Reduced IgG anti-small nuclear ribonucleoprotein autoantibody production in systemic lupus erythematosus patients with positive IgM anti-cytomegalovirus antibodies

Arthritis Research and Therapy

Volumn 11, Issue 1, 2008, Pages

  Sánchez, Claudia Azucena Palafox ^a   Satoh, Minoru ^b   Chan, Edward K L ^c   Carcamo, Wendy C ^c   Valle, José Francisco Muñoz ^a   Barocio, Gerardo Orozco ^d   Romero, Edith Oregon ^a   Hernández, Rosa Elena Navarro ^a   Páramo, Mario Salazar ^a   Castañeda, Antonio Cabral ^e   del Mercado, Mónica Vázquez ^a,f  

^a UNIVERSITY OF GUADALAJARA   (Mexico)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF FLORIDA   (United States)

^d HOSPITAL GENERAL DE OCCIDENTE   (Mexico)

^e INSTITUTO NACIONAL DE CIENCIAS MÉDICAS Y NUTRICIÓN SALVADOR ZUBIRÁN   (Mexico)

^f HOSPITAL CIVIL DE GUADALAJARA FRAY ANTONIO ALCALDE   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; AZATHIOPRINE; BETA2 GLYCOPROTEIN 1 ANTIBODY; CHLOROQUINE; CYCLOPHOSPHAMIDE; CYTOMEGALOVIRUS ANTIBODY; DOUBLE STRANDED DNA ANTIBODY; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M; IMMUNOGLOBULIN M ANTIBODY; METHOTREXATE; PREDNISONE; RHEUMATOID FACTOR; RO ANTIBODY; SMALL NUCLEAR RIBONUCLEOPROTEIN ANTIBODY; UNCLASSIFIED DRUG; VIRUS CAPSID ANTIGEN;

ADOLESCENT; ADULT; AGED; ANTIBODY PRODUCTION; ANTIGEN BINDING; ARTICLE; CONTROLLED STUDY; CYTOMEGALOVIRUS; DNA PROTEIN COMPLEX; EPSTEIN BARR VIRUS; FALSE POSITIVE RESULT; FEMALE; HUMAN; IMMUNOREGULATION; MAJOR CLINICAL STUDY; MALE; NONHUMAN; SYSTEMIC LUPUS ERYTHEMATOSUS;

EID: 62349104353     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar2621     Document Type: Article

References (56)

1. Reeves WH Narain S Satoh M Autoantibodies in systemic lupus erythematosus Arthritis and Allied Conditions A Textbook of Rheumatology Philadelphia: Lippincott Williams and Wilkins Koopman WJ, Moreland LW 15 2005:1497-1521.
2. Denman AM Systemic lupus erythematosus - is a viral aetiology a credible hypothesis? J Infect 2000, 40:229-233. 10908016
3. Barzilai O Ram M Shoenfeld Y Viral infection can induce the production of autoantibodies Curr Opin Rheumatol 2007, 19:636-643. 17917546
4. James JA Kaufman KM Farris AD Taylor-Albert E Lehman TJ Harley JB An increased prevalence of Epstein-Barr virus infection in young patients suggests a possible etiology for systemic lupus erythematosus J Clin Invest 1997, 100:3019-3026. 508514 9399948
5. Poole BD Scofield RH Harley JB James JA Epstein-Barr virus and molecular mimicry in systemic lupus erythematosus Autoimmunity 2006, 39:63-70. 16455583
6. Arbuckle MR Reichlin M Harley JB James JA Shared early autoantibody recognition events in the development of anti-Sm B/B' in human lupus Scand J Immunol 1999, 50:447-455. 10564545
7. James JA Gross T Scofield RH Harley JB Immunoglobulin epitope spreading and autoimmune disease after peptide immunization: Sm B/B'-derived PPPGMRPP and PPPGIRGP induce spliceosomme autoimmunity J Exp Med 1995, 181:453-461. 2191871 7530756
8. Poole BD Gross T Maier S Harley JB James JA Lupus-like autoantibody development in rabbits and mice after immunization with EBNA-1 fragments J Autoimmun 2008, 31:362-371. 18849143
9. St George K Rowe DT Rinaldo CR Jr Cytomegalovirus, varicella-zoster virus, and Epstein-Barr virus Clinical Virology Manual Washington, DC: ASM Press Spector S, Hodinka RL, Young SA 3 2000:410-449.
10. Britt W Manifestations of human cytomegalovirus infection: Proposed mechanisms of acute and chronic disease Curr Top Microbiol Immunol 2008, 325:417-470. 18637519
11. Newkirk MM van Venrooij WJ Marshall GS Autoimmune response to U1 small nuclear ribonucleoprotein (U1 snRNP) associated with cytomegalovirus infection Arthritis Res 2001, 3:253-258. 34115 11438044
12. Hrycek A Kusmierz D Mazurek U Wilczok T Human cytomegalovirus in patients with systemic lupus erythematosus Autoimmunity 2005, 38:487-491. 16373253
13. Hayashi T Lee S Ogasawara H Sekigawa I Iida N Tomino Y Hashimoto H Hirose S Exacerbation of systemic lupus erythematosus related to cytomegalovirus infection Lupus 1998, 7:561-564. 9863901
14. Curtis HA Singh T Newkirk MM Recombinant cytomegalovirus glycoprotein gB (UL55) induces an autoantibody response to the U1-70 kDa small nuclear ribonucleoprotein Eur J Immunol 1999, 29:3643-3653. 10556820
15. Lipes J Skamene E Newkirk MM The genotype of mice influences the autoimmune response to spliceosome proteins induced by cytomegalovirus gB immunization Clin Exp Immunol 2002, 129:19-26. 1906413 12100018
16. Marshall BC McPherson RA Greidinger E Hoffman R Adler SP Lack of autoantibody production associated with cytomegalovirus infection Arthritis Res 2002, 4:R6. 125300 12223109
17. Tan EM Cohen AS Fries JF Masi AT McShane DJ Rothfield NF Schaller JG Talal N Winchester RJ The 1982 revised criteria for the classification of systemic lupus erythematosus Arthritis Rheum 1982, 25:1271-1277. 7138600
18. Guzman J Cardiel MH Arce-Salinas A Sanchez-Guerrero J Alarcon-Segovia D Measurement of disease activity in systemic lupus erythematosus. Prospective validation of 3 clinical indices J Rheumatol 1992, 19:1551-1558. 1464867
19. Gladman DD Urowitz MB Goldsmith CH Fortin P Ginzler E Gordon C Hanly JG Isenberg DA Kalunian K Nived O Petri M Sanchez-Guerrero J Snaith M Sturfelt G The reliability of the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index in patients with systemic lupus erythematosus Arthritis Rheum 1997, 40:809-813. 9153540
20. Yamasaki Y Narain S Hernandez L Barker T Ikeda K Segal MS Richards HB Chan EK Reeves WH Satoh M Autoantibodies against the replication protein A complex in systemic lupus erythematosus and other autoimmune diseases Arthritis Res Ther 2006, 8:R111-R120. 1779422 16846524
21. Satoh M Langdon JJ Hamilton KJ Richards HB Panka D Eisenberg RA Reeves WH Distinctive immune response patterns of human and murine autoimmune sera to U1 small nuclear ribonucleoprotein C protein J Clin Invest 1996, 97:2619-2626. 507349 8647956
22. Magsaam J Gharavi AE Parnassa AP Weissbach H Brot N Elkon KB Quantification of lupus anti-ribosome P antibodies using a recombinant P2 fusion protein and determination of the predicted amino acid sequence of the autoantigen in patients' mononuclear cells Clin Exp Immunol 1989, 76:165-171. 1541824 2758693
23. Guldner HH Netter HJ Szostecki C Lakomek HJ Will H Epitope mapping with a recombinant human 68-kDa (U1) ribonucleoprotein antigen reveals heterogeneous autoantibody profiles in human autoimmune sera J Immunol 1988, 141:469-475. 2454993
24. Okano Y Targoff IN Oddis CV Fujii T Kuwana M Tsuzaka K Hirakata M Mimori T Craft J Medsger JT Anti-U5 small nuclear ribonucleoprotein(snRNP) antibodies: A rare anti-U snRNP specificity Clin Immunol Immunopathol 1996, 81:41-47. 8808640
25. Cannavan FP Costallat LT Bertolo MB Rossi CL Costa SC False positive IgM antibody tests for human cytomegalovirus (HCMV) in patients with SLE Lupus 1998, 7:61-62. 9493154
26. Bendiksen S Van Ghelue M Rekvig OP Gutteberg T Haga HJ Moens U A longitudinal study of human cytomegalovirus serology and viruria fails to detect active viral infection in 20 systemic lupus erythematosus patients Lupus 2000, 9:120-126. 10787009
27. Su BY Su CY Yu SF Chen CJ Incidental discovery of high systemic lupus erythematosus disease activity associated with cytomegalovirus viral activity Med Microbiol Immunol 2007, 196:165-170. 17318574
28. Sekigawa I Nawata M Seta N Yamada M Iida N Hashimoto H Cytomegalovirus infection in patients with systemic lupus erythematosus Clin Exp Rheumatol 2002, 20:559-564. 12175116
29. Nawata M Seta N Yamada M Sekigawa I Lida N Hashimoto H Possible triggering effect of cytomegalovirus infection on systemic lupus erythematosus Scand J Rheumatol 2001, 30:360-362. 11846056
30. Stratta P Colla L Santi S Grill A Besso L Godio L Davico-Bonino L Mazzucco G Ghisetti V Barbui A Canavese C IgM antibodies against cytomegalovirus in SLE nephritis: Viral infection or aspecific autoantibody? J Nephrol 2002, 15:88-92. 11936434
31. Yoon KH Fong KY Tambyah PA Fatal cytomegalovirus infection in two patients with systemic lupus erythematosus undergoing intensive immunosuppressive therapy: Role for cytomegalovirus vigilance and prophylaxis? J Clin Rheumatol 2002, 8:217-222. 17041367
32. Rawlinson WD Broadsheet. Number 50: Diagnosis of human cytomegalovirus infection and disease Pathology 1999, 31:109-115. 10399165
33. Yoda Y Hanaoka R Ide H Isozaki T Matsunawa M Yajima N Shiozawa F Miwa Y Negishi M Kasama T Clinical evaluation of patients with inflammatory connective tissue diseases complicated by cytomegalovirus antigenemia Mod Rheumatol 2006, 16:137-142. 16767551
34. Stratta P Canavese C Ciccone G Santi S Quaglia M Ghisetti V Marchiaro G Barbui A Fop F Cavallo R Piccoli G Correlation between cytomegalovirus infection and Raynaud's phenomenon in lupus nephritis Nephron 1999, 82:145-154. 10364707
35. James JA Neas BR Moser KL Hall T Bruner GR Sestak AL Harley JB Systemic lupus erythematosus in adults is associated with previous Epstein-Barr virus exposure Arthritis Rheum 2001, 44:1122-1126. 11352244
36. Rider JR Ollier WE Lock RJ Brookes ST Pamphilon DH Human cytomegalovirus infection and systemic lupus erythematosus Clin Exp Rheumatol 1997, 15:405-409. 9272302
37. Hoffman RW Greidinger EL Mixed connective tissue disease Curr Opin Rheumatol 2000, 12:386-390. 10990174
38. Greidinger EL Hoffman RW The appearance of U1 RNP antibody specificities in sequential autoimmune human antisera follows a characteristic order that implicates the U1-70 kd and B'/B proteins as predominant U1 RNP immunogens Arthritis Rheum 2001, 44:368-375. 11229468
39. Schleiss MR Bernstein DI Passo M Parker S Meric C Verdier F Newkirk MM Lack of induction of autoantibody responses following immunization with cytomegalovirus (CMV) glycoprotein B (gB) in healthy CMV-seronegative subjects Vaccine 2004, 23:687-692. 15542191
40. Munuswamy-Ramanujam G Khan KA Lucas AR Viral anti-inflammatory reagents: the potential for treatment of arthritic and vasculitic disorders Endocr Metab Immune Disord Drug Targets 2006, 6:331-343. 17214579
41. Kelly KM Zhuang H Nacionales DC Scumpia PO Lyons R Akaogi J Lee P Williams B Yamamoto M Akira S Satoh M Reeves WH 'Endogenous adjuvant' activity of the RNA components of lupus autoantigens Sm/RNP and Ro 60 Arthritis Rheum 2006, 54:1557-1567. 16645989
42. Nacionales DC Kelly-Scumpia KM Lee PY Weinstein JS Lyons R Sobel E Satoh M Reeves WH Deficiency of the type I interferon receptor protects mice from experimental lupus Arthritis Rheum 2007, 56:3770-3783. 17968932
43. Lee PY Kumagai Y Li Y Takeuchi O Yoshida H Weinstein J Kellner ES Nacionales D Barker T Kelly-Scumpia K van Rooijen N Kumar H Kawai T Satoh M Akira S Reeves WH TLR7-dependent production of type-I interferon in murine lupus J Exp Med 2008, 205:2995-3006. 19047436
44. Marshall JD Heeke DS Gesner ML Livingston B Van Nest G Negative regulation of TLR9-mediated IFN-α induction by a small-molecule, synthetic TLR7 ligand J Leukoc Biol 2007, 82:497-508. 17565046
45. Berghofer B Haley G Frommer T Bein G Hackstein H Natural and synthetic TLR7 ligands inhibit CpG-A- and CpG-C-oligodeoxynucleotide-induced IFN-α production J Immunol 2007, 178:4072-4079. 17371961
46. Basta S Bennink JR A survival game of hide and seek: Cytomegaloviruses and MHC class I antigen presentation pathways Viral Immunol 2003, 16:231-242. 14583141
47. Mocarski ES Jr Immune escape and exploitation strategies of cytomegaloviruses: Impact on and imitation of the major histocompatibility system Cell Microbiol 2004, 6:707-717. 15236638
48. Soderberg-Naucler C Human cytomegalovirus persists in its host and attacks and avoids elimination by the immune system Crit Rev Immunol 2006, 26:231-264. 16928188
49. Powers C DeFilippis V Malouli D Fruh K Cytomegalovirus immune evasion Curr Top Microbiol Immunol 2008, 325:333-359. 18637515
50. Richards HB Satoh M Jennete JC Croker BP Yoshida H Reeves WH Interferon γ is required for lupus nephritis in mice treated with the hydrocarbon oil pristane Kidney Int 2001, 60:2173-2180. 11737591
51. Richards HB Satoh M Shaw M Libert C Poli V Reeves WH Interleukin 6 dependence of anti-DNA antibody production: Evidence for two pathways of autoantibody formation in pristane-induced lupus J Exp Med 1998, 188:985-990. 2213386 9730900
52. Satoh M Weintraub JP Yoshida H Shaheen VM Richards HB Shaw M Reeves WH Fas and Fas ligand mutations inhibit autoantibody production in pristane-induced lupus J Immunol 2000, 165:1036-1043. 10878381
53. Yoshida H Satoh M Behney KM Lee C-G Richards HB Shaheen VM Yang JQ Singh RR Reeves WH Effect of an exogenous trigger on the pathogenesis of lupus in NZB × NZW (F1) mice Arthritis Rheum 2002, 46:223- 2244. 2291543 12209530
54. Satoh M Mizutani A Behney KM Kuroda Y Akaogi J Yoshida H Nacionales DC Hirakata M Ono N Reeves WH X-linked immunodeficient mice spontaneously produce lupus-related anti-RNA helicase A autoantibodies, but are resistant to pristane-induced lupus Int Immunol 2003, 15:1117-1124. 12917264
55. Zhuang H Narain S Sobel E Lee PY Nacionales DC Kelly KM Richards HB Segal M Stewart C Satoh M Reeves WH Association of anti-nucleoprotein autoantibodies with upregulation of type I interferon-inducible gene transcripts and dendritic cell maturation in systemic lupus erythematosus Clin Immunol 2005, 117:238-250. 16126005
56. Jakymiw A Ikeda K Fritzler MJ Reeves WH Satoh M Chan EK Autoimmune targeting of key components of RNA interference Arthritis Res Ther 2006, 8:R87. 1779426 16684366