 2001.
4. Requena L, Kiryu H, Ackerman AB. Neoplasms with Apocrine Differentiation. Philadelphia, NY: Lippincott-Raven; 1998.
5. Kazakov DV, Michal M. Trichoepithelioma with giant and multinucleated neoplastic epithelial cells. Am J Dermatopathol. 2006;28:63-64.
6. Kazakov DV, Bisceglia M, Spagnolo DV, et al. Apocrine mixed tumors of the skin with architectural and/or cytologic atypia: a retrospective clinico-pathologic study of 18 cases. Am J Surg Pathol. 2007;31:1094-1102.
7. DiLeonardo M, Ackerman AB. Sebaceous carcinoma revisited. Dermatopathol Pract Conceptual. 1998;4:214-215.
8. Nussen S, Ackerman AB. Sebaceous "adenoma" is sebaceous carcinoma. Dermatopathol Pract Conceptual. 1998;4:5-14.
9. Misago N, Narisawa Y. Sebaceous neoplasms in Muir-Torre syndrome. Am J Dermatopathol. 2000;22:155-161.
10. Kazakov DV, Kutzner H, Rutten A, et al. Carcinoid-like pattern in sebaceous neoplasms: another distinctive, previously unrecognized pattern in extraocular sebaceous carcinoma and sebaceoma. Am J Dermatopathol. 2005;27:195-203.
11. Rutten A, Burgdorf W, Hugel H, et al. Cystic sebaceous tumors as marker lesions for the Muir-Torre syndrome: a histopathologic and molecular genetic study. Am J Dermatopathol. 1999;21:405-413.
12. Abbott JJ, Hernandez-Rios P, Amirkhan RH, et al. Cystic sebaceous neoplasms in Muir-Torre syndrome. Arch Pathol Lab Med. 2003;127: 614-617.
13. Ackerman AB, Lee SN. Neoplasms in all organs of Muir-Torre syndrome are carcinomas: sebaceous carcinomas and squamous-cell carcinomas (keratoacanthomas) in skin and adenocarcinomas, squamous-cell carcinomas, and transitional-cell carcinomas in internal organs. Dermatopathol Pract Conceptual. 1999;5:312-318.
14. Cesinaro AM, Ubiali A, Sighinolfi P, et al. Mismatch repair proteins expression and microsatellite instability in skin lesions with sebaceous differentiation: a study in different clinical subgroups with and without extracutaneous cancer. Am J Dermatopathol. 2007;29:351-358.
15. Popnikolov NK, Gatalica Z, Colome-Grimmer MI, et al. Loss of mismatch repair proteins in sebaceous gland tumors. J Cutan Pathol. 2003;30: 178-184.
16. Singh RS, Grayson W, Redston M, et al. Site and tumor type predicts DNA mismatch repair status in cutaneous sebaceous neoplasia. Am J Surg Pathol. 2008;32:936-942.
17. Baker K, Zlobec I, Tornillo L, et al. Differential significance of tumour infiltrating lymphocytes in sporadic mismatch repair deficient versus proficient colorectal cancers: a potential role for dysregulation of the transforming growth factor-beta pathway. Eur J Cancer. 2007;43: 624-631.
18. Halvarsson B, Anderson H, Domanska K, et al. Clinicopathologic factors identify sporadic mismatch repair-defective colon cancers. Am J Clin Pathol. 2008;129:238-244.
19. Jenkins MA, Hayashi S, O'Shea AM, et al. Pathology features in Bethesda guidelines predict colorectal cancer microsatellite instability: a population-based study. Gastroenterology. 2007;133:48-56.
20. Orla L, Klimstra DS, Mecca P, et al. Intra-and peri-tumoral lymphocytic response is associated with loss of DNA mismatch repair (MMR) protein in sebaceous neoplasms (SNs). Mod Pathol. 2008;21(Suppl 1): 99A.