Bistable switches for synaptic plasticity

Science Signaling

Volumn 2, Issue 56, 2009, Pages

  Ogasawara, Hideaki ^a,b   Kawato, Mitsuo ^b  

^a NATIONAL INSTITUTE OF INFORMATION AND COMMUNICATIONS TECHNOLOGY   (Japan)

^b ADVANCED TELECOMMUNICATIONS RESEARCH INSTITUTE INTERNATIONAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE C;

CEREBELLUM; ENZYME MECHANISM; LONG TERM DEPRESSION; NERVE CELL PLASTICITY; POSITIVE FEEDBACK; PRIORITY JOURNAL; PURKINJE FIBER; SHORT SURVEY; SIMULATION; SYNAPSE; ANIMAL; BIOLOGICAL MODEL; DENDRITE; HUMAN; METABOLISM; PHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION;

ANIMALS; DENDRITES; HUMANS; LONG-TERM SYNAPTIC DEPRESSION; MAP KINASE SIGNALING SYSTEM; MODELS, BIOLOGICAL; MODELS, NEUROLOGICAL; NEURONAL PLASTICITY; SIGNAL TRANSDUCTION; SYNAPSES; SYNAPTIC TRANSMISSION;

EID: 62349100060     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.256pe7     Document Type: Short Survey

References (18)

1. F. Crick, Memory and molecular turnover. Nature 312, 101 (1984).
2. J. E. Lisman, A mechanism for memory storage insensitive to molecular turnover: A bistable autophosphorylating kinase. Proc. Natl. Acad. Sci. U.S.A. 82, 3055-3057 (1985).
3. U. S. Bhalla, R. Iyengar, Emergent properties of networks of biological signaling pathways. Science 283, 381-387 (1999).
4. K. Tanaka, G. J. Augustine, A positive feedback signal transduction loop determines timing of cerebellar long-term depression. Neuron 59, 608-620 (2008).
5. J. E. Ferrell Jr., Building a cellular switch: More lessons from a good egg. Bioessays 21, 866-870 (1999).
6. C. Y. Huang, J. E. Ferrell Jr., Ultrasensitivity in the mitogen-activated protein kinase cascade. Proc. Natl. Acad. Sci. U.S.A. 93, 10078-10083 (1996).
7. M. Ito, Cerebellar long-term depression: Characterization, signal transduction, and functional roles. Physiol. Rev. 81, 1143-1195 (2001).
8. S. Kuroda, N. Schweighofer, M. Kawato, Exploration of signal transduction pathways in cerebellar long-term depression by kinetic simulation. J. Neurosci. 21, 5693-5702 (2001).
9. 2+ requirements for cerebellar long-term synaptic depression: Role for a postsynaptic leaky integrator. Neuron 54, 787-800 (2007).
10. D. J. Linden, A protein synthesis-dependent late phase of cerebellar long-term depression. Neuron 17, 483-490 (1996).
11. S. Ahn, D. D. Ginty, D. J. Linden, A late phase of cerebellar long-term depression requires activation of CaMKIV and CREB. Neuron 23, 559-568 (1999).
12. 2+ threshold dynamics detect spike timing in cerebellar Purkinje cells. J. Neurosci. 25, 950-961 (2005).
13. M. Kawato, From "understanding the brain by creating the brain" towards manipulative neuroscience. Philos. Trans. R. Soc. London Ser. B 363, 2201-2214 (2008).
14. H. Ogasawara, T. Doi, M. Kawato, Systems biology perspectives on cerebellar long-term depression. Neurosignals 16, 300-317 (2008).
15. H. Ogasawara, M. Kawato, in Systems Biology: The Challenge of Complexity, S. Nakanishi, R. Kageyama, D. Watanabe, Eds. (Springer, New York, in press).
16. T. C. Sacktor, PKMz, LTP maintenance, and the dynamic molecular biology of memory storage. Prog. Brain Res. 169, 27-40 (2008).
17. C. D. Harvey, A. G. Ehrhardt, C. Cellurale, H. Zhong, R. Yasuda, R. J. Davis, K. Svoboda, A genetically encoded fluorescent sensor of ERK activity. Proc. Natl. Acad. Sci. U.S.A. 105, 19264-19269 (2008).
18. F. Pinaud, M. Dahan, Zooming into live cells. Science 320, 187-188 (2008).