메뉴 건너뛰기




Volumn 16, Issue 2, 2009, Pages 70-76

Advancements in the molecular pathogenesis of myelodysplastic syndrome

Author keywords

Aging; DNA repair; Genetic instability; Microenvironment; Myelodysplasia

Indexed keywords

CASPASE 8; CYCLOSPORIN; FAS ANTIGEN; FLICE INHIBITORY PROTEIN; INTERLEUKIN 1; LENALIDOMIDE; THYMOCYTE ANTIBODY; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

EID: 62249219784     PISSN: 10656251     EISSN: 15317048     Source Type: Journal    
DOI: 10.1097/MOH.0b013e3283257ac7     Document Type: Review
Times cited : (38)

References (82)
  • 1
    • 47249150213 scopus 로고    scopus 로고
    • Rollison DE, Howlader N, Smith MT, et al. Epidemiology of myelodysplastic syndromes and chronic myeloproliferative disorders in the United States, 2001-2004, using data from the NAACCR and SEER programs. Blood 2008; 112:45-52. This article reports the incidence of MDS and chronic myeloproliferative disorders (CMDs) on the basis of population-based cancer registries in the United States. Representing approximately 82% of the US population with more than 40 000 observations reported, this study represents the largest ever reported in MDS.
    • Rollison DE, Howlader N, Smith MT, et al. Epidemiology of myelodysplastic syndromes and chronic myeloproliferative disorders in the United States, 2001-2004, using data from the NAACCR and SEER programs. Blood 2008; 112:45-52. This article reports the incidence of MDS and chronic myeloproliferative disorders (CMDs) on the basis of population-based cancer registries in the United States. Representing approximately 82% of the US population with more than 40 000 observations reported, this study represents the largest ever reported in MDS.
  • 2
    • 34247172535 scopus 로고    scopus 로고
    • Myelodysplastic syndromes: Incidence and survival in the United States
    • Ma X, Does M, Raza A, et al. Myelodysplastic syndromes: incidence and survival in the United States. Cancer 2007; 109:1536-1542.
    • (2007) Cancer , vol.109 , pp. 1536-1542
    • Ma, X.1    Does, M.2    Raza, A.3
  • 3
    • 34848831819 scopus 로고    scopus 로고
    • A population-based study of survival in patients with secondary myelodysplastic syndromes (MDS): Impact of type and treatment of primary cancers
    • De Roos AJ, Deeg HJ, Davis S. A population-based study of survival in patients with secondary myelodysplastic syndromes (MDS): impact of type and treatment of primary cancers. Cancer Causes Control 2007; 18:1199-1208.
    • (2007) Cancer Causes Control , vol.18 , pp. 1199-1208
    • De Roos, A.J.1    Deeg, H.J.2    Davis, S.3
  • 4
    • 0037112853 scopus 로고    scopus 로고
    • Myelodysplastic syndromes. Diagnosis and therapeutic strategies
    • Aul C, Giagounidis A, Germing U, et al. Myelodysplastic syndromes. Diagnosis and therapeutic strategies. Med Klin (Munich) 2002; 97:666-676.
    • (2002) Med Klin (Munich) , vol.97 , pp. 666-676
    • Aul, C.1    Giagounidis, A.2    Germing, U.3
  • 5
    • 0028955323 scopus 로고
    • Incidence of myelodysplastic syndromes in a Swedish population
    • Radlund A, Thiede T, Hansen S, et al. Incidence of myelodysplastic syndromes in a Swedish population. Eur J Haematol 1995; 54:153-156.
    • (1995) Eur J Haematol , vol.54 , pp. 153-156
    • Radlund, A.1    Thiede, T.2    Hansen, S.3
  • 6
    • 0030016365 scopus 로고    scopus 로고
    • Epidemiological characteristics of myelodysplastic syndrome in a well defined French population
    • Maynadie M, Verret C, Moskovtchenko P, et al. Epidemiological characteristics of myelodysplastic syndrome in a well defined French population. Br J Cancer 1996; 74:288-290.
    • (1996) Br J Cancer , vol.74 , pp. 288-290
    • Maynadie, M.1    Verret, C.2    Moskovtchenko, P.3
  • 7
    • 39149083040 scopus 로고    scopus 로고
    • Hypocellularity in myelodysplastic syndrome is an independent factor which predicts a favorable outcome
    • Yue G, Hao S, Fadare O, et al. Hypocellularity in myelodysplastic syndrome is an independent factor which predicts a favorable outcome. Leuk Res 2008; 32:553-558.
    • (2008) Leuk Res , vol.32 , pp. 553-558
    • Yue, G.1    Hao, S.2    Fadare, O.3
  • 8
    • 0345701967 scopus 로고    scopus 로고
    • A pilot study of antithymocyte globulin (ATG) in the treatment of patients with 'low-risk' myelodysplasia
    • Killick SB, Mufti G, Cavenagh JD, et al. A pilot study of antithymocyte globulin (ATG) in the treatment of patients with 'low-risk' myelodysplasia. Br J Haematol 2003; 120:679-684.
    • (2003) Br J Haematol , vol.120 , pp. 679-684
    • Killick, S.B.1    Mufti, G.2    Cavenagh, J.D.3
  • 9
    • 35848960369 scopus 로고    scopus 로고
    • Immunosuppressive treatment strategies in low-risk MDS
    • Ganser A, Passweg J, Stadler M, et al. Immunosuppressive treatment strategies in low-risk MDS. Cancer Treat Rev 2007; 33 (Suppl 1):S11-S14.
    • (2007) Cancer Treat Rev , vol.33 , Issue.SUPPL. 1
    • Ganser, A.1    Passweg, J.2    Stadler, M.3
  • 10
    • 0033973769 scopus 로고    scopus 로고
    • Myelodysplastic syndrome and aplastic anemia: Distinct entities or diseases linked by a common pathophysiology?
    • Barrett J, Saunthararajah Y, Molldrem J. Myelodysplastic syndrome and aplastic anemia: distinct entities or diseases linked by a common pathophysiology? Semin Hematol 2000; 37:15-29.
    • (2000) Semin Hematol , vol.37 , pp. 15-29
    • Barrett, J.1    Saunthararajah, Y.2    Molldrem, J.3
  • 11
    • 0028372859 scopus 로고
    • The role of bone marrow study in diagnosis and prognosis of myelodysplastic syndrome
    • Saad ST, Vassallo J, Arruda VA, et al. The role of bone marrow study in diagnosis and prognosis of myelodysplastic syndrome. Pathologica 1994; 86:47-51.
    • (1994) Pathologica , vol.86 , pp. 47-51
    • Saad, S.T.1    Vassallo, J.2    Arruda, V.A.3
  • 12
    • 0028784950 scopus 로고
    • Hypocellular myelodysplastic syndromes (MDS): New proposals
    • Tuzuner N, Cox C, Rowe JM, et al. Hypocellular myelodysplastic syndromes (MDS): new proposals. Br J Haematol 1995; 91:612-617.
    • (1995) Br J Haematol , vol.91 , pp. 612-617
    • Tuzuner, N.1    Cox, C.2    Rowe, J.M.3
  • 13
    • 0032921413 scopus 로고    scopus 로고
    • Biologic characteristics of patients with hypocellular myelodysplastic syndromes
    • Goyal R, Qawi H, Ali I, et al. Biologic characteristics of patients with hypocellular myelodysplastic syndromes. Leuk Res 1999; 23:357-364.
    • (1999) Leuk Res , vol.23 , pp. 357-364
    • Goyal, R.1    Qawi, H.2    Ali, I.3
  • 14
    • 22344449046 scopus 로고    scopus 로고
    • Hypocellular myelodysplastic syndromes: Clinical and biological significance
    • Marisavljevic D, Cemerikic V, Rolovic Z, et al. Hypocellular myelodysplastic syndromes: clinical and biological significance. Med Oncol 2005; 22:169-175.
    • (2005) Med Oncol , vol.22 , pp. 169-175
    • Marisavljevic, D.1    Cemerikic, V.2    Rolovic, Z.3
  • 15
    • 0037356452 scopus 로고    scopus 로고
    • A prognostic impact of separation of refractory cytopenia with multilineage dysplasia and 5q- syndrome from refractory anemia in primary myelodysplastic syndrome
    • Cermak J, Michalova K, Brezinova J, et al. A prognostic impact of separation of refractory cytopenia with multilineage dysplasia and 5q- syndrome from refractory anemia in primary myelodysplastic syndrome. Leuk Res 2003; 27:221-229.
    • (2003) Leuk Res , vol.27 , pp. 221-229
    • Cermak, J.1    Michalova, K.2    Brezinova, J.3
  • 16
    • 36148993604 scopus 로고    scopus 로고
    • Prevalence and prognostic significance of allelic imbalance by single-nucleotide polymorphism analysis in low-risk myelodysplastic syndromes
    • Mohamedali A, Gaken J, Twine NA. Prevalence and prognostic significance of allelic imbalance by single-nucleotide polymorphism analysis in low-risk myelodysplastic syndromes. Blood 2007; 110:3365-3373.
    • (2007) Blood , vol.110 , pp. 3365-3373
    • Mohamedali, A.1    Gaken, J.2    Twine, N.A.3
  • 17
    • 0016725149 scopus 로고
    • A new hematologic syndrome with a distinct karyotype: The 5q chromosome
    • Sokal G, Michaux JL, Van Den Berghe H, et al. A new hematologic syndrome with a distinct karyotype: the 5q chromosome. Blood 1975; 46:519-533.
    • (1975) Blood , vol.46 , pp. 519-533
    • Sokal, G.1    Michaux, J.L.2    Van Den Berghe, H.3
  • 18
    • 13444256401 scopus 로고    scopus 로고
    • Efficacy of lenalidomide in myelodysplastic syndromes
    • List A, Kurtin S, Roe DJ, et al. Efficacy of lenalidomide in myelodysplastic syndromes. N Engl J Med 2005; 352:549-557.
    • (2005) N Engl J Med , vol.352 , pp. 549-557
    • List, A.1    Kurtin, S.2    Roe, D.J.3
  • 19
    • 23444462111 scopus 로고    scopus 로고
    • List AF. Emerging data on IMiDs in the treatment of myelodysplastic syndromes (MDS). Semin Oncol 2005; 32:331-S35.
    • List AF. Emerging data on IMiDs in the treatment of myelodysplastic syndromes (MDS). Semin Oncol 2005; 32:331-S35.
  • 20
    • 38349088899 scopus 로고    scopus 로고
    • Ebert BL, Pretz J, Bosco J, et al. Identification of RPS14 as a 5q- syndrome gene by RNA interference screen. Nature 2008; 451:335-339. An RNA-mediated interference (RNAi)-based approach was used to replicate the partial loss of genes in 5q- syndrome. The authors identified a novel linkage with a ribosomal subunit protein RPS14 and bone marrow failure in 5q- syndrome. Finally, this work describes the molecular pathophysiology of the 5q- syndrome in relationship to Diamond-Blackfan anemia.
    • Ebert BL, Pretz J, Bosco J, et al. Identification of RPS14 as a 5q- syndrome gene by RNA interference screen. Nature 2008; 451:335-339. An RNA-mediated interference (RNAi)-based approach was used to replicate the partial loss of genes in 5q- syndrome. The authors identified a novel linkage with a ribosomal subunit protein RPS14 and bone marrow failure in 5q- syndrome. Finally, this work describes the molecular pathophysiology of the 5q- syndrome in relationship to Diamond-Blackfan anemia.
  • 21
    • 13044266374 scopus 로고    scopus 로고
    • Mutations in ribosomal protein S19 gene and diamond blackfan anemia: Wide variations in phenotypic expression
    • Willig TN, Draptchinskaia N, Dianzani I, et al. Mutations in ribosomal protein S19 gene and diamond blackfan anemia: wide variations in phenotypic expression. Blood 1999; 94:4294-4306.
    • (1999) Blood , vol.94 , pp. 4294-4306
    • Willig, T.N.1    Draptchinskaia, N.2    Dianzani, I.3
  • 22
    • 0032907438 scopus 로고    scopus 로고
    • The gene encoding ribosomal protein S19 is mutated in Diamond-Blackfan anaemia
    • Draptchinskaia N, Gustavsson P, Andersson B, et al. The gene encoding ribosomal protein S19 is mutated in Diamond-Blackfan anaemia. Nat Genet 1999; 21:169-175.
    • (1999) Nat Genet , vol.21 , pp. 169-175
    • Draptchinskaia, N.1    Gustavsson, P.2    Andersson, B.3
  • 23
    • 33845303558 scopus 로고    scopus 로고
    • Ribosomal protein S24 gene is mutated in Diamond-Blackfan anemia
    • Gazda HT, Grabowska A, Merida-Long LB, et al. Ribosomal protein S24 gene is mutated in Diamond-Blackfan anemia. Am J Hum Genet 2006; 79:1110-1118.
    • (2006) Am J Hum Genet , vol.79 , pp. 1110-1118
    • Gazda, H.T.1    Grabowska, A.2    Merida-Long, L.B.3
  • 24
    • 33745063192 scopus 로고    scopus 로고
    • Ribosomes and marrow failure: Coincidental association or molecular paradigm?
    • Liu JM, Ellis SR. Ribosomes and marrow failure: coincidental association or molecular paradigm? Blood 2006; 107:4583-4588.
    • (2006) Blood , vol.107 , pp. 4583-4588
    • Liu, J.M.1    Ellis, S.R.2
  • 25
    • 48249117726 scopus 로고    scopus 로고
    • Ribosomal mutations cause p53-mediated dark skin and pleiotropic effects
    • McGowan KA, Li JZ, Park CY, et al. Ribosomal mutations cause p53-mediated dark skin and pleiotropic effects. Nat Genet 2008; 40:963-970.
    • (2008) Nat Genet , vol.40 , pp. 963-970
    • McGowan, K.A.1    Li, J.Z.2    Park, C.Y.3
  • 26
    • 38049113182 scopus 로고    scopus 로고
    • Phase 2 study of lenalidomide in transfusion-dependent, low-risk, and intermediate-1 risk myelodysplastic syndromes with karyotypes other than deletion 5q
    • Raza A, Reeves JA, Feldman EJ, et al. Phase 2 study of lenalidomide in transfusion-dependent, low-risk, and intermediate-1 risk myelodysplastic syndromes with karyotypes other than deletion 5q. Blood 2008; 111:86-93.
    • (2008) Blood , vol.111 , pp. 86-93
    • Raza, A.1    Reeves, J.A.2    Feldman, E.J.3
  • 27
    • 39849099704 scopus 로고    scopus 로고
    • An erythroid differentiation signature predicts response to lenalidomide in myelodysplastic syndrome
    • Ebert BL, Galili N, Tamayo P. An erythroid differentiation signature predicts response to lenalidomide in myelodysplastic syndrome. PLoS Med 2008; 5:e35.
    • (2008) PLoS Med , vol.5
    • Ebert, B.L.1    Galili, N.2    Tamayo, P.3
  • 28
    • 35448934364 scopus 로고    scopus 로고
    • Apoptosis and antiapoptotic mechanisms in the progression of myelodysplastic syndrome
    • Kerbauy DB, Deeg HJ. Apoptosis and antiapoptotic mechanisms in the progression of myelodysplastic syndrome. Exp Hematol 2007; 35:1739-1746.
    • (2007) Exp Hematol , vol.35 , pp. 1739-1746
    • Kerbauy, D.B.1    Deeg, H.J.2
  • 29
    • 0035892123 scopus 로고    scopus 로고
    • Expression of tumor necrosis factor-related apoptosis-inducing ligand, Apo2L, and its receptors in myelodysplastic syndrome: Effects on in vitro hemopoiesis
    • Zang DY, Goodwin RG, Loken MR, et al. Expression of tumor necrosis factor-related apoptosis-inducing ligand, Apo2L, and its receptors in myelodysplastic syndrome: effects on in vitro hemopoiesis. Blood 2001; 98:3058-3065.
    • (2001) Blood , vol.98 , pp. 3058-3065
    • Zang, D.Y.1    Goodwin, R.G.2    Loken, M.R.3
  • 30
    • 20844462217 scopus 로고    scopus 로고
    • Rescue of early-stage myelodysplastic syndrome-deriving erythroid precursors by the ectopic expression of a dominant-negative form of FADD
    • Claessens YE, Park S, Dubart-Kupperschmitt A, et al. Rescue of early-stage myelodysplastic syndrome-deriving erythroid precursors by the ectopic expression of a dominant-negative form of FADD. Blood 2005; 105: 4035-4042.
    • (2005) Blood , vol.105 , pp. 4035-4042
    • Claessens, Y.E.1    Park, S.2    Dubart-Kupperschmitt, A.3
  • 31
    • 0346025550 scopus 로고    scopus 로고
    • Expression of FLIP(Long) and FLIP(Short) in bone marrow mononuclear and CD34+ cells in patients with myelodysplastic syndrome: Correlation with apoptosis
    • Benesch M, Platzbecker U, Ward J, et al. Expression of FLIP(Long) and FLIP(Short) in bone marrow mononuclear and CD34+ cells in patients with myelodysplastic syndrome: correlation with apoptosis. Leukemia 2003; 17:2460-2466.
    • (2003) Leukemia , vol.17 , pp. 2460-2466
    • Benesch, M.1    Platzbecker, U.2    Ward, J.3
  • 32
    • 0031656518 scopus 로고    scopus 로고
    • A role for tumour necrosis factor-alpha, Fas and Fas-ligand in marrow failure associated with myelodysplastic syndrome
    • Gersuk GM, Beckham C, Loken MR, et al. A role for tumour necrosis factor-alpha, Fas and Fas-ligand in marrow failure associated with myelodysplastic syndrome. Br J Haematol 1998; 103:176-188.
    • (1998) Br J Haematol , vol.103 , pp. 176-188
    • Gersuk, G.M.1    Beckham, C.2    Loken, M.R.3
  • 33
    • 0032941565 scopus 로고    scopus 로고
    • Bone marrow stroma from refractory anemia of myelodysplastic syndrome is defective in its ability to support normal CD34-positive cell proliferation and differentiation in vitro
    • Aizawa S, Nakano M, Iwase O, et al. Bone marrow stroma from refractory anemia of myelodysplastic syndrome is defective in its ability to support normal CD34-positive cell proliferation and differentiation in vitro. Leuk Res 1999; 23:239-246.
    • (1999) Leuk Res , vol.23 , pp. 239-246
    • Aizawa, S.1    Nakano, M.2    Iwase, O.3
  • 34
    • 0034022396 scopus 로고    scopus 로고
    • Negative regulators of hemopoiesis and stroma function in patients with myelodysplastic syndrome
    • Deeg HJ, Beckham C, Loken MR, et al. Negative regulators of hemopoiesis and stroma function in patients with myelodysplastic syndrome. Leuk Lymphoma 2000; 37:405-414.
    • (2000) Leuk Lymphoma , vol.37 , pp. 405-414
    • Deeg, H.J.1    Beckham, C.2    Loken, M.R.3
  • 35
    • 24544481893 scopus 로고    scopus 로고
    • Endothelial precursors and mature endothelial cells are increased in the peripheral blood of myelodys-plastic syndromes
    • Cortelezzi A, Fracchiolla NS, Mazzeo LM, et al. Endothelial precursors and mature endothelial cells are increased in the peripheral blood of myelodys-plastic syndromes. Leuk Lymphoma 2005; 46:1345-1351.
    • (2005) Leuk Lymphoma , vol.46 , pp. 1345-1351
    • Cortelezzi, A.1    Fracchiolla, N.S.2    Mazzeo, L.M.3
  • 36
    • 42949095542 scopus 로고    scopus 로고
    • Dysregulation of IL-32 in myelodysplastic syndrome and chronic myelomonocytic leukemia modulates apoptosis and impairs NK function
    • Marcondes AM, Mhyre AJ, Stirewalt DL, et al. Dysregulation of IL-32 in myelodysplastic syndrome and chronic myelomonocytic leukemia modulates apoptosis and impairs NK function. Proc Natl Acad Sci U S A 2008; 105:2865-2870.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 2865-2870
    • Marcondes, A.M.1    Mhyre, A.J.2    Stirewalt, D.L.3
  • 37
    • 38349113450 scopus 로고    scopus 로고
    • Tumour necrosis factor-induced gene expression in human marrow stroma: Clues to the pathophysiology of MDS?
    • Stirewalt DL, Mhyre AJ, Marcondes M, et al. Tumour necrosis factor-induced gene expression in human marrow stroma: clues to the pathophysiology of MDS? Br J Haematol 2008; 140:444-453.
    • (2008) Br J Haematol , vol.140 , pp. 444-453
    • Stirewalt, D.L.1    Mhyre, A.J.2    Marcondes, M.3
  • 38
    • 12444304581 scopus 로고    scopus 로고
    • Interleukin-32: A cytokine and inducer of TNFalpha
    • Kim SH, Han SY, Azam T, et al. Interleukin-32: a cytokine and inducer of TNFalpha. Immunity 2005; 22:131-142.
    • (2005) Immunity , vol.22 , pp. 131-142
    • Kim, S.H.1    Han, S.Y.2    Azam, T.3
  • 39
    • 31544432072 scopus 로고    scopus 로고
    • Involvement of IL-32 in activation-induced cell death in T cells
    • Goda C, Kanaji T, Kanaji S, et al. Involvement of IL-32 in activation-induced cell death in T cells. Int Immunol 2006; 18:233-240.
    • (2006) Int Immunol , vol.18 , pp. 233-240
    • Goda, C.1    Kanaji, T.2    Kanaji, S.3
  • 40
    • 33846689827 scopus 로고    scopus 로고
    • Modulation of autoimmunity by the latest interleukins (with special emphasis on IL-32)
    • Conti P, Youinou P, Theoharides TC. Modulation of autoimmunity by the latest interleukins (with special emphasis on IL-32). Autoimmun Rev 2007; 6:131-137.
    • (2007) Autoimmun Rev , vol.6 , pp. 131-137
    • Conti, P.1    Youinou, P.2    Theoharides, T.C.3
  • 41
    • 34249740754 scopus 로고    scopus 로고
    • Reduced natural killer (NK) function associated with high-risk myelodysplastic syndrome (MDS) and reduced expression of activating NK receptors
    • Epling-Burnette PK, Bai F, Painter JS, et al. Reduced natural killer (NK) function associated with high-risk myelodysplastic syndrome (MDS) and reduced expression of activating NK receptors. Blood 2007; 109:4816-4824.
    • (2007) Blood , vol.109 , pp. 4816-4824
    • Epling-Burnette, P.K.1    Bai, F.2    Painter, J.S.3
  • 42
    • 0035136385 scopus 로고    scopus 로고
    • Coincident myelodysplastic syndrome and T-cell large granular lymphocytic disease: Clinical and pathophysiological features
    • Saunthararajah Y, Molldrem JL, Rivera M, et al. Coincident myelodysplastic syndrome and T-cell large granular lymphocytic disease: clinical and pathophysiological features. Br J Haematol 2001; 112:195-200.
    • (2001) Br J Haematol , vol.112 , pp. 195-200
    • Saunthararajah, Y.1    Molldrem, J.L.2    Rivera, M.3
  • 43
    • 0037114692 scopus 로고    scopus 로고
    • Fas-mediated apoptosis is important in regulating cell replication and death in trisomy 8 hematopoietic cells but not in cells with other cytogenetic abnormalities
    • Sloand EM, Kim S, Fuhrer M, et al. Fas-mediated apoptosis is important in regulating cell replication and death in trisomy 8 hematopoietic cells but not in cells with other cytogenetic abnormalities. Blood 2002; 100:4427-4432.
    • (2002) Blood , vol.100 , pp. 4427-4432
    • Sloand, E.M.1    Kim, S.2    Fuhrer, M.3
  • 44
    • 0034765667 scopus 로고    scopus 로고
    • Increased cytotoxic T cells with effector phenotype in aplastlc anemia and myelodysplasia
    • Kook H, Zeng W, Guibin C, et al. Increased cytotoxic T cells with effector phenotype in aplastlc anemia and myelodysplasia. Exp Hematol 2001; 29:1270-1277.
    • (2001) Exp Hematol , vol.29 , pp. 1270-1277
    • Kook, H.1    Zeng, W.2    Guibin, C.3
  • 45
    • 33947388858 scopus 로고    scopus 로고
    • Prevalence and clinical association of clonal T-cell expansions in myelodysplastic syndrome
    • Epling-Burnette PK, Painter JS, Rollison DE, et al. Prevalence and clinical association of clonal T-cell expansions in myelodysplastic syndrome. Leukemia 2007; 21:659-667.
    • (2007) Leukemia , vol.21 , pp. 659-667
    • Epling-Burnette, P.K.1    Painter, J.S.2    Rollison, D.E.3
  • 46
    • 0141923848 scopus 로고    scopus 로고
    • A simple method to predict response to immunosuppressive therapy in patients with myelodysplastic syndrome
    • Saunthararajah Y, Nakamura R, Wesley R, et al. A simple method to predict response to immunosuppressive therapy in patients with myelodysplastic syndrome. Blood 2003; 102:3025-3027.
    • (2003) Blood , vol.102 , pp. 3025-3027
    • Saunthararajah, Y.1    Nakamura, R.2    Wesley, R.3
  • 47
    • 0030695069 scopus 로고    scopus 로고
    • Antithymocyte globulin for patients with myelodysplastic syndrome
    • Molldrem JJ, Caples M, Mavroudis D, et al. Antithymocyte globulin for patients with myelodysplastic syndrome. Br J Haematol 1997; 99:699-705.
    • (1997) Br J Haematol , vol.99 , pp. 699-705
    • Molldrem, J.J.1    Caples, M.2    Mavroudis, D.3
  • 48
    • 0036720903 scopus 로고    scopus 로고
    • HLA-DR15 (DR2) is over-represented in myelodysplastic syndrome and aplastic anemia and predicts a response to immunosuppression in myelodysplastic syndrome
    • Saunthararajah Y, Nakamura R, Nam JM, et al. HLA-DR15 (DR2) is over-represented in myelodysplastic syndrome and aplastic anemia and predicts a response to immunosuppression in myelodysplastic syndrome. Blood 2002; 100:1570-1574.
    • (2002) Blood , vol.100 , pp. 1570-1574
    • Saunthararajah, Y.1    Nakamura, R.2    Nam, J.M.3
  • 49
    • 45149093744 scopus 로고    scopus 로고
    • Factors affecting response and survival in patients with myelodysplasia treated with immunosuppressive therapy
    • Sloand EM, Wu CO, Greenberg P, et al. Factors affecting response and survival in patients with myelodysplasia treated with immunosuppressive therapy. J Clin Oncol 2008; 26:2505-2511.
    • (2008) J Clin Oncol , vol.26 , pp. 2505-2511
    • Sloand, E.M.1    Wu, C.O.2    Greenberg, P.3
  • 50
    • 23044473715 scopus 로고    scopus 로고
    • Preferential suppression of trisomy 8 compared with normal hematopoietic cell growth by autologous lymphocytes in patients with trisomy 8 myelodysplastic syndrome
    • Sloand EM, Mainwaring L, Fuhrer M, et al. Preferential suppression of trisomy 8 compared with normal hematopoietic cell growth by autologous lymphocytes in patients with trisomy 8 myelodysplastic syndrome. Blood 2005; 106:841-851.
    • (2005) Blood , vol.106 , pp. 841-851
    • Sloand, E.M.1    Mainwaring, L.2    Fuhrer, M.3
  • 51
    • 33947224233 scopus 로고    scopus 로고
    • CD34 cells from patients with trisomy 8 myelodysplastic syndrome (MDS) express early apoptotic markers but avoid programmed cell death by up-regulation of antiapoptotic proteins
    • Sloand EM, Pfannes L, Chen G, et al. CD34 cells from patients with trisomy 8 myelodysplastic syndrome (MDS) express early apoptotic markers but avoid programmed cell death by up-regulation of antiapoptotic proteins. Blood 2007; 109:2399-2405.
    • (2007) Blood , vol.109 , pp. 2399-2405
    • Sloand, E.M.1    Pfannes, L.2    Chen, G.3
  • 52
    • 39649091183 scopus 로고    scopus 로고
    • Inappropriate Notch activity and limited mesenchymal stem cell plasticity in the bone marrow of patients with myelodysplastic syndromes
    • Varga G, Kiss J, Varkonyi J, et al. Inappropriate Notch activity and limited mesenchymal stem cell plasticity in the bone marrow of patients with myelodysplastic syndromes. Pathol Oncol Res 2007; 13:311-319.
    • (2007) Pathol Oncol Res , vol.13 , pp. 311-319
    • Varga, G.1    Kiss, J.2    Varkonyi, J.3
  • 53
    • 37349027319 scopus 로고    scopus 로고
    • Polymorphisms in TGFbeta and TNFalpha are associated with the myelodysplastic syndrome phenotype
    • Powers MP, Nishino H, Luo Y, et al. Polymorphisms in TGFbeta and TNFalpha are associated with the myelodysplastic syndrome phenotype. Arch Pathol Lab Med 2007; 131:1789-1793.
    • (2007) Arch Pathol Lab Med , vol.131 , pp. 1789-1793
    • Powers, M.P.1    Nishino, H.2    Luo, Y.3
  • 54
    • 38049144636 scopus 로고    scopus 로고
    • Reduced activation of protein kinase B, Rac, and F-actin polymerization contributes to an impairment of stromal cell derived factor-1 induced migration of CD34+ cells from patients with myelodysplasia
    • Fuhler GM, Drayer AL, Olthof SG, et al. Reduced activation of protein kinase B, Rac, and F-actin polymerization contributes to an impairment of stromal cell derived factor-1 induced migration of CD34+ cells from patients with myelodysplasia. Blood 2008; 111:359-368.
    • (2008) Blood , vol.111 , pp. 359-368
    • Fuhler, G.M.1    Drayer, A.L.2    Olthof, S.G.3
  • 55
    • 0042236482 scopus 로고    scopus 로고
    • Reduced expression of flavo-cytochrome b558, a component of the NADPH oxidase complex, in neutrophils from patients with myelodysplasia
    • Fuhler GM, Hooijenga F, Drayer AL, Vellenga E. Reduced expression of flavo-cytochrome b558, a component of the NADPH oxidase complex, in neutrophils from patients with myelodysplasia. Exp Hematol 2003; 31:752-759.
    • (2003) Exp Hematol , vol.31 , pp. 752-759
    • Fuhler, G.M.1    Hooijenga, F.2    Drayer, A.L.3    Vellenga, E.4
  • 56
    • 34548789121 scopus 로고    scopus 로고
    • Rassool FV, Gaymes TJ, Omidvar N, et al. Reactive oxygen species, DNA damage, and error-prone repair: a model for genomic instability with progression in myeloid leukemia? Cancer Res 2007; 67:8762-8771. This study describes a two-step mouse model of leukemic progression serving as the molecular basis of MDS pathogenesis. Mutant NRAS and BCL2 genes increased the frequency of DNA damage leading to an increased frequency of error-prone repair of double-strand breaks and an increase in reactive oxygen species.
    • Rassool FV, Gaymes TJ, Omidvar N, et al. Reactive oxygen species, DNA damage, and error-prone repair: a model for genomic instability with progression in myeloid leukemia? Cancer Res 2007; 67:8762-8771. This study describes a two-step mouse model of leukemic progression serving as the molecular basis of MDS pathogenesis. Mutant NRAS and BCL2 genes increased the frequency of DNA damage leading to an increased frequency of error-prone repair of double-strand breaks and an increase in reactive oxygen species.
  • 57
    • 51649103380 scopus 로고    scopus 로고
    • Whole genome scanning as a cytogenetic tool in hematologic malignancies
    • Maciejewski JP, Mufti GJ. Whole genome scanning as a cytogenetic tool in hematologic malignancies. Blood 2008; 112:965-974.
    • (2008) Blood , vol.112 , pp. 965-974
    • Maciejewski, J.P.1    Mufti, G.J.2
  • 58
    • 44449158040 scopus 로고    scopus 로고
    • Cytogenetic features in myelodysplastic syndromes
    • Haase D. Cytogenetic features in myelodysplastic syndromes. Ann Hematol 2008; 87:515-526.
    • (2008) Ann Hematol , vol.87 , pp. 515-526
    • Haase, D.1
  • 59
    • 38849123474 scopus 로고    scopus 로고
    • Influence of DNA damage and repair upon the risk of treatment related leukemia
    • Guillem V, Tormo M. Influence of DNA damage and repair upon the risk of treatment related leukemia. Leuk Lymphoma 2008; 49:204-217.
    • (2008) Leuk Lymphoma , vol.49 , pp. 204-217
    • Guillem, V.1    Tormo, M.2
  • 60
    • 33745968917 scopus 로고    scopus 로고
    • Clinical application and proposal for modification of the International Working Group (IWG) response criteria in myelodysplasia
    • Cheson BD, Greenberg PL, Bennett JM, et al. Clinical application and proposal for modification of the International Working Group (IWG) response criteria in myelodysplasia. Blood 2006; 108:419-425.
    • (2006) Blood , vol.108 , pp. 419-425
    • Cheson, B.D.1    Greenberg, P.L.2    Bennett, J.M.3
  • 61
    • 54049105351 scopus 로고    scopus 로고
    • High-resolution whole genome tiling path array CGH analysis of CD34+ cells from patients with low-risk myelodysplastic syndromes reveals cryptic copy number alterations and predicts overall and leukemia-free survival
    • Starczynowski DT, Vercauteren S, Telenius A, et al. High-resolution whole genome tiling path array CGH analysis of CD34+ cells from patients with low-risk myelodysplastic syndromes reveals cryptic copy number alterations and predicts overall and leukemia-free survival. Blood 2008; 112:3412-3424.
    • (2008) Blood , vol.112 , pp. 3412-3424
    • Starczynowski, D.T.1    Vercauteren, S.2    Telenius, A.3
  • 62
    • 36249012571 scopus 로고    scopus 로고
    • DNA profiling by arrayCGH in acute myeloid leukemia and myelodysplastic syndromes
    • Suela J, Alvarez S, Cigudosa JC. DNA profiling by arrayCGH in acute myeloid leukemia and myelodysplastic syndromes. Cytogenet Genome Res 2007; 118:304-309.
    • (2007) Cytogenet Genome Res , vol.118 , pp. 304-309
    • Suela, J.1    Alvarez, S.2    Cigudosa, J.C.3
  • 63
    • 35348987590 scopus 로고    scopus 로고
    • Molecular definition of chromosome arm 5q deletion end points and detection of hidden aberrations in patients with myelodysplastic syndromes and isolated del(5q) using oligonucleotide array CGH
    • Evers C, Beier M, Poelitz A, et al. Molecular definition of chromosome arm 5q deletion end points and detection of hidden aberrations in patients with myelodysplastic syndromes and isolated del(5q) using oligonucleotide array CGH. Genes Chromosomes Cancer 2007; 46:1119-1128.
    • (2007) Genes Chromosomes Cancer , vol.46 , pp. 1119-1128
    • Evers, C.1    Beier, M.2    Poelitz, A.3
  • 64
    • 34548329664 scopus 로고    scopus 로고
    • Chromosomal aberrations in congenital bone marrow failure disorders: An early indicator for leukemogenesis?
    • Gohring G, Karow A, Steinemann D, et al. Chromosomal aberrations in congenital bone marrow failure disorders: an early indicator for leukemogenesis? Ann Hematol 2007; 86:733-739.
    • (2007) Ann Hematol , vol.86 , pp. 733-739
    • Gohring, G.1    Karow, A.2    Steinemann, D.3
  • 65
    • 33646143341 scopus 로고    scopus 로고
    • High-resolution genome-wide array-based comparative genome hybridization reveals cryptic chromosome changes in AML and MDS cases with trisomy 8 as the sole cytogenetic aberration
    • Paulsson K, Heidenblad M, Strombeck B, et al. High-resolution genome-wide array-based comparative genome hybridization reveals cryptic chromosome changes in AML and MDS cases with trisomy 8 as the sole cytogenetic aberration. Leukemia 2006; 20:840-846.
    • (2006) Leukemia , vol.20 , pp. 840-846
    • Paulsson, K.1    Heidenblad, M.2    Strombeck, B.3
  • 66
    • 43249121366 scopus 로고    scopus 로고
    • SNP array karyotyping allows for the detection of uniparental disomy and cryptic chromosomal abnormalities in MDS/MPD-U and MPD
    • Gondek LP, Dunbar AJ, Szpurka H, et al. SNP array karyotyping allows for the detection of uniparental disomy and cryptic chromosomal abnormalities in MDS/MPD-U and MPD. PLoS ONE 2007; 2:e1225.
    • (2007) PLoS ONE , vol.2
    • Gondek, L.P.1    Dunbar, A.J.2    Szpurka, H.3
  • 67
    • 38949123096 scopus 로고    scopus 로고
    • Chromosomal lesions and uniparental disomy detected by SNP arrays in MDS, MDS/MPD, and MDS-derived AML
    • Gondek LP, Tiu R, O'Keefe CL, et al. Chromosomal lesions and uniparental disomy detected by SNP arrays in MDS, MDS/MPD, and MDS-derived AML. Blood 2008; 111:1534-1542.
    • (2008) Blood , vol.111 , pp. 1534-1542
    • Gondek, L.P.1    Tiu, R.2    O'Keefe, C.L.3
  • 68
    • 35448931911 scopus 로고    scopus 로고
    • Detection of cryptic chromosomal lesions including acquired segmental uniparental disomy in advanced and low-risk myelodysplastic syndromes
    • Gondek LP, Haddad AS, O'Keefe CL, et al. Detection of cryptic chromosomal lesions including acquired segmental uniparental disomy in advanced and low-risk myelodysplastic syndromes. Exp Hematol 2007; 35:1728-1738.
    • (2007) Exp Hematol , vol.35 , pp. 1728-1738
    • Gondek, L.P.1    Haddad, A.S.2    O'Keefe, C.L.3
  • 69
    • 36148993604 scopus 로고    scopus 로고
    • Prevalence and prognostic significance of allelic imbalance by single-nucleotide polymorphism analysis in low-risk myelodysplastic syndromes
    • Mohamedali A, Gaken J, Twine NA, et al. Prevalence and prognostic significance of allelic imbalance by single-nucleotide polymorphism analysis in low-risk myelodysplastic syndromes. Blood 2007; 110:3365-3373.
    • (2007) Blood , vol.110 , pp. 3365-3373
    • Mohamedali, A.1    Gaken, J.2    Twine, N.A.3
  • 70
    • 34447627193 scopus 로고    scopus 로고
    • Clonality of the stem cell compartment during evolution of myelodysplastic syndromes and other bone marrow failure syndromes
    • Tiu R, Gondek L, O'Keefe C, Maciejewski JP. Clonality of the stem cell compartment during evolution of myelodysplastic syndromes and other bone marrow failure syndromes. Leukemia 2007; 21:1648-1657.
    • (2007) Leukemia , vol.21 , pp. 1648-1657
    • Tiu, R.1    Gondek, L.2    O'Keefe, C.3    Maciejewski, J.P.4
  • 71
    • 4444302228 scopus 로고    scopus 로고
    • Mutations of AML1 are common in therapy-related myelodysplasia following therapy with alkylating agents and are significantly associated with deletion or loss of chromosome arm 7q and with subsequent leukemic transformation
    • Christiansen DH, Andersen MK, Pedersen-Bjergaard J. Mutations of AML1 are common in therapy-related myelodysplasia following therapy with alkylating agents and are significantly associated with deletion or loss of chromosome arm 7q and with subsequent leukemic transformation. Blood 2004; 104:1474-1481.
    • (2004) Blood , vol.104 , pp. 1474-1481
    • Christiansen, D.H.1    Andersen, M.K.2    Pedersen-Bjergaard, J.3
  • 72
    • 0028270494 scopus 로고
    • Consistent intergenic splicing and production of multiple transcripts between AML1 at 21q22 and unrelated genes at 3q26 in (3;21)(q26;q22) translocations
    • Nucifora G, Begy CR, Kobayashi H, et al. Consistent intergenic splicing and production of multiple transcripts between AML1 at 21q22 and unrelated genes at 3q26 in (3;21)(q26;q22) translocations. Proc Natl Acad Sci U S A 1994; 91:4004-4008.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 4004-4008
    • Nucifora, G.1    Begy, C.R.2    Kobayashi, H.3
  • 73
    • 0033791987 scopus 로고    scopus 로고
    • A novel dicentric deleted chromosome 21 arising from tandem translocation
    • Robinson L, Robson L, Sharma P, et al. A novel dicentric deleted chromosome 21 arising from tandem translocation. Cancer Genet Cytogenet 2000; 121: 208-211.
    • (2000) Cancer Genet Cytogenet , vol.121 , pp. 208-211
    • Robinson, L.1    Robson, L.2    Sharma, P.3
  • 74
    • 0036124315 scopus 로고    scopus 로고
    • Imai O, Kurokawa M, Izutsu K, et al. Mutational analyses of the AML1 gene in patients with myelodysplastic syndrome. LeukLymphoma2002; 43:617-621.
    • Imai O, Kurokawa M, Izutsu K, et al. Mutational analyses of the AML1 gene in patients with myelodysplastic syndrome. LeukLymphoma2002; 43:617-621.
  • 75
    • 1542373639 scopus 로고    scopus 로고
    • High incidence of somatic mutations in the AML1/RUNX1 gene in myelodysplastic syndrome and low blast percentage myeloid leukemia with myelodysplasia
    • Harada H, Harada Y, Niimi H, et al. High incidence of somatic mutations in the AML1/RUNX1 gene in myelodysplastic syndrome and low blast percentage myeloid leukemia with myelodysplasia. Blood 2004; 103:2316-2324.
    • (2004) Blood , vol.103 , pp. 2316-2324
    • Harada, H.1    Harada, Y.2    Niimi, H.3
  • 76
    • 0027286648 scopus 로고
    • Involvement of the AML1 gene in the t(3;21) in therapy-related leukemia and in chronic myeloid leukemia in blast crisis
    • Nucifora G, Birn DJ, Espinosa R 3rd, et al. Involvement of the AML1 gene in the t(3;21) in therapy-related leukemia and in chronic myeloid leukemia in blast crisis. Blood 1993; 81:2728-2734.
    • (1993) Blood , vol.81 , pp. 2728-2734
    • Nucifora, G.1    Birn, D.J.2    Espinosa 3rd, R.3
  • 77
    • 2942667930 scopus 로고    scopus 로고
    • Point mutations in the RUNX1/AML1 gene: Another actor in RUNX leukemia
    • Osato M. Point mutations in the RUNX1/AML1 gene: another actor in RUNX leukemia. Oncogene 2004; 23:4284-4296.
    • (2004) Oncogene , vol.23 , pp. 4284-4296
    • Osato, M.1
  • 78
    • 33645470588 scopus 로고    scopus 로고
    • Amplification of AML1 gene in association with karyotype, age and diagnosis in acute leukemia patients
    • Kirschnerova G, Tothova A, Babusikova O. Amplification of AML1 gene in association with karyotype, age and diagnosis in acute leukemia patients. Neoplasma 2006; 53:150-154.
    • (2006) Neoplasma , vol.53 , pp. 150-154
    • Kirschnerova, G.1    Tothova, A.2    Babusikova, O.3
  • 79
    • 33646475438 scopus 로고    scopus 로고
    • Hyperactivation of the RAS signaling pathway in myelodysplastic syndrome with AML1/RUNX1 point mutations
    • Niimi H, Harada H, Harada Y, et al. Hyperactivation of the RAS signaling pathway in myelodysplastic syndrome with AML1/RUNX1 point mutations. Leukemia 2006; 20:635-644.
    • (2006) Leukemia , vol.20 , pp. 635-644
    • Niimi, H.1    Harada, H.2    Harada, Y.3
  • 80
    • 43249103972 scopus 로고    scopus 로고
    • Watanabe-Okochi N, Kitaura J, Ono R, et al. AML1 mutations induced MDS and MDS/AML in a mouse BMT model. Blood 2008; 111:4297-4308. This study describes a murine bone marrow transplantation model expressing mutations of the transcription factor AML1/RUNX1 that are commonly associated with MDS/AML. Depending on the integration site of the AML1 mutant and the specific mutation, some mice developed pancytopenia and erythroid dysplasia, whereas others developed an AML-like phenotype. This manuscript therefore demonstrates the molecular basis of the heterogeneous phenotype observed in MDS and provides a mechanism for leukemia progression.
    • Watanabe-Okochi N, Kitaura J, Ono R, et al. AML1 mutations induced MDS and MDS/AML in a mouse BMT model. Blood 2008; 111:4297-4308. This study describes a murine bone marrow transplantation model expressing mutations of the transcription factor AML1/RUNX1 that are commonly associated with MDS/AML. Depending on the integration site of the AML1 mutant and the specific mutation, some mice developed pancytopenia and erythroid dysplasia, whereas others developed an AML-like phenotype. This manuscript therefore demonstrates the molecular basis of the heterogeneous phenotype observed in MDS and provides a mechanism for leukemia progression.
  • 81
    • 37549065049 scopus 로고    scopus 로고
    • Omidvar N, Kogan S, Beurlet S, et al. BCL-2 and mutant NRAS interact physically and functionally in a mouse model of progressive myelodysplasia. Cancer Res 2007; 67:11657-11667. This study describes two in-vivo models of mutant NRas and BCL-2 overexpression in mouse. One model involves a tetracycline regulated transgene expression and a constitutive model in which both NRas and BCL-2 are expressed by the myeloid-specific MRP8 promoter. The results demonstrate the relationship between expression of these proteins and leukemia progression.
    • Omidvar N, Kogan S, Beurlet S, et al. BCL-2 and mutant NRAS interact physically and functionally in a mouse model of progressive myelodysplasia. Cancer Res 2007; 67:11657-11667. This study describes two in-vivo models of mutant NRas and BCL-2 overexpression in mouse. One model involves a tetracycline regulated transgene expression and a constitutive model in which both NRas and BCL-2 are expressed by the myeloid-specific MRP8 promoter. The results demonstrate the relationship between expression of these proteins and leukemia progression.
  • 82
    • 33747873409 scopus 로고    scopus 로고
    • Chromatin structural elements and chromosomal translocations in leukemia
    • Zhang Y, Rowley JD. Chromatin structural elements and chromosomal translocations in leukemia. DNA Repair (Amst) 2006; 5:1282-1297.
    • (2006) DNA Repair (Amst) , vol.5 , pp. 1282-1297
    • Zhang, Y.1    Rowley, J.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.