Vascular endothelial cell-derived endothelin-1 mediates vascular inflammation and neointima formation following blood flow cessation

Cardiovascular Research

Volumn 82, Issue 1, 2009, Pages 143-151

  Anggrahini, Dyah W ^a   Emoto, Noriaki ^a,c   Nakayama, Kazuhiko ^a   Widyantoro, Bambang ^a   Adiarto, Suko ^a   Iwasa, Naoko ^a   Nonaka, Hidemi ^a   Rikitake, Yoshiyuki ^b   Kisanuki, Yaz Y ^d   Yanagisawa, Masashi ^e   Hirata, Ken Ichi ^a  

^a Division of Cardiovascular Medicine   (Japan)

^b KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c KOBE PHARMACEUTICAL UNIVERSITY   (Japan)

^d UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^e UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Atherosclerosis; Carotid ligation; Endothelin 1; Inflammation; Neointima formation

Indexed keywords

CD31 ANTIGEN; CELL ADHESION MOLECULE; ENDOTHELIN 1; ENDOTHELIN RECEPTOR ANTAGONIST; INTERCELLULAR ADHESION MOLECULE 1; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLOOD FLOW; BLOOD PRESSURE MEASUREMENT; BLOOD VESSEL INJURY; CAROTID ARTERY; CELL PROLIFERATION; CONTROLLED STUDY; ENDOTHELIUM CELL; HEMODYNAMICS; IMMUNOHISTOCHEMISTRY; INTIMA; ISCHEMIA; KNOCKOUT MOUSE; LEUKOCYTE MIGRATION; MALE; MORPHOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; REAL TIME POLYMERASE CHAIN REACTION; VASCULITIS; VASOCONSTRICTION;

ANIMALS; BLOOD PRESSURE; CAROTID ARTERIES; CAROTID ARTERY INJURIES; CELL ADHESION MOLECULES; CELL PROLIFERATION; CHEMOTAXIS, LEUKOCYTE; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; ENDOTHELIN-1; HEART RATE; HYPERPLASIA; INFLAMMATION; INTEGRASES; LIGATION; MACROPHAGES; MALE; MICE; MICE, KNOCKOUT; MUSCLE, SMOOTH, VASCULAR; RECEPTOR, TIE-2; RECEPTORS, ENDOTHELIN; REGIONAL BLOOD FLOW; TIME FACTORS; TUNICA INTIMA;

EID: 62349111262     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvp026     Document Type: Article

References (42)

1. Gibbons GH, Dzau VJ. The emerging concept of vascular remodeling. N Engl J Med 1994;330:1431-1438.
2. Kumar A, Hoover JL, Simmons CA, Lindner V, Shebuski RJ. Remodeling and neointimal formation in the carotid artery of normal and P-selectin deficient mice. Circulation 1997;96:4333-4342.
3. Walpola PL, Gotlieb AI, Cybulsky MI, Langille BL. Expression of ICAM-1 and VCAM-1 and monocyte adherence in arteries exposed to altered shear stress. Arterioscler Thromb Vasc Biol 1995;15:2-10.
4. Rao RM, Yang L, Garcia-Cardena G, Luscinskas FW. Endothelial-dependent mechanisms of leukocyte recruitment to the vascular wall. Circ Res 2007;101:234-247.
5. Libby P. Inflammation in atherosclerosis. Nature 2002;420:868-874.
6. Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y et al. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 1988;332:411-415.
7. Miyauchi T, Masaki T. Pathophysiology of endothelin in the cardiovascular system. Annu Rev Physiol 1999;61:391-415.
8. Kirchengast M, Munter K. Endothelin and restenosis. Cardiovasc Res 1998;39:550-555.
9. Rubanyi GM, Polokoff MA. Endothelins: molecular biology, biochemistry, pharmacology, physiology, and pathophysiology. Pharmacol Rev 1994;46:325-415.
10. Yang Z, Krasnici N, Luscher TF. Endothelin-1 potentiates human smooth muscle cell growth to PDGF. Effects of ETA and ETB receptor blockade. Circulation 1999;100:5-8.
11. Murohara T, Lefer AM. Autocrine effects of endothelin-1 on leukocyte-endothelial interaction: stimulation of endothelin B receptor subtype reduces endothelial adhesiveness via a nitric oxide-dependent mechanism. Blood 1996;88:3894-3900.
12. Ishizuka T, Takamizawa-Matsumoto M, Suzuki K, Kurita A. Endothelin-1 enhances vascular cell adhesion molecule-1 expression in tumor necrosis factor [alpha]-stimulated vascular endothelial cells. Eur J Pharmacol 1999;369:237-245.
13. Waters CE, Shi-Wen X, Denton CP, Abraham DJ, Pearson JD. Signaling pathways regulating intercellular adhesion molecule 1 expression by endothelin 1: comparison with interleukin-1beta in normal and scleroderma dermal fibroblasts. Arthritis Rheum 2006;54:649-660.
14. Hayasaki Y, Nakajima M, Kitano Y, Iwasaki T, Shimamura T, Iwaki K. ICAM-1 expression on cardiac myocytes and aortic endothelial cells via their specific endothelin receptor subtype. Biochem Biophys Res Commun 1996;229:817-824.
15. Barton M, Haudenschild CC, d'Luscio LV, Shaw S, Munter K, Luscher TF. Endothelin ET A receptor blockade restores NO-mediated endothelial function and inhibits atherosclerosis in apolipoprotein E-deficient mice. Proc Natl Acad Sci USA 1998;95:14367-14372.
16. McKenna CJ, Burke SE, Opgenorth TJ, Padley RJ, Camrud LJ, Camrud AR et al. Selective ETA receptor antagonism reduces neointimal hyperplasia in a porcine coronary stent model. Circulation 1998;97:2551-2556.
17. Pu Q, Neves MF, Virdis A, Touyz RM, Schiffrin EL. Endothelin antagonism on aldosterone-induced oxidative stress and vascular remodeling. Hypertension 2003;42:49-55.
18. Park JB, Schiffrin EL. ETA receptor antagonist prevents blood pressure elevation and vascular remodeling in aldosterone-infused rats. Hypertension 2001;37:1444-1449.
19. Takahashi M. The role of endothelin-1 in vascular remodeling in vivo. Cardiovasc Res 2006;71:4-5.
20. Zeiher AM, Goebel E, Schachinger O, Ihling C. Tissue endothelin-1 immunoreactivity in the active coronary atherosclerotic plaque. Circulation 1995;91:941-947.
21. Bacon CR, Cary NR, Davenport AP. Endothelin peptide and receptors in human atherosclerotic coronary artery and aorta. Circ Res 1996;79:794-801.
22. Dashwood MR, Noertersheuser P, Kirchengast M, Munter K. Altered endothelin-1 binding following balloon angioplasty of pig coronary arteries: effect of the ET receptor antagonist, LU 135252. Cardiovasc Res 1999;43:445-456.
23. Kurihara Y, Kurihara H, Suzuki H, Kodama T, Maemura K, Nagai R et al. Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1. Nature 1994;368:703-710.
24. Kumar A, Lindner V. Remodeling with neointima formation in the mouse carotid artery after cessation of blood flow. Arterioscler Thromb Vasc Biol 1997;17:2238-2244.
25. Kisanuki YY, Hammer RE, Miyazaki J, Williams SC, Richardson JA, Yanagisawa M. Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivo. Dev Biol 2001;230:230-242.
26. Chen J, Kuhlencordt PJ, Astern J, Gyurko R, Huang PL. Hypertension does not account for the accelerated atherosclerosis and development of aneurysms in male apolipoprotein E/endothelial nitric oxide synthase double knockout mice. Circulation 2001;104:2391-2394.
27. Stein O, Dabach Y, Ben-Naim M, Halperin G, Stein Y. Lower macrophage recruitment and atherosclerosis resistance in FVB mice. Atherosclerosis 2006;189:336-341.
28. Korshunov VA, Schwartz SM, Berk BC. Vascular remodeling: hemodynamic and biochemical mechanisms underlying Glagov's phenomenon. Arterioscler Thromb Vasc Biol 2007;27:1722-1728.
29. Bakker ENTP, Matlung HL, Bonta P, de Vries CJ, van Rooijen N, VanBavel E. Blood flow-dependent arterial remodelling is facilitated by inflammation but directed by vascular tone. Cardiovasc Res 2008;78:341-348.
30. Harison VJ, Ziegler T, Bouzourene K, Suciu A, Silacci P, Hayoz D. Endothelin-1 and endothelin-converting enzyme-1 gene regulation by shear stress and flow-induced pressure. J Cardiovasc Pharmacol 1998;31:S38-S41.
31. Callera GE, Montezano AC, Touyz RM, Zorn TMT, Carvalho MHC, Fortes ZB et al. ETA receptor mediates altered leukocyte-endothelial cell interaction and adhesion molecules expression in DOCA-Salt rats. Hypertension 2004;43:872-879.
32. Zouki C, Baron C, Fournier A, Filep JG. Endothelin-1 enhances neutrophil adhesion to human coronary artery endothelial cells: role of ETA receptors and platelet-activating factor. Br J Pharmacol 1999;127:969-979.
33. Muller DN, Mervaala EMA, Schmidt F, Park J-K, Dechend R, Genersch E et al. Effect of bosentan on NF-{kappa}B, inflammation, and tissue factor in angiotensin II-induced end-organ damage. Hypertension 2000;36:282-290.
34. Shah PK. Inflammation, neointimal hyperplasia, and restenosis: as the leukocytes roll, the arteries thicken. Circulation 2003;107:2175- 2177.
35. Chen S, Qiong Y, Gardner DG. A role of p38 mitogen-activated protein kinase and c-Myc in endothelin-dependent rat aortic smooth muscle cell proliferation. Hypertension 2006;47:1-7.
36. Hafizi S, Allen SP, Goodwin AT, Chester AH, Yacoub MH. Endothelin-1 stimulates proliferation of human coronary smooth muscle cells via the ETA receptor and is co-mitogenic with growth factors. Atherosclerosis 1999;146:351-359.
37. Sata M, Saiura A, Kunisato A, Tojo A, Seiji O, Takeshi Tet al. Hematopoietic stem cells differentiate into vascular cells that participate in the pathogenesis of atherosclerosis. Nat Med 2002;8:403-409.
38. Hu Y, Davison F, Ludewig B, Erdel M, Mayr M, Url M et al. Smooth muscle cells in transplant atherosclerotic lesions are originated from recipients, but not bone marrow progenitor cells. Circulation 2002;106:1834-1839.
39. Yamauchi J, Miyamoto Y, Kokubu H, Nishii H, Okamoto M, Sugawara Y et al. Endothelin suppresses cell migration via the JNK signaling pathway in a manner dependent upon Src kinase, Rac1, and Cdc42. FEBS Lett 2002;527:284-288.
40. Kohno M, Yokokawa K, Yasunari K, Kano H, Minami M, Yoshikawa J. Effect of the endothelin family of peptides on human coronary artery smoothmuscle cell migration. J Cardiovasc Pharmacol 1998;31:S84-S89.
41. Vanhoutte PM. Say NO to ET. J Auton Nerv Sys 2000;81:271- 277.
42. Kawashima S, Yamashita T, Ozaki M, Ohashi Y, Azumi H, Inoue N et al. Endothelial NO synthase overexpresion inhibits lesion formation in mouse model of vascular remodelling. Arterioscler Thromb Vasc Biol 2001;21:201-207.