High-performance liquid-chromatographic-atmospheric-pressure chemical-ionization ion-trap mass-spectrometric identification of isomeric C6-hydroxy and C20-hydroxy metabolites of methylprednisolone in the urine of patients receiving high-dose pulse therapy

Journal of Pharmacy and Pharmacology

Volumn 51, Issue 10, 1999, Pages 1155-1166

  Vree, Tom B ^a   Maljers, Louis ^b   Van Den Borg, Noud ^b   Nibbering, Nico M M ^c   Verwey Van Wissen, Corrien P W G M ^a   Lagerwerf, Aart J ^a   Maes, Robert A A ^d   Jongen, P Jozef H ^e  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b ThermoQuest   (Netherlands)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

^d UTRECHT UNIVERSITY   (Netherlands)

^e Multiple Sclerosis Centre Nijmegen   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID; ACETONITRILE; DRUG METABOLITE; METHYLPREDNISOLONE; METHYLPREDNISOLONE SODIUM SUCCINATE; PRODRUG;

ARTICLE; CLINICAL ARTICLE; DRUG ELIMINATION; DRUG HALF LIFE; DRUG METABOLISM; DRUG URINE LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; ISOMER; MASS SPECTROMETRY; MULTIPLE SCLEROSIS; OXIDATION REDUCTION REACTION; STEREOCHEMISTRY; STEROID THERAPY;

ANTI-INFLAMMATORY AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GLUCURONATES; HUMANS; MASS SPECTROMETRY; METHYLPREDNISOLONE; METHYLPREDNISOLONE HEMISUCCINATE; OXIDATION-REDUCTION; PRODRUGS; STEREOISOMERISM; WATER;

EID: 0032709704     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357991776697     Document Type: Article

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