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Volumn 36, Issue 9, 2008, Pages 852-860

Evaluation of a novel calpain inhibitor as a treatment for cataract

Author keywords

Calpain inhibitor; CAT0059; Cytoskeleton; Inherited cataract

Indexed keywords

CALPAIN 2; CALPASTATIN; CAT 0059; CYSTEINE PROTEINASE; CYTOSKELETON PROTEIN; EYE DROPS; EYE PROTEIN; PROTEINASE INHIBITOR; SJA 6017; UNCLASSIFIED DRUG;

EID: 62149139337     PISSN: 14426404     EISSN: 14429071     Source Type: Journal    
DOI: 10.1111/j.1442-9071.2009.01925.x     Document Type: Article
Times cited : (15)

References (49)
  • 1
    • 33644897573 scopus 로고    scopus 로고
    • Calpain inhibition: A therapeutic strategy targeting multiple disease states
    • Carragher NO. Calpain inhibition: A therapeutic strategy targeting multiple disease states. Curr Pharm Des 2006; 12: 615-38.
    • (2006) Curr Pharm Des , vol.12 , pp. 615-638
    • Carragher, N.O.1
  • 2
    • 0035088540 scopus 로고    scopus 로고
    • Cataract blindness-challenages for the 21st century
    • Brian G, Taylor H. Cataract blindness-challenages for the 21st century. Bull World Health Organ 2001; 79: 249-56.
    • (2001) Bull World Health Organ , vol.79 , pp. 249-256
    • Brian, G.1    Taylor, H.2
  • 3
    • 20344386015 scopus 로고    scopus 로고
    • Calpains and disease
    • Zatz M, Starling A. Calpains and disease. N Engl J Med 2005; 352: 2413-23.
    • (2005) N Engl J Med , vol.352 , pp. 2413-2423
    • Zatz, M.1    Starling, A.2
  • 4
    • 0001253821 scopus 로고
    • Calpain and calpastatin
    • Murachi T. Calpain and calpastatin. Trends Biochem Sci 1983; 8: 167-9.
    • (1983) Trends Biochem Sci , vol.8 , pp. 167-169
    • Murachi, T.1
  • 5
    • 34248165038 scopus 로고    scopus 로고
    • Development of calpain-specific inactivators by screening of positional-scanning epoxide libraries
    • Cuerrier D, Moldoveanu T, Campbell RL et al. Development of calpain-specific inactivators by screening of positional-scanning epoxide libraries. J Biol Chem 2007; 282: 9600-11.
    • (2007) J Biol Chem , vol.282 , pp. 9600-9611
    • Cuerrier, D.1    Moldoveanu, T.2    Campbell, R.L.3
  • 6
    • 0027988820 scopus 로고
    • Calpain inhibition: An overview of its therapeutic potential
    • Wang KKW, Yuen P. Calpain inhibition: An overview of its therapeutic potential. Trends Pharmacol Sci 1994; 15: 412-19.
    • (1994) Trends Pharmacol Sci , vol.15 , pp. 412-419
    • Wang, K.K.W.1    Yuen, P.2
  • 8
    • 0025988513 scopus 로고
    • Calcium-dependent and calcium-independent proteases activities in skeletal muscle during sepsis
    • Bhattacharyya J, Thomas K, Sayeed NM. Calcium-dependent and calcium-independent proteases activities in skeletal muscle during sepsis. Circ Shock 1991; 35: 117-22.
    • (1991) Circ Shock , vol.35 , pp. 117-122
    • Bhattacharyya, J.1    Thomas, K.2    Sayeed, N.M.3
  • 9
    • 0027474051 scopus 로고
    • Widespread activation of calcium dependant neural protease (calpain) in the brain in Alzheimer's disease: A potential molecular basis for neuronal degradation
    • Saido K, Elce JS, Hamos JE, Nixon RA. Widespread activation of calcium dependant neural protease (calpain) in the brain in Alzheimer's disease: a potential molecular basis for neuronal degradation. Proc Natl Acad Sci USA 1993; 90: 2628-32.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 2628-2632
    • Saido, K.1    Elce, J.S.2    Hamos, J.E.3    Nixon, R.A.4
  • 10
    • 0025779333 scopus 로고
    • Cysteine protease inhibitor E64 reduces rate of formation of selenite cataract in the whole animal
    • Azuma M, David LL, Shearer TR. Cysteine protease inhibitor E64 reduces rate of formation of selenite cataract in the whole animal. Curr Eye Res 1991; 10: 657-66.
    • (1991) Curr Eye Res , vol.10 , pp. 657-666
    • Azuma, M.1    David, L.L.2    Shearer, T.R.3
  • 11
    • 0026438813 scopus 로고
    • Superior prevention of calcium ionophore cataract by E64d
    • Azuma M, David LL, Shearer TR. Superior prevention of calcium ionophore cataract by E64d. Biochim Biophys Acta 1992; 1180: 215-20.
    • (1992) Biochim Biophys Acta , vol.1180 , pp. 215-220
    • Azuma, M.1    David, L.L.2    Shearer, T.R.3
  • 12
    • 0030707575 scopus 로고    scopus 로고
    • SJA6017, a newly synthesized peptide aldehyde inhibitor of calpain: Amelioration of cataract in cultured rat lenses
    • Fukiage C, Azuma M, Nakamura Y, Tamada Y, Nakamura M, Shearer TR. SJA6017, a newly synthesized peptide aldehyde inhibitor of calpain: amelioration of cataract in cultured rat lenses. Biochim Biophys Acta 1997; 1361: 304-12.
    • (1997) Biochim Biophys Acta , vol.1361 , pp. 304-312
    • Fukiage, C.1    Azuma, M.2    Nakamura, Y.3    Tamada, Y.4    Nakamura, M.5    Shearer, T.R.6
  • 13
    • 0027225428 scopus 로고
    • Role of calpain in hydrogen peroxide induced cataract
    • Kadoya K, Azuma M, David LL, Shearer TR. Role of calpain in hydrogen peroxide induced cataract. Curr Eye Res 1993; 12: 341-6.
    • (1993) Curr Eye Res , vol.12 , pp. 341-346
    • Kadoya, K.1    Azuma, M.2    David, L.L.3    Shearer, T.R.4
  • 14
    • 0030069596 scopus 로고    scopus 로고
    • Calcium ionophore induced proteolysis and cataract: Inhibition by cell permeable calpain antagonists
    • Sanderson J, Marcantonio JM, Duncan G. Calcium ionophore induced proteolysis and cataract: Inhibition by cell permeable calpain antagonists. Biochem Biophys Res Commun 1996; 218: 893-901.
    • (1996) Biochem Biophys Res Commun , vol.218 , pp. 893-901
    • Sanderson, J.1    Marcantonio, J.M.2    Duncan, G.3
  • 15
    • 0024300135 scopus 로고
    • Synthesis of a new cell penetrating calpain inhibitor (calpeptin)
    • Tsujinaka T, Kajiwara Y, Kambayashi J et al. Synthesis of a new cell penetrating calpain inhibitor (calpeptin). Biochem Biophys Res Commun 1988; 153: 1201-8.
    • (1988) Biochem Biophys Res Commun , vol.153 , pp. 1201-1208
    • Tsujinaka, T.1    Kajiwara, Y.2    Kambayashi, J.3
  • 16
    • 0037468475 scopus 로고    scopus 로고
    • Structure-activity relationship study and drug profile of N-(4-fluorophenylsulfonyl)-L-valyl-L-leucinal (SJA6017) as a potent calpain inhibitor
    • Inoue J, Nakamura M, Cui Y et al. Structure-activity relationship study and drug profile of N-(4-fluorophenylsulfonyl)-L-valyl-L-leucinal (SJA6017) as a potent calpain inhibitor. J Med Chem 2003; 46: 868-71.
    • (2003) J Med Chem , vol.46 , pp. 868-871
    • Inoue, J.1    Nakamura, M.2    Cui, Y.3
  • 21
    • 47349126656 scopus 로고    scopus 로고
    • Synthesis, biological evaluation and molecular modeling of N-heterocyclic dipeptide aldehydes as selective calpain inhibitors
    • Jones M, Abell A, Morton J et al. Synthesis, biological evaluation and molecular modeling of N-heterocyclic dipeptide aldehydes as selective calpain inhibitors. Bioorg Med Chem 2008; 16: 6911-23.
    • (2008) Bioorg Med Chem , vol.16 , pp. 6911-6923
    • Jones, M.1    Abell, A.2    Morton, J.3
  • 22
    • 0034653992 scopus 로고    scopus 로고
    • BODIPY fluorescent microplate assay for measuring activity of calpains and other proteases
    • Thompson VF, Saldaña S, Cong J, Goll DEA. BODIPY fluorescent microplate assay for measuring activity of calpains and other proteases. Anal Biochem 2000; 279: 170-8.
    • (2000) Anal Biochem , vol.279 , pp. 170-178
    • Thompson, V.F.1    Saldaña, S.2    Cong, J.3    Goll, D.E.A.4
  • 23
    • 0021679763 scopus 로고
    • Aqueous humour glucose concentration in cataract patients and its effect on the lens
    • Davies PD, Duncan G, Pynsent PB, Arber DL, Lucas VA. Aqueous humour glucose concentration in cataract patients and its effect on the lens. Exp Eye Res 1984; 39: 605-9.
    • (1984) Exp Eye Res , vol.39 , pp. 605-609
    • Davies, P.D.1    Duncan, G.2    Pynsent, P.B.3    Arber, D.L.4    Lucas, V.A.5
  • 24
    • 0021964787 scopus 로고
    • Factors influencing the penetration of therapeutic substances into the eye following topical application
    • Piercy DWT. Factors influencing the penetration of therapeutic substances into the eye following topical application. Vet Rec 1985; 14: 99-104.
    • (1985) Vet Rec , vol.14 , pp. 99-104
    • Piercy, D.W.T.1
  • 27
    • 0008615614 scopus 로고
    • Calpains and the cytoskeleton
    • In: Mellgren RL, Murachi T, eds. Boca Raton, FL: CRC Press
    • Shoeman RL, Traub P. Calpains and the cytoskeleton. In: Mellgren RL, Murachi T, eds. Intracellular Calcium-Dependent Proteolysis. Boca Raton, FL: CRC Press, 1990; 191-209.
    • (1990) Intracellular Calcium-Dependent Proteolysis , pp. 191-209
    • Shoeman, R.L.1    Traub, P.2
  • 29
    • 62149136213 scopus 로고    scopus 로고
    • Calcium-induced cytoskeletal proteolysis and lens opacification
    • Marcantonio JM, Sanderson J. Calcium-induced cytoskeletal proteolysis and lens opacification. Nova Acta Leopold 1997; 75: 145-452.
    • (1997) Nova Acta Leopold , vol.75 , pp. 145-452
    • Marcantonio, J.M.1    Sanderson, J.2
  • 30
    • 0022852854 scopus 로고
    • Topical ocular drug delivery: Recent developments and future challenages
    • Lee VHL, Robinson JR. Topical ocular drug delivery: Recent developments and future challenages. J Ocul Pharmacol 1986; 2: 76-108.
    • (1986) J Ocul Pharmacol , vol.2 , pp. 76-108
    • Lee, V.H.L.1    Robinson, J.R.2
  • 31
    • 0036343618 scopus 로고    scopus 로고
    • Lens Organelle degradation
    • Bassnett S. Lens Organelle degradation. Exp Eye Res 2002; 74: 1-6.
    • (2002) Exp Eye Res , vol.74 , pp. 1-6
    • Bassnett, S.1
  • 32
    • 0027468977 scopus 로고
    • Sequence analysis of lens beta-crystallins suggests involvement of calpain in cataract formation
    • David L, Shearer T, Shih M. Sequence analysis of lens beta-crystallins suggests involvement of calpain in cataract formation. J Biol Chem 1993; 268: 1937-40.
    • (1993) J Biol Chem , vol.268 , pp. 1937-1940
    • David, L.1    Shearer, T.2    Shih, M.3
  • 35
    • 0029872285 scopus 로고    scopus 로고
    • Calcium-induced disruption of the lens cytoskeleton
    • Marcantonio JM. Calcium-induced disruption of the lens cytoskeleton. Ophthalmic Res 1996; 28: 48-50.
    • (1996) Ophthalmic Res , vol.28 , pp. 48-50
    • Marcantonio, J.M.1
  • 36
    • 0025931128 scopus 로고
    • Calcium-induced degradation of the lens cytoskeleton
    • Marcantonio JM, Duncan G. Calcium-induced degradation of the lens cytoskeleton. Biochem Soc Trans 1991; 19: 1148-50.
    • (1991) Biochem Soc Trans , vol.19 , pp. 1148-1150
    • Marcantonio, J.M.1    Duncan, G.2
  • 37
    • 0037375654 scopus 로고    scopus 로고
    • Exploration of cornea permeable calpain inhibitors as anticataract agents
    • Nakamura M, Yamaguchi M, Sakai O, Inoue J. Exploration of cornea permeable calpain inhibitors as anticataract agents. Bioorg Med Chem 2003; 11: 1371-9.
    • (2003) Bioorg Med Chem , vol.11 , pp. 1371-1379
    • Nakamura, M.1    Yamaguchi, M.2    Sakai, O.3    Inoue, J.4
  • 39
    • 0024492203 scopus 로고
    • Protein composition of human aqueous humor: SDS-PAGE analysis of surgical and post-mortem samples
    • Tripathi RC, Millard CB, Tripathi BJ. Protein composition of human aqueous humor: SDS-PAGE analysis of surgical and post-mortem samples. Exp Eye Res 1989; 48: 117-30.
    • (1989) Exp Eye Res , vol.48 , pp. 117-130
    • Tripathi, R.C.1    Millard, C.B.2    Tripathi, B.J.3
  • 40
    • 0022325722 scopus 로고
    • Review: Corneal penetration and ocular bioavailability of drugs
    • Burstein NL. Review: Corneal penetration and ocular bioavailability of drugs. J Ocul Pharmacol 1985; 1: 309-26.
    • (1985) J Ocul Pharmacol , vol.1 , pp. 309-326
    • Burstein, N.L.1
  • 41
    • 0002831137 scopus 로고
    • Animal pharmacolinetic studies
    • In: Mitra AK, ed. New York: Marcel Dekker
    • Urtti A, Salminen L. Animal pharmacolinetic studies. In: Mitra AK, ed. Opthalmic Drug Delivery Systems. New York: Marcel Dekker, 1993; 121-36.
    • (1993) Opthalmic Drug Delivery Systems , pp. 121-136
    • Urtti, A.1    Salminen, L.2
  • 42
    • 0027499039 scopus 로고
    • A simple three-compartment model of anterior segment kinetics
    • McLaren JW, Ziai N, Brubaker R. A simple three-compartment model of anterior segment kinetics. Exp Eye Res 1993; 56: 355-66.
    • (1993) Exp Eye Res , vol.56 , pp. 355-366
    • McLaren, J.W.1    Ziai, N.2    Brubaker, R.3
  • 43
    • 0027451630 scopus 로고
    • Theoretical corneal permeation model for ionizable drugs
    • Friedrich SW, Cheng YL, Saville BA. Theoretical corneal permeation model for ionizable drugs. J Ocul Pharmacol 1993; 9: 229-49.
    • (1993) J Ocul Pharmacol , vol.9 , pp. 229-249
    • Friedrich, S.W.1    Cheng, Y.L.2    Saville, B.A.3
  • 44
    • 0034045780 scopus 로고    scopus 로고
    • Biopharmaceutical considerations in topical ocular drug delivery
    • Davis NM. Biopharmaceutical considerations in topical ocular drug delivery. Clin Exp Pharmacol P 2000; 27: 558-62.
    • (2000) Clin Exp Pharmacol P , vol.27 , pp. 558-562
    • Davis, N.M.1
  • 45
    • 0035953319 scopus 로고    scopus 로고
    • Property-based design: Optimization of drug absorption and pharmacokinetics
    • van De Waterbeemd H, Smith DA, Beaumont K, Walker DK. Property-based design: Optimization of drug absorption and pharmacokinetics. J Med Chem 2001; 44: 1313.
    • (2001) J Med Chem , vol.44 , pp. 1313
    • van De Waterbeemd, H.1    Smith, D.A.2    Beaumont, K.3    Walker, D.K.4
  • 46
    • 33746495537 scopus 로고    scopus 로고
    • Comparison of age-specific cataract prevalence in two population-based surveys 6years apart
    • Doi: 10.1186/1471-2415-6-17
    • Tan AG, Wang JJ, Rochtchina E, Mitchell P. Comparison of age-specific cataract prevalence in two population-based surveys 6years apart. Biomed Cent Ophthalmol 2006; 6: 17. Doi: 10.1186/1471-2415-6-17.
    • (2006) Biomed Cent Ophthalmol , vol.6 , pp. 17
    • Tan, A.G.1    Wang, J.J.2    Rochtchina, E.3    Mitchell, P.4
  • 47
    • 0028694904 scopus 로고
    • A population-based estimate of cataract prevalence: The Melbourne Visual Impairment Project experience
    • Livingston P, Guest C, Stanislavsky Y et al. A population-based estimate of cataract prevalence: The Melbourne Visual Impairment Project experience. Dev Ophthalmol 1994; 26: 1-6.
    • (1994) Dev Ophthalmol , vol.26 , pp. 1-6
    • Livingston, P.1    Guest, C.2    Stanislavsky, Y.3
  • 48
    • 0016743458 scopus 로고
    • Ion analyses of human cataractous lenses
    • Duncan G, Bushell AR. Ion analyses of human cataractous lenses. Exp Eye Res 1975; 20: 223-30.
    • (1975) Exp Eye Res , vol.20 , pp. 223-230
    • Duncan, G.1    Bushell, A.R.2
  • 49
    • 0033458940 scopus 로고    scopus 로고
    • The decrease of visual acuity in cataract patients waiting for surgery
    • Leinonen J, Laatikainen L. The decrease of visual acuity in cataract patients waiting for surgery. Acta Ophthalmol Scand 1999; 77: 681-4.
    • (1999) Acta Ophthalmol Scand , vol.77 , pp. 681-684
    • Leinonen, J.1    Laatikainen, L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.